Interaction between hippocampal serotonin and cannabinoid systems in reactivity to spatial and object novelty detection
Open accessAbstract
Functional interaction between cannabinoid and serotonin neuronal systems have been reported in different tasks related to memory assessment. The present study investigated the effect of serotonin 5-HT4 agents into the dorsal hippocampus (the CA1 region) on spatial and object novelty detection deficits induced by activation of cannabinoid CB1 receptors (CB1Rs) using arachidonylcyclopropylamide (ACPA) in a non-associative behavioral task designed to forecast the ability of rodents to encode spatial and non-spatial relationships between distinct stimuli. Post-training, intra-CA1 microinjection of 5-HT4 receptor agonist RS67333 or 5-HT4 receptor antagonist RS23597 both at the dose of 0.016μg/mouse impaired spatial memory, while cannabinoid CB1R antagonist AM251 (0.1μg/mouse) facilitated object novelty memory. Also, post-training, intraperitoneal administration of CB1R agonist ACPA (0.005-0.05mg/kg) impaired both memories. However, a subthreshold dose of RS67333 restored ACPA response on both memories. Moreover, a subthreshold dose of RS23597 potentiated ACPA (0.01mg/kg) and reversed ACPA (0.05mg/kg) responses on spatial memory, while it potentiated ACPA response at the dose of 0.005 or 0.05mg/kg on object novelty memory. Furthermore, effective dose of AM251 restored ACPA response at the higher dose. AM251 blocked response induced by combination of RS67333 or RS23597 and the higher dose of ACPA on both memories. Our results highlight that hippocampal 5-HT4 receptors differently affect cannabinoid signaling in spatial and object novelty memories. The inactivation of CB1 receptors blocks the effect of 5-HT4 agents into the CA1 region on memory deficits induced by activation of CB1Rs via ACPA.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Post-sample infusions of RS67333, a 5-HT4-R agonist, or RS23597, a 5-HT4-R antagonist, into the dorsal CA1 area impaired spatial recognition tested by the SNOP paradigm.
“Post-sample infusions of RS67333, a 5-HT4-R agonist, or RS23597, a 5-HT4-R antagonist, into the dorsal CA1 area impaired spatial recognition tested by the SNOP paradigm”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Nasehi et al., 2017
Microinjections of the cannabinoid 1-R antagonist AM251 into the CA1 region facilitated object novelty tested by the SNOP paradigm.
“Microinjections of the cannabinoid 1-R antagonist AM251 into the CA1 region facilitated object novelty tested by the SNOP paradigm”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Nasehi et al., 2017
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
A review of central 5-HT receptors and their function
Barnes, N. M., & Sharp, T. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00010-6 · Cited by 3,150 · see citing works
Molecular, pharmacological and functional diversity of 5-HT receptors
Hoyer, D., Hannon, J. P., & Martin, G. R. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00746-8 · Cited by 1,869 · see citing works
Shen, M., Piser, T. M., Seybold, V. S., & Thayer, S. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-14-04322.1996 · Cited by 605 · see citing works
Examining Object Location and Object Recognition Memory in Mice
Ciernia, A. V., & Wood, M. A. (2014) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0831s69 · Cited by 426 · see citing works
Yoshida, T., Fukaya, M., Uchigashima, M., Miura, E., Kamiya, H., Kano, M., & Watanabe, M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0054-06.2006 · Cited by 327 · see citing works
Deadwyler, S. A., Hampson, R. E., Mu, J., Whyte, A., & Childers, S. R. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)09495-9 · Cited by 241 · see citing works
Eglen, R. M. (1995) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)89081-1 · Cited by 241 · see citing works
Effects of endocannabinoid system modulation on cognitive and emotional behavior
Zanettini, C. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00057 · Cited by 214 · see citing works
Δ9-Tetrahydrocannabinol impairs spatial memory through a cannabinoid receptor mechanism
Lichtman, A. H., & Martin, B. R. (1996) · Psychopharmacology · doi:10.1007/bf02246347 · Cited by 213 · see citing works
Andrade, R., & Chaput, Y. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24797-8 · Cited by 163 · see citing works
Vilaró, M. T., Cortés, R., & Mengod, G. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20447 · Cited by 142 · see citing works
Lamirault, L., & Simon, H. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00123-x · Cited by 128 · see citing works
5-HT 4 Receptors Improve Social Olfactory Memory in the Rat
Letty, S., CHILD, R., Dumuis, A., Pantaloni, A., Bockaert, J., & Rondouin, G. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(96)00169-4 · Cited by 123 · see citing works
Pindon, A., Hecke, G. V., Gompel, P. V., et al. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.1.85 · Cited by 119 · see citing works
Basavarajappa, B. S., Ninan, I., & Arancio, O. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05685.x · Cited by 106 · see citing works
Subbanna, S., Shivakumar, M., Psychoyos, D., Xie, S., & Basavarajappa, B. S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3786-12.2013 · Cited by 102 · see citing works
Akirav, I. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00034 · Cited by 100 · see citing works
