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Cited by 19Axon Guidance and Neuronal SignalingNeurotransmitter Receptor Influence on BehaviorNeurogenesis and neuroplasticity mechanisms

Ephrin-A5 deficiency alters sensorimotor and monoaminergic development

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Sheleg, Michal, Yochum, Carrie L., Wagner, George C., Zhou, Renping, Richardson, Jason R.·2013·Behavioural Brain Research
DOI 10.1016/j.bbr.2012.08.032PMC PMC3482281
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Abstract

The Eph receptors and their ligands, the ephrins, play an important role during neural development. In particular, ephrin-A5 is highly expressed in the developing nervous system in several brain regions including the olfactory bulb, frontal cortex, striatum and hypothalamus. Although a number of studies have characterized the expression of ephrin-A5 in these regions, very little is known about the functional consequences that might follow alterations in the expression of this ligand. Previously, we demonstrated that ephrin-A5 acts as a guidance molecule regulating the trajectory of the ascending midbrain dopaminergic pathways. In light of this finding and the critical role of dopamine in modulating a number of behaviors, we sought to determine whether loss of ephrin-A5 altered neurobehavioral development. Our results indicate that ephrin-A5-null mice exhibit delays in reaching developmental milestones and in the maturation of motor skills. In addition, they exhibit increased locomotor activity and reduced levels of brain monoamines. Therefore, we conclude that ephrin-A5 expression appears to be critical for proper development of central monoaminergic pathways and that its loss results in a number of neurodevelopmental abnormalities. Because alterations in monoamine function are associated with a variety of neurodevelopmental disorders, these data suggest that further study on the potential role of ephrin-A5 in such disorders is warranted.

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  • Ephrin family members have a role in ADHD-related synaptogenesis alterations.

    “Moreover, it has been suggested that ephrin family members have a role in ADHD-related synaptogenesis alterations [92, 130].”

    From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [130]

    The Discussion (page unavailable) suggests that loss of ephrin-A5 may contribute to ADHD-like behavioral phenotypes through neurodevelopmental alterations, citing its role in neurite outgrowth and axon targeting. It does not specifically identify ADHD-related alterations in synaptogenesis; that part of the claim is unsupported by our copy. (LLM, conf=0.84)

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Research works printed but not linked: 42

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Authors
Sheleg, M., Yochum, C. L., Wagner, G. C., Zhou, R., & Richardson, J. R.
Affiliations
Rutgers, The State University of New Jersey (US)
Corresponding author
  • Zhou, Renping
  • Richardson, Jason R.
ORCID
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2013-01
Volume
236
Issue
1
Pages
139-147
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/j.bbr.2012.08.032
PMC
PMC3482281
OpenAlex
W2079834554
Cited by
19
References
2
Citations by year
2025: 1 · 2024: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 5 · 2014: 5
FWCI
1.32
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIH (R01ES015991, P30ES005022, T32ES007148, 2P01HD023315)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
ephrin-A5, Eph receptors, ephrin signaling, sensorimotor development, dopamine, brain monoamines, locomotor activity, neurodevelopmental disorders
MeSH terms
Aging, Animals, Axons, Behavior, Animal, Body Weight, Brain Chemistry, Chromatography, High Pressure Liquid, Postural Balance, Eye, Genotype, Interpersonal Relations, Mice, Inbred C57BL, Motor Neurons, Nervous System, Play and Playthings, Sensory Receptor Cells, Blotting, Western, Biogenic Monoamines, Neostriatum, Mice, Knockout, Hand Strength, Ephrin-A5, Dopamine Plasma Membrane Transport Proteins, Vesicular Monoamine Transport Proteins, Mice, Real-Time Polymerase Chain Reaction

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