The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The effects on health span indices such as time on rotarod, distance on treadmill, open field tests, cataract index, oral glucose tolerance tests, insulin tolerance, and cognitive function (Allard et al., 2016) were improved by ~30%.”
From Metformin as a tool to target aging (2016) · cites this paper as Allard et al., 2016
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Metformin improves healthspan and lifespan in mice
Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3192 · Cited by 1,445
Self-citationBDNF and synaptic plasticity, cognitive function, and dysfunction
Lu, B., Nagappan, G., & Lu, Y. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-45106-5_9 · Cited by 1,043
Accumulation of Metformin by Tissues of the Normal and Diabetic Mouse
Wilcock, C., & Bailey, C. J. (1994) · Xenobiotica · doi:10.3109/00498259409043220 · Cited by 418
Stephenne, X., Foretz, M., Taleux, N., van der Zon, G. C., Sokal, E., Hue, L., Viollet, B., & Guigas, B. (2011) · Diabetologia · doi:10.1007/s00125-011-2311-5 · Cited by 287
Anisimov, V. N., Berstein, L. M., Popovich, I. G., Zabezhinski, M. A., Egormin, P. A., Piskunova, T. S., Semenchenko, A. V., Tyndyk, M. L., Yurova, M. N., Kovalenko, I. G., et al. (2011) · Aging · doi:10.18632/aging.100273 · Cited by 285
Effects of metformin on weight loss: potential mechanisms
Malin, S. K., & Kashyap, S. R. (2014) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000095 · Cited by 223
Beeri, M. S., Schmeidler, J., Silverman, J. M., Gandy, S., Wysocki, M., Hannigan, C. M., Purohit, D. P., Lesser, G., Grossman, H. T., & Haroutunian, V. (2008) · Neurology · doi:10.1212/01.wnl.0000324925.95210.6d · Cited by 157
Kristensen, J. M., Larsen, S., Helge, J. W., Dela, F., & Wojtaszewski, J. F. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053533 · Cited by 48
Research works printed but not linked: 54
- Whiting, 2011, IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030, Diabetes Res. Clin. Pract., 94, 311, 10.1016/j.diabres.2011.10.029 · DOI
- Moses, 2010, Repaglinide/metformin fixed-dose combination to improve glycemic control in patients with type 2 diabetes: an update, Diabetes Metab. Syndr. Obes., 3, 145, 10.2147/DMSO.S6621 · DOI
- Mooradian, 1988, Cortical function in elderly non-insulin dependent diabetic patients. Behavioral and electrophysiologic studies, Arch. Intern. Med., 148, 2369, 10.1001/archinte.1988.00380110035007 · DOI
- Perlmuter, 1984, Decreased cognitive function in aging non-insulin-dependent diabetic patients, Am. J. Med., 77, 1043, 10.1016/0002-9343(84)90186-4 · DOI
- Hassenstab, 2010, Metabolic syndrome is associated with learning and recall impairment in middle age, Dement. Geriatr. Cogn. Disord., 29, 356, 10.1159/000296071 · DOI
- Akter, 2011, Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?, Br. J. Clin. Pharmacol., 71, 365, 10.1111/j.1365-2125.2010.03830.x · DOI · Paper page
- Strachan, 2010, The brain as a target organ in Type 2 diabetes: exploring the links with cognitive impairment and dementia, Diabet. Med., 28, 141, 10.1111/j.1464-5491.2010.03199.x · DOI
- Xu, 2009, Uncontrolled diabetes increases the risk of Alzheimer's disease: a population-based cohort study, Diabetologia, 52, 1031, 10.1007/s00125-009-1323-x · DOI · Paper page
- Ryan, 2006, Improving metabolic control leads to better working memory in adults with type 2 diabetes, Diabetes Care, 29, 345, 10.2337/diacare.29.02.06.dc05-1626 · DOI
- Zhou, 2001, Role of AMP-activated protein kinase in mechanism of metformin action, J. Clin. Investig., 108, 1167, 10.1172/JCI13505 · DOI · Paper page
- Bailey, 1995, Metformin and intestinal glucose handling, Diabetes. Metab. Rev., 11, S23, 10.1002/dmr.5610110505 · DOI
- Ikeda, 2000, Inhibitory effect of metformin on intestinal glucose absorption in the perfused rat intestine, Biochem. Pharmacol., 59, 887, 10.1016/S0006-2952(99)00396-2 · DOI
- Hettich, 2014, The anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complex, PloS One, 9, e102420, 10.1371/journal.pone.0102420 · DOI · Paper page
- Wang, 2012, Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation, Cell Stem Cell, 11, 23, 10.1016/j.stem.2012.03.016 · DOI · Paper page
- Imfeld, 2012, Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control study, J. Am. Geriatr. Soc., 60, 916, 10.1111/j.1532-5415.2012.03916.x · DOI
