Immunosenescence and human vaccine immune responses

Crooke, Stephen N.; Ovsyannikova, Inna G.; Poland, Gregory A.; Kennedy, Richard B.

doi:10.1186/s12979-019-0164-9

Cited by 530Immune responses and vaccinationsT-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Immunosenescence and human vaccine immune responses

Open access

Crooke, Stephen N., Ovsyannikova, Inna G., Poland, Gregory A., Kennedy, Richard B.·2019·Immunity & Ageing

DOI 10.1186/s12979-019-0164-9PMC PMC6743147

Open this paper in CoChat — free account Open PDF

Abstract

The age-related dysregulation and decline of the immune system—collectively termed “immunosenescence”—has been generally associated with an increased susceptibility to infectious pathogens and poor vaccine responses in older adults. While numerous studies have reported on the clinical outcomes of infected or vaccinated individuals, our understanding of the mechanisms governing the onset of immunosenescence and its effects on adaptive immunity remains incomplete. Age-dependent differences in T and B lymphocyte populations and functions have been well-defined, yet studies that demonstrate direct associations between immune cell function and clinical outcomes in older individuals are lacking. Despite these knowledge gaps, research has progressed in the development of vaccine and adjuvant formulations tailored for older adults in order to boost protective immunity and overcome immunosenescence. In this review, we will discuss the development of vaccines for older adults in light of our current understanding—or lack thereof—of the aging immune system. We highlight the functional changes that are known to occur in the adaptive immune system with age, followed by a discussion of current, clinically relevant pathogens that disproportionately affect older adults and are the central focus of vaccine research efforts for the aging population. We conclude with an outlook on personalized vaccine development for older adults and areas in need of further study in order to improve our fundamental understanding of adaptive immunosenescence.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1186/s12979-019-0164-9

Cites

207 of 207 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Vaccine responses are often lower in elderly adults, especially for hepatitis B, pneumococcal, and influenza vaccinations, and this reduced success is attributed to adaptive immunosenescence.
“Although vaccination is key to prevent infections, vaccine responses are often found to be lower in elderly adults.In numerous studies, the markedly reduced vaccine success in older adults has been attributed to adaptive immunosenescence.Reduced vaccination success in elderly adults is especially known for hepatitis B, pneumococcal, and influenza vaccinations [22,23].”
From Age-dependent Immune Response to the Biontech/Pfizer BNT162b2 Coronavirus Disease 2019 Vaccination (2021) · cites this paper as [23]
70-90% of influenza-related mortalities occur in people older than 65 years.
“70–90% of influenza-related mortalities occur in people older than 65 years232”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [232]
The decline in immune function with age (immunosenescence) has been well documented.
“The decline in immune function with age (known as immunosenescence) has been well documented79”
From A guide to vaccinology: from basic principles to new developments (2021) · cites this paper as [79]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Part of this paper’s reference list could not be split into single entries.

