Therapeutic Potentials of Microalgae and Their Bioactive Compounds on Diabetes Mellitus
Open accessAbstract
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to impaired insulin secretion, insulin resistance, or both. Oxidative stress and chronic low-grade inflammation play crucial roles in the pathophysiology of diabetes mellitus. There has been a growing interest in applying natural products to improve metabolic derangements without the side effects of anti-diabetic drugs. Microalgae biomass or extract and their bioactive compounds have been applied as nutraceuticals or additives in food products and health supplements. Several studies have demonstrated the therapeutic effects of microalgae and their bioactive compounds in improving insulin sensitivity attributed to their antioxidant, anti-inflammatory, and pancreatic β-cell protective properties. However, a review summarizing the progression in this topic is lacking despite the increasing number of studies reporting their anti-diabetic potential. In this review, we gathered the findings from in vitro, in vivo, and human studies to discuss the effects of microalgae and their bioactive compounds on diabetes mellitus and the mechanisms involved. Additionally, we discuss the limitations and future perspectives of developing microalgae-based compounds as a health supplement for diabetes mellitus. In conclusion, microalgae-based supplementation has the potential to improve diabetes mellitus and be applied in more clinical studies in the future.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Microalgae-derived supplements can enhance insulin sensitivity, modulate lipid metabolism, and lower systemic inflammation in individuals with metabolic syndrome and type 2 diabetes.
“A recent systematic review concluded that microalgae-derived supplements can enhance insulin sensitivity, modulate lipid metabolism, and lower systemic inflammation in individuals with metabolic syndrome and type 2 diabetes [71].”
From Microalgae Bioactives for Functional Food Innovation and Health Promotion (2025) · cites this paper as [71]
The Introduction says some microalgae compounds may improve insulin sensitivity, and §2.3 (Human Studies) reports improved lipid profiles in patients with type 2 diabetes. The anti-inflammatory findings cited here are principally from animal studies (§2.2); §2.3 says human trials are few and limited to patients with type 2 diabetes. The paper therefore does not establish all three effects in people with metabolic syndrome and type 2 diabetes, and the cited work is a review rather than an identified systematic review. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,311 · see citing works
Epidemiology of Type 2 Diabetes – Global Burden of Disease and Forecasted Trends
Khan, M. A., Hashim, M. J., King, J., Govender, R. D., Mustafa, H., & Alkaabi, J. (2019) · Journal of Epidemiology and Global Health · doi:10.2991/jegh.k.191028.001 · Cited by 3,162 · see citing works
The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas
Szkudelski, T. (2001) · Physiological Research · doi:10.33549/physiolres.930111 · Cited by 2,881 · see citing works
Atkinson, M. A., Eisenbarth, G. S., & Michels, A. W. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60591-7 · Cited by 2,713 · see citing works
Ambati, R., Phang, S. M., Ravi, S., & Ravishankar, G. A. (2014) · Marine Drugs · doi:10.3390/md12010128 · Cited by 1,993 · see citing works
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921 · see citing works
Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus
Nowotny, K., Jung, T., Höhn, A., Weber, D., & Grune, T. (2015) · Biomolecules · doi:10.3390/biom5010194 · Cited by 1,095 · see citing works
Tyagi, S., Gupta, P., Saini, A., Kaushal, C., & Sharma, S. (2011) · Journal of Advanced Pharmaceutical Technology & Research · doi:10.4103/2231-4040.90879 · Cited by 1,017 · see citing works
Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer
Manson, J. E., Cook, N. R., Lee, I.-M., Christen, W., Bassuk, S. S., Mora, S., Gibson, H., Albert, C. M., Gordon, D., Copeland, T., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1811403 · Cited by 979 · see citing works
Microalgae: A potential alternative to health supplementation for humans
Koyande, A. K., Chew, K. W., Rambabu, K., Tao, Y., Chu, D.-T., & Show, P.-L. (2019) · Food Science and Human Wellness · doi:10.1016/j.fshw.2019.03.001 · Cited by 908 · see citing works
Bioremediation of heavy metals using microalgae: Recent advances and mechanisms
Leong, Y. K., & Chang, J.-S. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.122886 · Cited by 874 · see citing works
Regulation of energy metabolism by long-chain fatty acids
Nakamura, M., Yudell, B. E., & Loor, J. J. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.12.001 · Cited by 829 · see citing works
Diabetes mellitus statistics on prevalence and mortality: facts and fallacies
Zimmet, P., Alberti, K. G. M. M., Magliano, D. J., & Bennett, P. H. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.105 · Cited by 791 · see citing works
Jager, J., Grémeaux, T., Cormont, M., MARCHAND‐BRUSTEL, Y. L., & Tanti, J. (2006) · Endocrinology · doi:10.1210/en.2006-0692 · Cited by 695 · see citing works
Kintscher, U., Hartge, M., Hess, K., Foryst-Ludwig, A., Clemenz, M., Wabitsch, M., Fischer-Posovszky, P., Barth, T. F. E., Dragun, D., Skurk, T., et al. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.165100 · Cited by 692 · see citing works
The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus
Ozougwu, O. (2013) · Journal of Physiology and Pathophysiology · doi:10.5897/jpap2013.0001 · Cited by 654 · see citing works
Burgos‐Morón, E., Abad‐Jiménez, Z., Marañón, A., Iannantuoni, F., Escribano‐López, I., López‐Domènech, S., Salom, C., Jover, A., Llabata, V. M., Torres, I. R., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091385 · Cited by 586 · see citing works
Battin, E. E., & Brumaghim, J. L. (2009) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-009-9054-7 · Cited by 479 · see citing works
Comparison of microalgal biomass profiles as novel functional ingredient for food products
