Trimethylamine N-oxide prime NLRP3 inflammasome via inhibiting ATG16L1-induced autophagy in colonic epithelial cells
Abstract
Recently, the intricate relationship between Trimethylamine N-oxide (TMAO) and inflammatory bowel disease (IBD) is of growing interest. The NLRP3 inflammasome plays crucial roles in gut homeostasis and determining the severity of inflammation in IBD, however, the precise roles of the NLRP3 inflammasome in IBD are still debated. ATG16L1 mediates the cellular degradative process of autophagy and is considered a critical regulator of inflammation based on its genetic association with IBD. Whether TMAO prime NLRP3 inflammasome via ATG16L1-induced autophagy remains unclear. This study observed the expression of ATG16L1, LC3-II and p62 and activation of NLRP3 inflammasome stimulated by TMAO in fetal human colon cells (FHCs), aiming to elucidate the mechanism by which the TMAO may contribute to colonic epithelial inflammation. Our results demonstrated that TMAO significantly inhibited ATG16L1, LC3-II and p62 expression, and triggered the activated NLRP3 inflammasome and production of ROS in a dose- and time-dependent manner. Furthermore, TMAO-mediated effects were observably reversed by over-expression ATG16L1 and siRNA-mediated knockdown NLRP3.The present results support the hypothesis that TMAO may be involved in the pathogenesis of IBD by impacting ATG16L1-induced autophagy and activating NLRP3 inflammasome, suggesting a potential therapeutic targets for the treatment of IBD and TMAO-associated complications.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There is convincing evidence suggesting an association between TMAO and inflammation.
“nowadays there is convincing evidence suggesting an association between TMAO and inflammation [8,9,10,11,12]”
From Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target (2018) · cites this paper as [12]
Cites
Seldin, M. M., Meng, Y., Qi, H., Zhu, W., Wang, Z., Hazen, S. L., Lusis, A. J., & Shih, D. M. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002767 · Cited by 911 · see citing works
Sun, X., Jiao, X., Ma, Y., Liu, Y., Zhang, L., He, Y., & Chen, Y. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.11.017 · Cited by 507 · see citing works
Trimethylamine N-oxide: the good, the bad and the unknown.
Velasquez, M., Ramezani, A., Manal, A., & Raj, D. (2016) · Toxins · doi:10.3390/toxins8110326 · Cited by 504 · see citing works
Homeostasis-altering molecular processes as mechanisms of inflammasome activation
Liston, A., & Masters, S. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.151 · Cited by 459 · see citing works
NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings
Kaufmann, F. N., Costa, A. P., Ghisleni, G., Diaz, A. P., Rodrigues, A. L. S., Peluffo, H., & Kaster, M. P. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.03.002 · Cited by 370 · see citing works
TMAO: A small molecule of great expectations
Ufnal, M., Żądło‐Dobrowolska, A., & Ostaszewski, R. (2015) · Nutrition · doi:10.1016/j.nut.2015.05.006 · Cited by 319 · see citing works
Nguyen, H. T. T., Dalmasso, G., Müller, S. K., Carrière, J., Seibold, F., & Darfeuille–Michaud, A. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.10.021 · Cited by 250 · see citing works
Trimethylamine- N -Oxide: Friend, Foe, or Simply Caught in the Cross-Fire?
