BCR-crosslinking induces a transcription of protein phosphatase component G5PR that is required for mature B-cell survival
Abstract
BCR-crosslinking triggers activation-induced cell death (AICD) selectively in the restricted stage of B-cell differentiation. We examined the transcription of a protein phosphatase subunit G5PR in immature and mature B-cells, because absence of this factor augmented cell sensitivity to AICD, associated with increased activation of JNK and Bim. BCR-crosslinking-induced G5pr transcription in AICD-resistant mature splenic IgM(lo)IgD(hi) B-cells but not in AICD susceptible immature IgM(hi)IgD(lo) B-cells. Thus, G5pr induction correlated with the prevention of AICD; High in mature splenic CD23(hi) B-cells but low in immature B-cells of neonatal mice, sub-lethally irradiated mice, or xid mice. Lack of G5pr upregulation was associated with the prolonged activation of JNK. The G5pr cDNA transfection protected an immature B-cell line WEHI-231 from BCR-mediated AICD. The differential expression of G5PR might be responsible for the antigen-dependent selection of B-cells.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
G5PR expression is upregulated in mature B-cells upon their activation.
“G5PR expression is upregulated in mature B-cells upon their activation [78].”
From Physiologic functions of PP2A: Lessons from genetically modified mice (2019) · cites this paper as [78]
Cites
Hardy, R. R., & Hayakawa, K. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.595 · Cited by 1,236 · see citing works
Transcription from the RAG1 Locus Marks the Earliest Lymphocyte Progenitors in Bone Marrow
Igarashi, H., Gregory, S. C., Yokota, T., Sakaguchi, N., & Kincade, P. W. (2002) · Immunity · doi:10.1016/s1074-7613(02)00366-7 · Cited by 452 · see citing works
Self-citationTransgenic Mice and Analysis of B-Cell Tolerance
Goodnow, C. C. (1992) · Annual Review of Immunology · doi:10.1146/annurev.iy.10.040192.002421 · Cited by 359 · see citing works
Molecular mechanisms of theprotein serine/threonine phosphatases
Barford, D. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)10060-8 · Cited by 358 · see citing works
Evidence for the clonal abortion theory of B-lymphocyte tolerance.
Nossal, G. J. V., & Pike, B. L. (1975) · The Journal of Experimental Medicine · doi:10.1084/jem.141.4.904 · Cited by 295 · see citing works
Transitional B cells: step by step towards immune competence
Chung, J. B., Silverman, M. A., & Monroe, J. G. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00119-4 · Cited by 264 · see citing works
Anti‐immunoglobulin antibodies induce apoptosis in immature B cell lymphomas
Hasbold, J., & Klaus, G. G. B. (1990) · European Journal of Immunology · doi:10.1002/eji.1830200810 · Cited by 247 · see citing works
Anti‐immunoglobulins induce death by apoptosis in WEHI‐231 B lymphoma cells
Benhamou, L. E., Cazenave, P., & Sarthou, P. (1990) · European Journal of Immunology · doi:10.1002/eji.1830200630 · Cited by 234 · see citing works
Engagement of the antigen-receptor on immature murine B lymphocytes results in death by apoptosis.
Norvell, A., Mandik, L., & Monroe, J. G. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.9.4404 · Cited by 214 · see citing works
Positive and negative selection events during B lymphopoiesis
Melchers, F., Rolink, A., Grawunder, U., et al. (1995) · Current Opinion in Immunology · doi:10.1016/0952-7915(95)80006-9 · Cited by 194 · see citing works
Protein serine/threonine phosphatases: life, death, and sleeping
Gallego, M., & Virshup, D. M. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.01.002 · Cited by 152 · see citing works
(2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.00611.x · Cited by 138 · see citing works
Kuwata, N., Igarashi, H., Ohmura, T., Aizawa, S., & Sakaguchi, N. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.12.6355 · Cited by 128 · see citing works
Self-citationYellen, A., Glenn, W., Sukhatme, V. P., et al. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.5.1446 · Cited by 110 · see citing works
Role of Bruton′s Tyrosine Kinase in B Cell Development
Maas, A., & Hendriks, R. W. (2001) · Journal of Immunology Research · doi:10.1155/2001/28962 · Cited by 106 · see citing works
Middendorp, S., Dingjan, G. M., Maas, A., Dahlenborg, K., & Hendriks, R. W. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.5988 · Cited by 103 · see citing works
Molecular mechanisms guiding late stages of B‐cell development
Rolink, A., Andersson, J., & Melchers, F. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.0101.x · Cited by 74 · see citing works
King, L. B., Norvell, A., & Monroe, J. G. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.5.2655 · Cited by 71 · see citing works
Nemazee, D. A. (1999) · Advances in immunology · doi:10.1016/s0065-2776(08)60909-8 · Cited by 70 · see citing works
