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Cited by 43Gut microbiota and healthNutritional Studies and DietAtherosclerosis and Cardiovascular Diseases

Intestinal Microbiota Metabolism and Atherosclerosis

Open access
Liu, Tian-Xing, Niu, Hai-Tao, Zhang, Shu-Yang·2015·Chinese Medical Journal
DOI 10.4103/0366-6999.167362PMC PMC4736892
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Abstract

OBJECTIVE: This review aimed to summarize the relationship between intestinal microbiota metabolism and cardiovascular disease (CVD) and to propose a novel CVD therapeutic target. DATA SOURCES: This study was based on data obtained from PubMed and EMBASE up to June 30, 2015. Articles were selected using the following search terms: "Intestinal microbiota", "trimethylamine N-oxide (TMAO)", "trimethylamine (TMA)", "cardiovascular", and "atherosclerosis". STUDY SELECTION: Studies were eligible if they present information on intestinal microbiota metabolism and atherosclerosis. Studies on TMA-containing nutrients were also included. RESULTS: A new CVD risk factor, TMAO, was recently identified. It has been observed that several TMA-containing compounds may be catabolized by specific intestinal microbiota, resulting in TMA release. TMA is subsequently converted to TMAO in the liver. Several preliminary studies have linked TMAO to CVD, particularly atherosclerosis; however, the details of this relationship remain unclear. CONCLUSIONS: Intestinal microbiota metabolism is associated with atherosclerosis and may represent a promising therapeutic target with respect to CVD management.

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Cited by

Sorted by citations

Authors
Liu, T.-X., Niu, H.-T., & Zhang, S.-Y.
Affiliations
Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
ORCID
Liu, Tian-Xing
Venue
Chinese Medical Journal
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-10-20
Volume
128
Issue
20
Pages
2805-2811
ISSN
0366-6999 (ISSN-L)
DOI
10.4103/0366-6999.167362
PMC
PMC4736892
OpenAlex
W1924241802
Cited by
43
References
10
Citations by year
2025: 4 · 2024: 1 · 2023: 8 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 2 · 2018: 6 · 2017: 4
FWCI
0.32
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Chinese Medical Journal (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords
gut microbiota, atherosclerosis, cardiovascular disease, trimethylamine N-oxide, trimethylamine, gut microbiota metabolism, cardiovascular risk factors, therapeutic target
MeSH terms
Gastrointestinal Microbiome, Humans, Methylamines, Atherosclerosis

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