Cas9-Induced Immune Response: A Potential Caution for Human Genome Editing
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As an exogenous protein, Cas9 can be regarded as a foreign antigen in animals and can be presented by APCs to lymphocytes to induce host immune responses.
“As an exogenous protein, Cas9 can be regarded as a foreign antigen in animals, and hence, can be presented by antigen-presenting cells (APC) to lymphocytes to induce host immune responses (Figure 1) [34].”
From Immune responses to gene editing by viral and non-viral delivery vectors used in retinal gene therapy (2022) · cites this paper as [34]
Cites
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
Cho, S. W., Kim, S., Kim, Y., Kweon, J., Kim, H. S., Bae, S., & Kim, J.-S. (2014) · Genome Research · doi:10.1101/gr.162339.113 · Cited by 1,356 · see citing works
CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response
Haapaniemi, E., Botla, S., Persson, J., Schmierer, B., & Taipale, J. (2018) · Nature Medicine · doi:10.1038/s41591-018-0049-z · Cited by 1,264 · see citing works
Identification of preexisting adaptive immunity to Cas9 proteins in humans
Charlesworth, C. T., Deshpande, P. S., Dever, D. P., Camarena, J., Lemgart, V. T., Cromer, M. K., Vakulskas, C. A., Collingwood, M. A., Zhang, L., Bode, N. M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0326-x · Cited by 1,093 · see citing works
CRISPR RNAs Trigger Innate Immune Responses in Human Cells
Kim, S., Koo, T., Jee, H.-G., Cho, H.-Y., Lee, G., Lim, D.-G., Shin, H. S., & Kim, J.-S. (2018) · Genome Research · doi:10.1101/gr.231936.117 · Cited by 222 · see citing works
The STING-STAT6 pathway drives Cas9-induced host response in human monocytes
Kang, R., Zhu, S., Zeh, H. J., & Tang, D. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.10.080 · Cited by 8 · see citing works
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Ren, D., Fisson, S., Dalkara, D., & Ail, D. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14091973 · Cited by 52 · see citing works
- Authors
- Zhang, C. C.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Zhang, Cheng Cheng
- ORCID
- Zhang, Cheng Cheng
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 520
- Issue
- 4
- Pages
- 706-707
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2990148280
- Cited by
- 4
- References
- 5
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1
- FWCI
- 0.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- hydroxychloroquine, adeno-associated virus vectors, AAV2, AAV8, gene therapy, viral transduction efficiency, retinal pigment epithelium, subretinal injection, photoreceptors, retinal gene therapy, immune response, Cas9
- MeSH terms
- Gene Editing, Genetic Vectors, Humans, Monocytes, Genome, Human, STAT6 Transcription Factor, CRISPR-Cas Systems
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