Batista, A. P., Gouveia, L., Bandarra, N. M., Franco, J. M., & Raymundo, A. (2013) · Algal Research · doi:10.1016/j.algal.2013.01.004 · Cited by 450 · see citing works
Röhrborn, D. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00386 · Cited by 446 · see citing works
Bioaccessibility of Carotenoids and Vitamin E from Their Main Dietary Sources
Reboul, E., Richelle, M., Perrot, E., Malezet‐Desmoulins, C., Pirisi, V., & Borel, P. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf061818s · Cited by 445 · see citing works
Inhibition mechanism of ferulic acid against α-amylase and α-glucosidase
Zheng, Y., Tian, J., Yang, W., Chen, S., Liu, D., Fang, H., Zhang, H., & Ye, X. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.126346 · Cited by 407 · see citing works
Carbohydrates and dietary fibre
Lunn, J., & Buttriss, J. (2007) · Nutrition Bulletin · doi:10.1111/j.1467-3010.2007.00616.x · Cited by 355 · see citing works
Long-term treatment with interleukin-1β induces insulin resistance in murine and human adipocytes
Lagathu, C., Yvan‐Charvet, L., Bastard, J., Maachi, M., Quignard‐Boulangé, A., Capeau, J., & Caron, M. (2006) · Diabetologia · doi:10.1007/s00125-006-0335-z · Cited by 323 · see citing works
Robertson, R. P., & Harmon, J. S. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.04.030 · Cited by 322 · see citing works
Unuofin, J. O., & Lebelo, S. L. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1356893 · Cited by 322 · see citing works
Microalgae as a new source of bioactive compounds in food supplements
Vaz, B. D. S., Moreira, J. B., de Morais, M. G., & Costa, J. A. V. (2016) · Current Opinion in Food Science · doi:10.1016/j.cofs.2015.12.006 · Cited by 316 · see citing works
Xu, A., Lam, M. C., Chan, K. W., Wang, Y., Zhang, J., Hoo, R. L. C., Xu, J. Y., Chen, B., Chow, W.-S., Tso, A. W. K., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408452102 · Cited by 315 · see citing works
Padanad, M. S., Konstantinidou, G., Venkateswaran, N., Melegari, M., Rindhe, S., Mitsche, M. A., Yang, C., Batten, K. G., Huffman, K. E., Liu, J., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.009 · Cited by 304 · see citing works
Antihyperglycemic and Antioxidant Properties of Caffeic Acid in db/db Mice
Jung, U. J., Lee, M., Park, Y. B., Jeon, S.-M., & Choi, M. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.105163 · Cited by 293 · see citing works
Concepts and studies on lipid and pigments of microalgae: A review
D’Alessandro, E. B., & Antoniosi Filho, N. R. (2016) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2015.12.162 · Cited by 289 · see citing works
Composition Diversity and Abundance of Gut Microbiome in Prediabetes and Type 2 Diabetes
Shah, V. O., Lambeth, S. M., Carson, T., Lowe, J. R., Ramaraj, T., Leff, J. W., Luo, L., & Bell, C. J. (2015) · Journal of Diabetes and Obesity · doi:10.15436/2376-0949.15.031 · Cited by 286 · see citing works
Lifestyle factors, self-management and patient empowerment in diabetes care
Lambrinou, E., Hansen, T. B., & Beulens, J. W. (2019) · European Journal of Preventive Cardiology · doi:10.1177/2047487319885455 · Cited by 261 · see citing works
Beutner, S., Bloedorn, B., Frixel, S., Hernández Blanco, I., Hoffmann, T., Martin, H., Mayer, B., Noack, P., Ruck, C., Schmidt, M., et al. (2001) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.849 · Cited by 253 · see citing works
Pascale, A., Marchesi, N., Govoni, S. M., Coppola, A., & Gazzaruso, C. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.03.011 · Cited by 240 · see citing works
Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus
Yong, J., Johnson, J. D., Arvan, P., Han, J., & Kaufman, R. J. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00510-4 · Cited by 234 · see citing works
Carotenoids from Marine Microalgae: A Valuable Natural Source for the Prevention of Chronic Diseases
Raposo, M., De Morais, A., & De Morais, R. (2015) · Marine Drugs · doi:10.3390/md13085128 · Cited by 228 · see citing works
Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications
Mularczyk, M., Michalak, I., & Marycz, K. (2020) · Marine Drugs · doi:10.3390/md18090459 · Cited by 228 · see citing works
Rodríguez‐Meizoso, I., Jaime, L., Santoyo, S., Señoráns, F. J., Cifuentes, A., & Ibáñez, E. (2009) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2009.03.014 · Cited by 223 · see citing works
Viktorínová, A., Tǒserová, E., Krizko, M., & Ďuračková, Z. (2009) · Metabolism · doi:10.1016/j.metabol.2009.04.035 · Cited by 214 · see citing works
Xanthophylls from the Sea: Algae as Source of Bioactive Carotenoids
Pereira, A. G., Otero, P., Echave, J., Carreira-Casais, A., Chamorro, F., Collazo, N., Jaboui, A., Lourenço‐Lopes, C., Simal‐Gándara, J., & Prieto, M. A. (2021) · Marine Drugs · doi:10.3390/md19040188 · Cited by 211 · see citing works
Zhang, B., Li, X., Sun, W., Xing, Y., Xiu, Z., Zhuang, C., & Dong, Y. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b02531 · Cited by 206 · see citing works
Astaxanthin protects β-cells against glucose toxicity in diabetic db/db mice
Uchiyama, K., Naito, Y., Hasegawa, G., Nakamura, N., Takahashi, J., & Yoshikawa, T. (2002) · Redox Report · doi:10.1179/135100002125000811 · Cited by 204 · see citing works
Zhao, C., Yang, C., Wai, S. T. C., Zhang, Y., P. Portillo, M., Paoli, P., Wu, Y., San Cheang, W., Liu, B., Carpéné, C., et al. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1501658 · Cited by 199 · see citing works
Zhang, Y., & Liu, D. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.08.011 · Cited by 193 · see citing works
Al‐Numair, K. S., Govindasamy, C., Veeramani, C., & Alsaif, M. A. (2014) · Redox Report · doi:10.1179/1351000214y.0000000117 · Cited by 193 · see citing works
Haddad, P. S., Eid, H., Nachar, A., Thong, F. S. L., & Sweeney, G. (2015) · Pharmacognosy Magazine · doi:10.4103/0973-1296.149708 · Cited by 189 · see citing works
Beta-glucans in the treatment of diabetes and associated cardiovascular risks
Chen, J. (2008) · Vascular Health and Risk Management · doi:10.2147/vhrm.s3803 · Cited by 184 · see citing works
Lutchmansingh, F., Hsu, J. W.-C., Bennett, F. I., Badaloo, A. V., McFarlane‐Anderson, N., Gordon-Strachan, G. M., Wright-Pascoe, R. A., Jahoor, F., & Boyne, M. S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198626 · Cited by 179 · see citing works