Tomlinson, M. G., Woods, D. B., McMahon, M., Wahl, M. I., Witte, O. N., Kurosaki, T., Bolen, J. B., & Johnston, J. A. (2001) · BMC Immunology · doi:10.1186/1471-2172-2-4 · Cited by 65 · see citing works
Transcription Factor STAT5A Is a Substrate of Bruton's Tyrosine Kinase in B Cells
Mahajan, S., Vassilev, A. O., Sun, N., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104874200 · Cited by 64 · see citing works
Receptor Editing in Positive and Negative Selection of B Lymphopoiesis
Edry, E., & Melamed, D. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.7.4265 · Cited by 63 · see citing works
Cellular and Molecular Mechanisms of B Lymphocyte Tolerance
Nossal, G. J. V. (1992) · Advances in immunology · doi:10.1016/s0065-2776(08)60878-0 · Cited by 61 · see citing works
BCR mediated signal transduction in immature and mature B cells
Koncz, G., Bödör, C., Kövesdi, D., et al. (2002) · Immunology Letters · doi:10.1016/s0165-2478(02)00017-2 · Cited by 51 · see citing works
Carman, J., Wechsler‐Reya, R. J., & Monroe, J. G. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.12.4562 · Cited by 46 · see citing works
Wu, H.-J. J., Venkataraman, C., Estus, S., Dong, C., Davis, R. J., Flavell, R. A., & Bondada, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1263 · Cited by 38 · see citing works
Tasker, L. (1997) · International Immunology · doi:10.1093/intimm/9.4.475 · Cited by 38 · see citing works
MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR
Kono, Y., Maeda, K., Kuwahara, K., Yamamoto, H., Miyamoto, E., Yonezawa, K., Takagi, K., & Sakaguchi, N. (2002) · Genes to Cells · doi:10.1046/j.1365-2443.2002.00562.x · Cited by 35 · see citing works
Self-citationProtein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis
Xing, Y., Igarashi, H., Wang, X., & Sakaguchi, N. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050637 · Cited by 30 · see citing works
Self-citationMetcalf, E. S., SIGAL, N. H., & Klinman, N. R. (1977) · The Journal of Experimental Medicine · doi:10.1084/jem.145.5.1382 · Cited by 24 · see citing works
Igarashi, H., Kuwahara, K., Nomura, J., et al. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.6.2381 · Cited by 16 · see citing works
Self-citationAntigen receptor-mediated signaling pathways in transitional immature B cells
Kövesdi, D., Pászty, K., Enyedi, Á., et al. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.01.005 · Cited by 16 · see citing works
Maeda, K., Inui, S., Tanaka, H., & Sakaguchi, N. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00571.x · Cited by 16 · see citing works
Self-citationChanges in B lineage cell population in liver and spleen of normal neonatal mice.
Jyonouchi, H., & Kincade, P. W. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.130.4.1616 · Cited by 15 · see citing works
Middendorp, S., & Hendriks, R. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.3.1371 · Cited by 14 · see citing works
Brink, R. A., Fulcher, D. A., Goodnow, C. C., & Basten, A. (1994) · International Immunology · doi:10.1093/intimm/6.12.1905 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Physiologic functions of PP2A: Lessons from genetically modified mice
Reynhout, S., & Janssens, V. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.07.010 · Cited by 124 · see citing works
Xing, Y., Wang, X., Igarashi, H., Kawamoto, H., & Sakaguchi, N. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2007.10.028 · Cited by 15 · see citing works
Self-citationKitabatake, M., Toda, T., Kuwahara, K., Igarashi, H., Ohtsuji, M., Tsurui, H., Hirose, S., & Sakaguchi, N. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102774 · Cited by 12 · see citing works
Self-citation
- Authors
- Huq Ronny, F. M., Igarashi, H., & Sakaguchi, N.
- Affiliations
- Japan Science and Technology Agency (JP)
- Corresponding author
- Sakaguchi, Nobuo
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 340
- Issue
- 1
- Pages
- 338-346
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2094133361
- Cited by
- 8
- References
- 36
- Citations by year
- 2022: 1 · 2018: 2 · 2016: 1 · 2015: 1 · 2012: 1
- FWCI
- 0.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Science and Technology Agency
- Core Research for Evolutional Science and Technology
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- protein phosphatase 2A, activation-induced cell death, B cell survival, JNK activation, building information modeling, CD23, WEHI-231 cells, xid mice
- MeSH terms
- Animals, Antigens, Differentiation, B-Lymphocyte, B-Lymphocytes, Cell Differentiation, Cell Line, Cell Survival, Cross-Linking Reagents, Phosphoprotein Phosphatases, Receptors, Antigen, B-Cell, Transcriptional Activation, Cell Proliferation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review