A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults
Oxman, M. N., Levin, M. J., Johnson, G. R., Schmader, K. E., Straus, S. E., Gelb, L. D., Arbeit, R. D., Simberkoff, M. S., Gershon, A. A., Davis, L. E., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051016 · Cited by 2,412 · see citing works
Respiratory Syncytial Virus Infection in Elderly and High-Risk Adults
Falsey, A. R., Hennessey, P., Formica, M. A., Cox, C., & Walsh, E. E. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043951 · Cited by 2,239 · see citing works
Control of adaptive immunity by the innate immune system
Iwasaki, A., & Medzhitov, R. (2015) · Nature Immunology · doi:10.1038/ni.3123 · Cited by 2,160 · see citing works
Effector and memory T-cell differentiation: implications for vaccine development
Kaech, S. M., Wherry, E. J., & Ahmed, R. (2002) · Nature Reviews Immunology · doi:10.1038/nri778 · Cited by 1,865 · see citing works
Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis
Osterholm, M. T., Kelley, N. S., Sommer, A., & Belongia, E. A. (2012) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70295-x · Cited by 1,789 · see citing works
Men and mice: Relating their ages
Dutta, S., & Sengupta, P. (2016) · Life Sciences · doi:10.1016/j.lfs.2015.10.025 · Cited by 1,710 · see citing works
Efficacy of an Adjuvanted Herpes Zoster Subunit Vaccine in Older Adults
Lal, H., Cunningham, A. L., Godeaux, O., Chlibek, R., Diez-Domingo, J., Hwang, S.-J., Levin, M. J., McElhaney, J. E., Poder, A., Puig-Barberà, J., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1501184 · Cited by 1,454 · see citing works
Polysaccharide Conjugate Vaccine against Pneumococcal Pneumonia in Adults
Bonten, M. J. M., Huijts, S. M., Bolkenbaas, M., Webber, C., Patterson, S., Gault, S., van Werkhoven, C. H., van Deursen, A. M. M., Sanders, E. A. M., Verheij, T. J. M., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1408544 · Cited by 1,248 · see citing works
The twilight of immunity: emerging concepts in aging of the immune system
Nikolich-Žugich, J. (2018) · Nature Immunology · doi:10.1038/s41590-017-0006-x · Cited by 1,240 · see citing works
Efficacy of the Herpes Zoster Subunit Vaccine in Adults 70 Years of Age or Older
Cunningham, A. L., Lal, H., Kovac, M., Chlibek, R., Hwang, S.-J., Díez-Domingo, J., Godeaux, O., Levin, M. J., McElhaney, J. E., Puig-Barberà, J., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1603800 · Cited by 1,070 · see citing works
Antibody response to influenza vaccination in the elderly: A quantitative review
GOODWIN, K., VIBOUD, C., & SIMONSEN, L. (2006) · Vaccine · doi:10.1016/j.vaccine.2005.08.105 · Cited by 1,064 · see citing works
Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes.
Bajénoff, M., Egen, J., Koo, L. Y., Laugier, J., Brau, F., Glaichenhaus, N., & Germain, R. N. (2006) · Immunity · doi:10.1016/j.immuni.2006.10.011 · Cited by 1,022 · see citing works
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
Pang, W. W., Price, E. A., Sahoo, D., Beerman, I., Maloney, W. J., Rossi, D. J., Schrier, S. L., & Weissman, I. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116110108 · Cited by 991 · see citing works
Vaccines for preventing pneumococcal infection in adults
Moberley, S. A., Holden, J., Tatham, D. P., & Andrews, R. M. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000422.pub3 · Cited by 970 · see citing works
Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion
Beerman, I., Bhattacharya, D., Zandi, S., Sigvardsson, M., Weissman, I. L., Bryder, D., & Rossi, D. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000834107 · Cited by 711 · see citing works
B-cell responses to vaccination at the extremes of age
Siegrist, C.-A., & Aspinall, R. (2009) · Nature Reviews Immunology · doi:10.1038/nri2508 · Cited by 659 · see citing works
Aging of the innate immune system
Shaw, A. C., Joshi, S., Greenwood, H., Panda, A., & Lord, J. M. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.05.003 · Cited by 647 · see citing works
Correlates of adjuvanticity: A review on adjuvants in licensed vaccines
Giudice, G. D., Rappuoli, R., & Didierlaurent, A. M. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.05.001 · Cited by 617 · see citing works
Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans
den Braber, I., Mugwagwa, T., Vrisekoop, N., Westera, L., Mögling, R., Bregje de Boer, A., Willems, N., Schrijver, E. H. R., Spierenburg, G., Gaiser, K., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.02.006 · Cited by 572 · see citing works
Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response
Panda, A., Qian, F., Mohanty, S., van Duin, D., Newman, F. K., Zhang, L., Chen, S., Towle, V., Belshe, R. B., Fikrig, E., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901022 · Cited by 548 · see citing works
Adjuvant system AS01: helping to overcome the challenges of modern vaccines
Didierlaurent, A. M., Laupèze, B., Pasquale, A. D., Hergli, N., Collignon, C., & Garçon, N. (2016) · Expert Review of Vaccines · doi:10.1080/14760584.2016.1213632 · Cited by 521 · see citing works
Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines
Saurwein-Teissl, M., Lung, T. L., Marx, F., Gschösser, C., Asch, E., Blasko, I., Parson, W., Böck, G., Schönitzer, D., Trannoy, E., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5893 · Cited by 499 · see citing works
Interleukin-17A Mediates Acquired Immunity to Pneumococcal Colonization
Lu, Y., Gross, J. A., Bogaert, D., Finn, A. H. R., Bagrade, L., Zhang, Q., Kolls, J. K., Srivastava, A., Lundgren, A., Forte, S., et al. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000159 · Cited by 493 · see citing works
The mechanism of action of MF59 – An innately attractive adjuvant formulation
O’Hagan, D. T., Ott, G. S., Gregorio, E. D., & Seubert, A. (2012) · Vaccine · doi:10.1016/j.vaccine.2011.09.061 · Cited by 492 · see citing works
Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus
Yager, E. J., Ahmed, M., Lanzer, K., Randall, T. D., Woodland, D. L., & Blackman, M. A. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071140 · Cited by 490 · see citing works
Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells
Sprent, J., & Surh, C. D. (2011) · Nature Immunology · doi:10.1038/ni.2018 · Cited by 480 · see citing works
Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study
Olsson, J., Wikby, A., Johansson, B., Löfgren, S., Nilsson, B.-O., & Ferguson, F. G. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00210-4 · Cited by 474 · see citing works
Longitudinal Studies of Clonally Expanded CD8 T Cells Reveal a Repertoire Shrinkage Predicting Mortality and an Increased Number of Dysfunctional Cytomegalovirus-Specific T Cells in the Very Elderly
Hadrup, S. R., Strindhall, J., Køllgaard, T., Seremet, T., Johansson, B. E. A., Pawelec, G., Straten, P. T., & Wikby, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2645 · Cited by 471 · see citing works
Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling
Britanova, O. V., Putintseva, E. V., Shugay, M., Merzlyak, E. M., Turchaninova, M. A., Staroverov, D. B., Bolotin, D. A., Lukyanov, S., Bogdanova, E. A., Mamedov, I. Z., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302064 · Cited by 465 · see citing works
Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus.
Cannon, M. J., Openshaw, P., & Askonas, B. A. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.168.3.1163 · Cited by 462 · see citing works
Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway
Agrawal, A., Agrawal, S., Cao, J.-N., Su, H., Osann, K., & Gupta, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6912 · Cited by 435 · see citing works
B‐cell diversity decreases in old age and is correlated with poor health status
Gibson, K. L., Wu, Y., Barnett, Y., Duggan, O., Vaughan, R., Kondeatis, E., Nilsson, B., Wikby, A., Kipling, D., & Dunn‐Walters, D. K. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2008.00443.x · Cited by 433 · see citing works
The impact of herpes zoster and post-herpetic neuralgia on quality-of-life
Johnson, R. W., Bouhassira, D., Kassianos, G. C., Leplège, A., Schmader, K. E., & Weinke, T. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-37 · Cited by 406 · see citing works
Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals
Goronzy, J. J., Fulbright, J. W., Crowson, C. S., Poland, G. A., O'Fallon, W. M., & Weyand, C. M. (2001) · Journal of Virology · doi:10.1128/jvi.75.24.12182-12187.2001 · Cited by 402 · see citing works
Self-citation
Severe Morbidity and Mortality Associated With Respiratory Syncytial Virus Versus Influenza Infection in Hospitalized Older Adults
Ackerson, B. K., Tseng, H. F., Sy, L. S., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy991 · Cited by 393 · see citing works