Cho, C. E., & Caudill, M. A. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.10.005 · Cited by 218 · see citing works
Pellegrini, C., Antonioli, L., López‐Castejón, G., Blandizzi, C., & Fornai, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00036 · Cited by 212 · see citing works
Kabat, A. M., Harrison, O. J., Riffelmacher, T., Moghaddam, A. E., Pearson, C. F., Laing, A., Abeler-Dörner, L., Forman, S. P., Grencis, R. K., Sattentau, Q., et al. (2016) · eLife · doi:10.7554/elife.12444 · Cited by 193 · see citing works
Jabir, M. S., Hopkins, L., Ritchie, N. D., Ullah, I., Bayes, H. K., Li, D., Tourlomousis, P., Lupton, A., Puleston, D. J., Simon, A. K., et al. (2015) · Autophagy · doi:10.4161/15548627.2014.981915 · Cited by 164 · see citing works
Microbiome, trimethylamine N-oxide, and cardiometabolic disease
Tang, W. H. W., & Hazen, S. L. (2017) · Translational Research · doi:10.1016/j.trsl.2016.07.007 · Cited by 160 · see citing works
Role of autophagy in the pathogenesis of inflammatory bowel disease
Iida, T., Onodera, K., & Nakase, H. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i11.1944 · Cited by 146 · see citing works
ATG16L1: A multifunctional susceptibility factor in Crohn disease
Salem, M. A., Ammitzboell, M., Nys, K., Seidelin, J. B., & Nielsen, O. H. (2015) · Autophagy · doi:10.1080/15548627.2015.1017187 · Cited by 144 · see citing works
Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects
Mejías-Peña, Y., Estébanez, B., Rodriguez-Miguelez, P., Fernandez-Gonzalo, R., Almar, M., de Paz, J. A., González-Gallego, J., & Cuevas, M. J. (2017) · Aging · doi:10.18632/aging.101167 · Cited by 102 · see citing works
Trimethylamine-N-oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease
Wilson, A. S., Teft, W. A., Morse, B. L., Choi, Y., Woolsey, S., DeGorter, M. K., Hegele, R. A., Tirona, R. G., & Kim, R. B. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3797-3 · Cited by 97 · see citing works
Symington, J., Wang, C., Twentyman, J., Owusu‐Boaitey, N., Schwendener, R. A., Núñez, G., Schilling, J. D., & Mysorekar, I. U. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.7 · Cited by 81 · see citing works
Intestinal Autophagy and Its Pharmacological Control in Inflammatory Bowel Disease
Ke, P., Shao, B., Xu, Z., Chen, X., & Liu, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00695 · Cited by 71 · see citing works
NLRPs , microbiota, and gut homeostasis: unravelling the connection
Zambetti, L. P., & Mortellaro, A. (2014) · The Journal of Pathology · doi:10.1002/path.4357 · Cited by 70 · see citing works
Zhang, H., Wang, Z., Lu, X., Wang, Y., Zhong, J., & Liu, J. (2014) · Inflammation Research · doi:10.1007/s00011-014-0774-9 · Cited by 63 · see citing works
Lewis, G. J., Massey, D. C. O., Zhang, H., Bredin, F., Tremelling, M., Lee, J. C., Berzuini, C., & Parkes, M. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21499 · Cited by 58 · see citing works
Dai, J., Li, W., Zhao, X., Wang, G., Yang, J., Zhang, L., Chen, X., Xu, Y., & Li, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042706 · Cited by 56 · see citing works
Intestinal Microbiota Metabolism and Atherosclerosis
Liu, T.-X., Niu, H.-T., & Zhang, S.-Y. (2015) · Chinese Medical Journal · doi:10.4103/0366-6999.167362 · Cited by 43 · see citing works
Wu, D., Cao, M., Peng, J., Li, N., Yi, S., Song, L., Wang, X., Zhang, M., & Zhao, J. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.11.032 · Cited by 37 · see citing works
Divya, T., Anandasadagopan, S. K., & Sudhandiran, G. (2017) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2017.04.003 · Cited by 36 · see citing works
Potential Impact of Diet on Treatment Effect from Anti-TNF Drugs in Inflammatory Bowel Disease
Andersen, V. C., Hansen, A. K., & Heitmann, B. L. (2017) · Nutrients · doi:10.3390/nu9030286 · Cited by 34 · see citing works
Perfluorodecanoic acid stimulates NLRP3 inflammasome assembly in gastric cells
