Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats
Open accessAbstract
The aim of this study was to analyze the effects of chronic administration of high doses of quercetin on metabolic syndrome abnormalities, including obesity, dyslipidemia, hypertension, and insulin resistance. For this purpose, obese Zucker rats and their lean littermates were used. The rats received a daily dose of quercetin (2 or 10 mg/kg of body weight) or vehicle for 10 weeks. Body weight and systolic blood pressure (SBP) were recorded weekly. At the end of the treatment, plasma concentrations of triglycerides, total cholesterol, free-fatty acids (FFAs), glucose, insulin, adiponectin, and nitrate plus nitrite (NOx) were determined. Tumor necrosis factor-alpha (TNF-alpha) production, inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS) protein expression were analyzed in visceral adipose tissue (VAT). The raised SBP and high plasma concentrations of triglycerides, total cholesterol, FFA, and insulin found in obese Zucker rats were reduced in obese rats that received either of the doses of quercetin assayed. The higher dose also improved the inflammatory status peculiar to this model, as it increased the plasma concentration of adiponectin, reduced NOx levels in plasma, and lowered VAT TNF-alpha production in obese Zucker rats. Furthermore, chronic intake of the higher dose of quercetin enhanced VAT eNOS expression among obese Zucker rats, whereas it downregulated VAT iNOS expression. In conclusion, both doses of quercetin improved dyslipidemia, hypertension, and hyperinsulinemia in obese Zucker rats, but only the high dose produced antiinflammatory effects in VAT together with a reduction in body weight gain.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Administration of quercetin improves components of metabolic syndrome such as dyslipidemia, hypertension, and insulin resistance.
“Furthermore, it was shown that the administration of quercetin improves the components of the MetS such as dyslipidemia, hypertension, and insulin resistance [47].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [47]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154 · see citing works
Eckel, R. H., Alberti, K., Grundy, S. M., & Zimmet, P. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61794-3 · Cited by 6,283 · see citing works
Eckel, R. H., Grundy, S. M., & Zimmet, P. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66378-7 · Cited by 5,566 · see citing works
Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882 · see citing works
Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study
Hertog, M. G. L., Feskens, E. J. M., Kromhout, D., Hertog, M. G. L., Hollman, P. C. H., Hertog, M. G. L., & Katan, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)92876-u · Cited by 4,336 · see citing works
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,702 · see citing works
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543 · see citing works
Obesity and the Metabolic Syndrome in Children and Adolescents
Weiss, R., Dziura, J., Burgert, T. S., Tamborlane, W. V., Taksali, S. E., Yeckel, C. W., Allen, K., Lopes, M., Savoye, M., Morrison, J. A., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031049 · Cited by 3,458 · see citing works
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824 · see citing works
Flavonoid intake and risk of chronic diseases
Knekt, P., Kumpulainen, J. T., Järvinen, R., Rissanen, H. A., Heliövaara, M., Reunanen, A., Hakulinen, T., & Aromaa, A. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.3.560 · Cited by 1,748 · see citing works
Effects of a Mediterranean-Style Diet on Cardiovascular Risk Factors: A Randomized Trial
Estruch, R., Martínez-González, M. Á., Corella, D., Salas-Salvadó, J., Ruiz-Gutiérrez, V., Covas, M. I., Fiol, M., Gómez-Gracia, E., López-Sabater, M. C., Vinyoles, E., et al. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-1-200607040-00004 · Cited by 1,704 · see citing works
Increasing Prevalence of the Metabolic Syndrome Among U.S. Adults