Type 1 and Type 2 Cytokine Imbalance in Acute Respiratory Syncytial Virus Bronchiolitis
Legg, J. P., Hussain, I. R., Warner, J. A., Johnston, S. L., & Warner, J. O. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200210-1148oc · Cited by 390 · see citing works
Immunosenescence: Implications for response to infection and vaccination in older people
Pera, A., Campos, C., López, N., Hassouneh, F., Alonso, C., Tarazona, R., & Solana, R. (2015) · Maturitas · doi:10.1016/j.maturitas.2015.05.004 · Cited by 373 · see citing works
High Morbidity and Mortality in Adults Hospitalized for Respiratory Syncytial Virus Infections
Lee, N. L. S., Lui, G. C.-Y., Wong, K. T., et al. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit471 · Cited by 362 · see citing works
Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans
Wertheimer, A. M., Bennett, M. S., Park, B., Uhrlaub, J. L., Martinez, C., Pulko, V., Currier, N. L., Nikolich-Žugich, D., Kaye, J., & Nikolich-Žugich, J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301721 · Cited by 352 · see citing works
Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
Li, G., Yu, M., Lee, W.-W., Tsang, M., Krishnan, E., Weyand, C. M., & Goronzy, J. J. (2012) · Nature Medicine · doi:10.1038/nm.2963 · Cited by 349 · see citing works
Naive T Cell Maintenance and Function in Human Aging
Goronzy, J. J., Fang, F., Cavanagh, M., Qi, Q., & Weyand, C. M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500046 · Cited by 348 · see citing works
Vaccines, new opportunities for a new society
Rappuoli, R., Pizza, M., Giudice, G. D., & Gregorio, E. D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402981111 · Cited by 337 · see citing works
Lineage Structure of the Human Antibody Repertoire in Response to Influenza Vaccination
Jiang, N., He, J., Weinstein, J. A., Penland, L., Sasaki, S., He, X.-S., Dekker, C. L., Zheng, N.-Y., Huang, M., Sullivan, M., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004794 · Cited by 335 · see citing works
Aging Down-Regulates the Transcription Factor E2A, Activation-Induced Cytidine Deaminase, and Ig Class Switch in Human B Cells
Frasca, D., Landin, A. M., Lechner, S. C., Ryan, J. G., Schwartz, R., Riley, R. L., & Blomberg, B. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5283 · Cited by 333 · see citing works
Age-related physiological changes and their clinical significance.
Boss, G. R., & Seegmiller, J. E. (1981) · PubMed · Cited by 325 · see citing works
Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies
Sasaki, S., Sullivan, M., Narvaez, C. F., Holmes, T. H., Furman, D., Zheng, N.-Y., Nishtala, M., Wrammert, J., Smith, K., James, J. A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57834 · Cited by 300 · see citing works
T cells and follicular dendritic cells in germinal center B‐cell formation and selection
Vinuesa, C. G., Linterman, M. A., Goodnow, C. C., & Randall, K. L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00937.x · Cited by 298 · see citing works
Long-term Persistence of Zoster Vaccine Efficacy
Morrison, V. A., Johnson, G. R., Schmader, K. E., Levin, M. J., Zhang, J. H., Looney, D. J., Betts, R. F., Gelb, L., Guatelli, J., Harbecke, R., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu918 · Cited by 293 · see citing works
Impaired Antibody-Mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus
Habibi, M. S., Jóźwik, A., Makris, S., Dunning, J. W., Paras, A., DeVincenzo, J. P., de Haan, C. A. M., Wrammert, J., Openshaw, P., & Chiu, C. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201412-2256oc · Cited by 289 · see citing works
Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human peripheral blood
Jing, Y., Shaheen, E., Drake, R. R., Chen, N., Gravenstein, S., & Deng, Y. (2009) · Human Immunology · doi:10.1016/j.humimm.2009.07.005 · Cited by 284 · see citing works
The aging lung
Kovacs, E. J., Lowery, E. M., Kuhlmann, E. A., & Brubaker, A. L. (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s51152 · Cited by 280 · see citing works
A double-negative (IgD−CD27−) B cell population is increased in the peripheral blood of elderly people
Colonna-Romano, G., Bulati, M., Aquino, A., Pellicanò, M., Vitello, S., Lio, D., Candore, G., & Caruso, C. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.08.003 · Cited by 270 · see citing works
Human T cell immunosenescence and inflammation in aging
Bektas, A., Schurman, S. H., Sen, R., & Ferrucci, L. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ri0716-335r · Cited by 270 · see citing works
The Role of Immunosenescence in the Development of Age-Related Diseases
Fülöp, T., Dupuis, G., Witkowski, J. M., & Larbi, A. (2016) · Revista de investigaci�n Cl�nica · doi:10.1016/s0034-8376(25)00212-8 · Cited by 269 · see citing works
Age‐related loss of naïve T cells and dysregulation of T‐cell/B‐cell interactions in human lymph nodes
Lazuardi, L., Jenewein, B., Wolf, A. M., Pfister, G., Tzankov, A., & Grubeck‐Loebenstein, B. (2005) · Immunology · doi:10.1111/j.1365-2567.2004.02006.x · Cited by 263 · see citing works
Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells
Quinn, K. M., Fox, A., Harland, K. L., Russ, B. E., Li, J., Nguyen, T. H. O., Loh, L., Olshanksy, M., Naeem, H., Tsyganov, K., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.057 · Cited by 262 · see citing works
Aging of the T Cell Compartment in Mice and Humans: From No Naive Expectations to Foggy Memories
Nikolich-Žugich, J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401174 · Cited by 259 · see citing works
Effectiveness of the 23-Valent Pneumococcal Polysaccharide Vaccine (PPV23) against Pneumococcal Disease in the Elderly: Systematic Review and Meta-Analysis
Falkenhorst, G., Remschmidt, C., Harder, T., Hummers, E., Wichmann, O., & Bogdan, C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169368 · Cited by 253 · see citing works
Effectiveness of influenza vaccines in preventing severe influenza illness among adults: A systematic review and meta- analysis of test-negative design case-control studies
Rondy, M., El Omeiri, N., Thompson, M. G., Levêque, A., Moren, A., & Sullivan, S. G. (2017) · Journal of Infection · doi:10.1016/j.jinf.2017.09.010 · Cited by 247 · see citing works
E-proteins directly regulate expression of activation-induced deaminase in mature B cells
Sayegh, C. E., Quong, M. W., Agata, Y., & Murre, C. (2003) · Nature Immunology · doi:10.1038/ni923 · Cited by 246 · see citing works
Role of Cytomegalovirus in the T Cell Changes Seen in Elderly Individuals
Looney, R. J., Falsey, A. R., Campbell, D., Torres, A., Kolassa, J. E., Brower, C. A., McCann, R. M., Menegus, M. A., McCormick, K., Frampton, M. W., et al. (1999) · Clinical Immunology · doi:10.1006/clim.1998.4638 · Cited by 246 · see citing works
Large Numbers of Dysfunctional CD8+ T Lymphocytes Bearing Receptors for a Single Dominant CMV Epitope in the Very Old
Ouyang, Q., Wagner, W. M., Wikby, A., Walter, S., Aubert, G., Dodi, A. I., Travers, P. J., & Pawelec, G. (2003) · Journal of Clinical Immunology · doi:10.1023/a:1024580531705 · Cited by 239 · see citing works
Immune System Dysfunction in the Elderly
Eduardo Fuentes, Q., FUENTES, M., Alarcón, M. A., & Palomo, I. F. (2017) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201720160487 · Cited by 234 · see citing works
VZV T Cell-Mediated Immunity
Weinberg, A., & Levin, M. J. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_31 · Cited by 232 · see citing works
Age-Related Impaired Type 1 T Cell Responses to Influenza: Reduced Activation Ex Vivo, Decreased Expansion in CTL Culture In Vitro, and Blunted Response to Influenza Vaccination In Vivo in the Elderly
Deng, Y., Jing, Y., Campbell, A. E., & Gravenstein, S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3437 · Cited by 230 · see citing works
Effectiveness of MF59-adjuvanted seasonal influenza vaccine in the elderly: A systematic review and meta-analysis
Domnich, A., Arata, L., Amicizia, D., Puig-Barberà, J., Gasparini, R., & Panatto, D. (2017) · Vaccine · doi:10.1016/j.vaccine.2016.12.011 · Cited by 229 · see citing works
Pathogenesis and Current Approaches to Control of Varicella-Zoster Virus Infections
Gershon, A. A., & Gershon, M. D. (2013) · Clinical Microbiology Reviews · doi:10.1128/cmr.00052-13 · Cited by 229 · see citing works
Respiratory Syncytial Virus Infection in Elderly Adults
Falsey, A. R., & Walsh, E. E. (2005) · Drugs & Aging · doi:10.2165/00002512-200522070-00004 · Cited by 222 · see citing works
Animal models of respiratory syncytial virus infection
Taylor, G. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.11.054 · Cited by 219 · see citing works
When aging reaches CD4+ T-cells: phenotypic and functional changes
