Effects of endocannabinoid system modulation on cognitive and emotional behavior

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.

Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292 · see citing works

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.

Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.2.274 · Cited by 3,262 · see citing works

Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study

Herkenham, M., Lynn, A., Johnson, M., Melvin, L., de Costa, B., & Rice, K. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-02-00563.1991 · Cited by 2,159 · see citing works

The endogenous cannabinoid system controls extinction of aversive memories

Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728 · see citing works

Neural Mechanisms of Extinction Learning and Retrieval

Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645 · see citing works

Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses

Wilson, R. I., & Nicoll, R. A. (2001) · Nature · doi:10.1038/35069076 · Cited by 1,607 · see citing works

Modulation of anxiety through blockade of anandamide hydrolysis

Kathuria, S., Gaetani, S., Fegley, D., Valiño, F., Duranti, A., Tontini, A., Mor, M., Tarzia, G., Rana, G. L., Calignano, A., et al. (2003) · Nature Medicine · doi:10.1038/nm803 · Cited by 1,293 · see citing works

Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons

Katona, I., Sperlágh, B., Sı́k, A., Käfalvi, A., Vizi, E. S., Mackie, K., & Freund, T. F. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04544.1999 · Cited by 1,218 · see citing works

CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity

Marsicano, G., Goodenough, S., Monory, K., Hermann, H., Eder, M., Cannich, A., Azad, S. C., Cascio, M. G., Gutiérrez, S. O., van der Stelt, M., et al. (2003) · Science · doi:10.1126/science.1088208 · Cited by 1,208 · see citing works

Memory Reconsolidation and Extinction Have Distinct Temporal and Biochemical Signatures

Suzuki, A., Josselyn, S. A., Frankland, P. W., Masushige, S., Silva, A. J., & Kida, S. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5491-03.2004 · Cited by 1,127 · see citing works

The neurobiology and control of anxious states

Millan, M. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00087-x · Cited by 963 · see citing works

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

Long, J. Z., Li, W., Booker, L., Burston, J. J., Kinsey, S. G., Schlosburg, J. E., Pavón, F. J., Serrano, A., Selley, D. E., Parsons, L. H., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.129 · Cited by 938 · see citing works

Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol

Kirkham, T. C., Williams, C. M., Fezza, F., & Marzo, V. D. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704767 · Cited by 788 · see citing works

An endocannabinoid mechanism for stress-induced analgesia

Hohmann, A. G., Suplita, R. L., Bolton, N. M., Neely, M. H., Fegley, D., Mangieri, R., Krey, J. F., Michael Walker, J., Holmes, P. V., Crystal, J. D., et al. (2005) · Nature · doi:10.1038/nature03658 · Cited by 778 · see citing works

Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis

Gobbi, G., Bambico, F. R., Mangieri, R. A., Bortolato, M., Campolongo, P., Solinas, M., Cassano, T., Morgese, M. G., Debonnel, G., Duranti, A., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509591102 · Cited by 676 · see citing works

Distribution of CB1 cannabinoid receptors in the amygdala and their role in the control of GABAergic transmission

Katona, I., Rancz, E. A., Acsády, L., Ledent, C., Mackie, K., Hájos, N., & Freund, T. F. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09506.2001 · Cited by 668 · see citing works

Endocannabinoid signaling as a synaptic circuit breaker in neurological disease

Katona, I., & Freund, T. F. (2008) · Nature Medicine · doi:10.1038/nm.f.1869 · Cited by 579 · see citing works

The acute effects of cannabinoids on memory in humans: a review

Ranganathan, M., & D’Souza, D. C. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0508-y · Cited by 517 · see citing works

Involvement of CB1 cannabinoid receptors in emotional behaviour

Martín, M., Ledent, C. A., Parmentier, M., Maldonado, R. J., & Valverde, O. (2002) · Psychopharmacology · doi:10.1007/s00213-001-0946-5 · Cited by 507 · see citing works

The CB1 Cannabinoid Receptor Is the Major Cannabinoid Receptor at Excitatory Presynaptic Sites in the Hippocampus and Cerebellum

Kawamura, Y., Fukaya, M., Maejima, T., Yoshida, T., Miura, E., Watanabe, M., Ohno‐Shosaku, T., & Kano, M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4872-05.2006 · Cited by 489 · see citing works

Pain modulation by release of the endogenous cannabinoid anandamide

Walker, J. M., Huang, S. M., Strangman, N. M., Tsou, K., & Sañudo-Peña, M. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12198 · Cited by 486 · see citing works

Pharmacological Profile of the Selective FAAH Inhibitor KDS-4103 (URB597)

Piomelli, D., Tarzia, G., Duranti, A., Tontini, A., Mor, M., Compton, T. R., Dasse, O. A., Monaghan, E. P., Parrott, J. A., & Putman, D. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2006.00021.x · Cited by 445 · see citing works

CB1 Cannabinoid Receptor Inhibits Synaptic Release of Glutamate in Rat Dorsolateral Striatum

Gerdeman, G. L., & Lovinger, D. M. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.1.468 · Cited by 436 · see citing works

Characterization of the Fatty Acid Amide Hydrolase Inhibitor Cyclohexyl Carbamic Acid 3′-Carbamoyl-biphenyl-3-yl Ester (URB597): Effects on Anandamide and Oleoylethanolamide Deactivation

Fegley, D., Gaetani, S., Duranti, A., Tontini, A., Mor, M., Tarzia, G., & Piomelli, D. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.078980 · Cited by 427 · see citing works

Production and Release of Neuroprotective Tumor Necrosis Factor by P2X₇Receptor-Activated Microglia

Suzuki, T., Hide, I., Ido, K., Kohsaka, S., Inoue, K., & Nakata, Y. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3792-03.2004 · Cited by 394 · see citing works

Pharmacological Evaluation of Cannabinoid Receptor Ligands in a Mouse Model of Anxiety: Further Evidence for an Anxiolytic Role for Endogenous Cannabinoid Signaling

Patel, S., & Hillard, C. J. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.101287 · Cited by 390 · see citing works

Levels, Metabolism, and Pharmacological Activity of Anandamide in CB1 Cannabinoid Receptor Knockout Mice

Marzo, V. D., Breivogel, C. S., Tao, Q., Bridgen, D. T., Razdan, R. K., Zimmer, A. M., Zimmer, A., & Martin, B. R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0752434.x · Cited by 389 · see citing works

Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear

Chhatwal, J. P., Davis, M., Maguschak, K. A., & Ressler, K. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300655 · Cited by 376 · see citing works

The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety

Haller, J., Bakos, N., Szirmay, M., Ledent, C., & Freund, T. F. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02192.x · Cited by 354 · see citing works

Antidepressant-like Activity of the Fatty Acid Amide Hydrolase Inhibitor URB597 in a Rat Model of Chronic Mild Stress

Bortolato, M., Mangieri, R. A., Fu, J., Kim, J. H., Arguello, O., Duranti, A., Tontini, A., Mor, M., Tarzia, G., & Piomelli, D. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.12.001 · Cited by 347 · see citing works

Inhibition of exocytotic noradrenaline release by presynaptic cannabinoid CB1receptors on peripheral sympathetic nerves

Ishac, E. J. N., Jiang, L., Lake, K. D., Varga, K., Abood, M. E., & Kunos, G. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15639.x · Cited by 345 · see citing works

Puberty as a highly vulnerable developmental period for the consequences of cannabis exposure

Schneider, M. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00110.x · Cited by 330 · see citing works

Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats

Lichtman, A. H., Dimen, K. R., & Martin, B. R. (1995) · Psychopharmacology · doi:10.1007/bf02246292 · Cited by 311 · see citing works

Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory

Campolongo, P., Roozendaal, B., Trezza, V., Hauer, D., Schelling, G., McGaugh, J. L., & Cuomo, V. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900835106 · Cited by 294 · see citing works

Adolescent Rats Find Repeated Δ9-THC Less Aversive Than Adult Rats but Display Greater Residual Cognitive Deficits and Changes in Hippocampal Protein Expression Following Exposure

Quinn, H. R., Matsumoto, I., Callaghan, P. D., Long, L. E., Arnold, J. C., Gunasekaran, N., Thompson, M. R., Dawson, B., Mallet, P. E., Kashem, M. A., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301475 · Cited by 293 · see citing works

Context‐dependent effects of CB1 cannabinoid gene disruption on anxiety‐like and social behaviour in mice

Haller, J., Varga, B., Ledent, C., Barna, I., & Freund, T. F. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03293.x · Cited by 284 · see citing works

Improvement of memory in rodents by the selective CB1 cannabinoid receptor antagonist, SR 141716

