The yeast Pdr5p multidrug transporter: How does it recognize so many substrates?

Multidrug resistance in cancer: role of ATP–dependent transporters

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P-glycoprotein: from genomics to mechanism

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PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1.

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Structural Basis of Multiple Drug-Binding Capacity of the AcrB Multidrug Efflux Pump

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ATPase and Multidrug Transport Activities of the Overexpressed Yeast ABC Protein Yor1p

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Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

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Anticancer Drugs, Ionophoric Peptides, and Steroids as Substrates of the Yeast Multidrug Transporter Pdr5p

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The pleitropic drug ABC transporters from Saccharomyces cerevisiae.

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Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance.

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Yeast ABC transporters – A tale of sex, stress, drugs and aging

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In Vivo Characterization of the Drug Resistance Profile of the Major ABC Transporters and Other Components of the Yeast Pleiotropic Drug Resistance Network

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The power of the pump: Mechanisms of action of P-glycoprotein (ABCB1)

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Transcriptional control of the yeast PDR5 gene by the PDR3 gene product.

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Gene SNQ2 of Saccharomyces cerevislae, which confers resistance to 4-nitroquinoline-N-oxide and other chemicals, encodes a 169 kDa protein homologous to ATP-dependent permeases

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Cloning by gene amplification of two loci conferring multiple drug resistance in Saccharomyces.

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A Computational Ensemble Pharmacophore Model for Identifying Substrates of P-Glycoprotein

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Interaction of the yeast pleiotropic drug resistance genes PDR1 and PDR5

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Genetic Separation of FK506 Susceptibility and Drug Transport in the Yeast Pdr5 ATP-binding Cassette Multidrug Resistance Transporter

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High-resolution mapping of replication fork movement through the amplified dihydrofolate reductase domain in CHO cells by in-gel renaturation analysis.

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Functional Characterization of <i>Candida albicans</i> ABC Transporter Cdr1p

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Solubilization and characterization of the overexpressed PDR5 multidrug resistance nucleotide triphosphatase of yeast.

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Structural mechanism of the simultaneous binding of two drugs to a multidrug‐binding protein

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Quantification and Characterization of P-Glycoprotein−Substrate Interactions

Gatlik-Landwojtowicz, E., Äänismaa, P., & Seelig, A. (2006) · Biochemistry · doi:10.1021/bi051380+ · Cited by 110 · see citing works

[10] Saccharomyces cerevisiae ABC proteins and their relevance to human health and disease

Taglicht, D., & Michaelis, S. (1998) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(98)92012-2 · Cited by 101 · see citing works

Studies with Novel Pdr5p Substrates Demonstrate a Strong Size Dependence for Xenobiotic Efflux

Golin, J. E., Ambudkar, S. V., Gottesman, M. M., Habib, A., SCZEPANSKI, J. J., Ziccardi, W., & May, L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210908200 · Cited by 87 · see citing works

Camptothecin Sensitivity Is Mediated by the Pleiotropic Drug Resistance Network in Yeast

Reid, R. J. D., Kauh, E. A., & Bjornsti, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.18.12091 · Cited by 67 · see citing works

Zinc Cluster Protein Rdr1p Is a Transcriptional Repressor of the PDR5 Gene Encoding a Multidrug Transporter

Hellauer, K., Akache, B., MacPherson, S., Sirard, E., & Turcotte, B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201637200 · Cited by 58 · see citing works

Mutational analysis of the yeast multidrug resistance ABC transporter Pdr5p with altered drug specificity

Ţuţulan-Cuniţă, A. C., Mikoshi, M., Mizunuma, M., Hirata, D., & Miyakawa, T. (2005) · Genes to Cells · doi:10.1111/j.1365-2443.2005.00847.x · Cited by 54 · see citing works

Loss of function mutation in the yeast multiple drug resistance gene PDR5 causes a reduction in chloramphenicol efflux

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On the Mechanism of Constitutive Pdr1 Activator-mediated PDR5 Transcription in Saccharomyces cerevisiae

Gao, C., Wang, L., Milgrom, E. M., & Shen, W. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406363200 · Cited by 41 · see citing works

Chemical Specificity of thePDR5Multidrug Resistance Gene Product ofSaccharomyces cerevisiaeBased on Studies with Tri-n-Alkyltin Chlorides

Golin, J. E., Barkatt, A., Cronin, S., Eng, G., & May, L. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.1.134-138.2000 · Cited by 27 · see citing works

The Role of Hydrogen Bond Acceptor Groups in the Interaction of Substrates with Pdr5p, a Major Yeast Drug Transporter

Hanson, L., May, L., Tuma, P. L., Keeven, J., Mehl, P. M., Ferenz, M., Ambudkar, S. V., & Golin, J. E. (2005) · Biochemistry · doi:10.1021/bi0502994 · Cited by 20 · see citing works

Modulator-Induced Interference in Functional Cross Talk between the Substrate and the ATP Sites of Human P-glycoprotein

Maki, N., Moitra, K., Silver, C., et al. (2006) · Biochemistry · doi:10.1021/bi0521745 · Cited by 16 · see citing works

ELM1 Is Required for Multidrug Resistance in Saccharomyces cerevisiae

Souid, A., Gao, C., Wang, L., Milgrom, E. M., & Shen, W.-C. W. (2006) · Genetics · doi:10.1534/genetics.106.057596 · Cited by 16 · see citing works

Efflux-Mediated Antifungal Drug Resistance

Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Baret, P. V., Keniya, M. V., Tanabe, K., Niimi, M., Goffeau, A., & Monk, B. C. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00051-08 · Cited by 608 · see citing works

A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5

Ernst, R., Kueppers, P., Klein, C. M., Schwarzmueller, T., Kuchler, K., & Schmitt, L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800191105 · Cited by 146 · see citing works

Abnormal Ergosterol Biosynthesis Activates Transcriptional Responses to Antifungal Azoles

Hu, C., Zhou, M., Wang, W., Sun, X., Yarden, O., & Li, S. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00009 · Cited by 114 · see citing works

Why most transporter mutations that cause antibiotic resistance are to efflux pumps rather than to import transportersPreprint

Mendes, P., Girardi, E., Superti‐Furga, G., & Kell, D. B. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.16.909507 · Cited by 8 · see citing works

The role of RND-type efflux pumps in multidrug-resistant mutants of Klebsiella pneumoniae

Ni, R. T., Onishi, M., Mizusawa, M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-67820-x · Cited by 84 · see citing works

Antimicrobial Resistance: Two-Component Regulatory Systems and Multidrug Efflux Pumps

Gaetano, G. V. D., Lentini, G., Famà, A., Coppolino, F., & Beninati, C. (2023) · Antibiotics · doi:10.3390/antibiotics12060965 · Cited by 97 · see citing works

Function and Inhibitory Mechanisms of Multidrug Efflux Pumps

Nishino, K., Yamasaki, S., Nakashima, R., Zwama, M., & Hayashi, M. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.737288 · Cited by 232 · see citing works

Reversing Agents for ATP-Binding Cassette (ABC) Transporters: Application in Modulating Multidrug Resistance (MDR)

Lee, C. (2004) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1568011043482197 · Cited by 52 · see citing works