Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis
Open accessAbstract
B cell receptor (BCR) cross-linking induces B cell proliferation and sustains survival through the phosphorylation-dependent signals. We report that a loss of the protein phosphatase component G5PR increased the activation-induced cell death (AICD) and thus impaired B cell survival. G5PR associates with GANP, whose expression is up-regulated in mature B cells of the peripheral lymphoid organs. To study G5PR function, the G5pr gene was conditionally targeted with the CD19-Cre combination (G5pr(-/-) mice). The G5pr(-/-) mice had a decreased number of splenic B cells (60% of the controls). G5pr(-/-) B cells showed a normal proliferative response to lipopolysaccharide or anti-CD40 antibody stimulation but not to BCR cross-linking with or without IL-4 in vitro. G5pr(-/-) B cells did not show abnormalities in the BCR-mediated activation of Erks and NF-kappaB, cyclin D2 induction, or Akt activation. However, G5pr(-/-) B cells were sensitive to AICD caused by BCR cross-linking. This was associated with an increased depolarization of the mitochondrial membrane and the enhanced activation of c-Jun NH(2)-terminal protein kinase and Bim. These results suggest that G5PR is required for the BCR-mediated proliferation associated with the prevention of AICD in mature B cells.
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These results imply the existence of a G5PR-dependent resistance mechanism to BCR-activation-induced apoptosis in mature B-cells.
“These results imply the existence of a G5PRdependent resistance mechanism to BCR-activation-induced apoptosis in mature B-cells [76]”
From Physiologic functions of PP2A: Lessons from genetically modified mice (2019) · cites this paper as [76]
G5PR knockout cells showed prolonged Bim phosphorylation after BCR cross-linking, accompanied by sustained JNK activation and enhanced mitochondrial membrane depolarization.
“Upon analysis, cells showed prolonged Bim phosphorylation after BCR cross-linking, accompanied by sustained JNK activation and enhanced mitochondrial membrane depolarization.”
From Physiologic functions of PP2A: Lessons from genetically modified mice (2019) · cites this paper as [76]
In contrast to G5PR-deficient B-cells, apoptosis in G5PR-deficient thymocytes seemed caspase-3 dependent and Bim-independent.
“in contrast to the mechanism in G5PR-deficient B-cells [76], apoptosis seemed to be caspase-3 dependent and Bim-independent.”
From Physiologic functions of PP2A: Lessons from genetically modified mice (2019) · cites this paper as [76]
The reduced number of mature B-cells in B-cell-specific B′′γ/G5PR knockout mice was attributed to impaired B-cell survival and increased BCR-activation-induced apoptosis, rather than to a proliferation defect.
“the reduced number of mature B-cells in spleen, lymph nodes and peripheral blood that was seen in a B-cell specific KO of B″γ/G5PR (Ppp2r3c), was attributed to impaired B-cell survival and increased BCR-activation-induced apoptosis, rather than to a proliferation defect [76].”
From Physiologic functions of PP2A: Lessons from genetically modified mice (2019) · cites this paper as [76]
Transgenic overexpression of G5PR in lymphoid cells achieved a 4.5-times overexpression in isolated splenocytes.
“in which a 4.5-times overexpression of G5PR was confirmed in isolated splenocytes.”
