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Increased expression of PPARγ in high fat diet-induced liver steatosis in mice
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Hepatic PPARγ plays important roles in HFD-induced up-regulation of lipogenic genes and de novo lipogenesis.
“and this may also have contributed to the reduced hepatic lipogenesis, as hepatic PPARγ plays important roles in HFD-induced up-regulation of lipogenic genes and de novo lipogenesis.53–55”
From (Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice From Diet-Induced Obesity and Hepatosteatosis (2018) · cites this paper as [53]
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The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
Braissant, O., Foufelle, F., Scotto, C., Dauça, M., & Wahli, W. (1996) · Endocrinology · doi:10.1210/endo.137.1.8536636 · Cited by 2,217
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Research works printed but not linked: 32
- Lemberger, 1996, Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology, Annu. Rev. Cell. Dev. Biol., 12, 335, 10.1146/annurev.cellbio.12.1.335 · DOI
- Spiegelman, 1996, Adipogenesis and obesity: rounding out the big picture, Cell, 84, 377, 10.1016/S0092-8674(00)81359-8 · DOI
- Tontonoz, 1994, mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer, Genes Dev., 8, 1224, 10.1101/gad.8.10.1224 · DOI
- Zhu, 1995, Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms, Proc. Natl. Acad. Sci. USA, 92, 7921, 10.1073/pnas.92.17.7921 · DOI
- Rosen, 2002, C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway, Genes Dev., 16, 22, 10.1101/gad.948702 · DOI
- Nolan, 1994, Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone, N. Engl. J. Med., 331, 1188, 10.1056/NEJM199411033311803 · DOI
- Ricote, 1998, The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation, Nature, 391, 79, 10.1038/34178 · DOI · Paper page
- Xin, 1999, Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo, J. Biol. Chem., 274, 9116, 10.1074/jbc.274.13.9116 · DOI
- Li, 2000, Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice, J. Clin. Invest., 106, 523, 10.1172/JCI10370 · DOI
- Sarraf, 1998, Differentiation and reversal of malignant changes in colon cancer through PPARgamma, Nat. Med., 4, 1046, 10.1038/2030 · DOI
- Brockman, 1998, Activation of PPARγ leads to inhibition of anchorage-independent growth of human colorectal cancer cells, Gastroenterology, 115, 1049, 10.1016/S0016-5085(98)70072-1 · DOI
- Tontonoz, 1997, Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptorγ and the retinoid X receptor, Proc. Natl. Acad. Sci. USA, 94, 237, 10.1073/pnas.94.1.237 · DOI
- Takahashi, 1999, Activation of PPARγ inhibits cell growth and induces apoptosis in human gastric cancer cells, FEBS Lett., 455, 135, 10.1016/S0014-5793(99)00871-6 · DOI
- Motomura, 2000, Activation of peroxisome proliferator-activated receptor γ by troglitazone inhibits cell growth through the increase of p27Kip1 in human pancreatic carcinoma cells, Cancer Res., 60, 5558
- Motomura, 2004, Growth arrest by troglitazone is mediated by p27Kip1 accumulation which is resulted from dual inhibition of proteasome activity and Skp2 expression in human hepatocellular carcinoma cells, Int. J. Cancer, 108, 41, 10.1002/ijc.11561 · DOI
- Memon, 2000, Endocrinology, 141, 4021, 10.1210/endo.141.11.7771 · DOI
- Rahimian, 2001, Hepatic over-expression of peroxisome proliferator activated receptor gamma2 in the ob/ob mouse model of non-insulin dependent diabetes mellitus, Mol. Cell. Biochem., 224, 29, 10.1023/A:1011927113563 · DOI
- Chao, 2000, Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones, J. Clin. Invest., 106, 1221, 10.1172/JCI11245 · DOI
- Burant, 1997, Troglitazone action is independent of adipose tissue, J. Clin. Invest., 100, 2900, 10.1172/JCI119839 · DOI
- Bedoucha, 2001, Diabetic KKAy mice exhibit increased hepatic PPARgamma1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones, J. Hepatol., 35, 17, 10.1016/S0168-8278(01)00066-6 · DOI
- Matsusue, 2003, Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes, J. Clin. Invest., 111, 737, 10.1172/JCI200317223 · DOI · Paper page
