10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARγ and stimulates adipogenesis
Abstract
Our previous study has shown that gut lactic acid bacteria generate various kinds of fatty acids from polyunsaturated fatty acids such as linoleic acid (LA). In this study, we investigated the effects of LA and LA-derived fatty acids on the activation of peroxisome proliferator-activated receptors (PPARs) which regulate whole-body energy metabolism. None of the fatty acids activated PPARδ, whereas almost all activated PPARα in luciferase assays. Two fatty acids potently activated PPARγ, a master regulator of adipocyte differentiation, with 10-oxo-12(Z)-octadecenoic acid (KetoA) having the most potency. In 3T3-L1 cells, KetoA induced adipocyte differentiation via the activation of PPARγ, and increased adiponectin production and insulin-stimulated glucose uptake. These findings suggest that fatty acids, including KetoA, generated in gut by lactic acid bacteria may be involved in the regulation of host energy metabolism.
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10-oxo-cis-12-octadecenoic acid increases adiponectin production and glucose uptake in a PPARγ-dependent manner, and contributes to the prevention of obesity-related metabolic perturbations.
“Another hydroxylated CLA intermediate - 10-oxo-cis-12-octadecenoic acid (KetoA) - increases adiponectin production and glucose uptake in a PPARγ-dependent manner, and contributes to the prevention of obesity-related metabolic perturbations [28].”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [28]
Cites
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Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
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Dietary lipids, gut microbiota and lipid metabolism
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- Authors
- Goto, T., Kim, Y.-I., Furuzono, T., Takahashi, N., Yamakuni, K., Yang, H.-E., Li, Y., Ohue, R., Nomura, W., Sugawara, T., Yu, R., Kitamura, N., Park, S.-B., Kishino, S., Ogawa, J., & Kawada, T.
- Affiliations
- Kyoto University (JP)
- University of Ulsan (KR)
- Corresponding author
- Goto, Tsuyoshi
- ORCID
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 459
- Issue
- 4
- Pages
- 597-603
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W1972101838
- Cited by
- 80
- References
- 3
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 9 · 2023: 11 · 2022: 9 · 2021: 4 · 2020: 3 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 6 · 2015: 3
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Agriculture, Forestry and Fisheries
- Bio-oriented Technology Research Advancement Institution
- Ministry of Education, Culture, Sports, Science and Technology (22228001, 24688015)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- linoleic acid metabolites, lactic acid bacteria, gut microbiota, PPARγ activation, PPARα, PPARδ, adipogenesis, 3T3-L1 cells, adiponectin, insulin-stimulated glucose uptake, energy metabolism, polyunsaturated fatty acids
- MeSH terms
- Animals, Energy Metabolism, Lactobacillus, Linoleic Acids, Polymerase Chain Reaction, NIH 3T3 Cells, PPAR gamma, Adipogenesis, Mice
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