From Physiologic functions of PP2A: Lessons from genetically modified mice (2019) · cites this paper as [76]
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Cites
Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289 · see citing works
Self-citationSignal transduction by the JNK group of MAP kinases
Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237 · see citing works
Cellular survival: a play in three Akts
Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216 · see citing works
Chen, L., Willis, S. N., Wei, A., Smith, B. J., Fletcher, J. I., Hinds, M. G., Colman, P. M., Day, C. L., Adams, J. M., & Huang, D. C. S. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.12.030 · Cited by 1,816 · see citing works
Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway
Tournier, C., Hess, P., Yang, D. D., Xu, J., Turner, T. K., Nimnual, A., Bar-Sagi, D., Jones, S. N., Flavell, R. A., & Davis, R. J. (2000) · Science · doi:10.1126/science.288.5467.870 · Cited by 1,728 · see citing works
Cheng, E. H. Y., Wei, M. C., Weiler, S., Flavell, R. A., Mak, T. W., Lindsten, T., & Korsmeyer, S. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00320-3 · Cited by 1,708 · see citing works
The JNK signal transduction pathway
Weston, C. R. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00258-1 · Cited by 1,545 · see citing works
Bouillet, P., Metcalf, D., Huang, D. C. S., Tarlinton, D. M., Kay, T. W. H., Köntgen, F., Adams, J. M., & Strasser, A. (1999) · Science · doi:10.1126/science.286.5445.1735 · Cited by 1,504 · see citing works
McDonnell, T. J., Deane, N., Platt, F. M., Nunez, G., Jaeger, U., McKearn, J. P., & Korsmeyer, S. J. (1989) · Cell · doi:10.1016/0092-8674(89)90174-8 · Cited by 1,213 · see citing works
Kuwana, T., Bouchier-Hayes, L., Chipuk, J. E., Bonzon, C., Sullivan, B. A., Green, D. R., & Newmeyer, D. D. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.003 · Cited by 1,185 · see citing works
Lam, K., Kühn, R., & Rajewsky, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80373-6 · Cited by 1,101 · see citing works
JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis
Lei, K., & Davis, R. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438011100 · Cited by 1,068 · see citing works
Puthalakath, H., Huang, D. C. S., O'REILLY, L. A., King, S. M., & Strasser, A. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80456-6 · Cited by 1,053 · see citing works
Yamamoto, K., Ichijo, H., & Korsmeyer, S. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8469 · Cited by 1,003 · see citing works
Strasser, A., Whittingham, S., Vaux, D. L., Bath, M. L., Adams, J. M., Cory, S., & Harris, A. W. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8661 · Cited by 861 · see citing works
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
Bouillet, P., Purton, J. F., Godfrey, D. I., Zhang, L.-C., Coultas, L., Puthalakath, H., Pellegrini, M., Cory, S., Adams, J. M., & Strasser, A. (2002) · Nature · doi:10.1038/415922a · Cited by 782 · see citing works
Defective B cell development and function in Btk-deficient mice
Khan, W. N., Alt, F. W., Gerstein, R. M., Malynn, B. A., Larsson, I., Rathbun, G. A., Davidson, L., Müller, S., Kantor, A. B., Herzenberg, L. A., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90114-0 · Cited by 726 · see citing works
Regulation of B-cell fate by antigen-receptor signals
Niiro, H., & Clark, E. A. (2002) · Nature reviews. Immunology · doi:10.1038/nri955 · Cited by 626 · see citing works
Lee, H. H., Dadgostar, H., Cheng, Q., Shu, J., & Cheng, G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9136 · Cited by 522 · see citing works
Cambier, J. C. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.7.3281 · Cited by 467 · see citing works
Maundrell, K., Antonsson, B. E., Magnenat, E. M., Camps, M., Muda, M., Chabert, C., Gilliéron, C., Boschert, U., Vial-Knecht, E., Martinou, J., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.25238 · Cited by 399 · see citing works
The MAGUK Family Protein CARD11 Is Essential for Lymphocyte Activation