Terranova, J.-P., Storme, J.-J., Lafon, N., Perio, A., Rinaldi, M. L., Fur, G. L., & Soubrié, P. (1996) · Psychopharmacology · doi:10.1007/bf02246352 · Cited by 283 · see citing works

Role in Anxiety Behavior of the Endocannabinoid System in the Prefrontal Cortex

Rubino, T., Realini, N., Castiglioni, C., Guidali, C., Viganò, D., Marras, E., Petrosino, S., Perletti, G., Maccarrone, M., Marzo, V. D., et al. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm161 · Cited by 283 · see citing works

Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors

Moreira, F. A., Kaiser, N., Monory, K., & Lutz, B. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.07.005 · Cited by 282 · see citing works

Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood

Rubino, T., Realini, N., Braida, D., Guidi, S., Capurro, V., Viganò, D., Guidali, C., Pinter, M., Sala, M., Bartesaghi, R., et al. (2009) · Hippocampus · doi:10.1002/hipo.20554 · Cited by 282 · see citing works

Cyclohexylcarbamic Acid 3‘- or 4‘-Substituted Biphenyl-3-yl Esters as Fatty Acid Amide Hydrolase Inhibitors: Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling Studies

Mor, M., Rivara, S., Lodola, A., Plazzi, P. V., Tarzia, G., Duranti, A., Tontini, A., Piersanti, G., Kathuria, S., & Piomelli, D. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm031140x · Cited by 276 · see citing works

Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression

Moreira, F. A., Grieb, M., & Lutz, B. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.09.003 · Cited by 272 · see citing works

Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats

de Bitencourt, R. M., Pamplona, F. A., & Takahashi, R. N. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.07.001 · Cited by 264 · see citing works

Effects of the cannabinoid CB1 receptor antagonist rimonabant in models of emotional reactivity in rodents

Griebel, G., Stemmelin, J., & Scatton, B. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.032 · Cited by 253 · see citing works

Marijuana Intoxication : Common Experiences

TART, C. T. (1970) · Nature · doi:10.1038/226701a0 · Cited by 252 · see citing works

Effects of delta-9-tetrahydrocannabinol on delayed match to sample performance in rats: alterations in short-term memory associated with changes in task specific firing of hippocampal cells.

Heyser, C. J., Hampson, R. E., & Deadwyler, S. A. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10268-1 · Cited by 245 · see citing works

Evaluation of CB1 Receptor Knockout Mice in the Morris Water Maze

Varvel, S. A., & Lichtman, A. H. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.3.915 · Cited by 245 · see citing works

CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-specific agents

Haller, J., Varga, B., Ledent, C., & Freund, T. F. (2004) · Behavioural Pharmacology · doi:10.1097/01.fbp.0000135704.56422.40 · Cited by 241 · see citing works

Hippocampal ensemble activity during spatial delayed-nonmatch-to-sample performance in rats

Deadwyler, S., Bunn, T., & Hampson, R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-01-00354.1996 · Cited by 234 · see citing works

Cannabinoid Function in Learning, Memory and Plasticity

Riedel, G., & Davies, S. N. (2005) · Springer eBooks · doi:10.1007/3-540-26573-2_15 · Cited by 219 · see citing works

Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors

Urigüen, L., Pérez-Rial, S., Ledent, C., Palomo, T., & Manzanares, J. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.01.003 · Cited by 218 · see citing works

Cannabinoid CB1 Receptor Mediates Fear Extinction via Habituation-Like Processes

Kamprath, K., Marsicano, G., Tang, J., Monory, K., Bisogno, T., Marzo, V. D., Lutz, B., & Wotjak, C. T. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0153-06.2006 · Cited by 217 · see citing works

Non-CB1, Non-CB2 Receptors for Endocannabinoids, Plant Cannabinoids, and Synthetic Cannabimimetics: Focus on G-protein-coupled Receptors and Transient Receptor Potential Channels

PETROCELLIS, L. D., & Marzo, V. D. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9177-z · Cited by 216 · see citing works

Δ9-Tetrahydrocannabinol impairs spatial memory through a cannabinoid receptor mechanism

Lichtman, A. H., & Martin, B. R. (1996) · Psychopharmacology · doi:10.1007/bf02246347 · Cited by 213 · see citing works

The cannabinoid receptor agonist WIN 55,212-2 facilitates the extinction of contextual fear memory and spatial memory in rats

Pamplona, F. A., Prediger, R. D. S., Pandolfo, P., & Takahashi, R. N. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0514-0 · Cited by 211 · see citing works

Cannabinoids Reveal the Necessity of Hippocampal Neural Encoding for Short-Term Memory in Rats

Hampson, R. E., & Deadwyler, S. A. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08932.2000 · Cited by 207 · see citing works

Anxiolytic Effects in Mice of a Dual Blocker of Fatty Acid Amide Hydrolase and Transient Receptor Potential Vanilloid Type-1 Channels

Micale, V., Cristino, L., Tamburella, A., Petrosino, S., Leggio, G. M., Drago, F., & Di Marzo, V. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.98 · Cited by 207 · see citing works

Electrically evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid receptor agonist, WIN 55212-2, and is potentiated by the cannabinoid antagonist, SR 141716A.

Gifford, A. N., & Ashby, C. R. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13092-9 · Cited by 199 · see citing works

Pharmacological separation of cannabinoid sensitive receptors on hippocampal excitatory and inhibitory fibers

Hájos, N., & Freund, T. F. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00157-0 · Cited by 198 · see citing works

Inhibition of serotonin release in the mouse brain via presynaptic cannabinoid CB1 receptors

Nakazi, M., Bauer, U. S., Nickel, T., Kathmann, M., & Schlicker, E. (2000) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002109900147 · Cited by 197 · see citing works

Hippocampal Ablation and Passive Avoidance

Isaacson, R. L., & Wickelgren, W. O. (1962) · Science · doi:10.1126/science.138.3545.1104 · Cited by 193 · see citing works

On-demand activation of the endocannabinoid system in the control of neuronal excitability and epileptiform seizures

Lutz, B. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.07.007 · Cited by 192 · see citing works

PRECLINICAL STUDY: Acute and chronic cannabinoid treatment differentially affects recognition memory and social behavior in pubertal and adult rats

Schneider, M., Schömig, E., & Leweke, F. M. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00117.x · Cited by 189 · see citing works

Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality

Naidu, P. S., Varvel, S. A., Ahn, K., Cravatt, B. F., Martin, B. R., & Lichtman, A. H. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0689-4 · Cited by 184 · see citing works

CB1 Receptor Knockout Mice Display Reduced Ethanol-Induced Conditioned Place Preference and Increased Striatal Dopamine D2 Receptors

Houchi, H., Babovic, D., Pierrefiche, O., Ledent, C. A., Daoust, M., & Naassïla, M. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300568 · Cited by 181 · see citing works

The cannabinoid CB 1 receptor antagonist SR141716A attenuates the memory impairment produced by ? 9 -tetrahydrocannabinol or anandamide

Mallet, P. E., & Beninger, R. J. (1998) · Psychopharmacology · doi:10.1007/s002130050733 · Cited by 178 · see citing works

Cannabinoids and anxiety

Moreira, F. A., & Wotjak, C. T. (2009) · Current topics in behavioral neurosciences · doi:10.1007/7854_2009_16 · Cited by 177 · see citing works

Inhibition of Fatty-Acid Amide Hydrolase Accelerates Acquisition and Extinction Rates in a Spatial Memory Task

Varvel, S. A., Wise, L. E., Niyuhire, F., Cravatt, B. F., & Lichtman, A. H. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301224 · Cited by 173 · see citing works

Cannabinoid receptor activation in the basolateral amygdala blocks the effects of stress on the conditioning and extinction of inhibitory avoidance

Ganon-Elazar, E., & Akirav, I. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1223-09.2009 · Cited by 173 · see citing works

SR 141716A enhances spatial memory as assessed in a radial-arm maze task in rats

Lichtman, A. H. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00615-4 · Cited by 171 · see citing works

Design, Synthesis, and Structure−Activity Relationships of Alkylcarbamic Acid Aryl Esters, a New Class of Fatty Acid Amide Hydrolase Inhibitors

Tarzia, G., Duranti, A., Tontini, A., Piersanti, G., Mor, M., Rivara, S., Plazzi, P. V., Park, C., Kathuria, S., & Piomelli, D. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm021119g · Cited by 165 · see citing works

Cannabinoid–Dopamine Interaction in the Pathophysiology and Treatment of CNS Disorders

Fernández‐Ruíz, J., Hernández, M., & Ramos, J. A. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00144.x · Cited by 163 · see citing works

Differential effects of Δ 9 -THC on spatial reference and working memory in mice

Varvel, S. A., Hamm, R. L., Martin, B. R., & Lichtman, A. H. (2001) · Psychopharmacology · doi:10.1007/s002130100780 · Cited by 160 · see citing works