Ford, E. S., Giles, W. H., & Mokdad, A. H. (2004) · Diabetes Care · doi:10.2337/diacare.27.10.2444 · Cited by 1,488 · see citing works
Dandona, P., Aljada, A., Chaudhuri, A., Mohanty, P., & Garg, R. (2005) · Circulation · doi:10.1161/01.cir.0000158483.13093.9d · Cited by 1,263 · see citing works
Pathophysiology of insulin resistance in human disease
Reaven, G. M. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.473 · Cited by 1,235 · see citing works
Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women
Mink, P. J., Scrafford, C. G., Barraj, L. M., Harnack, L., Hong, C.-P., Nettleton, J. A., & Jacobs, D. R. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.895 · Cited by 945 · see citing works
COSKUN, O., Kanter, M., Korkmaz, A., & Öter, Ş. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2004.06.002 · Cited by 815 · see citing works
Dietary Patterns and Risk for Type 2 Diabetes Mellitus in U.S. Men
van Dam, R. M., Rimm, E. B., Willett, W. C., Stampfer, M. J., & Hu, F. B. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-3-200202050-00008 · Cited by 801 · see citing works
Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation
Steinberg, H. O., Tarshoby, M., Monestel, R., Hook, G., Cronin, J., Johnson, A., Bayazeed, B., & Baron, A. D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119636 · Cited by 761 · see citing works
Perreault, M., & Marette, A. (2001) · Nature Medicine · doi:10.1038/nm1001-1138 · Cited by 540 · see citing works
Duplain, H., Burcelin, R., Sartori, C., Cook, S., Egli, M., Lepori, M., Vollenweider, P., Pedrazzini, T., Nicod, P., Thorens, B., et al. (2001) · Circulation · doi:10.1161/01.cir.104.3.342 · Cited by 533 · see citing works
Comalada, M., Ballester, I., Bailón, E., Sierra, S., Xaus, J., Gálvez, J., Medina, F. S. D., & Zarzuelo, A. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.07.016 · Cited by 440 · see citing works
Cardioprotective Effects of Dietary Polyphenols
Zern, T. L., & Fernández, M. L. (2005) · Journal of Nutrition · doi:10.1093/jn/135.10.2291 · Cited by 367 · see citing works
Du, X., Edelstein, D., Obici, S., Higham, N., Zou, M., & Brownlee, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci23354 · Cited by 344 · see citing works
TNF- downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents
Valerio, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28570 · Cited by 327 · see citing works
Sánchez, M., Galisteo, M., Vera, R., Villar, I. C., Zarzuelo, A., Tamargo, J. L., Pérez‐Vizcaíno, F., & Duarte, J. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000198029.22472.d9 · Cited by 315 · see citing works
Camuesco, D., Comalada, M., Rodríguez‐Cabezas, M. E., Nieto, A., Lorente, M., Concha, Á., Zarzuelo, A., & Gálvez, J. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705941 · Cited by 268 · see citing works
The Zucker fatty rat as a genetic model of obesity and hypertension.
Kurtz, T. W., Morris, R. C., & Pershadsingh, H. A. (1989) · Hypertension · doi:10.1161/01.hyp.13.6.896 · Cited by 261 · see citing works
Factor analysis of the metabolic syndrome: obesity vs insulin resistance as the central abnormality
Anderson, P., Critchley, J. A. J. H., Chan, J., Cockram, C., Lee, Z. S. K., Thomas, G. N., & Tomlinson, B. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801837 · Cited by 232 · see citing works
Esposito, K., Nappo, F., Giugliano, F., Palo, C. D., Ciotola, M., Barbieri, M., Paolisso, G., & Giugliano, D. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.6.1135 · Cited by 225 · see citing works
Peluso, M. R. (2006) · Experimental Biology and Medicine · doi:10.1177/153537020623100802 · Cited by 218 · see citing works
BÉDARD, S., Marcotte, B., & Marette, A. (1997) · Biochemical Journal · doi:10.1042/bj3250487 · Cited by 175 · see citing works
Protective effects of the flavonoid quercetin in chronic nitric oxide deficient rats
Duarte, J., Jiménez, R., O’Valle, F., Galisteo, M., Pérez‐Palencia, R., Vargas, F., Pérez‐Vizcaíno, F., Zarzuelo, A., & Tamargo, J. L. (2002) · Journal of Hypertension · doi:10.1097/00004872-200209000-00031 · Cited by 150 · see citing works