Hara, H., Wada, T., Bakal, C., Kozieradzki, I., Suzuki, S., Suzuki, N., Nghiem, M. P., Griffiths, E. K., Krawczyk, C. M., Bauer, B., et al. (2003) · Immunity · doi:10.1016/s1074-7613(03)00148-1 · Cited by 336 · see citing works
The complexity of signaling pathways activated by the BCR
DeFranco, A. L. (1997) · Current Opinion in Immunology · doi:10.1016/s0952-7915(97)80074-x · Cited by 318 · see citing works
Pham, L. V., Tamayo, A. T., Yoshimura, L. C., Lo, P., & Ford, R. J. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.1.88 · Cited by 318 · see citing works
Enders, A., Bouillet, P., Puthalakath, H., Xu, Y., Tarlinton, D. M., & Strasser, A. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030411 · Cited by 295 · see citing works
Okada, T., Maeda, A., Iwamatsu, A., Gotoh, K., & Kurosaki, T. (2000) · Immunity · doi:10.1016/s1074-7613(00)00079-0 · Cited by 287 · see citing works
Molecular Mechanisms of Transmembrane Signaling in B Lymphocytes
Cambier, J. C., & Ransom, J. T. (1987) · Annual Review of Immunology · doi:10.1146/annurev.iy.05.040187.001135 · Cited by 277 · see citing works
Ranger, A. M., Malynn, B. A., & Korsmeyer, S. J. (2001) · Nature Genetics · doi:10.1038/88815 · Cited by 265 · see citing works
Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells
Tew, J. G., Wu, J., Qin, D., et al. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb00957.x · Cited by 250 · see citing works
O’Reilly, L. A., Cullen, L., Visvader, J. E., Lindeman, G. J., Print, C. G., Bath, M. L., Huang, D. C. S., & Strasser, A. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64557-9 · Cited by 235 · see citing works
Amarante-Mendes, G. P., McGahon, A. J., Nishioka, W. K., Afar, D., Witte, O. N., & Green, D. R. (1998) · Oncogene · doi:10.1038/sj.onc.1201664 · Cited by 225 · see citing works
Molecular mechanisms in B cell antigen receptor signaling
Kurosaki, T. (1997) · Current Opinion in Immunology · doi:10.1016/s0952-7915(97)80075-1 · Cited by 192 · see citing works
Iκb Kinase α Is Essential for Mature B Cell Development and Function
Kaisho, T., Takeda, K., Tsujimura, T., Kawai, T., Nomura, F., Terada, N., & Akira, S. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.4.417 · Cited by 186 · see citing works
IκB Kinase Signaling Is Essential for Maintenance of Mature B Cells
Pasparakis, M., Schmidt‐Supprian, M., & Rajewsky, K. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020907 · Cited by 185 · see citing works
Recent advances in the study of dendritic cells and follicular dendritic cells
Caux, C., Liu, Y.-J., & Banchereau, J. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80061-1 · Cited by 185 · see citing works
Grillot, D., Merino, R., Pena, J. C., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.2.381 · Cited by 176 · see citing works
Graves, J. D., Draves, K. E., Craxton, A., Saklatvala, J., Krebs, E. G., & Clark, E. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13814 · Cited by 161 · see citing works
Pogue, S. L., Kurosaki, T., Bolen, J. B., & Herbst, R. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.3.1300 · Cited by 141 · see citing works
Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development
Solvason, N. W., Wu, W. W., Parry, D., Mahony, D., Lam, E. W. ‐., Glassford, J., Klaus, G. G. B., Siciński, P., Weinberg, R. A., Liu, Y.-J., et al. (2000) · International Immunology · doi:10.1093/intimm/12.5.631 · Cited by 135 · see citing works
Hsu, S. Y., Lin, P., & Hsueh, A. J. W. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.9.0166 · Cited by 129 · see citing works
Functional dissection of BCR signaling pathways
Kurosaki, T. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00087-x · Cited by 117 · see citing works
Katz, P., Whalen, G., & Kehrl, J. H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)89463-2 · Cited by 110 · see citing works
Wildey, G. M., Patil, S. D., & Howe, P. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211958200 · Cited by 97 · see citing works
B Cell Positive Selection: Road Map to the Primary Repertoire?
