The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
microRNA-221 regulates high glucose-induced endothelial dysfunction
Open accessAbstract
Persistent hyperglycemia in diabetes causes endothelial cell dysfunction. Exposure to high levels of glucose, which mimics hyperglycemia, induced expression of microRNA 221 (miR-221) but reduced expression of c-kit, the receptor for stem cell factor in human umbilical vein endothelial cells (HUVECs). In addition, high glucose treatment impaired endothelial cell migration. Incubation with the antisense miR-221 oligonucleotide AMO-221 reduced expression of miR-221 and restored c-kit protein expression in HUVECs treated with high levels of glucose. Furthermore, AMO-221 treatment abolished the inhibitory effect of high glucose exposure on HUVECs transmigration. Thus, under hyperglycemic conditions, miR-221 is induced in HUVECs, which consequently triggers inhibition of c-kit and impairment of HUVECs migration. These findings suggest that manipulation of the miR-221-c-kit pathway may offer a novel strategy for treatment of vascular dysfunction in diabetic patients.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Hyperglycemia increases the expression of several microRNAs found in the endothelium, including miR-320, miR-221, miR-503, and miR-125b.”
From The Vasculature in Prediabetes (2018) · cites this paper as [145]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Xu, C., Lu, Y., Pan, Z., Chu, W., Luo, X., Lin, H., Xiao, J., Shan, H., Wang, Z., & Yang, B. (2007) · Journal of Cell Science · doi:10.1242/jcs.010728 · Cited by 437
Self-citationRetractedBartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Miranda, K. C., Huynh, T., Tay, Y., Ang, Y.-S., Tam, W.-L., Thomson, A. M., Lim, B., & Rigoutsos, I. (2006) · Cell · doi:10.1016/j.cell.2006.07.031 · Cited by 2,063
Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA
van Rooij, E., Sutherland, L. B., Qi, X., Richardson, J. A., Hill, J. A., & Olson, E. N. (2007) · Science · doi:10.1126/science.1139089 · Cited by 1,666
van Rooij, E., Sutherland, L. B., Liu, N., Williams, A. H., McAnally, J., Gerard, R. D., Richardson, J. A., & Olson, E. N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608791103 · Cited by 1,498
Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus
Hink, U., Li, H., Mollnau, H., Oelze, M., Matheis, E., Hartmann, M., Skatchkov, M. P., Thaiss, F., Stahl, R. A. K., Warnholtz, A., et al. (2001) · Circulation Research · doi:10.1161/01.res.88.2.e14 · Cited by 1,191
Yang, B., Lin, H., Xiao, J., Lu, Y., Luo, X., Li, B., Zhang, Y., Xu, C., Bai, Y., Wang, H., et al. (2007) · Nature Medicine · doi:10.1038/nm1569 · Cited by 1,140
Self-citationJi, R., Cheng, Y., Yue, J., Yang, J., Liu, X., Chen, H., Dean, D. B., & Zhang, C. (2007) · Circulation Research · doi:10.1161/circresaha.106.141986 · Cited by 918
Role of microRNAs in vascular diseases, inflammation, and angiogenesis
Urbich, C., Kuehbacher, A., & Dimmeler, S. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn156 · Cited by 880
MicroRNAs modulate the angiogenic properties of HUVECs
Poliseno, L., Tuccoli, A., Mariani, L., Evangelista, M., Citti, L., Woods, K., Mercatanti, A., Hammond, S. M., & Rainaldi, G. (2006) · Blood · doi:10.1182/blood-2006-01-012369 · Cited by 755