Zern, T. L., West, K. L., & Fernández, M. L. (2003) · Journal of Nutrition · doi:10.1093/jn/133.7.2268 · Cited by 147 · see citing works
Auger, C., Teissèdre, P., Gérain, P., Lequeux, N., Bornet, A., Serisier, S., Besançon, P., Caporiccio, B., Cristol, J., & Rouanet, J. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf048177q · Cited by 144 · see citing works
Kamada, C., da Silva, E. L., Ohnishi‐Kameyama, M., Moon, J., & Terao, J. (2005) · Free Radical Research · doi:10.1080/10715760400019638 · Cited by 123 · see citing works
Galisteo, M., Sánchez, M., Vera, R., González, M., Anguera, A., Duarte, J., & Zarzuelo, A. (2005) · Journal of Nutrition · doi:10.1093/jn/135.10.2399 · Cited by 97 · see citing works
Nettleton, J. A., Harnack, L., Scrafford, C., Mink, P. J., Barraj, L. M., & Jacobs, D. R. (2006) · Journal of Nutrition · doi:10.1093/jn/136.12.3039 · Cited by 96 · see citing works
Mechanism of adipose tissue iNOS induction in endotoxemia
Kapur, S., Marcotte, B., & Marette, A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.4.e635 · Cited by 78 · see citing works
Galisteo, M., Garcia-Saura, M. F., Jiménez, R., Villar, I. C., Zarzuelo, A., Vargas, F., & Duarte, J. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000021360.89867.64 · Cited by 67 · see citing works
Yugar‐Toledo, J. C., Tanus-Santos, J. E., Sabha, M., de Sousa, M. G., Cittadino, M., Tácito, L. H. B., & Moreno, H. (2004) · CHEST Journal · doi:10.1378/chest.125.3.823 · Cited by 67 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Quercetin, Inflammation and Immunity
Li, Y., Yao, J., Han, C., Yang, J., Chaudhry, M., Wang, S., Liu, H., & Yin, Y. (2016) · Nutrients · doi:10.3390/nu8030167 · Cited by 1,999 · see citing works
Metabolic Syndrome: Updates on Pathophysiology and Management in 2021
Fahed, G., Aoun, L., Bou Zerdan, M., Allam, S., Bou Zerdan, M., Bouferraa, Y., & Assi, H. I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020786 · Cited by 1,441 · see citing works
Impact of Dietary Polyphenols on Carbohydrate Metabolism
Hanhineva, K., Törrönen, R., Bondia‐Pons, I., Pekkinen, J., Kolehmainen, M., Mykkänen, H. M., & Poutanen, K. S. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11041365 · Cited by 1,160 · see citing works
Metabolic syndrome: pathophysiology, management, and modulation by natural compounds
Rochlani, Y. M., Pothineni, N. V. K., Kovelamudi, S., & Mehta, J. L. (2017) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944717711379 · Cited by 1,103 · see citing works
Therapeutic Potential of Moringa oleifera Leaves in Chronic Hyperglycemia and Dyslipidemia: A Review
Mbikay, M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00024 · Cited by 615 · see citing works
Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease
Vergara-Jiménez, M. D. J., Almatrafi, M. M., & Fernández, M. L. (2017) · Antioxidants · doi:10.3390/antiox6040091 · Cited by 593 · see citing works
Egert, S., Bosy‐Westphal, A., Seiberl, J., Kürbitz, C., Settler, U., Plachta‐Danielzik, S., Wagner, A. E., Frank, J., Schrezenmeir, J., Rimbach, G. H., et al. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509359127 · Cited by 580 · see citing works
Effects of Flavonoids and other Polyphenols on Inflammation
González, R., Ballester, I., López-Posadas, R., Suárez, M. D., Zarzuelo, A., Martínez‐Augustin, O., & de Medina, F. S. (2011) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903584094 · Cited by 572 · see citing works
Polyphenols and Glycemic Control
Kim, Y., Keogh, J. B., & Clifton, P. M. (2016) · Nutrients · doi:10.3390/nu8010017 · Cited by 557 · see citing works
Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids
Kawser Hossain, M., Abdal Dayem, A., Han, J., Yin, Y., Kim, K., Kumar Saha, S., Yang, G.-M., Choi, H., & Cho, S.-G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040569 · Cited by 495 · see citing works
Etxeberria, U., Arias, N., Boqué, N., Macarulla, M. T., Portillo, M. P., Martínez, J. A., & Milagro, F. I. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.01.002 · Cited by 446 · see citing works
The Effects of Flavonoids in Cardiovascular Diseases