Hagena, H., & Manahan‐Vaughan, D. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.06.014 · Cited by 97 · see citing works
Barthet, G., Framery, B., Gaven, F., Pellissier, L. P., Reiter, É., Claeysen, S., Bockaert, J., & Dumuis, A. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-12-1080 · Cited by 88 · see citing works
Egashira, N., Mishima, K., Katsurabayashi, S., Yoshitake, T., Matsumoto, Y., Ishida, J., Yamaguchi, M., Iwasaki, K., & Fujiwara, M. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01755-7 · Cited by 80 · see citing works
G Protein Activation by Serotonin Type 4 Receptor Dimers
Pellissier, L. P., Barthet, G., Gaven, F., Cassier, E., Trinquet, E., Pin, J., Marin, P., Dumuis, A., Bockaert, J., Banères, J., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.201939 · Cited by 80 · see citing works
Terry, A. V., Buccafusco, J. J., Jackson, W. J., Prendergast, M., Fontana, D. J., Wong, E. H. F., Bonhaus, D. W., Weller, P. E., & Eglen, R. M. (1998) · Psychopharmacology · doi:10.1007/s002130050529 · Cited by 78 · see citing works
Role of 5-HT4 Receptors in the Mouse Passive Avoidance Test
Galeotti, N., Ghelardini, C., & Bartolini, A. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37700-6 · Cited by 74 · see citing works
Kobayashi, K., Ikeda, Y., Haneda, E., & Suzuki, H. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1656-08.2008 · Cited by 71 · see citing works
A role for the endocannabinoid system in exercise-induced spatial memory enhancement in mice
Ferreira-Vieira, T. H., Bastos, C. P., Pereira, G. S., Moreira, F. A., & Massensini, A. R. (2013) · Hippocampus · doi:10.1002/hipo.22206 · Cited by 69 · see citing works
Maejima, T., Masseck, O. A., Mark, M. D., & Herlitze, S. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00040 · Cited by 62 · see citing works
Modifications of 5-HT4 receptor expression in rat brain during memory consolidation
Manuel‐Apolinar, L., Rocha, L., Pascoe, D., Castillo, E. F., Castillo, C., & Meneses, A. (2005) · Brain Research · doi:10.1016/j.brainres.2005.02.020 · Cited by 56 · see citing works
Mishima, K., Egashira, N., Matsumoto, Y., Iwasaki, K., & Fujiwara, M. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02274-9 · Cited by 52 · see citing works
Cannabinoid CB1Receptor-Dependent Long-Term Depression in Autaptic Excitatory Neurons
Kellogg, R. T., Mackie, K., & Straiker, A. J. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00266.2009 · Cited by 49 · see citing works
Levallet, G., Hotte, M., Boulouard, M., & Dauphin, F. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1283-8 · Cited by 41 · see citing works
Yousefi, B., Farjad, M., Nasehi, M., & Zarrindast, M. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.12.001 · Cited by 36 · see citing works
Self-citationGalanopoulos, A., Polissidis, A., Γεωργιάδου, Γ., Papadopoulou‐Daifoti, Z., Nomikos, G. G., Pitsikas, N., & Antoniou, K. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.05.014 · Cited by 28 · see citing works
Nasehi, M., Kafi, F., Khakpai, F., et al. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.03.011 · Cited by 19 · see citing works
Self-citationKhanegheini, A., Nasehi, M., & Zarrindast, M.-R. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.07.083 · Cited by 18 · see citing works
Self-citationInterplay between serotonin and cannabinoid function in the amygdala in fear conditioning
Nasehi, M., Davoudi, K., Ebrahimi-Ghiri, M., & Zarrindast, M. (2016) · Brain Research · doi:10.1016/j.brainres.2016.01.034 · Cited by 17 · see citing works
Self-citationModulation of cannabinoid signaling by hippocampal 5-HT4 serotonergic system in fear conditioning
Nasehi, M., Farrahizadeh, M., Ebrahimi-Ghiri, M., & Zarrindast, M. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116652584 · Cited by 17 · see citing works
Self-citationKhodayar, E., Oryan, S., Nasehi, M., & Zarrindast, M. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000174 · Cited by 13 · see citing works
Self-citationNasehi, M., Mafi, F., Ebrahimi-Ghiri, M., & Zarrindast, M. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.07.011 · Cited by 13 · see citing works
Self-citationMohammadi, M., Nasehi, M., & Zarrindast, M. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.11.003 · Cited by 12 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
- Authors
- Nasehi, M., Rostam-Nezhad, E., Ebrahimi-Ghiri, M., & Zarrindast, M.-R.
- Affiliations
- Islamic Azad University, Tehran (IR)
- University of Zanjan (IR)
- Corresponding author
- Nasehi, Mohammad
- Zarrindast, Mohammad-Reza
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 317
- Pages
- 272-278
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2527611595
- Cited by
- 10
- References
- 40
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Behavioural Brain Research (acceptedVersion)
- PubMed (publishedVersion)
- Funders
- Iran National Science Foundation
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampal serotonin, CB1 receptor, 5-HT4 receptor, spatial memory, AM251, non-associative learning, memory impairment, drug interactions
- MeSH terms
- Analysis of Variance, Aniline Compounds, Animals, Arachidonic Acids, Cannabinoids, Dose-Response Relationship, Drug, Hippocampus, Locomotion, Male, Piperidines, Pyrazoles, Serotonin, Signal Detection, Psychological, Serotonin Agents, Recognition, Psychology, Receptor, Cannabinoid, CB1, Mice, Spatial Learning
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
