The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Antioxidants: Molecules, medicines, and myths
Abstract
There is an industry-driven public obsession with antioxidants, which are equated to safe, health-giving molecules to be swallowed as mega-dose supplements or in fortified foods. Sometimes they are good for you, but sometimes they may not be, and pro-oxidants can be better for you in some circumstances. This article re-examines and challenges some basic assumptions in the nutritional antioxidant field.
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“The use of antioxidants has been markedly ineffective when not damaging (97, 390, 400, 785).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [390]
Citations
Cites
Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
Self-citation[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Self-citationA Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics
Kohanski, M. A., Dwyer, D. J., Hayete, B., Lawrence, C. A., & Collins, J. J. (2007) · Cell · doi:10.1016/j.cell.2007.06.049 · Cited by 2,982
Reactive Species and Antioxidants. Redox Biology Is a Fundamental Theme of Aerobic Life
Halliwell, B. B. (2006) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.077073 · Cited by 2,402
Self-citationAntioxidants prevent health-promoting effects of physical exercise in humans
Ristow, M., Zarse, K., Oberbach, A., Klöting, N., Birringer, M., Kiehntopf, M., Stumvoll, M., Kahn, C. R., & Blüher, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903485106 · Cited by 1,582
Free radicals in biology and medicine
Lucy, J. A. (1985) · FEBS Letters · doi:10.1016/0014-5793(85)80903-0 · Cited by 912
LIPID PEROXIDATION, OXYGEN RADICALS, CELL DAMAGE, AND ANTIOXIDANT THERAPY
Halliwell, B. B., & Gutteridge, J. C. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91886-5 · Cited by 796
Self-citationHalliwell, B. B. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.01.028 · Cited by 764
Self-citationHalliwell, B., Rafter, J., & Jenner, A. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.268s · Cited by 711
Self-citationBjelaković, G., Nikolova, D., Simonetti, R. G., & Gluud, C. N. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17138-9 · Cited by 619
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Graves, D. B. (2012) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/45/26/263001 · Cited by 1,534
13 reasons why the brain is susceptible to oxidative stress
Cobley, J. N., Fiorello, M. L., & Bailey, D. M. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.008 · Cited by 1,215
Free radicals and antioxidants: updating a personal view
Halliwell, B. B. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00476.x · Cited by 946
Self-citationUnraveling the biological roles of reactive oxygen species
Murphy, M. P., Holmgren, A., Larsson, N.-G., Halliwell, B., Chang, C. J., Kalyanaraman, B., Rhee, S. G., Thornalley, P. J., Partridge, L., Gems, D., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.010 · Cited by 836
Self-citationRuiz, S., Pérgola, P. E., Zager, R. A., & Vaziri, N. D. (2013) · Kidney International · doi:10.1038/ki.2012.439 · Cited by 730
Metadata
- Authors
- Gutteridge, J. M. C., & Halliwell, B.
- Affiliations
- National University of Singapore (SG)
- Corresponding author
- Halliwell, Barry
- ORCID
- Halliwell, Barry
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 393
- Issue
- 4
- Pages
- 561-564
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W1970851794
- Cited by
- 405
- References
- 38
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 8 · 2023: 15 · 2022: 18 · 2021: 22 · 2020: 23 · 2019: 17 · 2018: 30 · 2017: 25 · 2016: 34 · 2015: 39 · 2014: 43 · 2013: 37 · 2012: 39
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- antioxidants, antioxidant supplements, pro-oxidants, oxidative stress, dietary antioxidants, health claims, fortified foods
- MeSH terms
- Antioxidants, Humans, Oxidation-Reduction, Vitamins, Reactive Oxygen Species, Dietary Supplements
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