Recent advancements in astaxanthin production from microalgae: A review
Patel, A. K., Tambat, V. S., Chen, C., Chauhan, A. S., Kumar, P., Vadrale, A. P., Huang, C.-Y., Dong, C., & Singhania, R. R. (2022) · Bioresource Technology · doi:10.1016/j.biortech.2022.128030 · Cited by 179 · see citing works
Wang, X., Liu, R., Zhang, W., Zhang, X., Liao, N., Wang, Z., Li, W., Qin, X., & Hai, C. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.06.014 · Cited by 172 · see citing works
Astaxanthin: How much is too much? A safety review
Brendler, T., & Williamson, E. M. (2019) · Phytotherapy Research · doi:10.1002/ptr.6514 · Cited by 171 · see citing works
Jang, S.-M., Yee, S., Choi, J., Choi, M., Do, G., Jeon, S.-M., Yeo, J., Kim, M., Seo, K., & Lee, M. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2008.10.013 · Cited by 167 · see citing works
Chen, M.-D., Liou, S.-J., Lin, P., Yang, V. C., Alexander, P. S., & Lin, W.-H. (1998) · Biological Trace Element Research · doi:10.1007/bf02789090 · Cited by 166 · see citing works
Narasimhan, A., Mayilvanan, C., & Karundevi, B. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0002 · Cited by 164 · see citing works
Jung, U. J., Cho, Y.-Y., & Choi, M. (2016) · Nutrients · doi:10.3390/nu8050305 · Cited by 160 · see citing works
de Melo, C. L., de Queiroz, M. G. R., Fonseca, S. G. C., Bizerra, A. M. C., Lemos, T. L. G., de Melo, T. S., Santos, F. A., & Rao, V. S. N. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.02.028 · Cited by 151 · see citing works
Venkatesan, A., Vijayakumar, N., Indumathi, D., & Arumugam, R. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.09.039 · Cited by 150 · see citing works
Wang, Z. Q., Zhang, X. H., Russell, J. C., Hulver, M. W., & Cefalu, W. T. (2006) · Journal of Nutrition · doi:10.1093/jn/136.2.415 · Cited by 148 · see citing works
Role and mechanism of the action of angiopoietin-like protein ANGPTL4 in plasma lipid metabolism
Kersten, S. (2021) · Journal of Lipid Research · doi:10.1016/j.jlr.2021.100150 · Cited by 146 · see citing works
Impact of Astaxanthin on Diabetes Pathogenesis and Chronic Complications
Landon, R., Gueguen, V., Petite, H., Letourneur, D., Pavon‐Djavid, G., & Anagnostou, F. (2020) · Marine Drugs · doi:10.3390/md18070357 · Cited by 143 · see citing works
Inbaraj, B. S., Chien, J. T., & Chen, B. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.10.055 · Cited by 141 · see citing works
Fish oil supplementation and insulin sensitivity: a systematic review and meta-analysis
Gao, H., Geng, T., Huang, T., & Zhao, Q. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0528-0 · Cited by 140 · see citing works
Haoujar, I., Cacciola, F., Abrini, J., Mangraviti, D., Giuffrida, D., Majdoub, Y. O. E., Kounnoun, A., Miceli, N., Taviano, M. F., Mondello, L., et al. (2019) · Molecules · doi:10.3390/molecules24224037 · Cited by 140 · see citing works
Cholesterol metabolism, pancreatic β-cell function and diabetes
Perego, C., Dalt, L. D., Pirillo, A., Galli, A., Catapano, A. L., & Norata, G. D. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.04.012 · Cited by 135 · see citing works
Ramos-Romero, S., Torrella, J. R., Pagès, T., Viscor, G., & Torres, J. L. (2021) · Nutrients · doi:10.3390/nu13020563 · Cited by 134 · see citing works
Barros de Medeiros, V. P., da Costa, W. K. A., da Silva, R. T., Pimentel, T. C., & Magnani, M. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1879729 · Cited by 134 · see citing works
Microalgae as a Source of Valuable Phenolic Compounds and Carotenoids
Cichoński, J., & Chrzanowski, G. (2022) · Molecules · doi:10.3390/molecules27248852 · Cited by 129 · see citing works
Pyruvate carboxylase and cancer progression
Kiesel, V. A., Sheeley, M. P., Coleman, M. F., Kulkoyluoglu‐Cotul, E., Donkin, S. S., Hursting, S. D., Wendt, M. K., & Teegarden, D. (2021) · Cancer & Metabolism · doi:10.1186/s40170-021-00256-7 · Cited by 123 · see citing works
Jubaidi, F. F., Zainalabidin, S., Taib, I. S., Hamid, Z. A., & Budin, S. B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105094 · Cited by 123 · see citing works
Li, T., Huang, Z., Jia, R., Lv, X., Zhao, C., & Liu, B. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110530 · Cited by 122 · see citing works
Protective action of arachidonic acid against alloxan-induced cytotoxicity and diabetes mellitus
Suresh, Y., & Das, U. N. (2001) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2000.0236 · Cited by 117 · see citing works
Lin, H.-T., Tsou, Y.-C., Chen, Y.-T., Lu, W.-J., & Hwang, P.-A. (2017) · Marine Drugs · doi:10.3390/md15040113 · Cited by 114 · see citing works
Feruloylated oligosaccharides and ferulic acid alter gut microbiome to alleviate diabetic syndrome
Song, Y., Wu, M.-S., Tao, G., Lu, M., Lin, J., & Huang, J. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109410 · Cited by 114 · see citing works
Short Chain Fatty Acids, pancreatic dysfunction and type 2 diabetes
Mandaliya, D. K., & Seshadri, S. (2019) · Pancreatology · doi:10.1016/j.pan.2019.01.021 · Cited by 112 · see citing works
Bioactive peptides from microalgae: Focus on anti‐cancer and immunomodulating activity
Skjånes, K., Aesöy, R., Herfindal, L., & Skomedal, H. (2021) · Physiologia Plantarum · doi:10.1111/ppl.13472 · Cited by 112 · see citing works
Ibrahim, T. N. B. T., Feisal, N. A. S., Kamaludin, N. H., Cheah, W. Y., How, V., Bhatnagar, A., Ma, Z., & Show, P. L. (2023) · Bioresource Technology · doi:10.1016/j.biortech.2023.128661 · Cited by 111 · see citing works
Hypoglycemic and Hypolipidemic Effects of Glucomannan Extracted from Konjac on Type 2 Diabetic Rats
Chen, H., Nie, Q., Hu, J., Huang, X., Zhang, K., Pan, S., & Nie, S. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b01192 · Cited by 107 · see citing works
Gentscheva, G., Nikolova, K., Panayotova, V., Peycheva, K., Makedonski, L., Slavov, P., Radusheva, P., Petrova, P., & Yotkovska, I. (2023) · Life · doi:10.3390/life13030845 · Cited by 106 · see citing works
Maslinic Acid Reduces Blood Glucose in KK-Ay Mice
Liu, J., Sun, H., Duan, W., Mu, D., & Zhang, L. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.2075 · Cited by 105 · see citing works