Interactions between environmental aversiveness and the anxiolytic effects of enhanced cannabinoid signaling by FAAH inhibition in rats

Haller, J., Barna, I., Barsvari, B., Gyimesi Pelczer, K., Yasar, S., Panlilio, L. V., & Goldberg, S. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1494-7 · Cited by 159 · see citing works

The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition

Scherma, M., Medalie, J., Fratta, W., Vadivel, S. K., Makriyannis, A., Piomelli, D., Mikics, É., Haller, J., Yaşar, S., Tanda, G., et al. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.08.011 · Cited by 151 · see citing works

Age‐related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour

Maccarrone, M., Valverde, O., Barbaccia, M. L., Castañé, A., Maldonado, R. J., Ledent, C. A., Parmentier, M., & Finazzi‐Agrò, A. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01957.x · Cited by 151 · see citing works

Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice

Steiner, M. A., Marsicano, G., Nestler, E. J., Holsboer, F., Lutz, B., & Wotjak, C. T. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.09.008 · Cited by 142 · see citing works

WIN 55212-2 impairs contextual fear conditioning through the activation of CB1 cannabinoid receptors

Pamplona, F. A., & Takahashi, R. N. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.12.026 · Cited by 141 · see citing works

Estrogen recruits the endocannabinoid system to modulate emotionality.

Hill, M., Karacabeyli, E., & Gorzalka, B. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.02.003 · Cited by 141 · see citing works

The role of the hippocampus in object recognition in rats: examination of the influence of task parameters and lesion size

Ainge, J. A., Heron-Maxwell, C., Theofilas, P., Wright, P., de Hoz, L., & Wood, E. R. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.09.005 · Cited by 140 · see citing works

Genetic Deletion of Fatty Acid Amide Hydrolase Alters Emotional Behavior and Serotonergic Transmission in the Dorsal Raphe, Prefrontal Cortex, and Hippocampus

Bambico, F. R., Cassano, T., Domínguez-López, S., Katz, N., Walker, C. D., Piomelli, D., & Gobbi, G. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.80 · Cited by 139 · see citing works

Hippocampal CB1 Receptors Mediate the Memory Impairing Effects of Δ9-Tetrahydrocannabinol

Wise, L. E., Thorpe, A. J., & Lichtman, A. H. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.31 · Cited by 136 · see citing works

Fat-induced satiety factor oleoylethanolamide enhances memory consolidation

Campolongo, P., Roozendaal, B., Trezza, V., Cuomo, V., Astarita, G., Fu, J., McGaugh, J. L., & Piomelli, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903038106 · Cited by 133 · see citing works

Disruption of CB1 receptor signaling impairs extinction of spatial memory in mice

Varvel, S. A., Anum, E. A., & Lichtman, A. H. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2121-2 · Cited by 131 · see citing works

Chronic URB597 treatment at adulthood reverted most depressive-like symptoms induced by adolescent exposure to THC in female rats

Realini, N., Viganò, D., Guidali, C., Zamberletti, E., Rubino, T., & Parolaro, D. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.09.003 · Cited by 130 · see citing works

Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-α nuclear receptorsPreprint

Mazzola, C., Medalie, J., Scherma, M., Panlilio, L. V., Solinas, M., Tanda, G., Drago, F., Cadet, J. L., Goldberg, S. R., & Yaşar, S. (2009) · Learning & Memory · doi:10.1101/lm.1145209 · Cited by 130 · see citing works

CB1 cannabinoid receptors modulate kinase and phosphatase activity during extinction of conditioned fear in mice

Cannich, A., Wotjak, C. T., Kamprath, K., Hermann, H., Lutz, B., & Marsicano, G. (2004) · Learning & Memory · doi:10.1101/lm.77904 · Cited by 130 · see citing works

Influence of Cannabinoids on Electrically Evoked Dopamine Release and Cyclic AMP Generation in the Rat Striatum

Cadogan, A., Alexander, S. P. H., Boyd, E. A., & Kendall, D. A. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69031131.x · Cited by 127 · see citing works

Alterations in Corticolimbic Dendritic Morphology and Emotional Behavior in Cannabinoid CB1 Receptor-Deficient Mice Parallel the Effects of Chronic Stress

Hill, M. N., Hillard, C. J., & McEwen, B. S. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq280 · Cited by 127 · see citing works

Short- and long-term effects of cannabinoids on the extinction of contextual fear memory in rats

Pamplona, F. A., Bitencourt, R. M., & Takahashi, R. N. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.04.003 · Cited by 123 · see citing works

Activation of endocannabinoid transmission induces antidepressant-like effects in rats.

Adamczyk, P., Gołda, A., McCreary, A. C., Filip, M., & Przegaliński, E. (2008) · PubMed · Cited by 123 · see citing works

Blockade of Nicotine Reward and Reinstatement by Activation of Alpha-Type Peroxisome Proliferator-Activated Receptors

Mascia, P., Pistis, M., Justinová, Z., Panlilio, L. V., Luchicchi, A., Lecca, S., Scherma, M., Fratta, W., Fadda, P., Barnes, C., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.009 · Cited by 118 · see citing works

Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat

Cippitelli, A., Cannella, N., Braconi, S., Duranti, A., Tontini, A., Bilbao, A., de Fonseca, F. R., Piomelli, D., & Ciccocioppo, R. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1104-0 · Cited by 112 · see citing works

Learning Impairment Produced in Rats by the Cannabinoid Agonist HU 210 in a Water-Maze Task

Ferrari, F., Ottani, A., Vivoli, R., & Giuliani, D. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00106-9 · Cited by 111 · see citing works

SR 141716A prevents Δ9-tetrahydrocannabinol-induced spatial learning deficit in a Morris-type water maze in mice

Silva, G. E. D., & Takahashi, R. N. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00275-5 · Cited by 110 · see citing works

The disruptive effects of the CB1 receptor antagonist rimonabant on extinction learning in mice are task-specific

Niyuhire, F., Varvel, S. A., Thorpe, A. J., Stokes, R. J., Wiley, J. L., & Lichtman, A. H. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0650-6 · Cited by 110 · see citing works

Reversible effects of acute and long-term administration of Δ-9-tetrahydrocannabinol (THC) on memory in the rat

Nakamura, E. M., da Silva, E. A., Concilio, G. V., Wilkinson, D. A., & Masur, J. (1991) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(91)90072-7 · Cited by 110 · see citing works

The cannabinoid agonist WIN 55,212-2 reduces sensorimotor gating and recognition memory in rats

Schneider, M., & Koch, M. (2002) · Behavioural Pharmacology · doi:10.1097/00008877-200202000-00003 · Cited by 108 · see citing works

Correlated species differences in the effects of cannabinoid ligands on anxiety and on GABAergic and glutamatergic synaptic transmission

Haller, J., Mátyás, F., Soproni, K., Varga, B., Barsy, B., Németh, B., Mikics, É., Freund, T. F., & Hájos, N. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05476.x · Cited by 103 · see citing works

SR141716A, a cannabinoid CB1 receptor antagonist, improves memory in a delayed radial maze task

Wolff, M. C., & Leander, J. D. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.025 · Cited by 103 · see citing works

Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step

Adermark, L., & Lovinger, D. (2007) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0706873104 · Cited by 103 · see citing works

Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT)2A receptors in the prefrontal cortex

Egashira, N., Iwasaki, K., Ishibashi, A., Hayakawa, K., Okuno, R., Abe, M., Uchida, N., Mishima, K., Takasaki, K., Nishimura, R., et al. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.05.010 · Cited by 103 · see citing works

Cannabinoid CB1 receptor is dispensable for memory extinction in an appetitively-motivated learning task

Hölter, S. M., Kallnik, M., Wurst, W., Marsicano, G., Lutz, B., & Wotjak, C. T. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.01.008 · Cited by 100 · see citing works

Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice

Umathe, S. N., Manna, S. S. S., & Jain, N. S. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.031 · Cited by 96 · see citing works

Endocannabinoids render exploratory behaviour largely independent of the test aversiveness: role of glutamatergic transmission

Jacob, W., Yassouridis, A., Marsicano, G., Monory, K., Lutz, B., & Wotjak, C. T. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00512.x · Cited by 95 · see citing works

Endocannabinoids in the Treatment of Mood Disorders: Evidence from Animal Models

Bambico, F. R., Duranti, A., Tontini, A., Tarzia, G., & Gobbi, G. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168029 · Cited by 91 · see citing works

Peroxisome Proliferator-Activated Receptors-Alpha Modulate Dopamine Cell Activity Through Nicotinic Receptors

Melis, M., Carta, S., Fattore, L., Tolu, S., Yasar, S., Goldberg, S. R., Fratta, W., Maskos, U., & Pistis, M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.016 · Cited by 89 · see citing works

