Exosomes Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells Stimulates Rejuvenation of Human Skin
Abstract
Human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) play an important role in cutaneous wound healing, and recent studies suggested that MSC-derived exosomes activate several signaling pathways, which are conducive in wound healing and cell growth. In this study, we investigated the roles of exosomes that are derived from USC-CM (USC-CM Exos) in cutaneous collagen synthesis and permeation. We found that USC-CM has various growth factors associated with skin rejuvenation. Our in vitro results showed that USC-CM Exos integrate in Human Dermal Fibroblasts (HDFs) and consequently promote cell migration and collagen synthesis of HDFs. Moreover, we evaluated skin permeation of USC-CM Exos by using human skin tissues. Results showed that Exo-Green labeled USC-CM Exos approached the outermost layer of the epidermis after 3 h and gradually approached the epidermis after 18 h. Moreover, increased expressions of Collagen I and Elastin were found after 3 days of treatment on human skin. The results showed that USC-CM Exos is absorbed into human skin, it promotes Collagen I and Elastin synthesis in the skin, which are essential to skin rejuvenation and shows the potential of USC-CM integration with the cosmetics or therapeutics.
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Exosomes derived from human umbilical cord blood mesenchymal stem cells (MSCs) stimulated collagen production and other rejuvenation markers in human skin models.
“Kim et al. reported that exosomes derived from human umbilical cord blood mesenchymal stem cells (MSCs) stimulated collagen production and other rejuvenation markers in human skin models [23].”
Clinical and early human studies using animal- or human-origin exosomes have reported improvements in skin quality and wound repair through angiogenesis, collagen synthesis, and anti-inflammatory activities.
“While clinical studies on plant-derived EVs are currently scant, clinical and earlyhuman studies using animal-or human-origin exosomes have reported improvements in skin quality and wound repair through angiogenesis, collagen synthesis, and antiinflammatory activities [21,23].”
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- Authors
- Kim, Y.-J., Yoo, S. M., Park, H. H., Lim, H. J., Kim, Y.-L., Lee, S., Seo, K.-W., & Kang, K.-S.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Seo, Kwang-Won
- Kang, Kyung-Sun
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 493
- Issue
- 2
- Pages
- 1102-1108
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2756231443
- Cited by
- 212
- References
- 29
- Citations by year
- 2026: 22 · 2025: 41 · 2024: 28 · 2023: 30 · 2022: 25 · 2021: 25 · 2020: 18 · 2019: 16 · 2018: 7
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Keywords
- exosomes, umbilical cord blood mesenchymal stem cells, skin rejuvenation, dermal fibroblasts, collagen synthesis, type I collagen, elastin, skin permeation, epidermis, cell migration, growth factors, wound healing, cosmetics
- MeSH terms
- Adult, Cells, Cultured, Collagen, Cosmetics, Elastin, Female, Fetal Blood, Fibroblasts, Humans, Rejuvenation, Skin Absorption, Skin Physiological Phenomena, Intercellular Signaling Peptides and Proteins, Exosomes, Mesenchymal Stem Cells
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