Efficacy of Caffeic Acid on Diabetes and Its Complications in the Mouse
Oršolić, N., Sirovina, D., Odeh, D., Gajski, G., Balta, V., Šver, L., & Jembrek, M. J. (2021) · Molecules · doi:10.3390/molecules26113262 · Cited by 105 · see citing works
Comprehensive GCMS and LC-MS/MS Metabolite Profiling of Chlorella vulgaris
Pantami, H. A., Bustamam, M. S. A., Lee, S. Y., Ismail, I. S., Faudzi, S. M. M., Nakakuni, M., & Shaari, K. (2020) · Marine Drugs · doi:10.3390/md18070367 · Cited by 102 · see citing works
Raza, H., & John, A. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13055751 · Cited by 101 · see citing works
Wu, G., Bai, Z., Wan, Y., Shi, H., Huang, X., & Nie, S. (2019) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2019.105456 · Cited by 101 · see citing works
Antioxidant and Antidiabetic Activity of Algae
Abo-Shady, A. M., Gheda, S. F., Ismail, G. A., Cotas, J., Pereira, L., & Abdel-Karim, O. H. (2023) · Life · doi:10.3390/life13020460 · Cited by 98 · see citing works
D'souza, J. J., D'souza, P., Fazal, F., Kumar, A., Bhat, H. P., & Baliga, M. S. (2014) · Food & Function · doi:10.1039/c3fo60366k · Cited by 97 · see citing works
Gohara-Beirigo, A. K., Matsudo, M. C., Cezare-Gomes, E. A., de Carvalho, J. C. M., & Danesi, E. D. G. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.04.030 · Cited by 97 · see citing works
Oleanolic acid enhances insulin secretion in pancreatic β‐cells
Teodoro, T., Zhang, L., Alexander, T. R., Yue, J. T. Y., Vranić, M., & Volchuk, A. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.03.026 · Cited by 96 · see citing works
Mani, U. V., Desai, S., & Iyer, U. (2000) · Journal of Nutraceuticals, Functional & Medical Foods · doi:10.1300/j133v02n03_03 · Cited by 94 · see citing works
Chen, Y., Liu, X., Wu, L., Tong, A., Zhao, L., Liu, B., & Zhao, C. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.12.077 · Cited by 94 · see citing works
Linoleic acid, glycemic control and Type 2 diabetes
Belury, M. A., Cole, R. M., Snoke, D. B., Banh, T., & Angelotti, A. (2018) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2018.03.001 · Cited by 94 · see citing works
Abdel-Moneim, A., El-Twab, S. M. A., Yousef, A. I., Abdel-Reheim, E. S., & Ashour, M. B. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.096 · Cited by 92 · see citing works
Seedevi, P., Ganesan, A. R., Moovendhan, M., Mohan, K., Sivasankar, P., Loganathan, S., Vairamani, S., & Shanmugam, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-57486-w · Cited by 91 · see citing works
Fucosterol of Marine Macroalgae: Bioactivity, Safety and Toxicity on Organism
Meinita, M. D. N., Harwanto, D., Tirtawijaya, G., Negara, B. F. S. P., Sohn, J. H., Kim, J., & Choi, J. (2021) · Marine Drugs · doi:10.3390/md19100545 · Cited by 90 · see citing works
Lycopene: A Potent Antioxidant for the Amelioration of Type II Diabetes Mellitus
Leh, H. E., & Lee, L. K. (2022) · Molecules · doi:10.3390/molecules27072335 · Cited by 90 · see citing works
Wan, X., Li, T.-T., Zhong, R.-T., Chen, H., Xia, X., Gao, L., Gao, X., Liu, B., Zhang, H., & Zhao, C. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.04.017 · Cited by 89 · see citing works
Linoleic acid and the regulation of glucose homeostasis: A review of the evidence
Hamilton, J., & Klett, E. L. (2021) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2021.102366 · Cited by 88 · see citing works
Antidiabetic potential of phycocyanin: Effects on KKAy mice
Ou, Y., Lin, L., Yang, X., Pan, Q., & Cheng, X. (2013) · Pharmaceutical Biology · doi:10.3109/13880209.2012.747545 · Cited by 85 · see citing works
Sadek, K. M., Lebda, M. A., Nasr, S. M., & Shoukry, M. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.06.023 · Cited by 84 · see citing works
Advances in delivery methods of Arthrospira platensis (spirulina) for enhanced therapeutic outcomes
ElFar, O. A., Billa, N., Lim, H. R., Chew, K. W., Cheah, W. Y., Munawaroh, H. S. H., Deepanraj, B., & Show, P. L. (2022) · Bioengineered · doi:10.1080/21655979.2022.2100863 · Cited by 84 · see citing works
Casas-Arrojo, V., Decara, J. M., Arrojo, M. Á., Pérez, C. I., & Abdala‐Díaz, R. (2021) · Biomolecules · doi:10.3390/biom11040488 · Cited by 83 · see citing works
Nasirian, F., Dadkhah, M., Moradikor, N., & Obeidavi, Z. (2018) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s172104 · Cited by 82 · see citing works
Tarry‐Adkins, J. L., Grant, I. D., Ozanne, S. E., Reynolds, R. M., & Aiken, C. (2021) · Diabetes Therapy · doi:10.1007/s13300-021-01058-2 · Cited by 82 · see citing works
Goto, T., Kim, Y.-I., Furuzono, T., Takahashi, N., Yamakuni, K., Yang, H.-E., Li, Y., Ohue, R., Nomura, W., Sugawara, T., et al. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.02.154 · Cited by 80 · see citing works
Jones‐Hall, Y., Kozik, A. J., & Nakatsu, C. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119441 · Cited by 80 · see citing works
Enzymes Inhibition and Antidiabetic Effect of Isolated Constituents fromDillenia indica
Kumar, S., Kumar, V., & Prakash, O. (2013) · BioMed Research International · doi:10.1155/2013/382063 · Cited by 79 · see citing works
Wang, H., Sun, X., Zhang, N., Ji, Z., Ma, Z., Fu, Q., Qu, R., & Ma, S. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.10.001 · Cited by 78 · see citing works
Amelioration of streptozotocin-induced type 2 diabetes mellitus in Wistar rats by arachidonic acid
Gundala, N. K. V., Naidu, V. G. M., & Das, U. N. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.01.007 · Cited by 78 · see citing works
Preventive Effects of Kaempferol on High‐Fat Diet‐Induced Obesity Complications in C57BL/6 Mice
Wang, T., Wu, Q., & Zhao, T. (2020) · BioMed Research International · doi:10.1155/2020/4532482 · Cited by 78 · see citing works
Cazarolli, L. H., Folador, P., Moresco, H. H., Brighente, I. M. C., Pizzolatti, M. G., & Silva, F. R. M. B. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.11.012 · Cited by 76 · see citing works
Antidiabetic Effects of Corosolic Acid in KK-Ay Diabetic Mice
Miura, T., Ueda, N., Yamada, K., Fukushima, M., Ishida, T., Kaneko, T., Matsuyama, F., & Seino, Y. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.585 · Cited by 76 · see citing works
