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Cited by 24Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorFlavonoids in Medical Research

Effects of quercetin on the neuromotor function and behavioral responses of Wistar and Zucker rats fed a high-fat and high-carbohydrate diet

Mzhelskaya, Kristina V., Shipelin, Vladimir A., Shumakova, Antonina A., Musaeva, Anna D., Soto, Jorge S., Riger, Nikolay A., Trusov, Nikita V., Kirbaeva, Natalya V. +2 more·2020·Behavioural Brain Research
DOI 10.1016/j.bbr.2019.112270
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Abstract

Quercetin can affect some pathological manifestations in obesity. The mechanism underlying the presumed therapeutic effect of quercetin is probably related to the influence on the central processes regulating energy homeostasis. Thus, the purpose of this study was to examine the effect of quercetin on the neuromotor and behavioral functions in Zucker (Z) and Wistar (W) rats with genetically and/or diet-induced obesity. Rats of both strains received balanced or high fat and fructose diet (HFCD) in a 62-day experiment or the same diets supplemented with quercetin at the dose of 50 mg/kg body weight per day. The neuromotor function and behavioral responses were examined using the grip strength test, open field test, elevated plus maze test and conditioned passive avoidance response (CPAR) test. The quercetin potentiated a decrease in anxiety in W rats consumed HFCD and this effect was absent in Z rats with a defect in the leptin receptor gene. In contrast, quercetin increased locomotor activity and impaired short-term memory in the CPAR test only in Z rats with the absence of normal leptin reception. Against the background of the identified changes quercetin exerted significant effects on the lipid and nitrogen metabolism indices such as HDL cholesterol, AsAT/AlAT activities ratio, urea level as well as body and fat mass that were different in Z and W rats. The data obtained show that the effects of quercetin on behavior vary significantly between two strains of rat and consequently are mediated by processes of leptin reception.

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  • The anxiolytic effect observed during EPM testing in animals that consumed FFI was manifested in a longer (three times compared to IMM) stay of rats in open arms, indicating a decrease in their anxiety-like functions.

    “The anxiolytic effect observed during EPM testing in animals that consumed FFI was manifested in a longer (three times compared to IMM) stay of rats in open arms, which indicates a decrease in their anxiety-like functions [41].”

    From Adaptogenic Properties of a Phytoecdysteroid-Rich Extract from the Leaves of Spinacia oleracea L. (2021) · cites this paper as [41]

  • The assessment of behavior and short-term memory of animals was carried out using the CRPA test according to methodology and equipment described earlier [41].

    “The assessment of the behavior and short-term memory of animals was carried out on the 15th day of the experiment using the “Conditioned reflex of passive Avoidance” (CRPA) test according to the methodology and on equipment described earlier [41].”

    From Adaptogenic Properties of a Phytoecdysteroid-Rich Extract from the Leaves of Spinacia oleracea L. (2021) · cites this paper as [41]

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Authors
Mzhelskaya, K. V., Shipelin, V. A., Shumakova, A. A., Musaeva, A. D., Soto, J. S., Riger, N. A., Trusov, N. V., Kirbaeva, N. V., Apryatin, S. A., & Gmoshinski, I. V.
Affiliations
Federal Research Centre of Nutrition and Biotechnology (RU)
ORCID
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2020-01
Volume
378
Pages
112270
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/j.bbr.2019.112270
OpenAlex
W2977898178
Cited by
24
References
32
Citations by year
2026: 3 · 2025: 4 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 3
FWCI
1.80
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Russian Science Foundation
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
Keywords
quercetin, diet-induced obesity, high-fat high-carbohydrate diet, leptin receptor, Zucker rats, Wistar rats, anxiety, locomotor activity, short-term memory, neuromotor function, behavioral responses, lipid metabolism, nitrogen metabolism, strain differences
MeSH terms
Diet, Carbohydrate Loading, Animals, Antioxidants, Anxiety, Behavior, Animal, Disease Models, Animal, Learning, Locomotion, Male, Obesity, Quercetin, Rats, Zucker, Rats, Wistar, Rats, Muscle Strength, Receptors, Leptin, Diet, High-Fat

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