Moro‐García, M. A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00107 · Cited by 212 · see citing works
Influenza Illness and Hospitalizations Averted by Influenza Vaccination in the United States, 2005–2011
Kostova, D., Reed, C., Finelli, L., Cheng, P., Gargiullo, P. M., Shay, D. K., Singleton, J. A., Meltzer, M. I., Lu, P.-J., & Bresee, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066312 · Cited by 208 · see citing works
Immune Responses to a Recombinant Glycoprotein E Herpes Zoster Vaccine in Adults Aged 50 Years or Older
Cunningham, A. L., Heineman, T. C., Lal, H., Godeaux, O., Chlíbek, R., Hwang, S., McElhaney, J. E., Vesikari, T., Andrews, C. P., Choi, W. S., et al. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy095 · Cited by 205 · see citing works
Advances in RSV vaccine research and development – A global agenda
Higgins, D., Trujillo, C., & Keech, C. A. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.03.109 · Cited by 203 · see citing works
Old and new adjuvants
McKee, A. S., & Marrack, P. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.06.005 · Cited by 198 · see citing works
Age-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine
Kang, I., Hong, M. S., Nolasco, H., Park, S. H., Dan, J. M., Choi, J.-Y., & Craft, J. E. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.673 · Cited by 197 · see citing works
Personalized vaccinology: A review
Poland, G. A., Ovsyannikova, I. G., & Kennedy, R. B. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.07.062 · Cited by 196 · see citing works
Self-citation
Respiratory Syncytial Virus and Associations With Cardiovascular Disease in Adults
Ivey, K. S., Edwards, K. M., & Talbot, H. K. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.02.013 · Cited by 195 · see citing works
Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection
Tu, W., & Rao, S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02111 · Cited by 189 · see citing works
Humoral and Mucosal Immunity in Protection from Natural Respiratory Syncytial Virus Infection in Adults
Walsh, E. E., & Falsey, A. R. (2004) · The Journal of Infectious Diseases · doi:10.1086/421524 · Cited by 181 · see citing works
The Biology of Recent Thymic Emigrants
Fink, P. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100010 · Cited by 174 · see citing works
Immune dysregulation in the aging human lung
Meyer, K. C., Ershler, W., Rosenthal, N. S., Lu, X. G., & Peterson, K. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.3.8630547 · Cited by 173 · see citing works
Relationship of Serum Antibody to Risk of Respiratory Syncytial Virus Infection in Elderly Adults
Falsey, A. R., & Walsh, E. E. (1998) · The Journal of Infectious Diseases · doi:10.1086/517376 · Cited by 173 · see citing works
Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity
Sridharan, A., Esposo, M., Kaushal, K., Tay, J., Osann, K., Agrawal, S., Gupta, S., & Agrawal, A. (2011) · AGE · doi:10.1007/s11357-010-9191-3 · Cited by 165 · see citing works
Body composition changes in diabetes and aging
Al‐Sofiani, M. E., Ganji, S. S., & Kalyani, R. R. (2019) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2019.03.007 · Cited by 158 · see citing works
Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis.
Simell, B., Vuorela, A., Ekström, N., Palmu, A., Reunanen, A., Meri, S., Käyhty, H., & Väkeväinen, M. (2011) · Vaccine · doi:10.1016/j.vaccine.2010.12.121 · Cited by 155 · see citing works
Role of Dendritic Cells in Inflammation and Loss of Tolerance in the Elderly
Agrawal, A., Agrawal, S., & Gupta, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00896 · Cited by 154 · see citing works
Declining Effectiveness of Herpes Zoster Vaccine in Adults Aged ≥60 Years
Tseng, H. F., Harpaz, R., Luo, Y., Hales, C. M., Sy, L. S., Tartof, S. Y., Bialek, S. R., Hechter, R. C., & Jacobsen, S. J. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw047 · Cited by 152 · see citing works
Reduced naïve <scp>CD</scp> 8 <sup>+</sup> <scp>T</scp> ‐cell priming efficacy in elderly adults
Briceño, O., Lissina, A., Wanke, K., Afonso, G., Braun, A., Ragon, K., Miquel, T., Gostick, E., Papagno, L., Stiasny, K., et al. (2016) · Aging Cell · doi:10.1111/acel.12384 · Cited by 151 · see citing works
Impaired Interferon Signaling in Dendritic Cells From Older Donors Infected In Vitro With West Nile Virus
Qian, F., Wang, X., Zhang, L., Lin, A., Zhao, H., Fikrig, E., & Montgomery, R. R. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir048 · Cited by 151 · see citing works
Aging Population and Future Burden of Pneumococcal Pneumonia in the United States
Wroe, P. C., Finkelstein, J. A., Ray, G. T., Linder, J. A., Johnson, K. M., Rifas‐Shiman, S. L., Moore, M. R., & Huang, S. S. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis240 · Cited by 151 · see citing works
Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase
Frasca, D., Van der Put, E., Riley, R. L., & Blomberg, B. B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2155 · Cited by 150 · see citing works
Nonrandom attrition of the naive CD8 + T-cell pool with aging governed by T-cell receptor:pMHC interactions
Rudd, B. D., Venturi, V., Li, G., Samadder, P. P., Ertelt, J. M., Way, S. S., Davenport, M. P., & Nikolich‐Žugich, J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107594108 · Cited by 149 · see citing works
Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors
Henry, C. J., Casás-Selves, M., Kim, J., Zaberezhnyy, V., Aghili, L., Daniel, A. E., Jimenez, L., Azam, T., McNamee, E. N., Clambey, E. T., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci83024 · Cited by 148 · see citing works
The Human Thymus During Aging
Haynes, B. F., Sempowski, G. D., Wells, A. F., & Hale, L. P. (2000) · Immunologic Research · doi:10.1385/ir:22:2-3:253 · Cited by 147 · see citing works
In Vitro Evidence That Cytokine Receptor Signals Are Required for Differentiation of Double Positive Thymocytes into Functionally Mature CD8+ T Cells
Yu, Q., Erman, B., Bhandoola, A., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021765 · Cited by 143 · see citing works
CD27 Is Acquired by Primed B Cells at the Centroblast Stage and Promotes Germinal Center Formation
Xiao, Y., Hendriks, J., Langerak, P., Jacobs, H., & Borst, J. G. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.12.7432 · Cited by 141 · see citing works
A Study of Serum Immunoglobulin Levels in Elderly Persons That Provides New Insights into B Cell Immunosenescence
Listı̀, F., Candore, G., Modica, M. A., Russo, M., Lorenzo, G. D., Esposito-Pellitteri, M., Colonna‐Romano, G., Aquino, A., Bulati, M., Lio, D., et al. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1386.013 · Cited by 140 · see citing works
T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines
McElhaney, J. E., Kuchel, G. A., Zhou, X., Swain, S. L., & Haynes, L. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00041 · Cited by 139 · see citing works
Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals
Steger, M. M., Maczek, C., & Grubeck-Loebenstein, B. (1996) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1996.d01-790.x · Cited by 138 · see citing works
Long-term Effectiveness of Varicella Vaccine: A 14-Year, Prospective Cohort Study
Baxter, R. P., Ray, P., Tran, T. N., et al. (2013) · PEDIATRICS · doi:10.1542/peds.2012-3303 · Cited by 138 · see citing works
Cutting Edge: Central Memory CD8 T Cells in Aged Mice Are Virtual Memory Cells
Chiu, B.-C., Martin, B. E., Stolberg, V. R., & Chensue, S. W. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1302509 · Cited by 136 · see citing works
Immunosenescence and pneumococcal disease: an imbalance in host-pathogen interactions.
Krone, C. L., van de Groep, K., Trzciński, K., Sanders, E. A. M., & Bogaert, D. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70165-6 · Cited by 134 · see citing works
The effectiveness of pneumococcal polysaccharide vaccine 23 (PPV23) in the general population of 50 years of age and older: A systematic review and meta-analysis
Kraicer‐Melamed, H., O’Donnell, S., & Quach, C. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.02.024 · Cited by 134 · see citing works
<scp>CMV</scp> seropositivity and T‐cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study
Spyridopoulos, I., Martin‐Ruiz, C., Hilkens, C., Yadegarfar, M. E., Isaacs, J., Jagger, C., Kirkwood, T., & von Zglinicki, T. (2016) · Aging Cell · doi:10.1111/acel.12430 · Cited by 133 · see citing works
An Adjuvanted, Postfusion F Protein–Based Vaccine Did Not Prevent Respiratory Syncytial Virus Illness in Older Adults
Falloon, J., Yu, J. H., Esser, M. T., Villafana, T. L., Li, Y., Dubovsky, F., Takas, T., Levin, M. J., & Falsey, A. R. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix503 · Cited by 131 · see citing works
