Cited by 196Cytokine Signaling Pathways and InteractionsBiomarkers in Disease MechanismsAnimal health and immunology

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Up-regulation of the expression of leucine-rich α2-glycoprotein in hepatocytes by the mediators of acute-phase response

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Shirai, Ryoichi, Hirano, Fumiyasu, Ohkura, Naoki, Ikeda, Kiyoshi, Inoue, Seiji·2009·Biochemical and Biophysical Research Communications

DOI 10.1016/j.bbrc.2009.03.104PMC PMC7092932

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Abstract

Leucine-rich alpha(2)-glycoprotein (LRG) is a plasma protein in which leucine-rich repeats (LRRs) were first discovered. Although the physiological function of LRG is not known, increases in the serum level of LRG have been reported in various diseases. In this study, we found that LRG was induced by recombinant human IL-6 in human hepatoma HepG2 cells. The induction of LRG by IL-6 was up-regulated synergistically with either IL-1beta or TNFalpha in a pattern similar to those for type 1 acute-phase proteins. We also found that lipopolysaccharide (LPS) administered intraperitoneally to mice enhanced dose-dependently the expression of LRG mRNA in the liver as well as those for mouse major acute-phase proteins. These results strongly suggest that LRG was a secretory type 1 acute-phase protein whose expression was up-regulated by the mediator of acute-phase response.

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Authors: Shirai, R., Hirano, F., Ohkura, N., Ikeda, K., & Inoue, S.
Affiliations: Osaka University of Pharmaceutical Sciences (JP)
Teikyo University (JP)
Corresponding author: Inoue, Seiji
ORCID: Ikeda, Kiyoshi
Inoue, Seiji
Venue: Biochemical and Biophysical Research Communications
Publisher: Elsevier BV
Published: 2009-05
Volume: 382
Issue: 4
Pages: 776-779
ISSN: 0006-291X (ISSN-L)
DOI: 10.1016/j.bbrc.2009.03.104
PMC: PMC7092932
OpenAlex: W2028863735
Cited by: 193
References: 31
Citations by year: 2026: 9 · 2025: 12 · 2024: 17 · 2023: 18 · 2022: 17 · 2021: 20 · 2020: 26 · 2019: 10 · 2018: 11 · 2017: 8 · 2016: 4 · 2015: 9 · 2014: 4 · 2013: 5 · 2012: 4
FWCI: 3.83
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochemical and Biophysical Research Communications (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal health and immunology
Keywords: acute phase response, hepatocytes, interleukin-6, IL-1β, TNF-α, lipopolysaccharide, gene upregulation, liver, HepG2 cells
MeSH terms: Acute-Phase Reaction, Animals, Cell Line, Disease Models, Animal, Glycoproteins, Humans, Mice, Inbred ICR, Up-Regulation, Cytokines, Endotoxemia, Hepatocytes, Mice

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Up-regulation of the expression of leucine-rich α2-glycoprotein in hepatocytes by the mediators of acute-phase response

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