- Yu, 2003, Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression, J. Biol. Chem., 278, 498, 10.1074/jbc.M210062200 · DOI
- Angulo, 2002, Nonalcoholic fatty liver disease, N. Engl. J. Med., 346, 1221, 10.1056/NEJMra011775 · DOI · Paper page
- Bedoucha, 2001, Diabetic KKAy mice exhibit increased hepatic PPARgamma1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones, J. Hepatol., 38, 17, 10.1016/S0168-8278(01)00066-6 · DOI
- Takahashi, 2004, A novel aminosterol reverses diabetes and fatty liver disease in obese mice, J. Hepatol., 41, 391, 10.1016/j.jhep.2004.05.006 · DOI
- Gregoire, 2002, Diet-induced obesity and hepatic gene expression alterations in C57BL/6J and ICAM-1-deficient mice, Am. J. Physiol., 282, E703
- Herzig, 2003, CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma, Nature, 426, 190, 10.1038/nature02110 · DOI
- Matsui, 2004, Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet, Diabetes, 53, 2844, 10.2337/diabetes.53.11.2844 · DOI
- Nicholson, 2001, Role of CD36, the macrophage class B scavenger receptor, in atherosclerosis, Ann. N. Y. Acad. Sci., 947, 224, 10.1111/j.1749-6632.2001.tb03944.x · DOI
- Motojima, 1998, Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner, J. Biol. Chem., 273, 16710, 10.1074/jbc.273.27.16710 · DOI
- Walczak, 2002, PPARadigms and PPARadoxes: expanding roles for PPARgamma in the control of lipid metabolism, J. Lipid Res., 43, 177, 10.1016/S0022-2275(20)30159-0 · DOI
- Herzig, 2001, CREB regulates hepatic gluconeogenesis through the coactivator PGC-1, Nature, 413, 179, 10.1038/35093131 · DOI · Paper page
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Rivera, C. A., Adegboyega, P., van Rooijen, N., Tagalicud, A., Allman, M., & Wallace, M. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.04.019 · Cited by 693
Systems proteomics of liver mitochondria function
Williams, E. G., Wu, Y., Jha, P., Dubuis, S., Blattmann, P., Argmann, C. A., Houten, S. M., Amariuta, T., Wolski, W., Zamboni, N., et al. (2016) · Science · doi:10.1126/science.aad0189 · Cited by 289
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Wada, T., Kenmochi, H., Miyashita, Y., Sasaki, M., Ojima, M., Sasahara, M., Koya, D., Tsuneki, H., & Sasaoka, T. (2010) · Endocrinology · doi:10.1210/en.2009-0869 · Cited by 189
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Dysregulation of systemic iron metabolism in alcoholic liver diseases
Kohgo, Y., Ohtake, T., Ikuta, K., Suzuki, Y., Torimoto, Y., & Kato, J. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05290.x · Cited by 66
Self-citationRen, L., Sun, Y., Lu, H., Ye, D., Han, L., Wang, N., Daugherty, A., Li, F., Wang, M., Su, F., et al. (2018) · Circulation Research · doi:10.1161/circresaha.117.312422 · Cited by 59
Samson, S. L., Gonzalez, E. V., Yechoor, V., Bajaj, M., Oka, K., & Chan, L. (2008) · Molecular Therapy · doi:10.1038/mt.2008.198 · Cited by 54
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Seo, M. H., Lee, J., Hong, S.-W., Rhee, E.-J., Park, S. E., Park, C. Y., Oh, K. W., Park, S. W., & Lee, W.-Y. (2016) · PLOS ONE · doi:10.1371/journal.pone.0166913 · Cited by 37
Baik, M., Jeong, J. Y., Park, S. J., Yoo, S. P., Lee, J. O., Lee, J. S., Haque, M. N., & Lee, H.-J. (2020) · Genes & Nutrition · doi:10.1186/s12263-020-00673-1 · Cited by 24
Chen, K. L. A., Zhao, Y. C., Hieronymi, K., Smith, B. P., & Madak-Erdogan, Z. (2017) · PLOS ONE · doi:10.1371/journal.pone.0189911 · Cited by 19
Physiological and pathophysiological actions of insulin in the liver
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The effect of early-life stress and chronic high-sucrose diet on metabolic outcomes in female rats
Maniam, J., Antoniadis, C. P., & Morris, M. J. (2015) · Stress · doi:10.3109/10253890.2015.1079617 · Cited by 13
Metadata
- Authors
- Inoue, M., Ohtake, T., Motomura, W., Takahashi, N., Hosoki, Y., Miyoshi, S., Suzuki, Y., Saito, H., Kohgo, Y., & Okumura, T.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 336
- Issue
- 1
- Pages
- 215-222
- ISSN
- 0006-291X
- Cited by
- 340
- References
- 2
- Language
- en
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
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