Activation of CB1 cannabinoid receptors in rat hippocampal slices inhibits potassium-evoked cholecystokinin release, a possible mechanism contributing to the spatial memory defects produced by cannabinoids

Beinfeld, M. C., & Connolly, K. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01591-9 · Cited by 86 · see citing works

Interaction between cannabinoid compounds and diazepam on anxiety-like behaviour of mice

Naderi, N., Haghparast, A., Saber-Tehrani, A. S., Rezaii, N., Alizadeh, A.-M., Khani, A., & Motamedi, F. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.11.001 · Cited by 85 · see citing works

Intracerebral microinjections of Δ9-tetrahydrocannabinol: search for the impairment of spatial memory in the eight-arm radial maze in rats

Egashira, N., 三島, 健., Iwasaki, K., & Fujiwara, M. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03247-x · Cited by 83 · see citing works

Characteristics of Learning and Memory Impairment Induced by ⊿9-Tetrahydrocannabinol in Rats

Mishima, K., Egashira, N., Hirosawa, N., Fujii, M., Matsumoto, Y., Iwasaki, K., & Fujiwara, M. (2001) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.87.297 · Cited by 82 · see citing works

Differential response to acute and repeated stress in cannabinoid CB1 receptor knockout newborn and adult mice

Fride, E., Suris, R., Weidenfeld, J., & Mechoulam, R. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00016 · Cited by 81 · see citing works

Metabolism of anandamide and 2‐arachidonoylglycerol: An historical overview and some recent developments

Marzo, V. D., PETROCELLIS, L. D., Bisogno, T., & Melck, D. J. (1999) · Lipids · doi:10.1007/bf02562332 · Cited by 81 · see citing works

Conditional cannabinoid receptor type 1 mutants reveal neuron subpopulation-specific effects on behavioral and neuroendocrine stress responses

Steiner, M. A., Marsicano, G., Wotjak, C. T., & Lutz, B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.06.004 · Cited by 80 · see citing works

D2 dopamine receptors enable Δ9‐tetrahydrocannabinol induced memory impairment and reduction of hippocampal extracellular acetylcholine concentration

Nava, F. A., Carta, G., Battasi, A. M., & Gessa, G. L. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703413 · Cited by 79 · see citing works

Effects of chronic Δ9-tetrahydrocannabinol treatment on hippocampal extracellular acetylcholine concentration and alternation performance in the T-maze

Nava, F. A., Carta, G., Colombo, G., & Gessa, G. L. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00075-2 · Cited by 77 · see citing works

Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect

McLaughlin, R. J., Hill, M. N., Morrish, A. C., & Gorzalka, B. B. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282ee7b44 · Cited by 77 · see citing works

Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice

Cassano, T., Gaetani, S., Macheda, T., Laconca, L., Romano, A., Morgese, M. G., Cimmino, C. S., Chiarotti, F., Bambico, F. R., Gobbi, G., et al. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2051-0 · Cited by 72 · see citing works

Repeated exposure to Δ9-tetrahydrocannabinol reduces prefrontal cortical dopamine metabolism in the rat

Jentsch, D., Verrico, C. D., Le, D., & Roth, R. H. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00254-7 · Cited by 72 · see citing works

Activation of cannabinoid CB1 receptors in the dorsolateral periaqueductal gray induces anxiolytic effects in rats submitted to the Vogel conflict test

Lisboa, S. F. D. S., Resstel, L. B. M., de Aguiar, D. C., & Guimarães, F. S. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.07.032 · Cited by 66 · see citing works

The effects of cannabinoids on contextual conditioned fear in CB1 knockout and CD1 mice

Mikics, É., Dombi, T., Barsvári, B., Varga, B., Ledent, C., Freund, T., & Haller, J. (2006) · Behavioural Pharmacology · doi:10.1097/00008877-200605000-00003 · Cited by 61 · see citing works

Genetic deletion and pharmacological blockade of CB1 receptors modulates anxiety in the shock‐probe burying test

Degroot, A., & Nomikos, G. G. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03556.x · Cited by 58 · see citing works

The cannabinoid CB1 receptor is expressed on serotonergic and dopaminergic neurons

Lau, T., & Schloss, P. D. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.09.022 · Cited by 57 · see citing works

WIN55,212-2 induced deficits in spatial learning are mediated by cholinergic hypofunction

Robinson, L., Goonawardena, A. V., Pertwee, R. G., Hampson, R. E., Platt, B., & Riedel, G. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.01.004 · Cited by 56 · see citing works

Alterations in behavioral flexibility by cannabinoid CB1 receptor agonists and antagonists

Hill, M. N., Froese, L. M., Morrish, A. C., Sun, J. C., & Floresco, S. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0421-4 · Cited by 55 · see citing works

An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters

Moise, A. M., Eisenstein, S. A., Astarita, G., Piomelli, D., & Hohmann, A. G. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1209-5 · Cited by 55 · see citing works

Cannabinoid and cholinergic systems interact during performance of a short-term memory task in the ratPreprint

Goonawardena, A. V., Robinson, L., Hampson, R. E., & Riedel, G. (2010) · Learning & Memory · doi:10.1101/lm.1893710 · Cited by 55 · see citing works

Cannabinoid signaling in inhibitory autaptic hippocampal neurons

Straiker, A. J., & Mackie, K. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.06.004 · Cited by 52 · see citing works

Involvement of reduced acetylcholine release in Δ9-tetrahydrocannabinol-induced impairment of spatial memory in the 8-arm radial maze

Mishima, K., Egashira, N., Matsumoto, Y., Iwasaki, K., & Fujiwara, M. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02274-9 · Cited by 52 · see citing works

Short-term memory is modulated by the spontaneous release of endocannabinoids: evidence from hippocampal population codes

Deadwyler, S. A., Goonawardena, A. V., & Hampson, R. E. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282ee2adb · Cited by 51 · see citing works

Distribution of indoleamines and [3H]paroxetine binding in rat brain regions following acute or perinatal ?9-tetrahydrocannabinol treatments

Molina‐Holgado, F., Molina‐Holgado, E., Leret, M. L., Gonz�lez, M. I., & Reader, T. A. (1993) · Neurochemical Research · doi:10.1007/bf00978372 · Cited by 49 · see citing works

Oleamide modulates memory in rats

Murillo‐Rodríguez, E., Giòrdano, M., Cabeza, R. D. J., Henriksen, S. J., Méndez‐Díaz, M., Navarro, L., & Prospero-Garcia, O. E. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02256-x · Cited by 49 · see citing works

Combination of Rimonabant and Donepezil Prolongs Spatial Memory Duration

Wise, L. E., Iredale, P. A., Stokes, R. J., & Lichtman, A. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301297 · Cited by 48 · see citing works

The effects of anandamide on memory consolidation in mice involve both D1and D2 dopamine receptors

Castellano, C., Cabib, S., Palmisano, A., Marzo, V. D., & Puglisi‐Allegra, S. (1997) · Behavioural Pharmacology · doi:10.1097/00008877-199712000-00005 · Cited by 48 · see citing works

Fatty Acid Amide Hydrolase (–/–) Mice Exhibit an Increased Sensitivity to the Disruptive Effects of Anandamide or Oleamide in a Working Memory Water Maze Task

Varvel, S. A., Cravatt, B. F., Engram, A. E., & Lichtman, A. H. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.095059 · Cited by 47 · see citing works

Differential endocannabinoid regulation of extinction in appetitive and aversive Barnes maze tasksPreprint

Harloe, J. P., Thorpe, A. J., & Lichtman, A. H. (2008) · Learning & Memory · doi:10.1101/lm.1113008 · Cited by 46 · see citing works

Behavioral sequelae following acute diisopropylfluorophosphate intoxication in rats: Comparative effects of atropine and cannabinomimetics

Wright, L. K. M., Liu, J., Nallapaneni, A., & Pope, C. (2009) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2009.12.006 · Cited by 45 · see citing works

The CB1 inverse agonist AM251, but not the CB1 antagonist AM4113, enhances retention of contextual fear conditioning in rats

Sink, K. S., Segovia, K. N., Collins, L. E., Markus, E. J., Vemuri, K. V., Makriyannis, A., & Salamone, J. D. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.03.011 · Cited by 44 · see citing works

Influence of intracerebral administration of NO agents in dorsal hippocampus (CA1) on cannabinoid state-dependent memory in the step-down passive avoidance test

Nasehi, M. M., Piri, M., Jamali-Raeufy, N., & Zarrindast, M. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.02.025 · Cited by 44 · see citing works

Neurochemical changes in the striatum of dyskinetic rats after administration of the cannabinoid agonist WIN55,212-2

Morgese, M. G., Cassano, T., Gaetani, S., Macheda, T., Laconca, L., Dipasquale, P., Ferraro, L., Antonelli, T., Cuomo, V., & Giuffrida, A. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.10.007 · Cited by 44 · see citing works

Memory impairment following combined exposure to Δ9-tetrahydrocannabinol and ethanol in rats

Ciccocioppo, R., Antonelli, L., Biondini, M., Perfumi, M. C., Pompei, P., & Massi, M. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01999-4 · Cited by 42 · see citing works

?9-THC-induced cognitive deficits in mice are reversed by the GABAA antagonist bicuculline

Varvel, S. A., Anum, E. A., Niyuhire, F., Wise, L. E., & Lichtman, A. H. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1988-2 · Cited by 40 · see citing works

Interactions between the anxiogenic effects of CB1 gene disruption and 5-HT3 neurotransmission

Mikics, É., Vas, J., Aliczki, M., Halász, J., & Haller, J. (2009) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32832c70b1 · Cited by 39 · see citing works

Effects of selective neonatal hippocampal lesions on tests of object and spatial recognition memory in monkeys.