Cancro, M. P., & Kearney, J. F. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.15 · Cited by 95 · see citing works
Bam32 Links the B Cell Receptor to ERK and JNK and Mediates B Cell Proliferation but Not Survival
Han, A. S., Saijo, K., Mecklenbräuker, I., Tarakhovsky, A., & Nussenzweig, M. C. (2003) · Immunity · doi:10.1016/s1074-7613(03)00275-9 · Cited by 84 · see citing works
Graves, J. D., Draves, K. E., Craxton, A., et al. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.1.168 · Cited by 66 · see citing works
Regulation and Function of Cyclin D2 in B Lymphocyte Subsets
Chiles, T. C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.5.2901 · Cited by 66 · see citing works
Ligand-independent tonic signaling in B-cell receptor function
Monroe, J. G. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.03.010 · Cited by 65 · see citing works
The tyrosine activation motif as a target of protein tyrosine kinases and SH2 domains
Flaswinkel, H., Barner, M., & Reth, M. G. (1995) · Seminars in Immunology · doi:10.1016/1044-5323(95)90004-7 · Cited by 65 · see citing works
Kuwahara, K., Yoshida, M., Kondo, E., Sakata, A., Watanabe, Y., Abe, E., Kouno, Y., Tomiyasu, S., Fujimura, S., Tokuhisa, T., et al. (2000) · Blood · doi:10.1182/blood.v95.7.2321 · Cited by 64 · see citing works
Self-citationKatz, E., Deehan, M. R., Seatter, S. D., Lord, C., Sturrock, R. D., & Harnett, M. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.137 · Cited by 58 · see citing works
Berard, M., Mondière, P., Casamayor‐Palleja, M., Hennino, A., Bella, C., & Defrance, T. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.9.4655 · Cited by 58 · see citing works
Chen, W., Wang, H., Srinivasula, S. M., Alnemri, E. S., & Cooper, N. R. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.5.2483 · Cited by 57 · see citing works
B‐cell receptor and Fas‐mediated signals for life and death
Carey, G. B., Donjerković, D., Mueller, C. M., et al. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.00502.x · Cited by 52 · see citing works
Kuwahara, K., Fujimura, S., Takahashi, Y., Nakagata, N., Takemori, T., Aizawa, S., & Sakaguchi, N. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307609100 · Cited by 47 · see citing works
Self-citationLens, S. M. A., den Drijver, B. F. A., Pötgens, A. J. G., Tesselaar, K., van Oers, M. H. J., & van Lier, R. A. W. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.12.6083 · Cited by 45 · see citing works
Doi, T., Motoyama, N., Tokunaga, A., et al. (1999) · International Immunology · doi:10.1093/intimm/11.6.933 · Cited by 44 · see citing works
Mechanisms of B cell receptor induced apoptosis
Eeva, J., & Pelkonen, J. (2004) · APOPTOSIS · doi:10.1023/b:appt.0000038032.22343.de · Cited by 42 · see citing works
Molecular dissection of B cell antigen receptor signaling (review).
Kurosaki, T. (1998) · International Journal of Molecular Medicine · doi:10.3892/ijmm.1.3.515 · Cited by 42 · see citing works
Kuwahara, K., Tomiyasu, S., Fujimura, S., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181335698 · Cited by 39 · see citing works
Signal Transduction by the B‐Cell Antigen Receptor
DeFranco, A. L., RICHARDS, J. D., BLUM, J. H., et al. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb26662.x · Cited by 37 · see citing works
Zhong, J., & Kyriakis, J. M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.9165-9175.2004 · Cited by 37 · see citing works
MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR
Kono, Y., Maeda, K., Kuwahara, K., Yamamoto, H., Miyamoto, E., Yonezawa, K., Takagi, K., & Sakaguchi, N. (2002) · Genes to Cells · doi:10.1046/j.1365-2443.2002.00562.x · Cited by 35 · see citing works
Self-citationChen, L., Kim, T. J., & Pillai, S. S. (1998) · Molecular Immunology · doi:10.1016/s0161-5890(98)00044-3 · Cited by 34 · see citing works
Determinations of B Cell Fate in Immunity and Autoimmunity
Noelle, R. J., & Erickson, L. D. (2004) · KARGER eBooks · doi:10.1159/000082084 · Cited by 31 · see citing works
Signaling through the B cell antigen receptor in developing B cells.