Ciumărnean, L., Milaciu, M. V., Runcan, O., Vesa, Ș. C., Răchişan, A. L., Negrean, V., Perné, M.-G., Donca, V., Alexescu, T., Para, I., et al. (2020) · Molecules · doi:10.3390/molecules25184320 · Cited by 447 · see citing works
Kleemann, R., Verschuren, L., Morrison, M. C., Zadelaar, S., van Erk, M. J., Wielinga, P. Y., & Kooistra, T. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.04.023 · Cited by 403 · see citing works
Rivera, L., Morón, R., Zarzuelo, A., & Galisteo, M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.11.027 · Cited by 391 · see citing works
Flavonols and cardiovascular disease
Perez-Vizcaino, F., & Duarte, J. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.09.002 · Cited by 393 · see citing works
Quercetin and metabolic syndrome: A review
Hosseini, A., Razavi, B. M., Banach, M., & Hosseinzadeh, H. (2021) · Phytotherapy Research · doi:10.1002/ptr.7144 · Cited by 390 · see citing works
Dietary Polyphenol, Gut Microbiota, and Health Benefits
Wang, X., Qi, Y., & Zheng, H. (2022) · Antioxidants · doi:10.3390/antiox11061212 · Cited by 412 · see citing works
Modulation of adipose tissue inflammation by bioactive food compounds
Siriwardhana, N., Kalupahana, N. S., Cekanova, M., LeMieux, M. J., Greer, B. P., & Moustaïd‐Moussa, N. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.12.013 · Cited by 345 · see citing works
A minireview of quercetin: from its metabolism to possible mechanisms of its biological activities
Ulusoy, H. G., & Şanlıer, N. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1683810 · Cited by 319 · see citing works
Antihypertensive effects of the flavonoid quercetin
Pérez‐Vizcaíno, F., Duarte, J., Jiménez, R., Santos‐Buelga, C., & Osuna, A. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70008-8 · Cited by 317 · see citing works
Role of quercetin as an alternative for obesity treatment: You are what you eat!
Nabavi, S. F., Russo, G. L., Daglia, M., & Nabavi, S. M. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.02.006 · Cited by 304 · see citing works
Flavonoids, Dairy Foods, and Cardiovascular and Metabolic Health
Mozaffarian, D., & Wu, J. H. Y. (2018) · Circulation Research · doi:10.1161/circresaha.117.309008 · Cited by 305 · see citing works
Oxidative stress and metabolic pathologies: from an adipocentric point of view
Le Lay, S., Simard, G., Martinez, M. C., & Andriantsitohaina, R. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/908539 · Cited by 291 · see citing works
Dong, J., Zhang, X., Zhang, L., Bian, H., Xu, N., Bao, B., & Liu, J. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m038786 · Cited by 295 · see citing works
Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing
Gantenbein, K. V., & Kanaka-Gantenbein, C. (2021) · Nutrients · doi:10.3390/nu13061951 · Cited by 288 · see citing works
Chuang, C., & McIntosh, M. (2011) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-072610-145149 · Cited by 271 · see citing works
Panchal, S. K., Poudyal, H., & Brown, L. (2012) · Journal of Nutrition · doi:10.3945/jn.111.157263 · Cited by 271 · see citing works
Jung, C. H., Cho, I.-J., Ahn, J., Jeon, T., & Ha, T. Y. (2012) · Phytotherapy Research · doi:10.1002/ptr.4687 · Cited by 265 · see citing works
Flavonoids: Antioxidant Powerhouses and Their Role in Nanomedicine
Zahra, M., Abrahamse, H., & George, B. P. A. (2024) · Antioxidants · doi:10.3390/antiox13080922 · Cited by 259 · see citing works
Kobori, M., Masumoto, S., Akimoto, Y., & Oike, H. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000392 · Cited by 256 · see citing works
Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review
Iqbal, I., Wilairatana, P., Saqib, F., Nasir, B., Wahid, M., Latif, M. F., Iqbal, A., Naz, R., & Mubarak, M. S. (2023) · Molecules · doi:10.3390/molecules28176403 · Cited by 257 · see citing works
Brüll, V., Burak, C., Stoffel‐Wagner, B., Wolffram, S., Nickenig, G., Müller, C., Langguth, P., Alteheld, B., Fimmers, R., Naaf, S., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515002950 · Cited by 239 · see citing works
Flavonoids in hypertension: a brief review of the underlying mechanisms.