Semwal, D. K., Kumar, A., Aswal, S., Chauhan, A., & Semwal, R. B. (2020) · Phytotherapy Research · doi:10.1002/ptr.6885 · Cited by 74 · see citing works
Wang, N., Yi, W. J., Tan, L., Zhang, J. H., Xu, J., Chen, Y., Qin, M., Yu, S., Guan, J. Z., & Zhang, R. (2017) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-017-0135-4 · Cited by 73 · see citing works
Bioactive Hydrolysates from Chlorella vulgaris: Optimal Process and Bioactive Properties
Cunha, S. A., Coscueta, E. R., Nova, P., Silva, J., & Pintado, M. M. (2022) · Molecules · doi:10.3390/molecules27082505 · Cited by 73 · see citing works
Zhang, Y., Wei, Z. C., Maechler, P., & Liu, D. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.03.008 · Cited by 72 · see citing works
Zhao, C., Wu, Y., Yang, C., Liu, B., & Huang, Y. (2015) · International Journal of Food Science & Technology · doi:10.1111/ijfs.12860 · Cited by 69 · see citing works
Wan, X., Li, T., Liu, D., Chen, Y., Liu, Y., Liu, B., Zhang, H., & Zhao, C. (2018) · Marine Drugs · doi:10.3390/md16120498 · Cited by 69 · see citing works
Sundaram, R., Nandhakumar, E., & Banu, H. H. (2019) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2019.1646370 · Cited by 69 · see citing works
Impact of Different Storage Methods on Bioactive Compounds in Arthrospira platensis Biomass
Papalia, T., Sidari, R., & Panuccio, M. R. (2019) · Molecules · doi:10.3390/molecules24152810 · Cited by 69 · see citing works
Gupta, L., Khandelwal, D., Maharaj Agrasen Hopsital, P. B., Lal, P. R., Gupta, Y., Kalra, S., & Dutta, D. (2019) · touchREVIEWS in Endocrinology · doi:10.17925/ee.2019.15.1.18 · Cited by 68 · see citing works
Sarbolouki, S., Javanbakht, M., Derakhshanian, H., Hosseinzadeh, P., Zareei, M., Hashemi, S., Motlagh, A. D., Eshraghian, M. R., & Djalali, M. (2013) · Singapore Medical Journal · doi:10.11622/smedj.2013139 · Cited by 67 · see citing works
Joventino, I. P., Alves, H. G. R., Neves, L. C., Joventino, F. P., Leal, L. K. A. M., Neves, S. D. A., Ferreira, F. V., Brito, G. A. D. C., & Viana, G. B. (2012) · Journal of Complementary and Integrative Medicine · doi:10.1515/1553-3840.1534 · Cited by 67 · see citing works
Esquivel-Hernandez, D. A., Rodríguez‐Rodríguez, J., Rostro‐Alanís, M. D. J., Cuéllar‐Bermúdez, S. P., Mancera-Andrade, E. I., Núñez-Echevarría, J. E., García‐Pérez, J. S., Chandra, R., & Parra‐Saldívar, R. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.10.061 · Cited by 66 · see citing works
Jörns, A., Tiedge, M., Lenzen, S., & Munday, R. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00325-6 · Cited by 65 · see citing works
GLP-1 receptor agonists in diabetes for stroke prevention: a systematic review and meta-analysis
Malhotra, K., Katsanos, A. H., Lambadiari, V., Goyal, N., Palaiodimou, L., Kosmidou, M., Krogias, C., Alexandrov, A. V., & Tsivgoulis, G. (2020) · Journal of Neurology · doi:10.1007/s00415-020-09813-4 · Cited by 65 · see citing works
Anti-obesity effects of DHA and EPA in high fat-induced insulin resistant mice
Wei, W., Hu, M., Huang, J., Yu, S., Li, X., Li, Y., & Mao, L. (2020) · Food & Function · doi:10.1039/d0fo02448a · Cited by 65 · see citing works
Etsassala, N. G. E. R., Badmus, J. A., Waryo, T., Marnewick, J. L., Cupido, C. N., Hussein, A. A., & Iwuoha, E. I. (2019) · Antioxidants · doi:10.3390/antiox8100421 · Cited by 63 · see citing works
Eicosapentaenoic and arachidonic acids purification from the red microalga Porphyridium cruentum
Guil‐Guerrero, J. L., Belarbi, E., & Rebolloso, M. M. (2000) · Bioseparation · doi:10.1023/a:1011124624001 · Cited by 62 · see citing works
Sommella, E., Conte, G. M., Salviati, E., Pepe, G., Bertamino, A., Ostacolo, C., Sansone, F., Prete, F. D., Aquino, R. P., & Campiglia, P. (2018) · Molecules · doi:10.3390/molecules23051152 · Cited by 62 · see citing works
FoxO1 signaling as a therapeutic target for type 2 diabetes and obesity
Benchoula, K., Arya, A., Parhar, I. S., & Wong, E. H. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173758 · Cited by 62 · see citing works
Amin, A., Lotfy, M. A., Mahmoud‐Ghoneim, D., Adeghate, E. A., Al-Akhras, M. A., Al-Saadi, M., Al-Rahmoun, S., & Hameed, R. (2011) · Journal of Diabetes Mellitus · doi:10.4236/jdm.2011.13006 · Cited by 61 · see citing works
Siti Halimatul Munawaroh, H., Gumilar, G. G., Nurjanah, F., Yuliani, G., Aisyah, S., Kurnia, D., Wulandari, A. P., Kurniawan, I., Ningrum, A., Koyande, A. K., et al. (2020) · Biochemical Engineering Journal · doi:10.1016/j.bej.2020.107666 · Cited by 61 · see citing works
Investigating the Role of Myeloperoxidase and Angiopoietin-like Protein 6 in Obesity and Diabetes
Qaddoumi, M. G., Alanbaei, M., Hammad, M. M., Khairi, I. A., Cherian, P., Channanath, A. M., Thanaraj, T. A., Al‐Mulla, F., Abu‐Farha, M., & Abubaker, J. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-63149-7 · Cited by 59 · see citing works
Li, Y., Aiello, G., Fassi, E. M. A., Boschin, G., Bartolomei, M., Bollati, C., Roda, G., Arnoldi, A., Grazioso, G., & Lammi, C. (2021) · Nutrients · doi:10.3390/nu13051624 · Cited by 59 · see citing works
Gray, B. E., Swick, J., & Ronnenberg, A. G. (2011) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00377.x · Cited by 58 · see citing works
Extraction of Bioactive Compounds Using Supercritical Carbon Dioxide
Molino, A., Larocca, V., Sanzo, G. D., Martino, M., Casella, P., Marino, T., Karatza, D., & Musmarra, D. (2019) · Molecules · doi:10.3390/molecules24040782 · Cited by 56 · see citing works
Wang, J., Hu, X., Ai, W., Zhang, F., Yang, K., Wang, L., Zhu, X., Gao, P., Shu, G., Jiang, Q., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.05.160 · Cited by 55 · see citing works
Total Lipids Content, Lipid Class and Fatty Acid Composition of Ten Species of Microalgae
Yang, Y., Du, L., Hosokawa, M., & Miyashita, K. (2020) · Journal of Oleo Science · doi:10.5650/jos.ess20140 · Cited by 54 · see citing works
Harvesting microalgae for health beneficial dietary supplements
Laamanen, C. A., Desjardins, S. M., Senhorinho, G. N. A., & Scott, J. A. (2021) · Algal Research · doi:10.1016/j.algal.2021.102189 · Cited by 54 · see citing works
Sustainable production and pharmaceutical applications of β-glucan from microbial sources