Cited by
Sorted by citations
Items 101–158 of 158
miRNAs in post-ischaemic angiogenesis and vascular remodelling
Saif, J., & Emanueli, C. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140263 · Cited by 19
Barreiro, K. A., Dwivedi, O. P., Rannikko, A. S., Holthöfer, H., Tuomilehto, J., Groop, P., & Puhka, M. (2023) · Genes · doi:10.3390/genes14071415 · Cited by 17
Nitric Oxide Decreases the Expression of Endothelin-Converting Enzyme-1 Through mRNA Destabilization
Raoch, V., Rodríguez‐Pascual, F., López-Martínez, V., Medrano-Andrés, D., Rodrı́guez-Puyol, M., Lamas, S., Rodrı́guez-Puyol, D., & López‐Ongil, S. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.232025 · Cited by 17
Combat Diabetic Nephropathy: From Pathogenesis to Treatment
Gohda, T., Mima, A., Moon, J.-Y., & Kanasaki, K. (2014) · Journal of Diabetes Research · doi:10.1155/2014/207140 · Cited by 17
Scott, E., Loya, K., Mountford, J. C., Milligan, G., & Baker, A. H. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.037 · Cited by 16
Metabolic stress in the myocardium: Adaptations of gene expression
Crawford, P. A., & Schaffer, J. E. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.06.008 · Cited by 15
VD3 mitigates breast cancer aggressiveness by targeting V-H+-ATPase
Santos, J. M., & Hussain, F. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.05.005 · Cited by 15
Moderate dose insulin promotes function of endothelial progenitor cells
Zhao, L., Cao, F., Yin, T., Sun, D., Cheng, K., Zhang, J., & Wang, H. (2011) · Cell Biology International · doi:10.1042/cbi20100205 · Cited by 15
Yu, X., Xu, J., Ming, S., Zhang, L., Li, Y., Han, L., Tang, M., Zhang, W., Zhong, M., & Wang, Z. (2021) · Angiology · doi:10.1177/00033197211034286 · Cited by 14
Self-citationmiRNA in the Progression of Diabetic Kidney Disease: New Insight
Zou, Z., Zhou, N., & Zhang, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010420 · Cited by 14
Zhang, Q., Long, J., Li, N., Ma, X., & Zheng, L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.594793 · Cited by 13
The Role of MicroRNAs in Cardiac Stem Cells
Purvis, N., Bahn, A., & Katare, R. (2015) · Stem Cells International · doi:10.1155/2015/194894 · Cited by 12
Monteiro, M. M., Lima, C. R., Gomes, C. C., Cruz, M. C., Horliana, A. C. R. T., & dos Santos, M. F. (2020) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-020-00932-3 · Cited by 12
Circulating hsa-miR-221 as a possible diagnostic and prognostic biomarker of diabetic nephropathy
Abdel-Tawab, M. S., Mohamed, M. G., Doudar, N. A., Rateb, E. E., Reyad, H. R., & Elazeem, N. A. A. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08846-y · Cited by 11
Mandraffino, G., Gullo, A. L., Cinquegrani, M., D’Ascola, A., Sinicropi, D., Imbalzano, E., Blando, G., Campo, G. M., Morace, C., Giuffrida, C., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9080860 · Cited by 11
Zhu, H., Li, Y., Wang, M., Wang, J., Du, W.-X., & Zhou, F. (2019) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1800631 · Cited by 11
Self-citationMicrovesicles and ectosomes in angiogenesis and diabetes - message in a bottle in the vascular ocean
Lichtenauer, M., & Jung, C. (2018) · Theranostics · doi:10.7150/thno.27154 · Cited by 11
Regulation of cardiac stem cells by microRNAs: State-of-the-art
