The transmembrane nucleoporin NDC1 is required for targeting of ALADIN to nuclear pore complexes
Abstract
NDC1 is a transmembrane nucleoporin that is required for NPC assembly and nucleocytoplasmic transport. We show here that NDC1 directly interacts with the nucleoporin ALADIN, mutations of which are responsible for triple-A syndrome, and that this interaction is required for targeting of ALADIN to nuclear pore complexes (NPCs). Furthermore, we show that NDC1 is required for selective nuclear import. Our findings suggest that NDC1-mediated localization of ALADIN to NPCs is essential for selective nuclear protein import, and that abrogation of the interaction between ALADIN and NDC1 may be important for the development of triple-A syndrome.
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NDC1 interacts with the scaffold Nup Aladin.
“NDC1 is known to interact with the poorly characterized scaffold Nup Aladin (41,42).”
From AI-based structure prediction empowers integrative structural analysis of human nuclear pores (2022) · cites this paper as [41]
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Self-citationNDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes
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The nuclear pore complex protein ALADIN is mislocalized in triple A syndrome
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AI-based structure prediction empowers integrative structural analysis of human nuclear pores
Mosalaganti, S., Obarska-Kosinska, A., Siggel, M., Taniguchi, R., Turoňová, B., Zimmerli, C. E., Buczak, K., Schmidt, F. H., Margiotta, E., Mackmull, M.-T., et al. (2022) · Science · doi:10.1126/science.abm9506 · Cited by 355 · see citing works
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- Authors
- Yamazumi, Y., Kamiya, A., Nishida, A., Nishihara, A., Iemura, S.-I., Natsume, T., & Akiyama, T.
- Affiliations
- The University of Tokyo (JP)
- Japan Biological Informatics Consortium (JP)
- Corresponding author
- Akiyama, Tetsu
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 389
- Issue
- 1
- Pages
- 100-104
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2077394864
- Cited by
- 34
- References
- 10
- Citations by year
- 2024: 2 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 3 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 3
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (21390075)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- NDC1, ALADIN, nucleoporins, nuclear pore complex, nuclear transport, triple A syndrome, protein-protein interaction, protein targeting
- MeSH terms
- HeLa Cells, Humans, Nerve Tissue Proteins, Active Transport, Cell Nucleus, Nuclear Pore, Nuclear Pore Complex Proteins, RNA Interference
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