Maaliki, D., Shaito, A. A., Pintus, G., El-Yazbi, A., & Eid, A. (2019) · Current opinion in pharmacology (Print) · doi:10.1016/j.coph.2019.04.014 · Cited by 208 · see citing works
Wang, C., Pan, Y., Zhang, Q.-Y., Wang, F., & Kong, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038285 · Cited by 233 · see citing works
Cocoa Polyphenols and Their Potential Benefits for Human Health
Andújar, I., Recio, M. C., Giner, R. M., & Rı́os, J. L. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/906252 · Cited by 232 · see citing works
The Beneficial Effects of Quercetin, Curcumin, and Resveratrol in Obesity
Zhao, Y., Chen, B., Shen, J., Wan, L., Zhu, Y., Yi, T., & Xiao, Z. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/1459497 · Cited by 214 · see citing works
Molecular mechanisms of the cardiovascular protective effects of polyphenols
Andriantsitohaina, R., Auger, C., Chataigneau, T., Étienne-Selloum, N., Li, H., Martínez, M. C., Schini‐Kerth, V. B., & Laher, I. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003406 · Cited by 215 · see citing works
Effects of the Dietary Flavonoid Quercetin Upon Performance and Health
Davis, J. M., Murphy, E. A., & Carmichael, M. D. (2009) · Current Sports Medicine Reports · doi:10.1249/jsr.0b013e3181ae8959 · Cited by 211 · see citing works
Beneficial Effects of Quercetin on Obesity and Diabetes
Portillo, M. P. (2011) · The Open Nutraceuticals Journal · doi:10.2174/1876396001104010189 · Cited by 212 · see citing works
Chuang, C., Martinez, K., Xie, G., Kennedy, A. J., Bumrungpert, A., Overman, A., Jia, W. P., & McIntosh, M. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29807 · Cited by 205 · see citing works
Liu, J., He, Z., Ma, N., & Chen, Z. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b06817 · Cited by 196 · see citing works
Targeting obesity with plant-derived pancreatic lipase inhibitors: A comprehensive review
Logesh, R., Palaniswamy, D. S., & Mohankumar, S. K. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104681 · Cited by 197 · see citing works
Egert, S., Boesch, C., Wolffram, S., Rimbach, G. H., & Müller, M. J. (2009) · Journal of Nutrition · doi:10.3945/jn.109.117655 · Cited by 194 · see citing works
The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese rats
Aldini, G., Orioli, M., Rossoni, G., Savi, F., Braidotti, P., Vistoli, G., Yeum, K., Negrisoli, G., & Carini, M. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01101.x · Cited by 189 · see citing works
Health promoting properties of blueberries: a review
Silva, S., Costa, E. M., Veiga, M., Morais, R. M. S. C., Calhau, C., & Pintado, M. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1518895 · Cited by 188 · see citing works
Marefati, N., Ghorani, V., Shakeri, F., Boskabady, M., Kianian, F., Rezaee, R., & Boskabady, M. H. (2021) · Pharmaceutical Biology · doi:10.1080/13880209.2021.1874028 · Cited by 182 · see citing works
Pfeuffer, M., Auinger, A., Bley, U., Kraus-Stojanowic, I., Laue, C., Winkler, P., Rüfer, C. E., Frank, J., Boesch‐Saadatmandi, C., Rimbach, G. H., et al. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.08.010 · Cited by 182 · see citing works
Effects of resveratrol and other wine polyphenols on vascular function: an update
Gresele, P., Cerletti, C., Guglielmini, G., Pignatelli, P., de Gaetano, G., & Violi, F. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.07.004 · Cited by 178 · see citing works
Panchal, S. K., Poudyal, H., Arumugam, T. V., & Brown, L. (2011) · Journal of Nutrition · doi:10.3945/jn.111.137877 · Cited by 177 · see citing works
Phytochemicals and their impact on adipose tissue inflammation and diabetes
Leiherer, A., Muendlein, A., & Drexel, H. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.09.002 · Cited by 169 · see citing works
Quercetin Protects against Obesity-Induced Skeletal Muscle Inflammation and Atrophy