Zhou, X., Dong, T., Fan, Z., Peng, Y., Zhou, R., Wang, X., Song, N., Han, M., Fan, B., Jia, J., et al. (2017) · Scientific Reports · doi:10.1038/srep45468 · Cited by 29 · see citing works
Polymorphism in the NLRP3 inflammasome-associated EIF2AK2 gene and inflammatory bowel disease
Paramel, G. V., UPOROVA, L., Halfvarson, J., Sirsjö, A., & Fransén, K. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3236 · Cited by 15 · see citing works
Flagged first, then by citations
2 of the 30 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD
Larabi, A. B., Barnich, N., & Nguyen, H. T. T. (2019) · Autophagy · doi:10.1080/15548627.2019.1635384 · Cited by 840 · see citing works
Janeiro, M., Ramírez, M., Milagro, F., Martínez, J., & Solas, M. (2018) · Nutrients · doi:10.3390/nu10101398 · Cited by 631 · see citing works
Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential
Roberts, A. B., Gu, X., Buffa, J. A., Hurd, A. G., Wang, Z., Zhu, W., Gupta, N., Skye, S. M., Cody, D. B., Levison, B. S., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0128-1 · Cited by 552 · see citing works
Yang, S., Li, X., Yang, F., Zhao, R., Pan, X., Liang, J., Tian, L., Li, X., Liu, L., Xing, Y., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01360 · Cited by 347 · see citing works
Kong, C., Liang, L., Liu, G., Du, L., Yang, Y., Liu, J., Shi, D., Li, X., & Ma, Y. (2023) · Gut · doi:10.1136/gutjnl-2022-327156 · Cited by 254 · see citing works
Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy
Campbell, C., Kandalgaonkar, M. R., Golonka, R. M., Yeoh, B. S., Vijay–Kumar, M., & Saha, P. (2023) · Biomedicines · doi:10.3390/biomedicines11020294 · Cited by 256 · see citing works
A Review of Gut Microbiota‐Derived Metabolites in Tumor Progression and Cancer Therapy
Yang, Q., Wang, B., Zheng, Q., Li, H., Meng, X., Zhou, F., & Zhang, L. (2023) · Advanced Science · doi:10.1002/advs.202207366 · Cited by 249 · see citing works
Hosseinkhani, F., Heinken, A., Thiele, I., Lindenburg, P. W., Harms, A. C., & Hankemeier, T. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1882927 · Cited by 244 · see citing works
Liu, Y., & Dai, M. (2020) · Mediators of Inflammation · doi:10.1155/2020/4634172 · Cited by 231 · see citing works
Arias, N., Arboleya, S., Allison, J., Kaliszewska, A., Higarza, S. G., Gueimonde, M., & Arias, J. L. (2020) · Nutrients · doi:10.3390/nu12082340 · Cited by 200 · see citing works
Autophagy: roles in intestinal mucosal homeostasis and inflammation
Haq, S., Grondin, J. A., Banskota, S., & Khan, W. I. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0512-2 · Cited by 159 · see citing works
Implication of Gut Microbiota in Cardiovascular Diseases
Zhou, W., Cheng, Y., Zhu, P., Nasser, M. I., Zhang, X., & Zhao, M. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5394096 · Cited by 138 · see citing works
Colon Carcinogenesis: The Interplay Between Diet and Gut Microbiota
Loke, Y. L., Chew, M. T., Ngeow, Y. F., Lim, W. W.-D., & Peh, S. C. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.603086 · Cited by 129 · see citing works
Is targeting autophagy mechanism in cancer a good approach? The possible double-edge sword effect
Lim, S. M., Hanif, E. A. M., & Chin, S. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00570-z · Cited by 128 · see citing works
Sánchez‐Alcoholado, L., Ordóñez, R., Otero, A. P., Plaza-Andrades, I. J., Laborda-Illanes, A., Medina, J. A., Ramos‐Molina, B., Gómez‐Millán, J., & Queipo‐Ortuño, M. I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186782 · Cited by 117 · see citing works
Gut Microbiota-Derived Metabolites in Colorectal Cancer: The Bad and the Challenges
Zhang, W., An, Y., Qin, X., Wu, X., Wang, X., Hou, H., Song, X., Liu, T., Wang, B., Huang, X., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.739648 · Cited by 119 · see citing works
Praveenraj, S. S., Sonali, S., Anand, N., Hediyal, T. A., Vichitra, C., Kalyan, M., Kanna, P. V., Chandana, K. A., Paneyala, S., Mahalakshmi, A. M., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02990-5 · Cited by 111 · see citing works
Chan, C. W. H., Law, B. M. H., Waye, M. M. Y., Chan, J. Y., So, W. K. W., & Chow, K. M. (2019) · Journal of Cancer · doi:10.7150/jca.31737 · Cited by 96 · see citing works
Bacterial Metabolites: A Link between Gut Microbiota and Dermatological Diseases
Stec, A., Sikora, M., Maciejewska, M., Paralusz-Stec, K., Michalska, M. N., Sikorska, E., & Rudnicka, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043494 · Cited by 85 · see citing works
Zhou, Y., Zhang, Y., Jin, S., Lv, J., Li, M., & Feng, N. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117031 · Cited by 92 · see citing works
Wang, M., Wang, Z., Lee, Y., Lai, H. T. M., Otto, M. C. D. O., Lemaître, R. N., Fretts, A. M., Sotoodehnia, N., Budoff, M. J., DiDonato, J. A., et al. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.316533 · Cited by 81 · see citing works
Fantastic voyage: The journey of NLRP3 inflammasome activation
Que, X., Zheng, S., Song, Q., Pei, H., & Zhang, P. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.01.009 · Cited by 85 · see citing works
Oktaviono, Y. H., Lamara, A. D., Saputra, P. B. T., Arnindita, J. N., Pasahari, D., Saputra, M. E., & Suasti, N. M. A. (2023) · Biomolecules and Biomedicine · doi:10.17305/bb.2023.8893 · Cited by 87 · see citing works
The role of the microbiome in gastrointestinal inflammation
Sanders, D. J., Inniss, S., Sebepos‐Rogers, G., Rahman, F. Z., & Smith, A. M. (2021) · Bioscience Reports · doi:10.1042/bsr20203850 · Cited by 78 · see citing works
The role of autophagy in colitis-associated colorectal cancer
Wu, Y., Yao, J., Xie, J., Liu, Z., Zhou, Y., Pan, H., & Han, W. (2018) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-018-0031-8 · Cited by 74 · see citing works
Roles of Gut Microbial Metabolites in Diabetic Kidney Disease
Fang, Q., Liu, N., Zheng, B., Guo, F., Zeng, X., Huang, X., & Ouyang, D. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.636175 · Cited by 69 · see citing works
Zhang, M., Liang, Y., Zhang, Y., Zhang, Y., Wang, N., Zhou, Y., Wang, Y., Cui, M., Yu, Z., Zhang, M., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.152842 · Cited by 71 · see citing works
Yang, G., Lin, C., Yang, Y., Li, Y., Wang, P., Wen, X., Pan, M., Zhao, H., Ho, C., & Li, S. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b01270 · Cited by 66 · see citing works
Balancing the Equation: A Natural History of Trimethylamine and Trimethylamine-N-oxide
Loo, R. L., Chan, Q. M., Nicholson, J. K., & Holmes, E. C. (2022) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00851 · Cited by 60 · see citing works
Farhangi, M. A., & Vajdi, M. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1770199 · Cited by 59 · see citing works
Tacconi, E., Palma, G., Biase, D. D., Luciano, A., Barbieri, M., de Nigris, F., & Bruzzese, F. (2023) · Nutrients · doi:10.3390/nu15030563 · Cited by 62 · see citing works
Impact of Autophagy of Innate Immune Cells on Inflammatory Bowel Disease
Iida, T., Yokoyama, Y., Wagatsuma, K., Hirayama, D., & Nakase, H. (2018) · Cells · doi:10.3390/cells8010007 · Cited by 59 · see citing works
Dey, P., Chaudhuri, S. R., Efferth, T., & Pal, S. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.09.026 · Cited by 55 · see citing works
Microbial Metabolite Dysbiosis and Colorectal Cancer
Niekamp, P., & Kim, C. H. (2023) · Gut and Liver · doi:10.5009/gnl220260 · Cited by 56 · see citing works
Combined Signature of the Fecal Microbiome and Plasma Metabolome in Patients with Ulcerative Colitis
Sun, M., Du, B., Shi, Y., Lu, Y., Zhou, Y. Y., & Liu, B.-R. (2019) · Medical Science Monitor · doi:10.12659/msm.916009 · Cited by 51 · see citing works
Voigt, R. M., Wang, Z., Brown, J. M., Engen, P. A., Naqib, A., Goetz, C. G., Hall, D. A., Metman, L. V., Shaikh, M., Forsyth, C. B., et al. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105780 · Cited by 51 · see citing works
The Nutritional Supplement L-Alpha Glycerylphosphorylcholine Promotes Atherosclerosis
Wang, Z., Hazen, J. E., Jia, X., Org, E., Zhao, Y., Osborn, L. J., Nimer, N. A., Buffa, J. A., Culley, M. K., Krajcik, D., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413477 · Cited by 52 · see citing works
Gut microbiota-derived trimethylamine N-Oxide: a novel target for the treatment of preeclampsia
Wang, J., Gao, Y., Ren, S., Li, J., Chen, S., Feng, J., He, B., Zhou, Y., & Xuan, R. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2311888 · Cited by 49 · see citing works
Prajapati, S. K., Yadav, D., Katiyar, S., Jain, S., & Yadav, H. (2025) · Biomolecules · doi:10.3390/biom15070954 · Cited by 34 · see citing works
Mödinger, Y., Schön, C., Wilhelm, M. G., & Hals, P. (2019) · Nutrients · doi:10.3390/nu11102548 · Cited by 34 · see citing works
The crosstalk between NLRP3 inflammasome and gut microbiome in atherosclerosis
Zhang, X., Yu, Z., Chen, J., Li, X., Wang, Z.-P., Wu, M., & Liu, L. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106289 · Cited by 33 · see citing works
Antioxidant Role of Probiotics in Inflammation-Induced Colorectal Cancer
Hamamah, S., Lobiuc, A., & Covașă, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169026 · Cited by 32 · see citing works
Xie, H., Jiang, J., Cao, S., Xu, X., Zhou, J., Zhang, R., Huang, B., Lu, P., Peng, L., & Liu, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031373 · Cited by 33 · see citing works
Shuai, W., Wen, J., Li, X., Wang, D., LI, Y., & Xiang, J. (2020) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2020.04.017 · Cited by 33 · see citing works
Zhang, W., Qin, X., Zhang, K., Ma, J., Li, M., Jin, G., Liu, X., Wang, S., Wang, B., Wu, J., et al. (2024) · Cellular Oncology · doi:10.1007/s13402-024-00920-2 · Cited by 30 · see citing works
Disentangling the molecular mystery of tumour–microbiota interactions: Microbial metabolites
Duan, Y.-W., Dai, J.-H., Lu, Y.-Q., Qiao, H., & Liu, N. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.70093 · Cited by 29 · see citing works
Wu, D., Cao, M., Li, N., Zhang, A., Yu, Z., Cheng, J., Xie, X., Wang, Z., Lu, S., Yan, S., et al. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.106026 · Cited by 27 · see citing works
Lin, X., Zhang, Y., He, X., Chen, Y., Chen, N., Liu, J., Wang, M., Li, Y., Yang, H., Fan, L., et al. (2021) · Diabetes · doi:10.2337/db21-0188 · Cited by 29 · see citing works
Gut microbiota: a novel target for exercise-mediated regulation of NLRP3 inflammasome activation
Chen, J., Jia, S.-H., Xue, X.-X., Guo, C.-G., & Dong, K.-W. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1476908 · Cited by 26 · see citing works
Camelo-Castillo, A. J., Rivera‐Caravaca, J. M., Orenes‐Piñero, E., Ramírez-Macías, I., Roldán, V., Lip, G. Y. H., & Marín, F. R. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10040715 · Cited by 28 · see citing works
Pedrogo, D. A. M., Sears, C. L., & Melia, J. (2024) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjae061 · Cited by 29 · see citing works
Liu, W., Wang, L., Ou, J., Peng, D., Zhang, Y., Chen, W., & Wang, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083752 · Cited by 31 · see citing works
Zhang, C., Li, H., Xu, M., Pu, C., Zhu, Y., Du, L., Luo, J. Q., He, Q., Huang, S., & Yang, Y. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116378 · Cited by 26 · see citing works
Abdullah, A. R., Seliem, M. A., Khidr, E. G., Sobhy, A. M., El‐Shiekh, R. A., Hafeez, M. S. A. E., & El-Husseiny, A. A. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-03980-9 · Cited by 31 · see citing works
Chang, Y., Wu, X., Lu, S., Du, J., Long, Y., Zhu, Y., & Qin, H. (2023) · Frontiers in Chemistry · doi:10.3389/fchem.2023.1089775 · Cited by 26 · see citing works
Guan, Y., Wang, C., Li, L., Dai, X., Liu, Y., Hsiang, T., Liu, S., & Wang, D. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133865 · Cited by 24 · see citing works
Crowe, W., Pan, X., Mackle, J., Harris, A., Hardiman, G., Elliott, C. T., & Green, B. D. (2022) · npj Science of Food · doi:10.1038/s41538-022-00174-y · Cited by 24 · see citing works
Relationships between gut microbiota, red meat consumption and colorectal cancer.
Diakité, M., Diakité, B., Koné, A., Balam, S., Fofana, D., Diallo, D., Kassogué, Y., Traoré, C. B., Kamaté, B., Ba, D. M., et al. (2022) · PubMed · Cited by 24 · see citing works
Trimethylamine N-Oxide (TMAO) and cancer risk: Insights into a possible link
Saha, B., Banerjee, A., Pathak, R., Duttaroy, A. K., & Pathak, S. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118592 · Cited by 24 · see citing works
Ge, P., Tai, T., Jiang, L., Ji, J., Mi, Q., Zhu, T., Li, Y., & Xie, H. (2023) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2022.10.010 · Cited by 24 · see citing works
Zhu, Y., Lai, Y.-C., Hu, Y., Fu, Y., Zhang, Z., Lin, N., Huang, W., & Zheng, L. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117050 · Cited by 23 · see citing works
The roles and functions of ergothioneine in metabolic diseases
Wen, T., Chen, W., Wang, F., Zhang, R., Chen, C., Zhang, M., & Ma, T. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.109895 · Cited by 20 · see citing works
Wang, Q., Sun, Y., Zhou, T., Jiang, C., Lan, A., & Xu, W. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1125463 · Cited by 20 · see citing works
Gut Dysbiosis and Its Role in the Anemia of Chronic Kidney Disease
Coll, E., Guldris, S. C., Portolés, J. M., & Cases, A. (2024) · Toxins · doi:10.3390/toxins16110495 · Cited by 19 · see citing works
The microbiome and rodent models of immune mediated diseases
Hansen, A. K., & Hansen, C. H. F. (2021) · Mammalian Genome · doi:10.1007/s00335-021-09866-4 · Cited by 19 · see citing works
Zhou, Y., Lv, J., Jin, S., Fu, C., Liu, B., Shen, Y., Li, M., Zhang, Y., & Feng, N. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1526051 · Cited by 19 · see citing works
Trimethylamine N-Oxide as a Mediator Linking Peripheral to Central Inflammation: An In Vitro Study
Janeiro, M. H., Solas, M., Orbe, J., Rodríguez, J. A., de Muniain, L. S., Escalada, P., Yip, P. K., & Ramírez, M. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417557 · Cited by 18 · see citing works
α-synuclein overexpression and the microbiome shape the gut and brain metabolome in mice
Morais, L. H., Boktor, J. C., MahmoudianDehkordi, S., Kaddurah-Daouk, R. F., & Mazmanian, S. K. (2024) · npj Parkinson s Disease · doi:10.1038/s41531-024-00816-w · Cited by 18 · see citing works
Mechanistic insight: Linking cardiovascular complications of inflammatory bowel disease
Kumarapperuma, H., Wang, R., Little, P. J., & Kamato, D. (2023) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2023.01.002 · Cited by 17 · see citing works
Liu, J., Ge, P., Luo, Y., Sun, Z., Luo, X., Li, H., Pei, B., Xun, L., Zhang, X., Jiang, Y., et al. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s512207 · Cited by 19 · see citing works
Fang, L., Shen, J., Xiao, N., & Tan, Z. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157441 · Cited by 16 · see citing works
Wang, S., Ni, Y., Zhou, S., Peng, H., Cao, Y., Zhu, Y., Gong, J., Lu, Q., Han, Z., Lin, Y., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1591151 · Cited by 16 · see citing works
Gao, Y., Bai, D., Zhao, Y., Zhu, Q., Zhou, Y., Li, Z., & Lu, N. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27739 · Cited by 15 · see citing works
Gut microbiota: A new therapeutic target for diabetic cardiomyopathy
Yuan, S., Cai, Z., Luan, X., Wang, H., Zhong, Y., Deng, L., & Feng, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.963672 · Cited by 15 · see citing works
Hong, Q., Que, D., Zhong, C., Huang, G., Zhai, W., Chen, D., Yan, J., & Yang, P. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113639 · Cited by 14 · see citing works
Luo, C., Sun, G., Duan, J., Han, H., Zhong, R., Chen, L., Wangdui, B., Zhu, Y., Wang, Z., & Zhang, H. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.968521 · Cited by 14 · see citing works
Signal Pathways and Intestinal Flora through Trimethylamine N-oxide in Alzheimer's Disease
Zhang, Y., & Jian, W. (2023) · Current Protein and Peptide Science · doi:10.2174/1389203724666230717125406 · Cited by 14 · see citing works
Mirzababaei, A., Mahmoodi, M. S., Keshtkar, A., Ashraf, H., Abaj, F., Soveid, N., Hajmir, M. M., Radmehr, M., Khalili, P., & Mirzaei, K. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1326782 · Cited by 15 · see citing works
NMR-based plasma metabolomics of adult B-cell acute lymphoblastic leukemia
Yang, F., Li, Q., Xiang, J., Zhang, H., Sun, H., Ruan, G., & Tang, Y. (2020) · Molecular Omics · doi:10.1039/d0mo00067a · Cited by 14 · see citing works
Systems Biology and Cytokines Potential Role in Lung Cancer Immunotherapy Targeting Autophagic Axis
Khilwani, R., & Singh, S. (2023) · Biomedicines · doi:10.3390/biomedicines11102706 · Cited by 12 · see citing works
Lung microbiota and potential treatment of respiratory diseases
Zhou, Y., Liu, M., Liu, K., Wu, G., & Tan, Y. (2023) · Microbial Pathogenesis · doi:10.1016/j.micpath.2023.106197 · Cited by 11 · see citing works
Tian, Q. B., Chen, S. J., Xiao, L. J., Xie, J. Q., Zhao, H., & Zhang, X. (2024) · Journal of Digestive Diseases · doi:10.1111/1751-2980.13256 · Cited by 11 · see citing works
Qin, Z., Wu, W., Yang, X., Wang, X., Ding, A., Huang, Y., Tang, J., Jiang, S., Zhang, P., Qian, C., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1592524 · Cited by 12 · see citing works
Blaak, E. E., & Canfora, E. E. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.11.11 · Cited by 10 · see citing works
A Promising Insight: The Potential Influence and Therapeutic Value of the Gut Microbiota in GI GVHD
Li, J., Zhang, X., Chen, Y., Zheng, Q., Zhao, M., & Jiang, H. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2124627 · Cited by 10 · see citing works
Gut microbiota and atrial cardiomyopathy
Sun, T., Song, B., & Li, B. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1541278 · Cited by 10 · see citing works
Rombouts, C., Meulebroek, L. V., Spiegeleer, M. D., Goethals, S., HECKE, T. V., SMET, S. D., Vos, W. H. D., & Vanhaecke, L. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000463 · Cited by 9 · see citing works
Gut Microbiota as a Mediator Between Intestinal Fibrosis and Creeping Fat in Crohn's Disease
Liu, C., Li, R., Nie, J., He, J., Lin, Z., Wu, X., Tan, J., Liu, Z., Zhou, L., Li, X., et al. (2025) · United European Gastroenterology Journal · doi:10.1002/ueg2.70027 · Cited by 8 · see citing works
TMAO and the gut microbiome: implications for the CVD-CKD-IBD axis
Kim, S. H., Yoon, M. Y., & Yoon, S. S. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2522324 · Cited by 8 · see citing works
Khodabakhshi, A., Monfared, V., Arabpour, Z., Vahid, F., & Hasani, M. (2022) · Nutrition and Cancer · doi:10.1080/01635581.2022.2129080 · Cited by 8 · see citing works
Zhong, X., Li, Z., Liu, H., Huang, L., Yang, F., & Wang, H. (2025) · Journal of Cardiology · doi:10.1016/j.jjcc.2025.06.011 · Cited by 6 · see citing works
Trimethylamine-N-oxide: the microbial cue in immune-mediated disorders
Mirji, G., Bhat, S. A., & Shinde, R. S. (2026) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2026.02.008 · Cited by 5 · see citing works
Association of TMAO levels with indicators of ulcerative colitis activity.
Laryushina, Y. M., Samoilova-Bedych, N., Turgunova, L., Marchenko, A., & Turgunov, Y. M. (2025) · PubMed Central · doi:10.22088/cjim.16.1.114 · Cited by 3 · see citing works
Bezerra, A. P. M., Moreira, A. C. D. O. M., Dionísio, A. P., Andrade, B. K. D. M., de Oliveira, K. A., Filho, E. G. A., de Brito, E. S., de Oliveira, A. C., da Silva, F. L., Viana, J. D. D. R., et al. (2025) · International Journal of Food Science & Technology · doi:10.1093/ijfood/vvaf078 · Cited by 2 · see citing works
Sun, B., & Wang, T. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1768792 · Cited by 2 · see citing works
Caradonna, E., Ferrara, F., Costantino, L., Iannuzzo, F., Testa, N., Giordano, L., Faversani, A., Setacci, C., Novellino, E., & Vanoli, E. (2026) · Antioxidants · doi:10.3390/antiox15060781 · Cited by 2 · see citing works
Wang, Y., Zhao, L., Zou, Y., & Nie, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1775938 · Cited by 2 · see citing works
Zhang, M., Zhou, Y., Huang, L., Hong, W., Li, Y., Chen, Z., & Zhou, L. (2024) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.14114 · Cited by 1 · see citing works
Qian, S., Shi, Y., Li, J., Zhao, H., Ye, X., & Li, W. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05833-9 · Cited by 1 · see citing works
The dual role of gastric microbiota dysbiosis in gastric cancer progression and therapy
Liu, Y., Shao, Q., Zhang, C., Zhang, F., Liu, J., Li, Y., & Huang, Z. (2026) · International Journal of Clinical Oncology · doi:10.1007/s10147-026-03052-9 · Cited by 1 · see citing works
- Authors
- Yue, C., Yang, X., Li, J., Chen, X., Zhao, X., Chen, Y., & Wen, Y.
- Affiliations
- Southwest Medical University (CN)
- Corresponding author
- Yang, Xiangdong
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 490
- Issue
- 2
- Pages
- 541-551
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2626783532
- Cited by
- 120
- References
- 30
- Citations by year
- 2026: 16 · 2025: 19 · 2024: 18 · 2023: 15 · 2022: 16 · 2021: 11 · 2020: 10 · 2019: 9 · 2018: 6
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- trimethylamine N-oxide, NLRP3 inflammasome, ATG16L1, autophagy, inflammatory bowel disease, colonic epithelial cells, reactive oxygen species, LC3-II, p62, gut microbiota metabolites, inflammation
- MeSH terms
- Autophagy-Related Proteins, NLR Family, Pyrin Domain-Containing 3 Protein, Autophagy, Cell Line, Colon, Humans, Intestinal Mucosa, Methylamines, Inflammatory Bowel Diseases, Down-Regulation, Reactive Oxygen Species, RNA Interference, RNA, Small Interfering
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