Dramatic increase in naïve T cell turnover is linked to loss of naïve T cells from old primates
Čičin-Šain, L., Messaoudi, I., Park, B., Currier, N., Planer, S., Fischer, M., Tackitt, S., Nikolich-Žugich, D., Legasse, A., Axthelm, M. K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705905104 · Cited by 130 · see citing works
Systems vaccinology: Enabling rational vaccine design with systems biological approaches
Hagan, T., Nakaya, H. I., Subramaniam, S., & Pulendran, B. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.03.072 · Cited by 127 · see citing works
Cytomegalovirus Infection Impairs Immune Responses and Accentuates T-cell Pool Changes Observed in Mice with Aging
Cicin-Sain, L., Brien, J. D., Uhrlaub, J. L., Drabig, A., Marandu, T. F., & Nikolich-Zugich, J. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002849 · Cited by 126 · see citing works
Stage-specific alterations in murine B lymphopoiesis with age
Stephan, R. P., Sanders, V. M., & Witte, P. L. (1996) · International Immunology · doi:10.1093/intimm/8.4.509 · Cited by 126 · see citing works
The aged lymphoid tissue environment fails to support naïve T cell homeostasis
Becklund, B. R., Purton, J. F., Ramsey, C., Favre, S., Vogt, T. K., Martin, C. E., Spasova, D. S., Sarkisyan, G., LeRoy, E., Tan, J. T., et al. (2016) · Scientific Reports · doi:10.1038/srep30842 · Cited by 126 · see citing works
Shingrix: The New Adjuvanted Recombinant Herpes Zoster Vaccine
James, S. F., Chahine, E. B., Sucher, A. J., & Hanna, C. (2018) · Annals of Pharmacotherapy · doi:10.1177/1060028018758431 · Cited by 126 · see citing works
Aging of the Innate Immune System: An Update
Mahbub, S., Brubaker, A. L., & Kovacs, E. J. (2011) · Current Immunology Reviews · doi:10.2174/157339511794474181 · Cited by 125 · see citing works
Older Adults Have a Low Capacity To Opsonize Pneumococci Due to Low IgM Antibody Response to Pneumococcal Vaccinations
Park, S., & Nahm, M. H. (2010) · Infection and Immunity · doi:10.1128/iai.00768-10 · Cited by 125 · see citing works
Changes in blood lymphocyte numbers with age in vivo and their association with the levels of cytokines/cytokine receptors
Lin, Y., Kim, J., Metter, E. J., Huy, N. V., Truong, T., Lustig, A., Ferrucci, L., & Weng, N. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0079-7 · Cited by 124 · see citing works
Single Cell RNA Sequencing of Rare Immune Cell Populations
Nguyen, A., Khoo, W. H., Moran, I., Croucher, P. I., & Phan, T. G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01553 · Cited by 123 · see citing works
Long-term immunogenicity and safety of an investigational herpes zoster subunit vaccine in older adults
Chlíbek, R., Pauksens, K., Rombo, L., van Rijckevorsel, G. G. C., Richardus, J. H., Plassmann, G., Schwarz, T. F., Catteau, G., Lal, H., & Heineman, T. C. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.09.073 · Cited by 122 · see citing works
B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans
Bulati, M., Buffa, S., Candore, G., Caruso, C., Dunn‐Walters, D. K., Pellicanò, M., Wu, Y.-C. B., & Romano, G. C. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.12.002 · Cited by 121 · see citing works
Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination
Derhovanessian, E., Theeten, H., Hähnel, K., Van Damme, P., Cools, N., & Pawelec, G. (2013) · Vaccine · doi:10.1016/j.vaccine.2012.11.041 · Cited by 121 · see citing works
Adults 65 Years Old and Older Have Reduced Numbers of Functional Memory T Cells to Respiratory Syncytial Virus Fusion Protein
Cherukuri, A., Patton, K., Gasser, R. A., Zuo, F., Woo, J. C., Esser, M. T., & Tang, R. S. (2012) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00580-12 · Cited by 120 · see citing works
Pneumococcal disease prevention among adults: Strategies for the use of pneumococcal vaccines
Pilishvili, T., & Bennett, N. M. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.05.102 · Cited by 120 · see citing works
High TNF-α levels in resting B cells negatively correlate with their response
Frasca, D., Diaz, A., Romero, M., Landin, A. M., & Blomberg, B. B. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.004 · Cited by 115 · see citing works
A CD153+CD4+ T Follicular Cell Population with Cell-Senescence Features Plays a Crucial Role in Lupus Pathogenesis via Osteopontin Production
Tahir, S., Fukushima, Y., Sakamoto, K., Sato, K., Fujita, H., Inoue, J., Uede, T., Hamazaki, Y., Hattori, M., & Minato, N. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500319 · Cited by 113 · see citing works
Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection
Richner, J. M., Gmyrek, G. B., Govero, J., Tu, Y., van der Windt, G. J. W., Metcalf, T. U., Haddad, E. K., Textor, J. C., Miller, M. J., & Diamond, M. S. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005027 · Cited by 110 · see citing works
Age-related differences in humoral and cellular immune responses after primary immunisation: indications for stratified vaccination schedules
Wagner, A., Garner‐Spitzer, E., Jasińska, J., Kollaritsch, H., Stiasny, K., Kundi, M., & Wiedermann, U. (2018) · Scientific Reports · doi:10.1038/s41598-018-28111-8 · Cited by 110 · see citing works
Two Separate Defects Affecting True Naive or Virtual Memory T Cell Precursors Combine To Reduce Naive T Cell Responses with Aging
Renkema, K. R., Li, G., Wu, A., Smithey, M. J., & Nikolich‐Žugich, J. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301453 · Cited by 109 · see citing works
Pneumococcal vaccination in older adults induces antibodies with low opsonic capacity and reduced antibody potency
Schenkein, J. G., Park, S., & Nahm, M. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.07.071 · Cited by 109 · see citing works
Effects of Ageing and Gender on Naturally Acquired Antibodies to Pneumococcal Capsular Polysaccharides and Virulence-Associated Proteins
Simell, B., Lahdenkari, M., Reunanen, A., Käyhty, H. M., & Väkeväinen, M. (2008) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00110-08 · Cited by 109 · see citing works
CyTOF supports efficient detection of immune cell subsets from small samples
Yao, Y., Liu, R., Shin, M. S., Trentalange, M. J., Allore, H. G., Nassar, A. F., Kang, I., Pober, J. S., & Montgomery, R. R. (2014) · Journal of Immunological Methods · doi:10.1016/j.jim.2014.10.010 · Cited by 108 · see citing works
Respiratory Syncytial Virus–Specific CD8 + Memory T Cell Responses in Elderly Persons
de Bree, G. J., Heidema, J., van Leeuwen, E. M. M., van Bleek, G. M., Jonkers, R. E., Jansen, H. M., van Lier, R. A. W., & Out, T. A. (2005) · The Journal of Infectious Diseases · doi:10.1086/429695 · Cited by 108 · see citing works
Fluad®-MF59®-Adjuvanted Influenza Vaccine in Older Adults
Tsai, T. F. (2013) · Infection & Chemotherapy · doi:10.3947/ic.2013.45.2.159 · Cited by 107 · see citing works
Effect of a Zoster Vaccine on Herpes Zoster–Related Interference with Functional Status and Health‐Related Quality‐of‐Life Measures in Older Adults
Schmader, K. E., Johnson, G. R., Saddier, P., Ciarleglio, M. M., Wang, W. W. B., Zhang, J. H., Chan, I. S. F., Yeh, S., Levin, M. J., Harbecke, R., et al. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.03021.x · Cited by 106 · see citing works
Pneumonia in the Elderly: A Review of the Epidemiology, Pathogenesis, Microbiology, and Clinical Features
Chong, C., & Street, P. R. (2008) · Southern Medical Journal · doi:10.1097/smj.0b013e318181d5b5 · Cited by 105 · see citing works
A comparative review of aging and B cell function in mice and humans
Scholz, J. L., Diaz, A., Riley, R. L., Cancro, M. P., & Frasca, D. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.07.006 · Cited by 103 · see citing works
Antibody and cell-mediated immunity to Streptococcus pneumoniae: implications for vaccine development
Malley, R. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0579-4 · Cited by 102 · see citing works
Age-Related Changes in Human Peripheral Blood IGH Repertoire Following Vaccination
Wu, Y.-C. B., Kipling, D., & Dunn‐Walters, D. K. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00193 · Cited by 101 · see citing works
The Burden of Influenza: a Complex Problem
Gordon, A. L., & Reingold, A. L. (2018) · Current Epidemiology Reports · doi:10.1007/s40471-018-0136-1 · Cited by 101 · see citing works
Plasma cell numbers decrease in bone marrow of old patients
Pritz, T., Lair, J., Ban, M., Keller, M., Weinberger, B., Krismer, M., & Grubeck‐Loebenstein, B. (2015) · European Journal of Immunology · doi:10.1002/eji.201444878 · Cited by 98 · see citing works
Many Routes to an Antibody Heavy-Chain CDR3: Necessary, Yet Insufficient, for Specific Binding