- Chen, 2009, Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription, Proc. Natl. Acad. Sci. U. S. A., 106, 3907, 10.1073/pnas.0807991106 · DOI · Paper page
- Palomba, 2014, Metformin and gonadotropins for ovulation induction in patients with polycystic ovary syndrome: a systematic review with meta-analysis of randomized controlled trials, Reprod. Biol. Endocrinol., 12, 3, 10.1186/1477-7827-12-3 · DOI
- Pernicova, 2014, Metformin?mode of action and clinical implications for diabetes and cancer, Nat. Rev. Endocrinol., 10, 143, 10.1038/nrendo.2013.256 · DOI
- Rosilio, 2014, Metformin: a metabolic disruptor and anti-diabetic drug to target human leukemia, Cancer Lett., 346, 188, 10.1016/j.canlet.2014.01.006 · DOI
- Beckmann, 1969, Absorption, distribution in the organism and elimination of metformin, Diabetologia, 5, 318, 10.1007/BF00452906 · DOI
- Lv, 2012, The effect of metformin on food intake and its potential role in hypothalamic regulation in obese diabetic rats, Brain Res., 1444, 11, 10.1016/j.brainres.2012.01.028 · DOI
- Labuzek, 2010, Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide, Pharmacol. Rep., 62, 956, 10.1016/S1734-1140(10)70357-1 · DOI
- Ashabi, 2014, Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: interference of AMPK/PGC-1alpha pathway, Metab. Brain Dis., 29, 47, 10.1007/s11011-013-9475-2 · DOI
- Jin, 2014, Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke, Brain Behav. Immun., 40, 131, 10.1016/j.bbi.2014.03.003 · DOI
- Patil, 2014, Neuroprotective effect of metformin in MPTP-induced Parkinson's disease in mice, Neuroscience, 277, 747, 10.1016/j.neuroscience.2014.07.046 · DOI
- Zhu, 2015, Chronic metformin preconditioning provides neuroprotection via suppression of nf-κb-mediated inflammatory pathway in rats with permanent cerebral ischemia, Mol. Neurobiol., 52, 375, 10.1007/s12035-014-8866-7 · DOI
- Aghili, 2014, Body composition in adults with newly diagnosed type 2 diabetes: effects of metformin, J. Diabetes Metab. Disord., 13, 88, 10.1186/s40200-014-0088-z · DOI
- Aubert, 2011, The anorexigenic effects of metformin involve increases in hypothalamic leptin receptor expression, Metabolism, 60, 327, 10.1016/j.metabol.2010.02.007 · DOI
- Duan, 2013, Metformin inhibits food intake and neuropeptide Y gene expression in the hypothalamus, Neural Regen. Res., 8, 2379
- Kim, 2013, Central administration of metformin into the third ventricle of C57BL/6 mice decreases meal size and number and activates hypothalamic S6 kinase, Am. J. Physiol. Regul. Integr. Comp. Physiol., 305, R499, 10.1152/ajpregu.00099.2013 · DOI
- Lee, 2012, Intracerebroventricular injection of metformin induces anorexia in rats, Diabetes Metab. J., 36, 293, 10.4093/dmj.2012.36.4.293 · DOI
- Collier, 2006, Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle, Am. J. Physiol. Endocrinol. Metab., 291, E182, 10.1152/ajpendo.00272.2005 · DOI
- Wang, 2014, Metformin suppresses lipid accumulation in skeletal muscle by promoting fatty acid oxidation, Clin. Lab., 60, 887, 10.7754/Clin.Lab.2013.130531 · DOI
- Ratzmann, 1979, Relationship between body fat mass, carbohydrate tolerance and IRI response during glucose infusion in subjects with early diabetes, Acta Diabetol. Lat., 16, 67, 10.1007/BF02590765 · DOI
- Kwankaew, 2014, Lean mass inversely predicts plasma glucose levels after oral glucose load independent of insulin secretion or insulin sensitivity in glucose intolerance subjects, Endocr. J., 61, 77, 10.1507/endocrj.EJ13-0241 · DOI
- Kahn, 2001, Obesity, body fat distribution, insulin sensitivity and Islet beta-cell function as explanations for metabolic diversity, J. Nutr., 131, 354S, 10.1093/jn/131.2.354S · DOI
- Rebuffe-Scrive, 1993, Regional fat distribution and metabolism in a new mouse model (C57BL/6J) of non-insulin-dependent diabetes mellitus, Metab. Clin. Exp., 42, 1405, 10.1016/0026-0495(93)90190-Y · DOI
- Kane, 2010, Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats, Free Radic. Biol. Med., 49, 1082, 10.1016/j.freeradbiomed.2010.06.022 · DOI · Paper page
- Andrzejewski, 2014, Metformin directly acts on mitochondria to alter cellular bioenergetics, Cancer Metab., 2, 12, 10.1186/2049-3002-2-12 · DOI
- Wessels, 2014, Metformin impairs mitochondrial function in skeletal muscle of both lean and diabetic rats in a dose-dependent manner, PloS One, 9, e100525, 10.1371/journal.pone.0100525 · DOI