Heuer, E., & Bachevalier, J. (2011) · Behavioral Neuroscience · doi:10.1037/a0022539 · Cited by 37 · see citing works

Role of Cannabinoid Receptor Type 1 Desensitization in Greater Tetrahydrocannabinol Impairment of Memory in Adolescent Rats

Moore, N. L. T., Greenleaf, A. L. R., Acheson, S. K., Wilson, W. A., Swartzwelder, H. S., & Kuhn, C. M. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.169359 · Cited by 35 · see citing works

The serotonin1A receptor agonist 8-OHDPAT reverses Δ9-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats

Inui, K., Egashira, N., Mishima, K., Yano, A., Matsumoto, Y., Hasebe, N., Abe, K., Hayakawa, K., Ikeda, T., Iwasaki, K., et al. (2004) · Neurotoxicity Research · doi:10.1007/bf03033218 · Cited by 31 · see citing works

Effects of intrahippocampal cannabinoid receptor agonist and antagonist on radial maze and T-maze delayed alternation performance in rats

Suenaga, T., Kaku, M., & Ichitani, Y. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.06.015 · Cited by 30 · see citing works

Fatty acid amide hydrolase (FAAH) knockout mice exhibit enhanced acquisition of an aversive, but not of an appetitive, Barnes maze task

Wise, L. E., Harloe, J. P., & Lichtman, A. H. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.06.001 · Cited by 30 · see citing works

Effects of anandamide and morphine combinations on memory consolidation in cd1 mice: Involvement of dopaminergic mechanisms

Costanzi, M., Battaglia, M., Rossi‐Arnaud, C., Cestari, V., & Castellano, C. (2003) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2003.09.003 · Cited by 30 · see citing works

Δ9-THC administered into the medial prefrontal cortex disrupts the spatial working memory

de Melo, L. C. S., Cruz, A. P., Valentim, S. J. R., Marinho-Buzelli, A. R., Mendonça, J. B., & Nakamura-Palacios, E. M. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0141-1 · Cited by 29 · see citing works

The synthetic cannabinoid WIN 55212-2 differentially modulates thigmotaxis but not spatial learning in adolescent and adult animals

Acheson, S. K., Moore, N. L. T., Kuhn, C. M., Wilson, W. A., & Swartzwelder, H. S. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.10.067 · Cited by 29 · see citing works

Effects of hippocampal administration of a cannabinoid receptor agonist WIN 55,212-2 on spontaneous object and place recognition in rats

Suenaga, T., & Ichitani, Y. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.029 · Cited by 28 · see citing works

Strain-dependent effects of anandamide on memory consolidation in mice are antagonized by naltrexone

Castellano, C., Ventura, R., Cabib, S., & Puglisi‐Allegra, S. (1999) · Behavioural Pharmacology · doi:10.1097/00008877-199909000-00003 · Cited by 24 · see citing works

Endocannabinoids modulate encoding of sequential memory in the rat hippocampus

Deadwyler, S. A., & Hampson, R. E. (2008) · Psychopharmacology · doi:10.1007/s00213-007-1055-x · Cited by 22 · see citing works

The cannabinoid CB1 receptor antagonist CE prolongs spatial memory duration in a rat delayed radial arm maze memory task

Wise, L. E., Iredale, P. A., & Lichtman, A. H. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.06.049 · Cited by 22 · see citing works

WIN-55,212-2 chronically implanted into the CA3 region of the dorsal hippocampus impairs learning: a novel method for studying chronic, brain-area-specific effects of cannabinoids

Barna, I., Soproni, K., Arszovszki, A., Csabai, K., & Haller, J. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282d9e9f9 · Cited by 21 · see citing works

Are CB1 receptor antagonists nootropic or cognitive impairing agents?

Varvel, S. A., Wise, L. E., & Lichtman, A. H. (2009) · Drug Development Research · doi:10.1002/ddr.20334 · Cited by 20 · see citing works

Effects of the synthetic cannabinoid nabilone on spatial learning and hippocampal neurotransmission

Diana, G., Malloni, M., & Pieri, M. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00127-8 · Cited by 18 · see citing works

Clozapine and SCH 23390 prevent the spatial working memory disruption induced by Δ9-THC administration into the medial prefrontal cortex

Rodrigues, L. C. D. M., Conti, C. L., & Nakamura-Palacios, E. M. (2011) · Brain Research · doi:10.1016/j.brainres.2011.01.069 · Cited by 17 · see citing works

Automatic recording of mediating behavior in delayed matching- and nonmatching-to-position procedures in rats

Panlilio, L. V., Yaşar, S., Thorndike, E. B., Goldberg, S. R., & Schindler, C. W. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2057-7 · Cited by 16 · see citing works

Δ9-Tetrahydrocannabinol-induced cognitive deficits are reversed by olanzapine but not haloperidol in rats

Egashira, N., Ishigami, N., Mishima, K., Iwasaki, K., Oishi, R., & Fujiwara, M. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.10.001 · Cited by 15 · see citing works

Inhibition of fatty acid amide hydrolase modulates anxiety-like behavior in PCP-treated rats

Seillier, A., & Giuffrida, A. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.03.010 · Cited by 10 · see citing works

Memory impairment following combined exposure to Delta9-tetrahydrocannabinol and ethanol in rats

Ciccocioppo, R., Perfumi, M. C., Pompei, P., MASSI, M., L., A., & Biondini, M. (2002) · Unicam Scientific Publications (University of Camerino) · Cited by 1 · see citing works

The endocannabinoid system: a modulator of brain-behavioral processes

Deadwyler, S. A. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1153-4

The endocannabinoid system and the brain.

Mechoulam, R., & Parker, L. A. (2013) · Annual Review of Psychology · doi:10.1146/annurev-psych-113011-143739 · Cited by 1,090 · see citing works

Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis

Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works

The neurobiology of social play and its rewarding value in rats

Vanderschuren, L. J. M. J., Achterberg, E. J. M., & Trezza, V. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.025 · Cited by 329 · see citing works

A systematic review of the antipsychotic properties of cannabidiol in humans

Iseger, T. A., & Bossong, M. G. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.01.033 · Cited by 261 · see citing works

Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain

Callén, L., Moreno, E., Barroso‐Chinea, P., Moreno‐Delgado, D., Cortés, A., Mallol, J., Casadó, V., Lanciego, J. L., Franco, R., Lluís, C., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.335273 · Cited by 239 · see citing works

Endocannabinoid system and mood disorders: Priming a target for new therapies

Micale, V., Marzo, V. D., Šulcová, A., Wotjak, C. T., & Drago, F. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.12.002 · Cited by 222 · see citing works

2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain

Baggelaar, M. P., Maccarrone, M., & van der Stelt, M. (2018) · Progress in Lipid Research · doi:10.1016/j.plipres.2018.05.002 · Cited by 224 · see citing works

Therapeutic potential of monoacylglycerol lipase inhibitors

Mulvihill, M. M., & Nomura, D. K. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.10.025 · Cited by 199 · see citing works

Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's Disease

Javed, H., Azimullah, S., Haque, M. E., & Ojha, S. K. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00321 · Cited by 199 · see citing works

Endocannabinoids in Amygdala and Nucleus Accumbens Mediate Social Play Reward in Adolescent Rats

Trezza, V., Damsteegt, R., Manduca, A., Petrosino, S., Van Kerkhof, L. W. M., Pasterkamp, R. J., Zhou, Y., Campolongo, P., Cuomo, V., Di Marzo, V., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0114-12.2012 · Cited by 190 · see citing works

Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus

Tabatadze, N., Huang, G., May, R. M., Jain, A., & Woolley, C. S. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1067-15.2015 · Cited by 191 · see citing works

