Cited by 42Extracellular vesicles in diseaseMesenchymal stem cell researchDrug-Induced Hepatotoxicity and Protection

ASCs-Derived Exosomes Loaded with Vitamin A and Quercetin Inhibit Rapid Senescence-like Response after Acute Liver Injury

Fang, Jia, Liang, Wulong·2021·Biochemical and Biophysical Research Communications

Abstract

Acute liver injury is a short-term burst of liver cell damage, which has many causes and complex mechanisms. Despite the unique ability of the liver to heal itself, there is still no effective treatment except liver transplantation for chronic liver injury or even liver failure caused by acute liver injury. Stem cell-derived exosomes are ideal drug carriers due to their unique immunomodulatory effects and structural characteristics. In this study, quercetin and vitamin A loaded adipose mesenchymal stem cells (ASCs)-derived exosomes were constructed and used to treat acute liver injury induced by CCl4 in mice. Quercetin enhances the therapeutic efficacy of exosomes, while vitamin A enhances the liver targeting of exosomes, and it was found that quercetin and vitamin A loaded mesenchymal stem cell exosomes reduce rapid senescence-like response induced by acute liver injury.

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Crossref · 10.1016/j.bbrc.2021.07.059

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Authors
Fang, J., & Liang, W.
Affiliations
  • Henan University (CN)
  • Fifth Affiliated Hospital of Zhengzhou University (CN)
Corresponding author
  • Fang, Jia
  • Liang, Wulong
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2021-10
Volume
572
Pages
125-130
ISSN
0006-291X (ISSN-L)
OpenAlex
W3189953549
Cited by
42
References
31
Citations by year
2026: 4 · 2025: 10 · 2024: 12 · 2023: 7 · 2022: 9
FWCI
2.20
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (32000511)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords
exosomes, adipose-derived stem cells, acute liver injury, quercetin, vitamin A, carbon tetrachloride-induced liver injury, liver targeting, drug delivery, immunomodulation, liver regeneration
MeSH terms
Adipose Tissue, Animals, Cells, Cultured, Quercetin, Vitamin A, Cellular Senescence, Mice, Exosomes, Chemical and Drug Induced Liver Injury, Mesenchymal Stem Cells

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