Le, N. H., Kim, C.-S., Park, T., Park, J. H. Y., Sung, M.-K., Lee, D. G., Hong, S.-M., Choe, S.-Y., Goto, T., Kawada, T., et al. (2014) · Mediators of Inflammation · doi:10.1155/2014/834294 · Cited by 167 · see citing works
Yi, H., Peng, H., Wu, X., Xu, X., Kuang, T., Zhang, J., Du, L., & Fan, G. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6678662 · Cited by 166 · see citing works
Phytochemicals as Anti-Inflammatory Agents in Animal Models of Prevalent Inflammatory Diseases
Shin, S. A., Joo, B. J., Lee, J. S., Ryu, G., Han, M., Kim, W. Y., Park, H. H., Lee, J. H., & Lee, C. S. (2020) · Molecules · doi:10.3390/molecules25245932 · Cited by 166 · see citing works
Zahedi, M., Ghiasvand, R., Feizi, A., Asgari, G., & Darvish, L. (2013) · Europe PMC (PubMed Central) · Cited by 157 · see citing works
Beneficial Effects of Natural Bioactive Compounds from Hibiscus sabdariffa L. on Obesity
Ojulari, O. V., Lee, S. G., & Nam, J. (2019) · Molecules · doi:10.3390/molecules24010210 · Cited by 142 · see citing works
Effects of daily quercetin-rich supplementation on cardiometabolic risks in male smokers
Lee, K.-H., Park, E., Lee, H.-J., Kim, M.-O., Cha, Y.-J., Kim, J.-M., Lee, H., & Shin, M. (2011) · Nutrition Research and Practice · doi:10.4162/nrp.2011.5.1.28 · Cited by 141 · see citing works
Flavonoids and metabolic syndrome
Galleano, M., Calabró, V., Prince, P. D., Litterio, M. C., Piotrkowski, B., Prieto, M. A. V., Miatello, R. M., Oteiza, P. I., & Fraga, C. G. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06511.x · Cited by 139 · see citing works
Efficacy of flavonoids in the management of high blood pressure
Clark, J. L., Zahradka, P. C., & Taylor, C. G. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuv048 · Cited by 135 · see citing works
Muralitharan, R. R., Jama, H. A., Xie, L., Peh, A., Snelson, M., & Marques, F. Z. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14473 · Cited by 131 · see citing works
Dietary polyphenols and their roles in fat browning
Silvester, A. J., Aseer, K. R., & Yun, J. W. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.09.028 · Cited by 131 · see citing works
Winiarska‐Mieczan, A., Kwiecień, M., Jachimowicz-Rogowska, K., Donaldson, J., Tomaszewska, E., & Baranowska‐Wójcik, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032258 · Cited by 136 · see citing works
Hu, Q., Wang, C., Li, J., Zhang, D., & Kong, L. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90767.2008 · Cited by 128 · see citing works
Polyphenols: Planting the seeds of treatment for the metabolic syndrome
Cherniack, E. P. (2011) · Nutrition · doi:10.1016/j.nut.2010.10.013 · Cited by 127 · see citing works
Nanoformulations of natural products for management of metabolic syndrome
Taghipour, Y. D., Hajialyani, M., Naseri, R., Hesari, M., Mohammadi, P., Stefanucci, A., Mollica, A., Farzaei, M. H., & Abdollahi, M. R. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s213831 · Cited by 127 · see citing works
Yarmohammadi, F., Rezaee, R., & Karimi, G. (2020) · Phytotherapy Research · doi:10.1002/ptr.6882 · Cited by 126 · see citing works
Baselga‐Escudero, L., Bladé, C., Ribas‐Latre, A., Casanova, E., Suárez, M., Torres, J. L., Salvadó, M. J., Arola, L., & Arola‐Arnal, A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1011 · Cited by 123 · see citing works
Singh, A. K., Rana, H. K., Tshabalala, T., Kumar, R., Gupta, A., Ndhlala, A. R., & Pandey, A. K. (2019) · South African Journal of Botany · doi:10.1016/j.sajb.2019.06.017 · Cited by 130 · see citing works
Prieto, M. A. V., Bettaieb, A., Haj, F. G., Fraga, C. G., & Oteiza, P. I. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.02.019 · Cited by 118 · see citing works
Son, Y. H., Lee, J. H., Chung, H., & Pae, H. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/639541 · Cited by 115 · see citing works
