Vaccine-induced protection in aging adults and pandemic response
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Vaccine responses are often lower in elderly adults, especially for hepatitis B, pneumococcal, and influenza vaccinations, and this reduced success is attributed to adaptive immunosenescence.
“Although vaccination is key to prevent infections, vaccine responses are often found to be lower in elderly adults.In numerous studies, the markedly reduced vaccine success in older adults has been attributed to adaptive immunosenescence.Reduced vaccination success in elderly adults is especially known for hepatitis B, pneumococcal, and influenza vaccinations [22,23].”
From Age-dependent Immune Response to the Biontech/Pfizer BNT162b2 Coronavirus Disease 2019 Vaccination (2021) · cites this paper as [22]
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Efficacy of the Herpes Zoster Subunit Vaccine in Adults 70 Years of Age or Older
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Factors Associated With US Adults’ Likelihood of Accepting COVID-19 Vaccination
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Covid-19 and Immunity in Aging Populations — A New Research Agenda
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- [8]8. Rondy M., El Omeiri N., Thompson M.G., Leveque A., Moren A., Sullivane S.G. Effectiveness of influenza vaccines in preventing severe influenza illness among adults: a systematic review and meta-analysis of test-negative design case-control studies. J. Infect. 2017 Nov;75(5):381–394. doi: 10.1016/j.jinf.2017.09.010. · DOI · Paper page
- Authors
- Schenkelberg, T.
- Affiliations
- Human Immunome Project (US)
- Corresponding author
- Schenkelberg, Theodore
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 538
- Pages
- 218-220
- ISSN
- 0006-291X (ISSN-L)
- PMC
- PMC7670259
- OpenAlex
- W3104035721
- Cited by
- 11
- References
- 13
- Citations by year
- 2023: 3 · 2022: 5 · 2021: 3
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Keywords
- vaccine-induced protection, older adults, pandemic response, COVID-19 vaccines, immunosenescence
- MeSH terms
- Immunosenescence, COVID-19, SARS-CoV-2, COVID-19 Vaccines, Adult, Humans, Pandemics
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