ASCs-Derived Exosomes Loaded with Vitamin A and Quercetin Inhibit Rapid Senescence-like Response after Acute Liver Injury
Abstract
Acute liver injury is a short-term burst of liver cell damage, which has many causes and complex mechanisms. Despite the unique ability of the liver to heal itself, there is still no effective treatment except liver transplantation for chronic liver injury or even liver failure caused by acute liver injury. Stem cell-derived exosomes are ideal drug carriers due to their unique immunomodulatory effects and structural characteristics. In this study, quercetin and vitamin A loaded adipose mesenchymal stem cells (ASCs)-derived exosomes were constructed and used to treat acute liver injury induced by CCl4 in mice. Quercetin enhances the therapeutic efficacy of exosomes, while vitamin A enhances the liver targeting of exosomes, and it was found that quercetin and vitamin A loaded mesenchymal stem cell exosomes reduce rapid senescence-like response induced by acute liver injury.
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Vitamin A in association with quercetin reduces rapid senescence-like response induced by acute liver injury.
“This combination has proven capable of reducing rapid senescence-like response induced by acute liver injury [113].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [113]
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The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
- Authors
- Fang, J., & Liang, W.
- Affiliations
- Henan University (CN)
- Fifth Affiliated Hospital of Zhengzhou University (CN)
- Corresponding author
- Fang, Jia
- Liang, Wulong
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2021-10
- Volume
- 572
- Pages
- 125-130
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W3189953549
- Cited by
- 42
- References
- 31
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 12 · 2023: 7 · 2022: 9
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (32000511)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- exosomes, adipose-derived stem cells, acute liver injury, quercetin, vitamin A, carbon tetrachloride-induced liver injury, liver targeting, drug delivery, immunomodulation, liver regeneration
- MeSH terms
- Adipose Tissue, Animals, Cells, Cultured, Quercetin, Vitamin A, Cellular Senescence, Mice, Exosomes, Chemical and Drug Induced Liver Injury, Mesenchymal Stem Cells
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