Zhang, X., Li, X., Fang, H., Guo, F., Li, F., Chen, A., & Huang, S. (2019) · Nutrition & Metabolism · doi:10.1186/s12986-019-0370-7 · Cited by 115 · see citing works
Miles, S. L., McFarland, M., & Niles, R. M. (2014) · Nutrition Reviews · doi:10.1111/nure.12152 · Cited by 114 · see citing works
Effects of a grapeseed procyanidin extract (GSPE) on insulin resistance
Montagut, G., Bladé, C., Blay, M., Fernández-Larrea, J., Pujadas, G., Salvadó, M. J., Arola, L., Pinent, M., & Ardèvol, A. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.08.001 · Cited by 114 · see citing works
Khorshidi, M., Moini, A., Alipoor, E., Rezvan, N., Gorgani‐Firuzjaee, S., Yaseri, M., & Hosseinzadeh‐Attar, M. J. (2018) · Phytotherapy Research · doi:10.1002/ptr.6166 · Cited by 112 · see citing works
Overman, A., Chuang, C.-C., & McIntosh, M. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.272 · Cited by 112 · see citing works
Albishi, T. S., John, J. A., Al-Khalifa, A. S., & Shahidi, F. (2013) · Journal of Functional Foods · doi:10.1016/j.jff.2013.02.005 · Cited by 111 · see citing works
Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome
Noce, A., Lauro, M. D., Daniele, F. D., Zaitseva, A. P., Marrone, G., Borboni, P., & Daniele, N. D. (2021) · Nutrients · doi:10.3390/nu13020630 · Cited by 116 · see citing works
Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes
Prieto, M. A. V., Bettaieb, A., Lanzi, C. R., Soto, V. C., Perdicaro, D. J., Galmarini, C. R., Haj, F. G., Miatello, R. M., & Oteiza, P. I. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400631 · Cited by 108 · see citing works
Cai, Y., Kong, H., Pan, Y., Jiang, L., Pan, X.-X., Hu, L., Qian, Y., Jiang, C., & Liu, W. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0520-z · Cited by 107 · see citing works
Dietary plant flavonoids in prevention of obesity and diabetes
Dinda, B., Dinda, M., Roy, A., & Dinda, S. (2019) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2019.08.006 · Cited by 106 · see citing works
Isoorientin: A dietary flavone with the potential to ameliorate diverse metabolic complications
Ziqubu, K., Dludla, P. V., Joubert, E., Muller, C. J. F., Louw, J., Tiano, L., Nkambule, B. B., Kappo, A. P., & Mazibuko-Mbeje, S. E. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104867 · Cited by 100 · see citing works
Phytochemicals as novel agents for the induction of browning in white adipose tissue
Azhar, Y., Parmar, A., Miller, C. N., Samuels, J. S., & Rayalam, S. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0150-6 · Cited by 99 · see citing works
Lalanza, J. F., Caimari, A., Bas-Prior, J. M. D., Torregrosa, D., Cigarroa, I., Pallàs, M., Capdevila, L., Arola, L., & Escorihuela, R. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085049 · Cited by 98 · see citing works
Quercetin enhances adiponectin secretion by a PPAR-γ independent mechanism
Wein, S., Behm, N., Petersen, R. K., Kristiansen, K., & Wolffram, S. (2010) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2010.05.004 · Cited by 95 · see citing works
ApoE genotype: from geographic distribution to function and responsiveness to dietary factors
Egert, S., Rimbach, G. H., & Huebbe, P. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000249 · Cited by 95 · see citing works
Seiva, F. R. F., Chuffa, L. G. D. A., Braga, C. P., Amorim, J. P. D. A., & Fernandes, A. A. H. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.07.009 · Cited by 93 · see citing works
Ali, F., Ismail, A., & Kersten, S. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300277 · Cited by 91 · see citing works
Das, D., Shruthi, N. R., Banerjee, A., Jothimani, G., Duttaroy, A. K., & Pathak, S. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1221438 · Cited by 90 · see citing works
Alegbeleye, O. O. (2017) · Food and Nutrition Bulletin · doi:10.1177/0379572117749814 · Cited by 89 · see citing works