Gorabi, A. M., Bianconi, V., Pirro, M., Banach, M., & Sahebkar, A. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109447 · Cited by 9
Epigenetics: The master control of endothelial cell fate in cancer
Subramaniam, A. V., Yehya, A. H. S., Cheng, W. K., Wang, X., & Oon, C. E. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116652 · Cited by 8
The Role of miRNA in Stem Cell Pluripotency and Commitment to the Vascular Endothelial Lineage
White, K. M., Kane, N. M., Milligan, G., & Baker, A. H. (2012) · Microcirculation · doi:10.1111/j.1549-8719.2012.00161.x · Cited by 7
Present Accomplishments and Future Prospects of Cell-Based Therapies for Type 1 Diabetes Mellitus
Chhabra, P., Clark, D. L., Daniel, J., & Kenneth, L. B. (2011) · InTech eBooks · doi:10.5772/22343 · Cited by 8
The admiR-able advances in cardiovascular biology through the zebrafish model system
Gays, D., & Santoro, M. M. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1181-4 · Cited by 7
microRNA Sequencing of CD34+ Sorted Adipose Stem Cells Undergoing Endotheliogenesis
Shaik, S. M., Martin, E. C., Hayes, D. J., Gimble, J. M., & Devireddy, R. V. (2021) · Stem Cells and Development · doi:10.1089/scd.2020.0173 · Cited by 7
Liao, J., Guo, X., Fan, X., Zhang, X., & Xu, M. (2022) · Cardiology in the Young · doi:10.1017/s1047951122003523 · Cited by 6
Gao, S., Gao, S., Sun, Z., Akesson, M., Shelat, H. S., & Geng, Y. (2023) · Cardiology Plus · doi:10.1097/cp9.0000000000000039 · Cited by 5
Self-citationMicroRNAs and Endothelial Dysfunction in Relation to Obesity and Type 2 Diabetes
Karolina, D. S. (2014) · Journal of Molecular and Genetic Medicine · doi:10.4172/1747-0862.s1-011 · Cited by 5
Monteiro, M. M., Gomes, C. C., Cruz, M. C., Horliana, A. C. R. T., Hamassaki‐Britto, D. E., Lima, C. R., & dos Santos, M. F. (2023) · Journal of Periodontal Research · doi:10.1111/jre.13217 · Cited by 4
Epigenetic role of micrornas in diabetic cardiomyopathy
Khullar, M., Raut, S. K., & Kumar, A. (2016) · Journal of the Practice of Cardiovascular Sciences · doi:10.4103/2395-5414.191519 · Cited by 4
The Role of microRNA in the Development of Ischemic Heart Disease
Kukava, N. G., Shkhnovich, R. M., Осьмак, Г. Ж., Baulina, N., Matveeva, N. A., & Favorova, O. O. (2019) · Kardiologiia · doi:10.18087/cardio.2019.10.n558 · Cited by 3
Emerging Roles of Micrornas in Diabetic Cardiomyopathy
Fomison‐Nurse, I. C. (2014) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000394 · Cited by 2
MicroRNomics of Diabetic Cardiomyopathy
Mishra, P. K., & Tyagi, S. C. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9317-4_10 · Cited by 3
Farr, R. J., Taylor, C. J., Satoor, S. N., Williams, M. D., & Joglekar, M. V. (2013) · Non-coding RNAs in Endocrinology · doi:10.2478/micrnado-2013-0004 · Cited by 2
Marei, E. S., & Youssef, H. M. G. (2021) · Egyptian Journal of Radiation Sciences and Applications · doi:10.21608/ejrsa.2021.53195.1110 · Cited by 2
micro RNAs as Therapeutic Agents and Targets
Karolina, D. S., & Jeyaseelan, K. (2013) · Wiley eBooks · doi:10.1002/9781118610749.ch19 · Cited by 2
Corrao, S., Orlando, V., Manno, S. B., Cangialosi, V., & Argano, C. (2026) · Internal and Emergency Medicine · doi:10.1007/s11739-026-04281-6 · Cited by 1
MicroRNAs in diabetes - are they perpetrators in disguise or just epiphenomena?