D’Angelo, S., Ferrara, F., Naranjo, L. A., Erasmus, M. F., Hraber, P., & Bradbury, A. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00395 · Cited by 98 · see citing works
Tristetraprolin, a Negative Regulator of mRNA Stability, Is Increased in Old B Cells and Is Involved in the Degradation of E47 mRNA
Frasca, D., Landin, A. M., Alvarez, J. P., Blackshear, P. J., Riley, R. L., & Blomberg, B. B. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.918 · Cited by 96 · see citing works
Effect of Preexisting Serum and Mucosal Antibody on Experimental Respiratory Syncytial Virus (RSV) Challenge and Infection of Adults
Bagga, B., Cehelsky, J. E., Vaishnaw, A. K., et al. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv281 · Cited by 96 · see citing works
Th1 memory differentiates recombinant from live herpes zoster vaccines
Levin, M. J., Kroehl, M., Johnson, M. J., Hammes, A., Reinhold, D., Lang, N., & Weinberg, A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci121484 · Cited by 93 · see citing works
Age-related impairment of humoral response to influenza is associated with changes in antigen specific T follicular helper cell responses
Lefebvre, J. S., Masters, A. R., Hopkins, J. W., & Haynes, L. (2016) · Scientific Reports · doi:10.1038/srep25051 · Cited by 91 · see citing works
Risk of mortality associated with respiratory syncytial virus and influenza infection in adults
Kwon, Y. S., Park, S. H., Kim, M. A., et al. (2017) · BMC Infectious Diseases · doi:10.1186/s12879-017-2897-4 · Cited by 90 · see citing works
Age Affects Quantity but Not Quality of Antibody Responses after Vaccination with an Inactivated Flavivirus Vaccine against Tick-Borne Encephalitis
Stiasny, K., Aberle, J. H., Keller, M., Grubeck‐Loebenstein, B., & Heinz, F. X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034145 · Cited by 88 · see citing works
Memory-phenotype CD4 + T cells spontaneously generated under steady-state conditions exert innate T H 1-like effector function
Kawabe, T., Jankovic, D. L., Kawabe, S., Huang, Y., Lee, P., Yamane, H., Zhu, J., Sher, A., Germain, R. N., & Paul, W. E. (2017) · Science Immunology · doi:10.1126/sciimmunol.aam9304 · Cited by 86 · see citing works
AID Activity in B Cells Strongly Correlates with Polyclonal Antibody Affinity Maturation in-vivo Following Pandemic 2009-H1N1 Vaccination in Humans
Khurana, S., Frasca, D., Blomberg, B., & Golding, H. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002920 · Cited by 85 · see citing works
Impact of age and pre-existing influenza immune responses in humans receiving split inactivated influenza vaccine on the induction of the breadth of antibodies to influenza A strains
Nuñez, I. A., Carlock, M. A., Allen, J. D., Owino, S. O., Geffel, K. M., Nowalk, M. P., Susick, M., Diagle, K., Sweeney, K., Mundle, S. T., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185666 · Cited by 85 · see citing works
Functional and Homeostatic Impact of Age-Related Changes in Lymph Node Stroma
Thompson, H. L., Smithey, M. J., Surh, C. D., & Nikolich‐Žugich, J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00706 · Cited by 84 · see citing works
The SENIEUR protocol after 16 years
Pawelec, G., Ferguson, F. G., & Wikby, A. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00240-2 · Cited by 83 · see citing works
Senescent B cells in aging and age-related diseases: Their role in the regulation of antibody responses
Frasca, D. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2017.07.002 · Cited by 82 · see citing works
Protective Mucosal Immunity in Aging Is Associated with Functional CD4+ T Cells in Nasopharyngeal-Associated Lymphoreticular Tissue
Hagiwara, Y., McGhee, J. R., Fujihashi, K., Kobayashi, R., Yoshino, N., Kataoka, K., Etani, Y., Kweon, M., Tamura, S., Kurata, T., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.4.1754 · Cited by 82 · see citing works
Persistence of immune response to an adjuvanted varicella-zoster virus subunit vaccine for up to year nine in older adults
Schwarz, T. F., Volpe, S. V., Catteau, G., Chlíbek, R., David, M. P., Richardus, J. H., Lal, H., Oostvogels, L., Pauksens, K., Ravault, S., et al. (2018) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2018.1442162 · Cited by 81 · see citing works
Effect of Influenza on Functional Decline
Gozalo, P. L., Pop-Vicas, A. E., Feng, Z., Gravenstein, S., & Mor, V. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2012.04048.x · Cited by 79 · see citing works
The Potential Role for Protein-Conjugate Pneumococcal Vaccine in Adults: What Is the Supporting Evidence?
Musher, D. M., Sampath, R., & Rodriguez‐Barradas, M. C. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/ciq207 · Cited by 78 · see citing works
Ferrets as Models for Influenza Virus Transmission Studies and Pandemic Risk Assessments
Belser, J. A., Barclay, W., Barr, I., Fouchier, R. A. M., Matsuyama, R., Nishiura, H., Peiris, M. J. S., Russell, C. J., Subbarao, K., Zhu, H., et al. (2018) · Emerging infectious diseases · doi:10.3201/eid2406.172114 · Cited by 78 · see citing works
Age‐associated alterations in CD8α+ dendritic cells impair CD8 T‐cell expansion in response to an intracellular bacterium
Li, G., Smithey, M. J., Rudd, B. D., & Nikolich‐Žugich, J. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00867.x · Cited by 77 · see citing works
Development and clinical evaluation of Prevnar 13, a 13‐valent pneumocococcal CRM197 conjugate vaccine
Gruber, W. C., Scott, D. A., & Emini, E. A. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06673.x · Cited by 75 · see citing works
System-Wide Associations between DNA-Methylation, Gene Expression, and Humoral Immune Response to Influenza Vaccination
Zimmermann, M. T., Oberg, A. L., Grill, D. E., Ovsyannikova, I. G., Haralambieva, I. H., Kennedy, R. B., & Poland, G. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152034 · Cited by 74 · see citing works
Self-citation
Altered Regulation of FcγRII on Aged Follicular Dendritic Cells Correlates with Immunoreceptor Tyrosine-Based Inhibition Motif Signaling in B Cells and Reduced Germinal Center Formation
Aydar, Y., Balogh, P., Tew, J. G., & Szakal, A. K. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.5975 · Cited by 73 · see citing works
Cytomegalovirus Infection and Memory T Cell Inflation
Kim, J., Kim, A.-R., & Shin, E. (2015) · Immune Network · doi:10.4110/in.2015.15.4.186 · Cited by 72 · see citing works
Cell-Intrinsic Defects in the Proliferative Response of Antiviral Memory CD8 T Cells in Aged Mice upon Secondary Infection
Decman, V., Laidlaw, B. J., DiMenna, L. J., Abdulla, S., Mozdzanowska, K., Erikson, J., Ertl, H. C. J., & Wherry, E. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902063 · Cited by 71 · see citing works
Influenza vaccine effectiveness in older adults compared with younger adults over five seasons
Russell, K. E. R., Chung, J. R., Monto, A. S., Martin, E. T., Belongia, E. A., McLean, H. Q., Gaglani, M., Murthy, K., Zimmerman, R. K., Nowalk, M. P., et al. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.01.045 · Cited by 71 · see citing works
Memory B Cell Subpopulations in the Aged
Colonna‐Romano, G., Aquino, A., Bulati, M., Lorenzo, G. D., Listı̀, F., Vitello, S., Lio, D., Candore, G., Clesi, G., & Caruso, C. (2006) · Rejuvenation Research · doi:10.1089/rej.2006.9.149 · Cited by 70 · see citing works
MicroRNAs miR-155 and miR-16 decrease AID and E47 in B cells from elderly individuals
Frasca, D., Diaz, A., Romero, M., Ferracci, F., & Blomberg, B. B. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500520 · Cited by 69 · see citing works
Antibody Quality in Old Age
Howard, W. A., Gibson, K. L., & Dunn‐Walters, D. K. (2006) · Rejuvenation Research · doi:10.1089/rej.2006.9.117 · Cited by 68 · see citing works
Age related changes in T cell mediated immune response and effector memory to Respiratory Syncytial Virus (RSV) in healthy subjects
Cusi, M. G., Martorelli, B., Genova, G. D., Terrosi, C., Campoccia, G., & Correale, P. (2010) · Immunity & Ageing · doi:10.1186/1742-4933-7-14 · Cited by 67 · see citing works
Lymphoid tissue fibrosis is associated with impaired vaccine responses
Kityo, C. M., Nganou‐Makamdop, K., Rothenberger, M. K., Chipman, J. G., Hoskuldsson, T., Beilman, G. J., Grzywacz, B. J., Mugyenyi, P. N., Ssali, F. N., Akondy, R. S., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97377 · Cited by 66 · see citing works
Immune response to pneumococcal polysaccharides 4 and 14 in elderly and young adults. I Antibody concentrations, avidity and functional activity
Kolibab, K., Smithson, S. L., Shriner, A. K., Khuder, S., Romero‐Steiner, S., Carlone, G. M., & Westerink, M. A. J. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-10 · Cited by 65 · see citing works
