Fucoidin enhances dendritic cell-mediated T-cell cytotoxicity against NY-ESO-1 expressing human cancer cells
Abstract
Scavenger receptor A (SR-A) plays a crucial role in affecting the dendritic cell-mediated presentation of cancer testis antigens to T cells against human cancer cells. Here we use a dendritic cell-mediated model to verify that a sulphated polysaccharide, fucoidin, can regulate the adverse regulatory function of SR-A, and lead to the up-regulation of the anti-tumor immunological response. SR-A is a receptor of calreticulin (CRT) existing on the surface of dendritic cells (DCs). CRT is a specific receptor for a NY-ESO-1 cancer testis antigen, and CRT itself is responsible for the cross-presentation of NY-ESO-1 to CD8+ cells and the induction of anti-tumor immunity. Flow cytometrical analysis (FACS) showed that fucoidin was able to significantly enhance the binding ratio of NY-ESO-1 to human DCs in a concentration dependent manner, and that the addition of fucoidin promoted the DC maturation upon stimulation of NY-ESO-1. Results from a cytotoxicity assay indicated that fucoidin-treated DCs stimulated the CD8+ T cells more effectively than non-treated DCs via a cross-presentation pathway. Furthermore, it was found that after stimulated by fucoidin-treated DCs, the CD8+ T cells can release more IFN-gamma than non-fucoidin-treated cells as detected by intracellular IFN-gamma staining. We conclude that fucoidin enhances the cross-presentation of NY-ESO-1 to T cells leading to an increase of T-cell cytotoxicity against NY-ESO-1 expressing human cancer cells.
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Fucoidan-treated DCs stimulated CD8+ T lymphocytes to release more interferon-γ than non-fucoidan-treated cells.
“The fucoidan-treated DCs stimulated the CD8+ T limphocytes to release more interferon-γ than non-fucoidan-treated cells.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [63]
Fucoidan enhanced cross-presentation of NY-ESO-1 cancer testis antigen to T cells and led to increased T-cell cytotoxicity against NY-ESO-1 human cancer cells.
“It was found that fucoidan enhanced the cross-presentation of NY-ESO-1 cancer testis antigen to T cells and it led to the increase of T-cell cytotoxicity against NY-ESO-1 human cancer cells [63].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [63]
SR-A plays a crucial role in DC-mediated presentation of cancer antigens to T cells in human cancer cells, and fucoidan promoted DC maturation.
“At a later date, it was confirmed that SR-A plays a crucial role in affecting the DC-mediated presentation of cancer antigens to T cells in human cancer cells, and it was also established that fucoidan promoted the DCs maturation.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [63]
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Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects
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- Authors
- Hu, Y., Cheng, S. C.-S., Chan, K.-T., Ke, Y., Xue, B., Sin, F. W.-Y., Zeng, C., & Xie, Y.
- Affiliations
- Hong Kong University of Science and Technology (HK)
- Corresponding author
- Xie, Yong
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 392
- Issue
- 3
- Pages
- 329-334
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W1973480631
- Cited by
- 32
- References
- 27
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 4 · 2021: 1 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 1
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- Hong Kong Research Grant Council
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- fucoidan, scavenger receptor A, calreticulin, NY-ESO-1, cancer-testis antigens, dendritic cell maturation, cross-presentation, CD8+ T cells, T cell cytotoxicity, interferon-gamma, sulfated polysaccharides, antitumor immunity
- MeSH terms
- Antigens, Neoplasm, Antineoplastic Agents, Cytotoxicity, Immunologic, Dendritic Cells, Humans, Membrane Proteins, Neoplasms, Polysaccharides, T-Lymphocytes, Cytotoxic, Cross-Priming, Cell Line, Tumor
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