Yankee, T. M., & Clark, E. A. (2000) · PubMed · Cited by 30 · see citing works
Itoh, S., Itoh, M., Nishida, K., Yamasaki, S., Yoshida, Y., Narimatsu, M., Park, S. J., Hibi, M., Ishihara, K., & Hirano, T. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.10.5110 · Cited by 27 · see citing works
Eeva, J., Postila, V., Mättö, M., et al. (2003) · European Journal of Immunology · doi:10.1002/eji.200324227 · Cited by 22 · see citing works
Immunoglobulin Receptor-Associated Molecules
Sakaguchi, N., Matsuo, T., Nomura, J., Kuwahara, K., Igarashi, H., & Inui, S. (1993) · Advances in immunology · doi:10.1016/s0065-2776(08)60538-6 · Cited by 19 · see citing works
Self-citationPittner, B. T., & Snow, E. C. (1998) · Cellular Immunology · doi:10.1006/cimm.1998.1292 · Cited by 13 · see citing works
B-cell antigen receptor-induced apoptosis: looking for clues
Eldering, E., & vanLier, R. A. W. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.09.003 · Cited by 13 · see citing works
Phosphatases PP1 and PP2A act after the G0/G1 interface in lymphocyte activation
Metcalfe, S. M., & Milner, J. (1990) · Immunology Letters · doi:10.1016/0165-2478(90)90142-d · Cited by 12 · see citing works
Caspase-3 activates endo-exonuclease: Further evidence for a role of the nuclease in apoptosis
Meng, X. W., Fraser, M. J., Feller, J. M., et al. (2000) · APOPTOSIS · doi:10.1023/a:1009604529237 · Cited by 10 · see citing works
Hoerr, I. (2000) · doi:10.1002/1521-4141(200001)30:1
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Physiologic functions of PP2A: Lessons from genetically modified mice
Reynhout, S., & Janssens, V. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.07.010 · Cited by 124 · see citing works
Zwaenepoel, K., Louis, J. V., Goris, J., & Janssens, V. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-393 · Cited by 30 · see citing works
Xing, Y., Wang, X., Igarashi, H., Kawamoto, H., & Sakaguchi, N. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2007.10.028 · Cited by 15 · see citing works
Self-citationKitabatake, M., Toda, T., Kuwahara, K., Igarashi, H., Ohtsuji, M., Tsurui, H., Hirose, S., & Sakaguchi, N. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102774 · Cited by 12 · see citing works
Self-citationHuq Ronny, F. M., Igarashi, H., & Sakaguchi, N. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.11.169 · Cited by 8 · see citing works
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Sarais, F., Krempien, F., Koehn, C., Brewing, L., Classen, C. F., Walter, M., & Shokraie, O. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03560-y · Cited by 8 · see citing works
- Authors
- Xing, Y., Igarashi, H., Wang, X., & Sakaguchi, N.
- Affiliations
- Japan Science and Technology Agency (JP)
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2005-08-29
- Volume
- 202
- Issue
- 5
- Pages
- 707-719
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2212881
- OpenAlex
- W2142184914
- Cited by
- 30
- References
- 74
- Citations by year
- 2025: 1 · 2024: 6 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2016: 2 · 2015: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- protein phosphatase, B cell receptor signaling, activation-induced cell death, B cell survival, GANP, B cell proliferation, mitochondrial depolarization, JNK, building information modeling, NF-κB, Akt, ERK, cyclin D2
- MeSH terms
- Bcl-2-Like Protein 11, Animals, B-Lymphocytes, Flow Cytometry, Membrane Proteins, Nuclear Proteins, Phosphoprotein Phosphatases, Phosphoproteins, Proto-Oncogene Proteins, Receptors, Antigen, B-Cell, Blotting, Western, Apoptosis, DNA Primers, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, In Situ Nick-End Labeling, Gene Silencing, Protein Subunits, JNK Mitogen-Activated Protein Kinases, Apoptosis Regulatory Proteins, Mitochondrial Membranes, Mice
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