Murphy, E. J., Rezoagli, E., Collins, C., Saha, S. K., Major, I., & Murray, P. (2023) · Microbiological Research · doi:10.1016/j.micres.2023.127424 · Cited by 54 · see citing works
Ou, Y., Ren, Z., Wang, J., & Yang, X. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.01.018 · Cited by 53 · see citing works
Soni, B., Visavadiya, N. P., & Madamwar, D. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114508162973 · Cited by 51 · see citing works
Gurunathan, S., Joseph, G. S., & Baskaran, V. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1283-0 · Cited by 51 · see citing works
Lee, S., Lee, H., Kim, Y., & Kim, E. Y. (2019) · Scientific Reports · doi:10.1038/s41598-019-49803-9 · Cited by 51 · see citing works
Gallego, R., Valdés, A., Suárez-Montenegro, Z. J., Sánchez-Martínez, J. D., Cifuentes, A., Ibáñez, E., & Herrero, M. (2022) · Algal Research · doi:10.1016/j.algal.2022.102830 · Cited by 51 · see citing works
Role of selenium in type 2 diabetes, insulin resistance and insulin secretion
Casanova, P., & Monleón, D. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i3.147 · Cited by 51 · see citing works
Vieira, M. V., Turkiewicz, I. P., Tkacz, K., Fuentes-Grünewald, C., Pastrana, L. M., Fuciños, P., Wojdyło, A., & Nowicka, P. (2021) · Molecules · doi:10.3390/molecules26247593 · Cited by 50 · see citing works
The effects of omega-3 fatty acids in type 2 diabetes: A systematic review and meta-analysis
Xiao, Y., Zhang, Q., Liao, X., Elbelt, U., & Weylandt, K. H. (2022) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2022.102456 · Cited by 50 · see citing works
Villaró, S., Jiménez-Márquez, S., Musari, E., Bermejo, R., & Lafarga, T. (2023) · Food Research International · doi:10.1016/j.foodres.2022.112270 · Cited by 50 · see citing works
Bioactive Diterpenoids and Flavonoids from the Aerial Parts of Scoparia dulcis
Liu, Q., Yang, Q., Hu, H.-J., Yang, L., Yang, Y., Chou, G., & Wang, Z. (2014) · Journal of Natural Products · doi:10.1021/np500150f · Cited by 49 · see citing works
Wu, J., Kuo, Y., Lin, C., Ho, H., & Shih, C. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf503334d · Cited by 48 · see citing works
Millao, S., & Uquiche, E. L. (2016) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2016.02.002 · Cited by 47 · see citing works
Evaluation of Moroccan microalgae: Spirulina platensis as a potential source of natural antioxidants
Bellahcen, T. O., Aamiri, A., Touam, I., Hmimid, F., Amrani, A. E., Chérif, A., & Cherki, M. (2020) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2019-0036 · Cited by 47 · see citing works
Zhou, N., Long, H., Wang, C., Zhu, Z., Yu, L., Yang, W., Ren, X., & Liu, X. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.08.100 · Cited by 47 · see citing works
Gkioni, M. D., Andriopoulos, V., Koutra, E., Hatziantoniou, S., Kornaros, M. E., & Lamari, F. N. (2022) · Antioxidants · doi:10.3390/antiox11061103 · Cited by 47 · see citing works
Safety assessment of the microalgae Nannochloropsis oculata
Kagan, M. L., & Matulka, R. A. (2015) · Toxicology Reports · doi:10.1016/j.toxrep.2015.03.008 · Cited by 46 · see citing works
Bohórquez-Medina, S. L., Bohórquez-Medina, A. L., Benites-Zapata, V. A., Ignacio-Cconchoy, F. L., Toro-Huamanchumo, C. J., Bendezú-Quispe, G., Pacheco‐Mendoza, J., & Hernández, A. V. (2021) · NFS Journal · doi:10.1016/j.nfs.2021.09.003 · Cited by 46 · see citing works
Anitha, L., & Chandralekha, K. (2010) · Cited by 45 · see citing works
Kawee‐ai, A., Kim, A. T., & Kim, S. M. (2019) · Journal of Oceanology and Limnology · doi:10.1007/s00343-019-8098-9 · Cited by 45 · see citing works
Ni, M., Pan, J., Hu, X., Gong, D., & Zhang, G. (2019) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9862 · Cited by 45 · see citing works
Kou, L., Du, M., Zhang, C., Dai, Z., Li, X., & Zhang, B. (2017) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-016-2372-5 · Cited by 44 · see citing works
Nasirian, F., Sarir, H., & Moradi-kor, N. (2019) · Biomolecular Concepts · doi:10.1515/bmc-2019-0004 · Cited by 42 · see citing works
Li, Y., Wang, C., Liu, H., Su, J., Lan, C. Q., Zhong, M., & Hu, X. (2020) · Algal Research · doi:10.1016/j.algal.2020.101883 · Cited by 42 · see citing works
Characterization and anti-diabetic evaluation of sulfated polysaccharide from Spirulina platensis
Liu, J., Zhu, X., Sun, L., & Gao, Y. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105155 · Cited by 42 · see citing works
Continuous Microalgal Cultivation for Antioxidants Production
López-Hernández, J. F., García, P. Á., Palma‐Ramírez, D., Álvarez‐González, C. A., Paredes-Rojas, J. C., & Márquez-Rocha, F. J. (2020) · Molecules · doi:10.3390/molecules25184171 · Cited by 41 · see citing works
Nacer, W., Ahmed, F. Z. B., Merzouk, H., Benyagoub, O., & Bouanane, S. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00681-3 · Cited by 41 · see citing works
Castro, A. J. G., Frederico, M. J. S., Cazarolli, L. H., Bretanha, L. C., Tavares, L. D. C., Buss, Z. D. S., Dutra, M. F., Zamoner, A., Pizzolatti, M. G., & Silva, F. R. M. B. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.11.020 · Cited by 39 · see citing works
Chlorella as a Source of Functional Food Ingredients: Short review
Widyaningrum, D., & Prianto, A. D. (2021) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/794/1/012148 · Cited by 38 · see citing works
Todorović, B., Grujić, V. J., Krajnc, A. U., Kranvogl, R., & Ambrožič‐Dolinšek, J. (2021) · Plants · doi:10.3390/plants10112413 · Cited by 38 · see citing works
Tayanloo-Beik, A., Kiasalari, Z., & Roghani, M. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01936-1 · Cited by 38 · see citing works
Hussain, S. A., Ahmed, Z. A., Mahwi, T., & Aziz, T. A. (2012) · Journal of Diabetes Mellitus · doi:10.4236/jdm.2012.21013 · Cited by 37 · see citing works
Juin, C., Bonnet, A., Nicolau, É., Bérard, J., Devillers, R., Thiéry, V., Cadoret, J., & Picot, L. (2015) · Marine Drugs · doi:10.3390/md13042541 · Cited by 37 · see citing works
Semaan, D. G., Igoli, J. O., Young, L., Gray, A. I., Rowan, E. G., & Marrero, E. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.01.014 · Cited by 37 · see citing works
Sadeghabadi, Z. A., Abbasalipourkabir, R., Mohseni, R., & Ziamajidi, N. (2019) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-019-00437-8 · Cited by 37 · see citing works
