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Cited by 746

The DOI matches its Crossref record; 167 of the 167 references it cites were found in a registry or an index.

Bacterial multidrug efflux pumps: Mechanisms, physiology and pharmacological exploitations

Open access
Sun, Jingjing, Deng, Ziqing, Yan, Aixin·2014·Biochemical and Biophysical Research Communications
DOI 10.1016/j.bbrc.2014.05.090
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Abstract

Multidrug resistance (MDR) refers to the capability of bacterial pathogens to withstand lethal doses of structurally diverse drugs which are capable of eradicating non-resistant strains. MDR has been identified as a major threat to the public health of human being by the World Health Organization (WHO). Among the four general mechanisms that cause antibiotic resistance including target alteration, drug inactivation, decreased permeability and increased efflux, drug extrusion by the multidrug efflux pumps serves as an important mechanism of MDR. Efflux pumps not only can expel a broad range of antibiotics owing to their poly-substrate specificity, but also drive the acquisition of additional resistance mechanisms by lowering intracellular antibiotic concentration and promoting mutation accumulation. Over-expression of multidrug efflux pumps have been increasingly found to be associated with clinically relevant drug resistance. On the other hand, accumulating evidence has suggested that efflux pumps also have physiological functions in bacteria and their expression is subject tight regulation in response to various of environmental and physiological signals. A comprehensive understanding of the mechanisms of drug extrusion, and regulation and physiological functions of efflux pumps is essential for the development of anti-resistance interventions. In this review, we summarize the development of these research areas in the recent decades and present the pharmacological exploitation of efflux pump inhibitors as a promising anti-drug resistance intervention.

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Metadata

Authors
Sun, J., Deng, Z., & Yan, A.
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2014-10
Volume
453
Issue
2
Pages
254-267
ISSN
0006-291X (ISSN-L)
DOI
10.1016/j.bbrc.2014.05.090
OpenAlex
W2065652119
Cited by
746
References
167
FWCI
21.13
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Bacterial multidrug efflux pumps: Mechanisms, physiology and pharmacological exploitations. https://app.cochat.ai/papers/10.1016/j.bbrc.2014.05.090
The paper
Sun, J., Deng, Z., & Yan, A. (2014). Bacterial multidrug efflux pumps: Mechanisms, physiology and pharmacological exploitations. Biochemical and Biophysical Research Communications. https://doi.org/10.1016/j.bbrc.2014.05.090

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.