The endocannabinoid system: An emotional buffer in the modulation of memory function

Morena, M., & Campolongo, P. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.12.010 · Cited by 143 · see citing works

Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies

Befort, K. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00006 · Cited by 134 · see citing works

Biphasic effects of THC in memory and cognition

Calabrese, E. J., & Rubio‐Casillas, A. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.12920 · Cited by 127 · see citing works

Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway

McLaughlin, R. J., Hill, M. N., Bambico, F. R., Stuhr, K. L., Gobbi, G., Hillard, C. J., & Gorzalka, B. B. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.01.004 · Cited by 113 · see citing works

Marijuana: Current Concepts†

Greydanus, D. E., Hawver, E. K., Greydanus, M. M., & Merrick, J. (2013) · Frontiers in Public Health · doi:10.3389/fpubh.2013.00042 · Cited by 112 · see citing works

Cannabinoid–dopamine interactions in the physiology and physiopathology of the basal ganglia

García, C., Palomo‐Garo, C., Gómez‐Gálvez, Y., & Fernández‐Ruíz, J. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13215 · Cited by 111 · see citing works

Inhibition of FAAH and activation of PPAR: New approaches to the treatment of cognitive dysfunction and drug addiction

Panlilio, L. V., Justinová, Z., & Goldberg, S. R. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.01.003 · Cited by 106 · see citing works

Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids

Puighermanal, E., Busquets-García, A., Maldonado, R. J., & Ozaita, A. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0384 · Cited by 101 · see citing works

Fatty Acid-binding Protein 5 (FABP5) Regulates Cognitive Function Both by Decreasing Anandamide Levels and by Activating the Nuclear Receptor Peroxisome Proliferator-activated Receptor β/δ (PPARβ/δ) in the Brain

Yu, S., Levi, L., Casadesús, G., Kunos, G., & Noy, N. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.559062 · Cited by 97 · see citing works

Activation of cannabinoid receptor type 2 attenuates surgery-induced cognitive impairment in mice through anti-inflammatory activity

Sun, L., Dong, R., Xu, X., Yang, X., & Peng, M. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0913-7 · Cited by 92 · see citing works

Cannabinoid receptor CNR1 expression and DNA methylation in human prefrontal cortex, hippocampus and caudate in brain development and schizophrenia

Tao, R., Li, C., Jaffe, A. E., Shin, J. H., Deep‐Soboslay, A., Yamin, R., Weinberger, D. R., Hyde, T. M., & Kleinman, J. E. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0832-8 · Cited by 88 · see citing works

Dissociation of the Pharmacological Effects of THC by mTOR Blockade

Puighermanal, E., Busquets-García, A., Gomis‐González, M., Marsicano, G., Maldonado, R. J., & Ozaita, A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.31 · Cited by 91 · see citing works

Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse

Justinová, Z., Panlilio, L. V., Moreno‐Sanz, G., Redhi, G. H., Auber, A., Secci, M. E., Mascia, P., Bandiera, T., Armirotti, A., Bertorelli, R., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.62 · Cited by 89 · see citing works

Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation

Busquets-García, A., Gomis‐González, M., Srivastava, R. K., Cutando, L., Ortega-Álvaro, A., Ruehle, S., Remmers, F., Bîndilă, L., Bellocchio, L., Marsicano, G., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525066113 · Cited by 85 · see citing works

Reviewing the Role of the Endocannabinoid System in the Pathophysiology of Depression

Gallego‐Landin, I., García-Baos, A., Castro‐Zavala, A., & Valverde, O. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.762738 · Cited by 84 · see citing works

Fear relief—toward a new conceptual frame work and what endocannabinoids gotta do with it

Riebe, C. J. N., Pamplona, F. A., Kamprath, K., & Wotjak, C. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.057 · Cited by 82 · see citing works

Sex‐specific behavioural deficits induced at early life by prenatal exposure to the cannabinoid receptor agonist WIN55, 212‐2 depend on mGlu5 receptor signalling

Manduca, A., Servadio, M., Melancia, F., Schiavi, S., Manzoni, O. J., & Trezza, V. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14879 · Cited by 77 · see citing works

The Potential of Cannabidiol as a Treatment for Psychosis and Addiction: Who Benefits Most? A Systematic Review

Batalla, A., Janssen, H., Gangadin, S. S., & Bossong, M. G. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8071058 · Cited by 77 · see citing works

Elevation of Plasma 2-Arachidonoylglycerol Levels in Alzheimer’s Disease Patients as a Potential Protective Mechanism against Neurodegenerative Decline

Altamura, C., Ventriglia, M., Martini, M. G., Montesano, D., Errante, Y., Piscitelli, F., Scrascia, F., Quattrocchi, C. C., Palazzo, P., Seccia, S., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142349 · Cited by 77 · see citing works

Neuronal populations mediating the effects of endocannabinoids on stress and emotionality

Häring, M., Guggenhuber, S., & Lutz, B. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.035 · Cited by 70 · see citing works

Training-Associated Emotional Arousal Shapes Endocannabinoid Modulation of Spatial Memory Retrieval in Rats

Morena, M., Castro, V. D., Gray, J. M., Palmery, M., Trezza, V., Roozendaal, B., Hill, M. N., & Campolongo, P. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1983-15.2015 · Cited by 70 · see citing works

Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety

Morena, M., Leitl, K. D., Vecchiarelli, H. A., Gray, J. M., Campolongo, P., & Hill, M. N. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.08.020 · Cited by 70 · see citing works

Altering endocannabinoid neurotransmission at critical developmental ages: impact on rodent emotionality and cognitive performance

Trezza, V., Campolongo, P., Manduca, A., Morena, M., Palmery, M., Vanderschuren, L. J. M. J., & Cuomo, V. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00002 · Cited by 69 · see citing works

Temporal changes in N‐acylethanolamine content and metabolism throughout the peri‐adolescent period

Lee, T. T. ‐., Hill, M. N., Hillard, C. J., & Gorzalka, B. B. (2012) · Synapse · doi:10.1002/syn.21609 · Cited by 68 · see citing works

Novelty-Induced Emotional Arousal Modulates Cannabinoid Effects on Recognition Memory and Adrenocortical Activity

Campolongo, P., Morena, M., Scaccianoce, S., Trezza, V., Chiarotti, F., Schelling, G., Cuomo, V., & Roozendaal, B. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.26 · Cited by 68 · see citing works

Targeting the endocannabinoid system to treat anxiety-related disorders

Korem, N., Zer‐Aviv, T. M., Ganon-Elazar, E., Abush, H., & Akirav, I. (2015) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2015-0058 · Cited by 64 · see citing works

Chronic exposure to cannabinoids during adolescence causes long‐lasting behavioral deficits in adult mice

Tomàs-Roig, J., Benito, E., Agís‐Balboa, R. C., Piscitelli, F., Hoyer‐Fender, S., Marzo, V. D., & Havemann‐Reinecke, U. (2016) · Addiction Biology · doi:10.1111/adb.12446 · Cited by 64 · see citing works

Strain- and context-dependent effects of the anandamide hydrolysis inhibitor URB597 on social behavior in rats

Manduca, A., Servadio, M., Campolongo, P., Palmery, M., Trabace, L., Vanderschuren, L. J. M. J., Cuomo, V., & Trezza, V. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.05.009 · Cited by 66 · see citing works

The neuropharmacology of cannabinoid receptor ligands in central signaling pathways

Brunt, T. M., & Bossong, M. G. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14982 · Cited by 61 · see citing works

Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase – Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology

Naidoo, V., Karanian, D. A., Vadivel, S. K., Locklear, J. R., Wood, J. T., Nasr, M. L., Quizon, P. M., Graves, E. E., Shukla, V. G., Makriyannis, A., et al. (2012) · Neurotherapeutics · doi:10.1007/s13311-011-0100-y · Cited by 60 · see citing works

Role of the endocannabinoid system in brain functions relevant for schizophrenia: an overview of human challenge studies with cannabis or ∆9-tetrahydrocannabinol (THC).