Liu, J. H., Wang, X., Chen, Y., Mao, L., Shang, J., Sun, H., & Zhang, L. (2014) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(14)60052-2 · Cited by 36 · see citing works
Effects of Caffeine and Lycopene in Experimentally Induced Diabetes Mellitus
Özmen, Ö., Topsakal, Ş., Halıgür, M., Aydoğan, A., & Dıncoglu, D. (2015) · Pancreas · doi:10.1097/mpa.0000000000000489 · Cited by 36 · see citing works
Short Chain Fatty Acids, pancreatic dysfunction and type 2 diabetes
Mandaliya, D. K., & Seshadri, S. (2019) · Pancreatology · doi:10.1016/j.pan.2019.04.013 · Cited by 36 · see citing works
Recent Advances in Micro and Macroalgal Processing
(2021) · Wiley eBooks · doi:10.1002/9781119542650 · Cited by 36 · see citing works
Hu, H. Q., Wang, H., Ma, L., Shen, X., & Zeng, R. J. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-8943-3 · Cited by 35 · see citing works
The Controversial Role of Adiponectin in Appetite Regulation of Animals
Tang, N., Zhang, X., Chen, D., & Li, Z. (2021) · Nutrients · doi:10.3390/nu13103387 · Cited by 35 · see citing works
Bigagli, E., Cinci, L., Niccolai, A., Tredici, M. R., Biondi, N., Rodolfi, L., Lodovici, M., D’Ambrosio, M., Mori, G., & Luceri, C. (2017) · Food Research International · doi:10.1016/j.foodres.2017.09.011 · Cited by 34 · see citing works
Gowd, V., Xiao, J., Wang, M., Chen, F., & Cheng, K. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100252 · Cited by 34 · see citing works
Rupérez, F. J., García-Martínez, D. L., Baena, B., Maeso, N., Vallejo, M., Angulo, S., Garcı́a, A., Ibáñez, E., Señoráns, F. J., Cifuentes, A., et al. (2009) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2008.12.041 · Cited by 33 · see citing works
Alam, M. A., Quamri, S., Fatima, S., Roqaiya, M., & Ahmad, Z. (2016) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000710 · Cited by 33 · see citing works
Esquivel-Hernandez, D. A., Rodríguez‐Rodríguez, J., Cuéllar‐Bermúdez, S. P., García‐Pérez, J. S., Mancera-Andrade, E. I., Núñez-Echevarría, J. E., Ontiveros‐Valencia, A., Rostro‐Alanís, M. D. J., García‐García, R., Torres, J. A., et al. (2017) · Marine Drugs · doi:10.3390/md15060174 · Cited by 33 · see citing works
Karizi, S. R., Armanmehr, F., Azadi, H. G., Zahroodi, H. S., Ghalibaf, A. M., Bazzaz, B. S. F., Abbaspour, M., Boskabadi, S. J., Eslami, S., & Taherzadeh, Z. (2023) · Phytotherapy Research · doi:10.1002/ptr.7674 · Cited by 32 · see citing works
Nataraju, A., Saini, D., Ramachandran, S., Benshoff, N., Liu, W., Chapman, W., & Mohanakumar, T. (2009) · Transplantation · doi:10.1097/tp.0b013e3181b9cbc4 · Cited by 31 · see citing works
Caffeic Acid Phenethyl Ester Regulates PPAR’s Levels in Stem Cells-Derived Adipocytes
Vanella, L., Tibullo, D., Godos, J., Pluchinotta, F. R., Giacomo, C. D., Sorrenti, V., Acquaviva, R., Russo, A., Volti, G. L., & Barbagallo, I. A. (2016) · PPAR Research · doi:10.1155/2016/7359521 · Cited by 31 · see citing works
Toxicity assessment of the green Dunaliella salina microalgae
El-Baz, F. K., Aly, H. F., & Salama, A. (2019) · Toxicology Reports · doi:10.1016/j.toxrep.2019.08.003 · Cited by 31 · see citing works
Quercetin improves oxidative stress-induced pancreatic beta cell alterations via mTOR-signaling
Dhanya, R., & Kartha, C. S. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04193-3 · Cited by 31 · see citing works
Martínez, R., García-Beltrán, A., Kapravelou, G., Mesas, C., Cabeza, L., Perazzoli, G., Guarnizo, P., Rodríguez-López, A., Vallejo, R. A., Galisteo, M., et al. (2022) · Marine Drugs · doi:10.3390/md20050318 · Cited by 31 · see citing works
Erythroprotective Potential of Phycobiliproteins Extracted from Porphyridium cruentum
Peña-Medina, R. L., Fimbres-Olivarría, D., Enríquez-Ocaña, L. F., Martínez‐Córdova, L. R., Del‐Toro‐Sánchez, C. L., López‐Elías, J. A., & González-Vega, R. I. (2023) · Metabolites · doi:10.3390/metabo13030366 · Cited by 31 · see citing works
Luo, X., Jia, R., Yao, Q., Xu, Y., Luo, Z., Luo, X., & Wang, N. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500714 · Cited by 30 · see citing works
Mahmoud, F. F., Haines, D. D., Dashti, A. A., El‐Shazly, S., & Al-Najjar, F. (2018) · Cell Stress and Chaperones · doi:10.1007/s12192-018-0903-4 · Cited by 30 · see citing works
Elvira-Torales, L. I., Martín‐Pozuelo, G., González‐Barrio, R., NAVARRO-GONZÁLEZ, I., Pallarés, F. J., Santaella, M., García‐Alonso, J., Sevilla, A., & Periago, M. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071662 · Cited by 30 · see citing works
Spirulina platensis, oxidative stress, and diabetes
Bitam, A., & Aissaoui, O. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815776-3.00033-4 · Cited by 30 · see citing works
Application of microalgae metabolites in food and pharmaceutical industry
Mishra, N., Gupta, E., Singh, P., & Prasad, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820284-5.00005-8 · Cited by 30 · see citing works
Haimeur, A., Mimouni, V., Ulmann, L., Martineau, A., Messaouri, H., Pineau‐Vincent, F., Tremblin, G., & Meskini, N. (2016) · Lipids · doi:10.1007/s11745-016-4177-2 · Cited by 28 · see citing works
Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword
Hughey, C. C., & Crawford, P. A. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.013 · Cited by 28 · see citing works
Characterisation of gut microbiota of obesity and type 2 diabetes in a rodent model
Ibrahim, K. S., BOURWIS, N., Dolan, S., Sue, L. A. N. G., Spencer, J., & Craft, J. A. (2020) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.2019-031 · Cited by 28 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Shah, M. A. R., Zhu, F., Cui, Y., Hu, X., Chen, H., Kayani, S., & Huo, S. (2024) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2024.104648 · Cited by 56 · see citing works
Microalgae Bioactives for Functional Food Innovation and Health Promotion
Guil-Guerrero, J. L., & Prates, J. A. M. (2025) · Foods · doi:10.3390/foods14122122 · Cited by 47 · see citing works
“A recent systematic review concluded that microalgae-derived supplements can enhance insulin sensitivity, modulate lipid metabolism, and lower systemic inflammation in individuals with metabolic syndrome and type 2 diabetes [71].”