Signal transduction changes in CD4 + and CD8 + T cell subpopulations with aging
Page, A. Y. L., Dupuis, G., Larbi, A., Witkowski, J. M., & Fülöp, T. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.01.005 · Cited by 65 · see citing works
The ageing human B cell repertoire: a failure of selection?
Dunn‐Walters, D. K. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12700 · Cited by 63 · see citing works
Vaccine adjuvant MF59 promotes the intranodal differentiation of antigen-loaded and activated monocyte-derived dendritic cells
Cioncada, R., Maddaluno, M., Vo, H. T. M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185843 · Cited by 59 · see citing works
Chronic CMV infection in older women: Longitudinal comparisons of CMV DNA in peripheral monocytes, anti-CMV IgG titers, serum IL-6 levels, and CMV pp65 (NLV)-specific CD8+ T-cell frequencies with twelve year follow-up
Li, H., Weng, P., Najarro, K. M., Xue, Q., Semba, R. D., Margolick, J. B., & Leng, S. X. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.010 · Cited by 57 · see citing works
A Combination of Flt3 Ligand cDNA and CpG Oligodeoxynucleotide as Nasal Adjuvant Elicits Protective Secretory-IgA Immunity to Streptococcus pneumoniae in Aged Mice
Fukuyama, Y., King, J. D., Kataoka, K., Kobayashi, R., Gilbert, R. S., Hollingshead, S. K., Briles, D. E., & Fujihashi, K. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002837 · Cited by 57 · see citing works
Differences in Antibody Responses of Individuals with Natural Infection and Those Vaccinated against Pandemic H1N1 2009 Influenza
Chan, K., To, K. K., Hung, I. F., Zhang, J., Chan, J. F., Cheng, V. C., Tse, H., Che, X.-Y., Chen, H., & Yuen, K. (2011) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00555-10 · Cited by 56 · see citing works
Fluzone® High-Dose Influenza Vaccine
Robertson, C. A., DiazGranados, C. A., Decker, M. D., Chit, A., Mercer, M., & Greenberg, D. P. (2016) · Expert Review of Vaccines · doi:10.1080/14760584.2016.1254044 · Cited by 56 · see citing works
The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics
Lambkin‐Williams, R., Noulin, N., Mann, A., Catchpole, A. P., & Gilbert, A. S. (2018) · Respiratory Research · doi:10.1186/s12931-018-0784-1 · Cited by 56 · see citing works
Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus
Uhrlaub, J. L., Pulko, V., DeFilippis, V. R., Broeckel, R. M., Streblow, D. N., Coleman, G. D., Park, B. S., Lindo, J., Vickers, I. E., Anzinger, J. J., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005891 · Cited by 54 · see citing works
Human B cells express a CD45 isoform that is similar to murine B220 and is downregulated with acquisition of the memory B‐cell marker CD27
Bleesing, J., & Fleisher, T. A. (2002) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.10007 · Cited by 50 · see citing works
Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency
Jin, R., Kaneko, H., Suzuki, H., Arai, T., Teramoto, T., Fukao, T., & Kondo, N. (2008) · International Journal of Molecular Medicine · doi:10.3892/ijmm.21.2.233 · Cited by 50 · see citing works
Effect of latent cytomegalovirus infection on the antibody response to influenza vaccination: a systematic review and meta-analysis
van den Berg, S. P. H., Warmink, K., Borghans, J. A. M., Knol, M. J., & van Baarle, D. (2019) · Medical Microbiology and Immunology · doi:10.1007/s00430-019-00602-z · Cited by 50 · see citing works
Infectious disease risk in the elderly
Bender, B. S. (2003) · Immunology and Allergy Clinics of North America · doi:10.1016/s0889-8561(02)00078-4 · Cited by 49 · see citing works
Age effects on mouse and human B cells
Blomberg, B. B., & Frasca, D. (2013) · Immunologic Research · doi:10.1007/s12026-013-8440-9 · Cited by 46 · see citing works
Will Systems Biology Deliver Its Promise and Contribute to the Development of New or Improved Vaccines?Preprint
Hagan, T., & Pulendran, B. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028894 · Cited by 45 · see citing works
Immunosenescence-Related Transcriptomic and Immunologic Changes in Older Individuals Following Influenza Vaccination
Kennedy, R. B., Ovsyannikova, I. G., Haralambieva, I. H., Oberg, A. L., Zimmermann, M. T., Grill, D. E., & Poland, G. A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00450 · Cited by 45 · see citing works
Self-citation
Herpes Zoster Vaccines
Cunningham, A. L., & Levin, M. J. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy382 · Cited by 44 · see citing works
Breadth and Functionality of Varicella-Zoster Virus Glycoprotein-Specific Antibodies Identified after Zostavax Vaccination in Humans
Sullivan, N., Monslow, M. A., Sei, J. J., Dürr, E., Davis, C. W., Chang, C. Y., McCausland, M. M., Wieland, A., Krah, D. L., Rouphael, N., et al. (2018) · Journal of Virology · doi:10.1128/jvi.00269-18 · Cited by 43 · see citing works
Alterations in dendritic cell function in aged mice: potential implications for immunotherapy design
Paula, C. B., Motta, A., Schmitz, C. R., Nunes, C. P., de Souza, A. P. D., & Bonorino, C. (2008) · Biogerontology · doi:10.1007/s10522-008-9150-x · Cited by 43 · see citing works
Rectification of Age-Associated Deficiency in Cytotoxic T Cell Response to Influenza A Virus by Immunization with Immune Complexes
Zheng, B. Q., Zhang, Y., He, H., Marinova, E., Switzer, K. C., Wansley, D. L., Mbawuike, I. N., & Han, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.9.6153 · Cited by 42 · see citing works
Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules
Gardner, J. K., Mamotte, C. D. S., Jackaman, C., & Nelson, D. J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.07.002 · Cited by 40 · see citing works
Negative Effect of Age, but Not of Latent Cytomegalovirus Infection on the Antibody Response to a Novel Influenza Vaccine Strain in Healthy Adults
van den Berg, S. P. H., Wong, A., Hendriks, M., Jacobi, R. H. J., van Baarle, D., & van Beek, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00082 · Cited by 40 · see citing works
Animal Models of Varicella Zoster Virus Infection
Haberthur, K., & Messaoudi, I. (2013) · Pathogens · doi:10.3390/pathogens2020364 · Cited by 39 · see citing works
Effects of Aging on the Adaptive Immune Response to Respiratory Virus Infections
Fulton, R. B., & Varga, S. M. (2009) · Aging Health · doi:10.2217/ahe.09.69 · Cited by 38 · see citing works
Transcriptional signatures of influenza A/H1N1-specific IgG memory-like B cell response in older individuals
Haralambieva, I. H., Ovsyannikova, I. G., Kennedy, R. B., Zimmermann, M. T., Grill, D. E., Oberg, A. L., & Poland, G. A. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.06.034 · Cited by 36 · see citing works
Self-citation
Th17/Th1 biased immunity to the pneumococcal proteins PcsB, StkP and PsaA in adults of different age
Schmid, P., Selak, S., Keller, M., Luhan, B., Magyarics, Z., Seidel, S., Schlick, P., Reinisch, C., Lingnau, K., Nagy, E., et al. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.03.081 · Cited by 34 · see citing works
Determining the Optimal Pneumococcal Vaccination Strategy for Adults
Metersky, M. L., Dransfield, M. T., & Jackson, L. A. (2010) · CHEST Journal · doi:10.1378/chest.10-0738 · Cited by 34 · see citing works
The importance of RSV F protein conformation in VLPs in stimulation of neutralizing antibody titers in mice previously infected with RSV
Cullen, L. M., Schmidt, M. R., & Morrison, T. G. (2017) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2017.1329069 · Cited by 32 · see citing works
The Mouse Model of Respiratory Syncytial Virus Disease
Openshaw, P. (2013) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-38919-1_18 · Cited by 30 · see citing works
Transcriptomic signatures of cellular and humoral immune responses in older adults after seasonal influenza vaccination identified by data-driven clustering
Voigt, E. A., Grill, D. E., Zimmermann, M. T., Simon, W. L., Ovsyannikova, I. G., Kennedy, R. B., & Poland, G. A. (2018) · Scientific Reports · doi:10.1038/s41598-017-17735-x · Cited by 30 · see citing works
Self-citation
Distinct aging profiles of CD8+ T cells in blood versus gastrointestinal mucosal compartments
Dock, J., Ramirez, C. M., Hultin, L. E., Hausner, M. A., Hultin, P. M., Elliott, J. E., Yang, O. O., Anton, P. A., Jamieson, B. D., & Effros, R. B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182498 · Cited by 29 · see citing works
Comparative Analysis of B-Cell Receptor Repertoires Induced by Live Yellow Fever Vaccine in Young and Middle-Age Donors
Davydov, A. N., Obraztsova, A., Lebedin, M. Y., Turchaninova, M. A., Staroverov, D. B., Merzlyak, E. M., Sharonov, G. V., Кладова, О. В., Shugay, M., Britanova, O. V., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02309 · Cited by 28 · see citing works