Bossong, M., Jansma, J., Bhattacharyya, S., & Ramsey, N. (2014) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.11.017 · Cited by 58 · see citing works

Spicing Up Pharmacology: A Review of Synthetic Cannabinoids From Structure to Adverse Events

Davidson, C., Opacka‐Juffry, J., Arévalo‐Martín, Á., García‐Ovejero, D., Molina‐Holgado, E., & Molina‐Holgado, F. (2017) · Advances in pharmacology · doi:10.1016/bs.apha.2017.05.001 · Cited by 54 · see citing works

Effects of delta-9-tetrahydrocannabinol on evaluation of emotional images

Ballard, M. E., Bedi, G., & de Wit, H. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112446530 · Cited by 53 · see citing works

Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 may protect against cognitive impairment in rats of chronic cerebral hypoperfusion via PI3K/AKT signaling

Su, S., Wang, Y.-Q., Wu, Y., Wang, D., Lin, Q. D., & Hai, J. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.07.009 · Cited by 52 · see citing works

Moderate-Vigorous Physical Activity across Body Mass Index in Females: Moderating Effect of Endocannabinoids and Temperament

Fernández‐Aranda, F., Sauchelli, S., Pastor, A., González, M. L., de la Torre, R., Granero, R., Jiménez‐Múrcia, S., Baños, R., Botella, C., Fernández‐Real, J. M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104534 · Cited by 50 · see citing works

Endocannabinoid system: Potential novel targets for treatment of schizophrenia

Saito, A., Ballinger, M. D., Pletnikov, M. V., Wong, D. F., & Kamiya, A. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.11.020 · Cited by 47 · see citing works

Cannabinoid modulation of zebrafish fear learning and its functional analysis investigated by c-Fos expression

Ruhl, T., Zeymer, M., & von der Emde, G. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.12.005 · Cited by 48 · see citing works

Anti-Microbial Activity of Phytocannabinoids and Endocannabinoids in the Light of Their Physiological and Pathophysiological Roles

Sionov, R. V., & Steinberg, D. (2022) · Biomedicines · doi:10.3390/biomedicines10030631 · Cited by 47 · see citing works

Cannabinoids and post-traumatic stress disorder: clinical and preclinical evidence for treatment and prevention

Zer‐Aviv, T. M., Segev, A., & Akirav, I. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000253 · Cited by 43 · see citing works

Cannabinoid CB2 Receptor Modulation by the Transcription Factor NRF2 is Specific in Microglial Cells

Galán-Ganga, M., del Río, R., Jiménez-Moreno, N., Díaz‐Guerra, M., & Lastres‐Becker, I. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00719-y · Cited by 43 · see citing works

Pharmacological modulation of the endocannabinoid signalling alters binge‐type eating behaviour in female rats

Scherma, M., Fattore, L., Satta, V., Businco, F., Pigliacampo, B., Goldberg, S. R., Dessì, C., Fratta, W., & Fadda, P. (2012) · British Journal of Pharmacology · doi:10.1111/bph.12014 · Cited by 42 · see citing works

Targeting the endocannabinoid system: a predictive, preventive, and personalized medicine-directed approach to the management of brain pathologies

Reddy, V. P., Grogan, D. P., Ahluwalia, M., Salles, É. L., Ahluwalia, P. K., Khodadadi, H., Alverson, K., Nguyen, A., Raju, S. P., Gaur, P., et al. (2020) · The EPMA Journal · doi:10.1007/s13167-020-00203-4 · Cited by 42 · see citing works

Adolescent cannabis exposure interacts with mutant DISC1 to produce impaired adult emotional memory

Ballinger, M. D., Saito, A., Abazyan, B. N., Taniguchi, Y., Huang, C.-H., Ito, K., Zhu, X., Segal‐Gavish, H., Jaaro-Peled, H., Sawa, A., et al. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.06.006 · Cited by 42 · see citing works

Cannabinoid Modulation of Memory Consolidation in Rats: Beyond the Role of Cannabinoid Receptor Subtype 1

Ratano, P., Palmery, M., Trezza, V., & Campolongo, P. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00200 · Cited by 41 · see citing works

The endocannabinoid receptors CB1 and CB2 affect the regenerative potential of adipose tissue MSCs

Ruhl, T., Karthaus, N., Kim, B., & Beier, J. P. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.111881 · Cited by 41 · see citing works

Cannabis and Anxiety: A Critical Review

Beletsky, A., Liu, C., Lochte, B., Samuel, N., & Grant, I. (2024) · Medical Cannabis and Cannabinoids · doi:10.1159/000534855 · Cited by 53 · see citing works

The effects of anandamide signaling enhanced by the FAAH inhibitor URB597 on coping styles in rats

Haller, J., Goldberg, S. R., Gyimesi-Pelczer, K., Aliczki, M., & Panlilio, L. V. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3161-2 · Cited by 39 · see citing works

Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats

Panlilio, L. V., Thorndike, E. B., Nikas, S. P., Alapafuja, S. O., Bandiera, T., Cravatt, B. F., Makriyannis, A., Piomelli, D., Goldberg, S. R., & Justinová, Z. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4140-6 · Cited by 39 · see citing works

Comparisons of Δ9-Tetrahydrocannabinol and Anandamide on a Battery of Cognition-Related Behavior in Nonhuman Primates

Kangas, B. D., Leonard, M. Z., Shukla, V., Alapafuja, S. O., Nikas, S. P., Makriyannis, A., & Bergman, J. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.228189 · Cited by 39 · see citing works

Single doses of THC and cocaine decrease proficiency of impulse control in heavy cannabis users

van Wel, J. H. P., Kuypers, K. P. C., Theunissen, E. L., Toennes, S. W., Spronk, D. B., Verkes, R. J., & Ramaekers, J. G. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12425 · Cited by 38 · see citing works

CB1 receptors in the formation of the different phases of memory-related processes in the inhibitory avoidance test in mice

Kruk-Słomka, M., & Biała, G. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.12.023 · Cited by 37 · see citing works

Marijuana Use Is Associated with Behavioral Approach and Depressive Symptoms in Adolescents and Emerging Adults

Wade, N. E., Scerpella, D. L., & Lisdahl, K. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166005 · Cited by 38 · see citing works

Emerging Therapeutic Role of PPAR–α in Cognition and Emotions

Nisbett, K. E., & Pinna, G. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00998 · Cited by 37 · see citing works

Acute administration of THC impairs spatial but not associative memory function in zebrafish

Ruhl, T., Prinz, N., Oellers, N., Seidel, N. I., Jonas, A., Albayram, Ö., Bilkei‐Gorzó, A., & von der Emde, G. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3522-5 · Cited by 37 · see citing works

Hippocampal Protein Kinase C Signaling Mediates the Short-Term Memory Impairment Induced by Delta9-Tetrahydrocannabinol

Busquets-García, A., Gomis‐González, M., Salgado-Mendialdúa, V., Galera-López, L., Puighermanal, E., Martín‐García, E., Maldonado, R. J., & Ozaita, A. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.175 · Cited by 37 · see citing works

Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome

Navarro-Romero, A., Vázquez‐Oliver, A., Gomis‐González, M., Garzón-Montesinos, C., Falcón‐Moya, R., Pastor, A., Martín‐García, E., Pizarro, N., Busquets-García, A., Revest, J., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.01.014 · Cited by 35 · see citing works

Kaempferol Facilitated Extinction Learning in Contextual Fear Conditioned Rats via Inhibition of Fatty-Acid Amide Hydrolase

Ahmad, H., Rauf, K., Zada, W., McCarthy, M. M., Abbas, G., Anwar, F., & Shah, A. J. (2020) · Molecules · doi:10.3390/molecules25204683 · Cited by 35 · see citing works

Decreased anxiety in juvenile rats following exposure to low levels of chlorpyrifos during development

Carr, R. L., Armstrong, N. H., Buchanan, A. T., Eells, J. B., Mohammed, A. N., Ross, M. K., & Nail, C. A. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2015.11.016 · Cited by 34 · see citing works

Neuregulin-1 Impairs the Long-term Depression of Hippocampal Inhibitory Synapses by Facilitating the Degradation of Endocannabinoid 2-AG

Du, H., Kwon, I., & Kim, J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5833-12.2013 · Cited by 33 · see citing works

The relationship between cannabis use and measures of anxiety and depression in a sample of college campus cannabis users and non-users post state legalization in Colorado

Troup, L. J., Andrzejewski, J. A., Braunwalder, J. T., & Torrence, R. D. (2016) · PeerJ · doi:10.7717/peerj.2782 · Cited by 33 · see citing works

Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 suppress chronic cerebral hypoperfusion-induced neuronal apoptosis by inhibiting c-Jun N-terminal kinase signaling

Su, S., Wu, Y.-F., Lin, Q., Yu, F., & Hai, J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.021 · Cited by 32 · see citing works

Oleoylethanolamide Modulates BDNF-ERK Signaling and Neurogenesis in the Hippocampi of Rats Exposed to Δ9-THC and Ethanol Binge Drinking During Adolescence

Silva‐Peña, D., Rivera, P., Alén, F., Vargas, A., Rubio, L., García‐Marchena, N., Pavón, F. J., Serrano, A., de Fonseca, F. R., & Suárez, J. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00096 · Cited by 32 · see citing works

Paracetamol—The outcome on neurotransmission and spatial learning in rats

Blecharz‐Klin, K., Piechal, A., Pyrzanowska, J., Joniec‐Maciejak, I., Kiliszek, P., & Widy‐Tyszkiewicz, E. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.07.008 · Cited by 31 · see citing works