Dimopoulou, M., Kolonas, A., Stagos, D., & Gortzi, O. (2025) · Biomass · doi:10.3390/biomass5010011 · Cited by 34 · see citing works
Bürck, M., Ramos, S. D. P., & Braga, A. R. C. (2024) · Foods · doi:10.3390/foods13121811 · Cited by 28 · see citing works
Odenthal, K., Nunes, E. B., Nunes, N., Fernandes, T., Fernandes, I. A., & de Carvalho, M. Â. A. P. (2024) · Algal Research · doi:10.1016/j.algal.2024.103610 · Cited by 19 · see citing works
Exploring the Potential and Challenges of Fermentation in Creating Foods: A Spotlight on Microalgae
Bürck, M., Lemes, A. C., Egea, M. B., & Braga, A. R. C. (2024) · Fermentation · doi:10.3390/fermentation10120649 · Cited by 19 · see citing works
Improving Undernutrition with Microalgae
Panchal, S. K., Heimann, K., & Brown, L. (2024) · Nutrients · doi:10.3390/nu16183223 · Cited by 15 · see citing works
Bioactive Lipids in Dunaliella salina: Implications for Functional Foods and Health
Pais, R., Conde, T., Neves, B., Pinho, M., Coelho, M. C., Pereira, H., Rodrigues, A. M. C., Domingues, P. M., Gomes, A., Urbatzka, R., et al. (2024) · Foods · doi:10.3390/foods13203321 · Cited by 14 · see citing works
Oslan, S. N. H., Xuan, N. J., Khodzori, F. A., Hakim, B. N. A., Huda, N., Julmohammad, N. B., & Barzkar, N. (2025) · Algal Research · doi:10.1016/j.algal.2025.104420 · Cited by 11 · see citing works
Sergi, D., Melloni, M., Passaro, A., & Neri, L. M. (2024) · Nutrients · doi:10.3390/nu16193243 · Cited by 9 · see citing works
Anti-diabetic Activity of Spirulina and Chlorella in In vivo Experimental Rats
Shaman, A. A., Zidan, N. S., Alzahrani, S., Albishi, L. A., Sakran, M., Almutairi, F. M., & Keshk, A. A. (2024) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/2911 · Cited by 8 · see citing works
Qoms, M. S., Wong, S. K., Fauzi, N. M., Husain, K., Makpol, S., & Tan, J. K. (2025) · Antioxidants · doi:10.3390/antiox14101170 · Cited by 8 · see citing works
Self-citationWang, P., Liu, C., & Zheng, L. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2582571 · Cited by 6 · see citing works
From sea to supplement: Algal protein extraction methods and functional benefits
Chaudhary, S., Singh, R., Mishra, S., Talwar, B., & Balhara, K. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147750 · Cited by 5 · see citing works
Gaida, D., Park, Y., & Kim, S. (2023) · Applied Sciences · doi:10.3390/app132111617 · Cited by 4 · see citing works
Pan-utai, W., Phomkaivon, N., Settachaimongkon, S., Pongponpai, P., & Songsiriritthigul, C. (2025) · Life · doi:10.3390/life15081213 · Cited by 3 · see citing works
Zhao, J., Guo, Y., Zhang, P., Zeng, W., Fan, J., Chen, C., & Zhang, W. (2025) · Animal nutrition · doi:10.1016/j.aninu.2025.09.002 · Cited by 3 · see citing works
Vujović, T., Brčić, S. B., Paradžik, T., Miloš, M., Perečinec, M. G., Vranjković, L., Starčević, A., Bojanić, K., Čož‐Rakovac, R., Šantek, M. I., et al. (2025) · Algal Research · doi:10.1016/j.algal.2025.104354 · Cited by 2 · see citing works
Bamahry, A. R., Ardiansyar, A. M., Safitri, ., Rampengan, D. D. C. H., Syahputra, R. A., Taslim, N. A., Santini, A., Vencio, S. A. C., & Nurkolis, F. (2025) · Discover Food · doi:10.1007/s44187-025-00636-8 · Cited by 1 · see citing works
Antidiabetic Properties of Microalgae Compounds
Machado, R. L. S., Dutra, D. A., Schneider, A. T., Dias, R. R., Deprá, M. C., Zepka, L. Q., & Jacob-Lopes, E. (2025) · Springer eBooks · doi:10.1007/978-981-95-0571-5_4 · Cited by 1 · see citing works
Acharjee, M. R., Das, U., Biswas, H., Metu, C. L. N., Islam, S., Saha, P., Das, K. K., Habibullah‐Al‐Mamun, M., Faruque, M. H., & Khatoon, H. (2026) · Journal of Food Science · doi:10.1111/1750-3841.71134 · Cited by 1 · see citing works
Romdhani, M., Dhaouafi, J., Deracinois, B., Flahaut, C., Nedjar, N., & Balti, R. (2025) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2025.103694
Evidence of use of microalgae on glycemic control and glucose metabolism
Pereira, L. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-22080-7.00035-1
Vieira, M. V. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-22080-7.00037-5
Clinical Trials and Patents Related to Anti-diabetic Properties of Algae
Esther Shoba, R., Ramachandran, D., & Angeline, M. S. (2025) · Springer eBooks · doi:10.1007/978-981-95-0571-5_13
Bioactivity and Chemical Profiling of the Sea-Ice Microalga Microglena antarctica (Chlorophyceae)
Trentin, R., Moschin, E., Custódio, L. M. B., & Moro, I. (2025) · Biomolecules · doi:10.3390/biom15121658
Gallege, J., Uduwana, S., Menaka, U., & Wickramasinghe, I. (2025) · Springer eBooks · doi:10.1007/978-981-95-0571-5_12
Sazlı, N., & Karataş, D. (2025) · Eurasian Journal of Biological and Chemical Sciences · doi:10.46239/ejbcs.1792071
Boscart, T., Barras, A., Plaisance, V., Pawlowski, V., Giovanelli, E., Bardor, M., d’Hulst, C., & Abderrahmani, A. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18020223
Andriawan, S., Handajani, H., & Jamil, A. S. (2026) · Journal of Research in Pharmacy · doi:10.12991/jrespharm.1638350
Yücetepe, A., Khalid, W., Harahap, I. A., Siddique, F., Savaş, S., Adefegha, S. A., Aderinola, T. A., Mertoğlu, K., & Esatbeyoglu, T. (2026) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2026.105778
Caetano, P. A., do Nascimento, T. C., da Silveira, M. V., Vieira, D. S., Silva, L. E. L. E., Schetinger, M. R. C., de Menezes, C. R., Wagner, R. C., Roca, M., Lopes, E. J., et al. (2026) · Life · doi:10.3390/life16091540
- Authors
- Tamel Selvan, K., Goon, J. A., Makpol, S., & Tan, J. K.
- Affiliations
- Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Jalan Ya’acob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia
- National University of Malaysia (MY)
- Corresponding author
- Tan, Jen Kit
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2023-08-23
- Volume
- 21
- Issue
- 9
- Pages
- 462
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC10532649
- OpenAlex
- W4386141674
- Cited by
- 32
- References
- 251
- Citations by year
- 2026: 5 · 2025: 18 · 2024: 8 · 2023: 1
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Higher Education, Malaysia with the Fundamental Research Grant Scheme (FRGS/1/2018/SKK08/UKM/03/1, FF-2023-133)
- Faculty of Medicine, Universiti Kebangsaan Malaysia (FRGS/1/2018/SKK08/UKM/03/1, FF-2023-133)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Keywords
- microalgae, diabetes mellitus, bioactive compounds, insulin sensitivity, insulin resistance, oxidative stress, inflammation, antioxidant activity, pancreatic beta-cell protection, nutraceuticals, dietary supplements, hyperglycemia
- MeSH terms
- Animals, Anti-Inflammatory Agents, Antioxidants, Biological Products, Diabetes Mellitus, Humans, Hypoglycemic Agents, Insulin Resistance, Oxidative Stress, Dietary Supplements, Microalgae
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review