- Alzoubi, 2014, Metformin Eased Cognitive Impairment Induced by Chronic l-methionine Administration: Potential Role of Oxidative Stress, Curr. Neuropharmacol., 12, 186, 10.2174/1570159X11666131120223201 · DOI
- Zhao, 2014, Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice, Biochem. Biophys. Res. Commun., 448, 414, 10.1016/j.bbrc.2014.04.130 · DOI
- Moore, 2013, Increased risk of cognitive impairment in patients with diabetes is associated with metformin, Diabetes Care, 36, 2981, 10.2337/dc13-0229 · DOI · Paper page
- DiTacchio, 2015, Metformin treatment alters memory function in a mouse model of Alzheimer's disease, J. Alzheimer's Dis., 44, 43, 10.3233/JAD-141332 · DOI
- Berry, 2012, Social deprivation stress is a triggering factor for the emergence of anxiety- and depression-like behaviours and leads to reduced brain BDNF levels in C57BL/6 J mice, Psychoneuroendocrinology, 37, 762, 10.1016/j.psyneuen.2011.09.007 · DOI
- Bothwell, 2014, NGF, BDNF, NT3, and NT4, Handb. Exp. Pharmacol., 220, 3, 10.1007/978-3-642-45106-5_1 · DOI
- Maier, 2009, Correlation of mRNA and protein in complex biological samples, FEBS Lett., 583, 3966, 10.1016/j.febslet.2009.10.036 · DOI · Paper page
- Srividhya, 2002, Metformin improves liver antioxidant potential in rats fed a high-fructose diet, Asia Pac. J. Clin. Nutr., 11, 319, 10.1046/j.1440-6047.2002.00306.x · DOI
- Esteghamati, 2013, Effects of metformin on markers of oxidative stress and antioxidant reserve in patients with newly diagnosed type 2 diabetes: a randomized clinical trial, Clin. Nutr., 32, 179, 10.1016/j.clnu.2012.08.006 · DOI
- Formoso, 2008, Decreased in vivo oxidative stress and decreased platelet activation following metformin treatment in newly diagnosed type 2 diabetic subjects, Diabetes Metab. Res. Rev., 24, 231, 10.1002/dmrr.794 · DOI
- Huang, 2002, Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription, J. Biol. Chem., 277, 42769, 10.1074/jbc.M206911200 · DOI
- Lewis, 2015, Regulation of Nrf2 signaling and longevity in naturally long-lived rodents, Proc. Natl. Acad. Sci. U. S. A., 112, 3722, 10.1073/pnas.1417566112 · DOI
- Picone, 2015, Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: use of insulin to attenuate metformin’s effect, Biochim. Biophys. Acta., 1853, 1046, 10.1016/j.bbamcr.2015.01.017 · DOI
- McNeilly, 2012, A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin, Diabetologia, 55, 3061, 10.1007/s00125-012-2686-y · DOI
Cited by
Sorted by citations
Metformin as a tool to target aging
Barzilai, N., Crandall, J. P., Kritchevsky, S. B., & Espeland, M. A. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.011 · Cited by 1,096
Justice, J. N., Ferrucci, L., Newman, A. B., Aroda, V. R., Bahnson, J. L., Divers, J., Espeland, M. A., Marcovina, S., Pollak, M. N., Kritchevsky, S. B., et al. (2018) · GeroScience · doi:10.1007/s11357-018-0042-y · Cited by 359
The road ahead for health and lifespan interventions
Gonzalez-Freire, M., Diaz-Ruiz, A., Hauser, D., Martinez-Romero, J., Ferrucci, L., Bernier, M., & de Cabo, R. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101037 · Cited by 118
Development of clinical trials to extend healthy lifespan
Justice, J. N., Niedernhofer, L., Robbins, P. D., Aroda, V. R., Espeland, M. A., Kritchevsky, S. B., Kuchel, G. A., & Barzilai, N. (2018) · Cardiovascular Endocrinology & Metabolism · doi:10.1097/xce.0000000000000159 · Cited by 84
Śmieszek, A., Stręk, Z., Kornicka, K., Grzesiak, J., Weiss, C., & Marycz, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040872 · Cited by 77
Metadata
- Authors
- Allard, J. S., Perez, E. J., Fukui, K., Carpenter, P., Ingram, D. K., & Cabo, R. D.
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 301
- Pages
- 1-9
- ISSN
- 0166-4328
- PMC
- PMC4823003
- Cited by
- 88
- References
- 8
- Language
- en
- Funders
- National Institute on Aging
- National Institutes of Health (1R25AG047843-01)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice. https://app.cochat.ai/papers/10.1016/j.bbr.2015.12.012
- The paper
- Allard, J. S., Perez, E. J., Fukui, K., Carpenter, P., Ingram, D. K., & Cabo, R. D. (2016). Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice. Behavioural Brain Research. https://doi.org/10.1016/j.bbr.2015.12.012