Neurobiological mechanisms underlying cannabis-induced memory impairment

Prini, P., Zamberletti, E., Manenti, C., Gabaglio, M., Parolaro, D., & Rubino, T. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.02.002 · Cited by 31 · see citing works

Regional changes in the type 1 cannabinoid receptor are associated with cognitive dysfunction in Parkinson’s disease

Ceccarini, J., Casteels, C., Ahmad, R. U., Crabbé, M., de Vliet, L. V., Vanhaute, H., Vandenbulcke, M., Vandenberghe, W., & Laere, K. V. (2019) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-019-04445-x · Cited by 31 · see citing works

Chronic Use of Synthetic Cannabinoids Is Associated With Impairment in Working Memory and Mental Flexibility

Cohen, K., Mama, Y., Rosca, P., Pinhasov, A., & Weinstein, A. M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00602 · Cited by 30 · see citing works

Examination of the Addictive and Behavioral Properties of Fatty Acid-Binding Protein Inhibitor SBFI26

Thanos, P. K., Clavin, B. H., Hamilton, J., O’Rourke, J. R., Maher, T., Koumas, C., Miao, E., Lankop, J., Elhage, A., Haj‐Dahmane, S., et al. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00054 · Cited by 30 · see citing works

The endocannabinoid system: a key modulator of emotions and cognition

Campolongo, P., & Trezza, V. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00073 · Cited by 29 · see citing works

Sexually-dimorphic alterations in cannabinoid receptor density depend upon prenatal/early postnatal history

Dow-Edwards, D. L., Frank, A., Wade, D., Weedon, J., & Izenwasser, S. (2016) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2016.09.004 · Cited by 29 · see citing works

Effects of the synthetic cannabinoid 5F-AMB on anxiety and recognition memory in mice

Ito, S., Deyama, S., Domoto, M., Zhang, T., Sasase, H., Fukao, A., Esaki, H., Hinoi, E., Kaneko, S., & Kaneda, K. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05222-2 · Cited by 29 · see citing works

Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention

Chen, J., Hutchison, K. E., Bryan, A. D., Filbey, F. M., Calhoun, V. D., Claus, E. D., Lin, D., Jing Sui （Beijing Normal University）， my correct affiliation is beijing normal university, N. Q. U. O. S. A. T., Du, Y., & Liu, J. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00594 · Cited by 28 · see citing works

Lower amygdala fatty acid amide hydrolase in violent offenders with antisocial personality disorder: an [11C]CURB positron emission tomography study

Kolla, N. J., Boileau, I., Karas, K. H., Watts, J. J., Rusjan, P., Houle, S., & Mizrahi, R. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01144-2 · Cited by 28 · see citing works

WIN55,212-2 impairs non-associative recognition and spatial memory in rats via CB1 receptor stimulation

Galanopoulos, A., Polissidis, A., Γεωργιάδου, Γ., Papadopoulou‐Daifoti, Z., Nomikos, G. G., Pitsikas, N., & Antoniou, K. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.05.014 · Cited by 28 · see citing works

Efficacy of cannabinoids in neurodevelopmental and neuropsychiatric disorders among children and adolescents: a systematic review

Rice, L. J., Cannon, L., Dadlani, N., Cheung, M. M. Y., Einfeld, S., Efron, D., Dossetor, D. R., & Elliott, E. J. (2023) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-023-02169-w · Cited by 27 · see citing works

The endocannabinoid system and associative learning and memory in zebrafish

Ruhl, T., Moesbauer, K., Oellers, N., & von der Emde, G. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.046 · Cited by 26 · see citing works

Opposite Cannabis-Cognition Associations in Psychotic Patients Depending on Family History

González-Pinto, A. M., González–Ortega, I., Alberich, S., de Azúa, S. R., Bernardo, M., Bioque, M., Cabrera, B., Corripio, I., Arango, C., Lobo, A., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160949 · Cited by 25 · see citing works

Prophylactic Palmitoylethanolamide Prolongs Survival and Decreases Detrimental Inflammation in Aged Mice With Bacterial Meningitis

Heide, E. C., Bîndilă, L., Post, J. M., Malzahn, D., Lutz, B., Seele, J., Nau, R., & Ribes, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02671 · Cited by 24 · see citing works

Physical Exercise Modulates L-DOPA-Regulated Molecular Pathways in the MPTP Mouse Model of Parkinson’s Disease

Klemann, C. J. H. M., Xicoy, H., Poelmans, G., Bloem, B. R., Martens, G. J. M., & Visser, J. E. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0775-0 · Cited by 24 · see citing works

Recovery of BDNF and CB1R in the Prefrontal Cortex Underlying Improvement of Working Memory in Prenatal DEHP-Exposed Male Rats after Aerobic Exercise

Wang, D., Lin, H., Lee, Y.-J., Yu, H.-F., Wu, S.-R., & Qamar, M. U. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113867 · Cited by 25 · see citing works

Long-term assessment of the cognitive effects of nabiximols in patients with multiple sclerosis: A pilot study

Alessandria, G., Meli, R., Infante, M. T., Vestito, L., Capello, E., & Bandini, F. (2020) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2020.105990 · Cited by 24 · see citing works

Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams–Beuren syndrome

Navarro-Romero, A., Galera-López, L., Ortiz‐Romero, P., Llorente‐Ovejero, A., Reyes‐Ramírez, L. D. L., de Tena, I. B., García-Elías, A., Mas‐Stachurska, A., Reixachs‐Solé, M., Pastor, A., et al. (2022) · eLife · doi:10.7554/elife.72560 · Cited by 24 · see citing works

Inhibition of fatty acid amide hydrolase by URB597 attenuates the anxiolytic-like effect of acetaminophen in the mouse elevated plus-maze test

Zaitone, S. A., El-Wakeil, A. F., & Abou‐El‐Ela, S. H. (2012) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3283566065 · Cited by 24 · see citing works

Cannabinoid modulation of mother-infant interaction: is it just about milk?

Manduca, A., Campolongo, P., & Trezza, V. (2012) · Reviews in the Neurosciences · doi:10.1515/revneuro-2012-0074 · Cited by 22 · see citing works

Acute Administration of URB597 Fatty Acid Amide Hydrolase Inhibitor Prevents Attentional Impairments by Distractors in Adolescent Mice

Contarini, G., Ferretti, V., & Papaleo, F. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00787 · Cited by 22 · see citing works

The Impact of Cannabis Use on Cognition in People with HIV: Evidence of Function-Dependent Effects and Mechanisms from Clinical and Preclinical Studies

Ayoub, S. M., Holloway, B. M., Miranda, A. H., Roberts, B. Z., Young, J. W., Minassian, A., & Ellis, R. J. (2024) · Current HIV/AIDS Reports · doi:10.1007/s11904-024-00698-w · Cited by 22 · see citing works

Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications

Grimsey, N. L., Savinainen, J. R., Attili, B. N. N. R., & Ahamed, M. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.10.004 · Cited by 22 · see citing works

Effects of the fatty acid amide hydrolase inhibitor URB597 on coping behavior under challenging conditions in mice

Haller, J., Aliczki, M., Gyimesi-Pelczer, K., Spitzer, K., Balogh, Z., & Kántor, S. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3273-8 · Cited by 21 · see citing works

Effects of CB1 receptor antagonism and stress exposures in adolescence on socioemotional behaviours, neuroendocrine stress responses, and expression of relevant proteins in the hippocampus and prefrontal cortex in rats

Simone, J. J., Baumbach, J. L., & McCormick, C. M. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.10.029 · Cited by 21 · see citing works

Endocannabinoid and steroid analysis in infant and adult nails by LC–MS/MS

Restin, T., Byland, N., Voegel, C. D., Ghaemmaghami, P., Baumgartner, M. R., Bassler, D., Kræmer, T., & Binz, T. M. (2022) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-022-04189-y · Cited by 20 · see citing works

The endocannabinoid system: An emotional buffer in the modulation of memory function

Morena, M., & Campolongo, P. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.12.010 · Cited by 143 · see citing works

The endocannabinoid system: a key modulator of emotions and cognition

Campolongo, P., & Trezza, V. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00073 · Cited by 29 · see citing works

Participation of the Cannabinoid System in the Regulation of Emotional- Like Behaviour

Valverde, O. (2005) · Current Pharmaceutical Design · doi:10.2174/138161205774370780 · Cited by 40 · see citing works

Cannabinoids and emotionality: a neuroanatomical perspective

McLaughlin, R. J., & Gobbi, G. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.052 · Cited by 82 · see citing works

Implications for Emotional Responses

Viveros, M.-P., Marco, E.-M., Llorente, R., & López-gallardo, M. (2013)