Recent Advances in Nanoencapsulation of Phytochemicals to Combat Obesity and Its Comorbidities
Göktaş, Z., Zu, Y., Abbasi, M., Galyean, S., Wu, D., Fan, Z., & Wang, S. F. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c00131 · Cited by 89 · see citing works
Tabrizi, R., Tamtaji, O. R., Mirhosseini, N., Lankarani, K. B., Akbari, M., Heydari, S. T., Dadgostar, E., & Asemi, Z. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1604491 · Cited by 88 · see citing works
Kobayashi, Y., Miyazawa, M., Kamei, A., Abe, K., & KOJIMA, T. (2010) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.100392 · Cited by 88 · see citing works
Polyphenols in fermented apple juice: Beneficial effects on human health
Zhang, S., Hu, C. Y., Guo, Y., Wang, X., & Meng, Y. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104294 · Cited by 87 · see citing works
Indra, M. R., Karyono, S., Ratnawati, R., & Malik, S. G. (2013) · BMC Research Notes · doi:10.1186/1756-0500-6-275 · Cited by 87 · see citing works
Dehghani, F., Jandaghi, S. H. S. S., Janani, L., Sarebanhassanabadi, M., Emamat, H., & Vafa, M. (2020) · Phytotherapy Research · doi:10.1002/ptr.6955 · Cited by 86 · see citing works
Flavonoids in Treatment of Chronic Kidney Disease
Cao, Y., Lin, J., Hammes, H., & Zhang, C. (2022) · Molecules · doi:10.3390/molecules27072365 · Cited by 89 · see citing works
Eitah, H. E., Maklad, Y. A., Abdelkader, N. F., el Din, A. A. G., Badawi, M., & Kenawy, S. A. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.12.011 · Cited by 85 · see citing works
Arias, N., Macarulla, M. T., Aguirre, L., Martínez-Castaño, M. G., & Portillo, M. P. (2013) · Genes & Nutrition · doi:10.1007/s12263-013-0361-7 · Cited by 86 · see citing works
Anhê, G. F., Okamoto, M. M., Kinote, A. P. B. D. M., Sollon, C. S., Lellis‐Santos, C., Anhê, F. F., Lima, G. A., Hirabara, S. M., Velloso, L. A., Bordin, S. A., et al. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.06.007 · Cited by 84 · see citing works
Molecular mechanisms of the anti-obesity effect of bioactive ingredients in common spices: a review
Lu, M., Cao, Y., Xiao, J., Song, M., & Ho, C. (2018) · Food & Function · doi:10.1039/c8fo01349g · Cited by 84 · see citing works
Cardiovascular Effects of Flavonoids
Sánchez, M., Romero, M., Gómez‐Guzmán, M., Tamargo, J. L., Pérez‐Vizcaíno, F., & Duarte, J. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867326666181220094721 · Cited by 85 · see citing works
- Authors
- Rivera, L., Morón, R., Sánchez, M., Zarzuelo, A., & Galisteo, M.
- Affiliations
- Universidad de Granada (ES)
- Corresponding author
- Galisteo, Milagros
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2008-09
- Volume
- 16
- Issue
- 9
- Pages
- 2081-2087
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2093497534
- Cited by
- 473
- References
- 41
- Citations by year
- 2026: 20 · 2025: 15 · 2024: 27 · 2023: 28 · 2022: 30 · 2021: 21 · 2020: 41 · 2019: 36 · 2018: 25 · 2017: 24 · 2016: 27 · 2015: 22 · 2014: 38 · 2013: 35 · 2012: 32
- FWCI
- 12.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Instituto de Salud Carlos III (Red HERACLES RD06/0009, RD 06/0009)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- quercetin, metabolic syndrome, Zucker rats, dyslipidemia, hypertension, insulin resistance, adiponectin, nitric oxide, inflammation, visceral adipose tissue, TNF-α, inducible nitric oxide synthase, endothelial nitric oxide synthase, hyperinsulinemia, weight gain
- MeSH terms
- Adipose Tissue, Animals, Antioxidants, Blood Glucose, Blood Pressure, Body Weight, Eating, Fatty Acids, Nonesterified, Insulin, Male, Nitric Oxide, Obesity, Quercetin, Rats, Zucker, Triglycerides, Tumor Necrosis Factor-alpha, Metabolic Syndrome, Rats, Adiponectin, Nitric Oxide Synthase Type II, Nitric Oxide Synthase Type III
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