Puthanveetil, P., Thomas, A. A., & Chakrabarti, S. (2014) · Non-coding RNAs in Endocrinology · doi:10.2478/micrnado-2014-0002 · Cited by 1
Hyperglycemia, Oxidative Stress, and Vascular Complications: Role of Epigenetic Mechanisms
Simo‐Cheyou, E. R., & Srivastava, A. K. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9317-4_6 · Cited by 1
Role of microRNAs in endothelial function
Xian-bing, C. H. E. N., Zheng, S., & Wu, H. (2013) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.20123480 · Cited by 1
Schroen, B. L. M., & Heymans, S. R. B. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-800039-7.00013-x · Cited by 1
Mechanisms of Action of Drugs for Treating Endothelial Dysfunction in Diabetes Mellitus
Nizami, H. L., & Banerjee, S. (2017) · Springer eBooks · doi:10.1007/978-3-319-60324-7_22 · Cited by 1
Functions of MicroRNAs in Angiogenesis
Li, X., Chang, Y., Ding, Z., Guo, Z., Mehta, J. L., & Wang, X. (2017) · Springer eBooks · doi:10.1007/978-3-319-61115-0_7 · Cited by 1
Regulation of Non-coding RNAs in Cardiometabolic Tissues and Tumors
Holvoet, P. (2021) · Springer eBooks · doi:10.1007/978-3-030-68844-8_8 · Cited by 1
Micro RNA s in Cardiovascular Disease
Neppl, R. L., & Wang, D. (2010) · Wiley eBooks · doi:10.1002/9780470015902.a0022431 · Cited by 1
Discovery and delivery of anti-angiogenic miRNAs for cancer treatment
Babae, N. (2013) · Utrecht University Repository (Utrecht University)
Xavier, D. J. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2013.tde-29082013-154529
Physiological effects of Type 2 diabetes on mRNA processing and gene expression
Morrison, F. S., Johnstone, K. A., & Harries, L. W. (2011) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.10.76
Microarray, MicroRNA, and Angiogenesis
Ding, Z., Wang, X., & Mehta, J. L. (2013) · Springer eBooks · doi:10.1007/978-1-4614-5857-9_24
MicroRNAs and Endothelial Dysfunction in Relation to Obesity and Type
Maskomani, S., Armugam, A., & Jeyaseelan, K. (2014)
The roles of microRNAs in human mesenchymal stem cell adipogenesis
Annette, E. K. (2012) · Arrow@dit (Dublin Institute of Technology) · doi:10.13025/17714
The impact of the extracellular matrix and type 1 diabetes on cardiac fibroblast activation
Shamhart, P. E. (2010) · OhioLink ETD Center (Ohio Library and Information Network)
The role of galectins in the vasculature
Heusschen, R. (2013) · Pure Amsterdam UMC
Monteiro, M. M. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2017.tde-26102017-121439
Cellular And Molecular Insight Into Autonomic Function And Dysfunction
Wu, Y. (2022) · Digital Archive @ GSU · doi:10.57709/12426547
Decoding the Interplay of Genes and MicroRNAs in Cardiovascular Disease
Gholamzad, A., Moulaeian, M., Khatibi, M., Nourikhani, M., Gholamzad, M., & Goudarzi, Y. (2023) · Journal de Téhéran · doi:10.61186/jhgg.7.1.2
Ibarra‐Salce, R., Doval-Caballero, J. L. E., Uribe-Cortés, D., Eugenio-Ponce, G. D., Ibarra-Salce, M., Jaime-Leal, O., & García-Sáenz, M. R. (2026) · Metabolites · doi:10.3390/metabo16070500
Thérapie génique de l'angiogenèse tumorale ciblée par des cellules endothéliales immatures
Collet, G. (2012) · theses.fr (ABES) · doi:10.70675/7e00daa0z60f1z4874za3c4zce11f3b40617
Environment, Epigenetic Changes, and Cardiovascular Damage
Paneni, F., & Cosentino, F. (2015) · Springer eBooks · doi:10.1007/978-3-319-17762-5_4
Metadata
- Authors
- Li, Y., Song, Y.-H., Li, F., Yang, T., Lu, Y. W., & Geng, Y.-J.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- The University of Texas MD Anderson Cancer Center (US)
- Jilin University (CN)
- Corresponding author
- Li, Yangxin
- Geng, Yong-Jian
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 381
- Issue
- 1
- Pages
- 81-83
- ISSN
- 0006-291X (ISSN-L)
- PMC
- PMC2670889
- OpenAlex
- W2001295759
- Cited by
- 158
- References
- 19
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 5 · 2021: 7 · 2020: 5 · 2019: 10 · 2018: 11 · 2017: 12 · 2016: 6 · 2015: 12 · 2014: 16 · 2013: 24 · 2012: 14
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Heart Association (0765149Y)
- Macdonald Stewart Foundation (07RDM008)
- National Institutes of Health (R01HL69509)
- U.S. Department of Defense
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- miR-221, CD117, high glucose, endothelial dysfunction, hyperglycemia, diabetes mellitus, human umbilical vein endothelial cells, endothelial cell migration, stem cell factor, antisense oligonucleotides, vascular dysfunction
- MeSH terms
- Cell Movement, Cells, Cultured, Endothelium, Vascular, Glucose, Humans, Hyperglycemia, Proto-Oncogene Proteins c-kit, MicroRNAs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
