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Cited by 31ATP Synthase and ATPases ResearchBone Metabolism and DiseasesIon Transport and Channel Regulation

Characterization of vacuolar-ATPase and selective inhibition of vacuolar-H(+)-ATPase in osteoclasts

Yao, GuanFeng, Feng, HaoTian, Cai, YanLing, Qi, WeiLi, Kong, KangMei·2007·Biochemical and Biophysical Research Communications
DOI 10.1016/j.bbrc.2007.04.082
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Abstract

V-ATPase plays important roles in controlling the extra- and intra-cellular pH in eukaryotic cell, which is most crucial for cellular processes. V-ATPases are composed of a peripheral V(1) domain responsible for ATP hydrolysis and integral V(0) domain responsible for proton translocation. Osteoclasts are multinucleated cells responsible for bone resorption and relate to many common lytic bone disorders such as osteoporosis, bone aseptic loosening, and tumor-induced bone loss. This review summarizes the structure and function of V-ATPase and its subunit, the role of V-ATPase subunits in osteoclast function, V-ATPase inhibitors for osteoclast function, and highlights the importance of V-ATPase as a potential prime target for anti-resorptive agents.

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  • The ruffled border membrane allows large vesicle transport, delivery of hydrochloric acid by V-ATPase and CLC-7, and release of lysosomal proteases such as cathepsin K, TRAP, and MMPs.

    “The ruffled border membrane allows large vesicle transport, the delivery of hydrochloric acid (by vacuolar-type H + ATPase186) and chloride ion channel-7 (CLC-7),187 and the release of several lysosomal proteases, such as cathepsin K, TRAP, and MMPs.188”

    From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [186]

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Authors
Yao, G., Feng, H., Cai, Y., Qi, W., & Kong, K.
Affiliations
  • Shantou University Medical College (CN)
  • The University of Western Australia (AU)
Corresponding author
Kong, KangMei
ORCID
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2007-06
Volume
357
Issue
4
Pages
821-827
ISSN
0006-291X (ISSN-L)
DOI
10.1016/j.bbrc.2007.04.082
OpenAlex
W2097682609
Cited by
31
References
73
Citations by year
2025: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2016: 1 · 2014: 3 · 2013: 1 · 2012: 2
FWCI
0.33
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
vacuolar ATPase, V-ATPase inhibitors, osteoclasts, bone resorption, osteoporosis, antiresorptive agents, V1 domain, intracellular pH, proton translocation, tumor-induced bone loss
MeSH terms
Adenosine Triphosphatases, Adenosine Triphosphate, Animals, Enzyme Activation, Humans, Osteoclasts, Vacuoles, Signal Transduction

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