Flagged first, then by citations

Sorted by citations

A guide to vaccinology: from basic principles to new developments
Pollard, A. J., & Bijker, E. M. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00479-7 · Cited by 1,593 · see citing works
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
Chaudhary, N., Weissman, D., & Whitehead, K. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00283-5 · Cited by 1,555 · see citing works
Aging, Immunity, and COVID-19: How Age Influences the Host Immune Response to Coronavirus Infections?
Bajaj, V., Gadi, N., Spihlman, A. P., Wu, S. C., Choi, C. H., & Moulton, V. R. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.571416 · Cited by 476 · see citing works
A Comprehensive Review of mRNA Vaccines
Gote, V., Bolla, P. K., Kommineni, N., Butreddy, A., Nukala, P. K., Palakurthi, S. S., & Khan, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032700 · Cited by 457 · see citing works
Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood
Duggal, N. A., Pollock, R. D., Lazarus, N. R., Harridge, S., & Lord, J. M. (2018) · Aging Cell · doi:10.1111/acel.12750 · Cited by 261 · see citing works
The Impact of Immune System Aging on Infectious Diseases
Quiros-Roldan, E., Sottini, A., Natali, P. G., & Imberti, L. (2024) · Microorganisms · doi:10.3390/microorganisms12040775 · Cited by 133 · see citing works
“Additionally, the production of cytokines is not optimal for adaptive immune response priming [243].”
The dark side of Tregs during aging
Palatella, M., Guillaume, S. M., Linterman, M. A., & Huehn, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.940705 · Cited by 58 · see citing works
Vaccine-induced protection in aging adults and pandemic response
Schenkelberg, T. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.10.090 · Cited by 11 · see citing works

Immunosenescence and its related comorbidities in older people living with HIV
He, X.-Y., Wang, X., Li, S., Li, N., Li, W., Hu, Y., Guo, N., Zheng, Y., Zheng, H., & Su, B. (2024) · Infectious Diseases & Immunity · doi:10.1097/id9.0000000000000134 · Cited by 11 · see citing works
Effects of Physical Exercise on Markers of Cellular Immunosenescence: A Systematic Review
Dinh, H. C., Beyer, I., Mets, T. F., Onyema, O. O., Njemini, R., Renmans, W., Waele, M. D., Jochmans, K., Meeren, S. V., & Bautmans, I. (2016) · Calcified Tissue International · doi:10.1007/s00223-016-0212-9 · Cited by 73 · see citing works
Nutrition, diet and immunosenescence
Maijó, M., Clements, S. J., Ivory, K., Nicoletti, C., & Carding, S. R. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.12.003 · Cited by 85 · see citing works
Diet and Immunosenescence
Accardi, G., Balistreri, C. R., Caruso, C., & Candore, G. (2013) · Springer eBooks · doi:10.1007/978-3-642-39495-9_21
Rheumatoid Arthritis: A Role for Immunosenescence?
Lindström, T. M., & Robinson, W. H. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02965.x · Cited by 122 · see citing works

Authors: Crooke, S. N., Ovsyannikova, I. G., Poland, G. A., & Kennedy, R. B.
Affiliations: Mayo Clinic (US)
Corresponding author: Kennedy, Richard B.
ORCID: Crooke, Stephen N.
Ovsyannikova, Inna G.
Poland, Gregory A.
Kennedy, Richard B.
Venue: Immunity & Ageing
Publisher: Springer Science and Business Media LLC
Published: 2019-09-13
Volume: 16
Issue: 1
Pages: 25-25
ISSN: 1742-4933 (ISSN-L)
DOI: 10.1186/s12979-019-0164-9
PMC: PMC6743147
OpenAlex: W2972334025
Cited by: 530
References: 207
Citations by year: 2026: 59 · 2025: 57 · 2024: 80 · 2023: 86 · 2022: 94 · 2021: 97 · 2020: 52 · 2019: 3 · 2018: 1
FWCI: 5.27
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Immunity & Ageing (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI089859, AI132348)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: immunosenescence, vaccine response, older adults, adaptive immunity, T cells, B cells, age-related immune decline, vaccine adjuvants, personalized vaccines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Immunosenescence and human vaccine immune responses

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks