The Flavonoid Quercetin Ameliorates Liver Inflammation and Fibrosis by Regulating Hepatic Macrophages Activation and Polarization in Mice

Li, Xi; Jin, Qianwen; Yao, Qunyan; Xu, Beili; Li, Lixin; Zhang, Shuncai; Tu, Chuantao

doi:10.3389/fphar.2018.00072

Cited by 171Liver physiology and pathologyFlavonoids in Medical ResearchLiver Disease Diagnosis and Treatment

The Flavonoid Quercetin Ameliorates Liver Inflammation and Fibrosis by Regulating Hepatic Macrophages Activation and Polarization in Mice

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Li, Xi, Jin, Qianwen, Yao, Qunyan, Xu, Beili, Li, Lixin, Zhang, Shuncai, Tu, Chuantao·2018·Frontiers in Pharmacology

DOI 10.3389/fphar.2018.00072PMC PMC5819566

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Abstract

At present, there are no effective antifibrotic drugs for patients with chronic liver disease; hence, the development of antifibrotic therapies is urgently needed. Here, we performed an experimental and translational study to investigate the potential and underlying mechanism of quercetin treatment in liver fibrosis, mainly focusing on the impact of quercetin on macrophages activation and polarization. BALB/c mice were induced liver fibrosis by carbon tetrachloride (CCl4) for 8 weeks and concomitantly treated with quercetin (50 mg/kg) or vehicle by daily gavage. Liver inflammation, fibrosis, and hepatic stellate cells (HSCs) activation were examined. Moreover, massive macrophages accumulation, M1 macrophages and their related markers, such as tumor necrosis factor (TNF)-, interleukin (IL)-1β, IL-6 and monocyte chemotactic protein 1(MCP-1) in livers were analyzed. In vitro, we used Raw 264.7 cells to examine the effect of quercetin on M1-polarized macrophages activation. Our results showed that quercetin dramatically ameliorated liver inflammation, fibrosis, and inhibited HSCs activation. These results were attributed to the reductive recruitment of macrophages (F4/80+ and CD68+) into the liver in quercetin-treated fibrotic mice confirmed by immunostaining and expression levels of marker molecules. Importantly, quercetin strongly inhibited M1 polarization and M1-related inflammatory cytokines in fibrotic livers when compared with vehicle-treated mice. In vitro, studies further revealed that quercetin efficiently inhibited macrophages activation and M1 polarization, as well as decreased the mRNA expression of M1 macrophage markers such as TNF-, IL-1β, IL-6 and nitric oxide synthase 2 (NOS2). Mechanistically, the inhibition of M1 macrophages by quercetin was associated with the decrease levels of Notch1 expression on macrophages both in vivo and in vitro. Taken together, our data indicated that quercetin attenuated CCl4-induced liver inflammation and fibrosis in mice through inhibiting macrophages infiltration and modulating M1 macrophages polarization via targeting Notch1 pathway. Hence, quercetin holds promise as potential therapeutic agent for human fibrotic liver disease.

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Exposure to supernatant from VIS cells induced macrophage activation marked by an M1-like polarization profile, CD86 upregulation, and signs of secondary macrophage senescence detected by SA-β-gal staining and senescence-typical gene expression.
“it was demonstrated that exposure to the supernatant of VIS cells induced macrophage activation that was marked by an M1-like polarization profile79,89, CD86 upregulation and signs of secondary macrophage senescence as detected by SA-β-gal staining and senescence-typical gene expression.”
From COVID-19 and cellular senescence (2023) · cites this paper as [89]

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Macrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335 · see citing works
Macrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684 · cited 1× · see citing works
“It has revealed that macrophage differentiation and activation is subjected to tight control by several mechanisms, including signaling molecules, transcription factors, epigenetic mechanisms, and posttranscriptional regulators (Lawrence and Natoli, 2011; Wynn et al., 2013; Xu et al., 2015b).”
Background
Macrophages in Tissue Repair, Regeneration, and Fibrosis
Wynn, T. A., & Vannella, K. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.015 · Cited by 4,481 · see citing works
Mechanisms of hepatic stellate cell activation
Tsuchida, T., & Friedman, S. L. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.38 · Cited by 2,909 · see citing works
Mechanisms of Hepatic Fibrogenesis
Friedman, S. L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.003 · Cited by 2,640 · see citing works
Transcriptional regulation of macrophage polarization: enabling diversity with identity
Lawrence, T., & Natoli, G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3088 · Cited by 2,284 · see citing works
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
Duffield, J. S., Forbes, S. J., Constandinou, C. M., Clay, S., Partolina, M., Vuthoori, S., Wu, S., Lang, R., & Iredale, J. P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200522675 · Cited by 1,649 · see citing works
Classification of chronic viral hepatitis: a need for reassessment
Scheuer, P. J. (1991) · Journal of Hepatology · doi:10.1016/0168-8278(91)90084-o · Cited by 1,588 · see citing works
Liver fibrosis and repair: Immune regulation of wound healing in a solid organ
Pellicoro, A., Ramachandran, P., Iredale, J. P., & Fallowfield, J. A. (2014) · Nature Reviews Immunology · doi:10.1038/nri3623 · Cited by 1,310 · see citing works
Macrophage heterogeneity in liver injury and fibrosis
Tacke, F., & Zimmermann, H. W. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.12.025 · Cited by 1,061 · see citing works
Targeting hepatic macrophages to treat liver diseases
Tacke, F. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.02.026 · Cited by 1,003 · see citing works
Hepatic inflammation and fibrosis: Functional links and key pathways
Seki, E., & Schwabe, R. F. (2015) · Hepatology · doi:10.1002/hep.27332 · Cited by 972 · see citing works
The flavonoid quercetin in disease prevention and therapy: Facts and fancies
Russo, M., Spagnuolo, C., Tedesco, I., Bilotto, S., & Russo, G. L. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.08.010 · Cited by 700 · see citing works
Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice
Pradere, J.-P., Kluwe, J., De Minicis, S., Jiao, J.-J., Gwak, G.-Y., Dapito, D. H., Jang, M.-K., Guenther, N. D., Mederacke, I., Friedman, R., et al. (2013) · Hepatology · doi:10.1002/hep.26429 · Cited by 613 · see citing works
M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease
Wan, J., Benkdane, M., Teixeira-Clerc, F., Bonnafous, S., Louvet, A., Lafdil, F., Pecker, F., Tran, A., Gual, P., Mallat, A., et al. (2014) · Hepatology · doi:10.1002/hep.26607 · Cited by 558 · see citing works
Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2
Miura, K., Yang, L., van Rooijen, N., Ohnishi, H., & Seki, E. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00365.2011 · Cited by 503 · see citing works
Macrophage Plasticity and Polarization in Liver Homeostasis and Pathology
Sica, A., Invernizzi, P., & Mantovani, A. (2014) · Hepatology · doi:10.1002/hep.26754 · Cited by 422 · see citing works
Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1
Dong, J., Zhang, X., Zhang, L., Bian, H., Xu, N., Bao, B., & Liu, J. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m038786 · Cited by 295 · see citing works
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways
Wu, L., Zhang, Q., Mo, W., Feng, J., Li, S., Li, J., Liu, T., Xu, S., Wang, W., Lu, X., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09673-5 · Cited by 272 · see citing works
NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation
Xu, J., Chi, F., Guo, T., Punj, V., Lee, W. N. P., French, S. W., & Tsukamoto, H. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76468 · Cited by 241 · see citing works
Notch signaling is activated by TLR stimulation and regulates macrophage functions
Palaga, T., Buranaruk, C., Rengpipat, S., Fauq, A. H., Golde, T. E., Kaufmann, S. H. E., & Osborne, B. A. (2007) · European Journal of Immunology · doi:10.1002/eji.200636999 · Cited by 233 · see citing works
Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway
Kobuchi, H., Roy, S., Sen, C. K., Nguyen, H. G., & Packer, L. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.277.3.c403 · Cited by 197 · see citing works
Quercetin Treatment Ameliorates Inflammation and Fibrosis in Mice with Nonalcoholic Steatohepatitis3
Marcolin, É., San‐Miguel, B., Vallejo, D., Tieppo, J., Marroni, N. P., González‐Gallego, J., & Tuñón, M. J. (2012) · Journal of Nutrition · doi:10.3945/jn.112.165274 · Cited by 177 · see citing works
NKp46(+) natural killer cells attenuate metabolism-induced hepatic fibrosis by regulating macrophage activation in mice
Tosello‐Trampont, A., Krueger, P., Narayanan, S., Landes, S. G., Leitinger, N., & Hahn, Y. S. (2016) · Hepatology · doi:10.1002/hep.28389 · Cited by 142 · see citing works
Anti‐Inflammatory Effect of Quercetin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic‐Polycytidylic Acid
Kim, Y., & Park, W. (2016) · Molecules · doi:10.3390/molecules21040450 · Cited by 124 · see citing works
Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media
Overman, A., Chuang, C.-C., & McIntosh, M. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.272 · Cited by 112 · see citing works
The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis
Bansal, R., van Baarlen, J., Storm, G., & Prakash, J. (2015) · Scientific Reports · doi:10.1038/srep18272 · Cited by 107 · see citing works
Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro‐fibrogenic/anti‐fibrogenic molecules balance
Hernández‐Ortega, L. D., Alcántar‐Díaz, B. E., Ruiz-Corro, L., Sandoval-Rodriguez, A. S., Bueno‐Topete, M. R., Armendáriz‐Borunda, J., & Salazar-Montes, A. M. (2012) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2012.07262.x · Cited by 106 · see citing works
Notch Regulates Macrophage-Mediated Inflammation in Diabetic Wound Healing
Kimball, A., Joshi, A., Boniakowski, A. E., Schaller, M. A., Chung, J., Allen, R., Bermick, J., Carson, W. F., Henke, P. K., Maillard, I. P., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00635 · Cited by 101 · see citing works
Hepatic Localization of Macrophage Phenotypes during Fibrogenesis and Resolution of Fibrosis in Mice and Humans
Beljaars, L., Schippers, M., Reker‐Smit, C., Martínez, F. O., Helming, L., Poelstra, K., & Melgert, B. N. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00430 · Cited by 97 · see citing works
CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism
Wilhelm, A., Aldridge, V., Haldar, D., Naylor, A. J., Weston, C. J., Hedegaard, D. L., Garg, A., Fear, J., Reynolds, G. M., Croft, A. P., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-308325 · Cited by 92 · see citing works
Antibody-Directed Glucocorticoid Targeting to CD163 in M2-Type Macrophages Attenuates Fructose-Induced Liver Inflammatory Changes
Svendsen, P., Graversen, J. H., Etzerodt, A., Hager, H., Røge, R., Grønbæk, H., Christensen, E. I., Møller, H. J., Vilstrup, H., & Moestrup, S. K. (2017) · Molecular Therapy - Methods & Clinical Development · doi:10.1016/j.omtm.2016.11.004 · Cited by 84 · see citing works
M1- and M2-macrophage polarization in rat liver cirrhosis induced by thioacetamide (TAA), focusing on Iba1 and galectin-3
Wijesundera, K. K., Izawa, T., Tennakoon, A. H., Murakami, H., Golbar, H. M., Katou-Ichikawa, C., Tanaka, M., Kuwamura, M., & Yamate, J. (2014) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2014.04.003 · Cited by 77 · see citing works
Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-κB signaling pathways
Li, X., Jin, Q., Yao, Q., Xu, B., Li, Z., & Tu, C. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2016.09.002 · Cited by 75 · see citing works
Self-citation
IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans
Alzaïd, F., Lagadec, F., Albuquerque, M., Ballaire, R., Orliaguet, L., Hainault, I., Blugeon, C., Lemoine, S., Lehuen, A., Saliba, D. G., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.88689 · Cited by 66 · see citing works
Comparative Protection against Liver Inflammation and Fibrosis by a Selective Cyclooxygenase-2 Inhibitor and a Nonredox-Type 5-Lipoxygenase Inhibitor
Horrillo, R., Planagumà, A., González‐Périz, A., Ferré, N., Titos, E., Miquel, R., López‐Parra, M., Masferrer, J. L., Arroyo, V., & Clària, J. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.128264 · Cited by 56 · see citing works
Quercetin Protects Mice from ConA-Induced Hepatitis by Inhibiting HMGB1-TLR Expression and Down-Regulating the Nuclear Factor Kappa B Pathway
Li, X., Liu, H., Yao, Q., Xu, B., Zhang, S., & Tu, C. (2015) · Inflammation · doi:10.1007/s10753-015-0227-9 · Cited by 51 · see citing works
Self-citation
Placental Growth Factor Contributes to Liver Inflammation, Angiogenesis, Fibrosis in Mice by Promoting Hepatic Macrophage Recruitment and Activation
Li, X., Jin, Q., Yao, Q., Zhou, Y., Zou, Y., Li, Z., Zhang, S., & Tu, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00801 · Cited by 48 · see citing works
Self-citation
Expression of scavenger receptor‐AI promotes alternative activation of murine macrophages to limit hepatic inflammation and fibrosis
Labonte, A. C., Sung, S. J., Jennelle, L. T., Dandekar, A. P., & Hahn, Y. S. (2016) · Hepatology · doi:10.1002/hep.28873 · Cited by 35 · see citing works
Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease
Li, X., Yao, Q., Liu, H., Jin, Q., Xu, B., Zhang, S., & Tu, C. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13158 · Cited by 35 · see citing works
Self-citation
M2 Macrophages Play Critical Roles in Progression of Inflammatory Liver Disease in Hepatitis C Virus Transgenic Mice
Ohtsuki, T., Kimura, K., Tokunaga, Y., Tsukiyama–Kohara, K., Tateno, C., Hayashi, Y. K., Hishima, T., & Kohara, M. (2015) · Journal of Virology · doi:10.1128/jvi.02293-15 · Cited by 26 · see citing works
Notch signaling and M1 macrophage activation in obesity-alcohol synergism
Xu, J., Chi, F., & Tsukamoto, H. (2015) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2015.05.016 · Cited by 25 · see citing works
Dual Notch signaling in proinflammatory macrophage activation
Eun, H. S., & Jeong, W. (2015) · Hepatology · doi:10.1002/hep.28386 · Cited by 8 · see citing works

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Wang, C., Ma, C., Gong, L., Guo, Y., Fu, K., Zhang, Y., Zhou, H., & Li, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.803037 · Cited by 583 · see citing works
Virus-induced senescence is a driver and therapeutic target in COVID-19
Lee, S., Yu, Y., Trimpert, J., Benthani, F., Mairhofer, M., Richter-Pechanska, P., Wyler, E., Belenki, D., Kaltenbrunner, S., Pammer, M., et al. (2021) · Nature · doi:10.1038/s41586-021-03995-1 · Cited by 350 · see citing works
Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages
Hu, Y. H., Gui, Z., Zhou, Y., Xia, L., Lin, K., & Xu, Y. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.09.024 · Cited by 291 · see citing works
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Wang, Y., Li, C., Wan, Y., Qi, M., Chen, Q., Sun, Y. L., Sun, X., Fang, J., Fu, L., Xu, L. H., et al. (2021) · Small · doi:10.1002/smll.202101505 · Cited by 228 · see citing works
Enhancement of bioavailability and bioactivity of diet-derived flavonoids by application of nanotechnology: a review
Teng, H., Zheng, Y., Cao, H., Huang, Q., Xiao, J., & Chen, L. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1947772 · Cited by 206 · see citing works
Hepatic macrophages: Key players in the development and progression of liver fibrosis
Cheng, D., Chai, J., Wang, H., Fu, L., Peng, S., & Ni, X. (2021) · Liver International · doi:10.1111/liv.14940 · Cited by 188 · see citing works
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Schmitt, C. A., Tchkonia, T., Niedernhofer, L. J., Robbins, P. D., Kirkland, J. L., & Lee, S. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-022-00785-2 · Cited by 153 · see citing works
Quercetin as a protective agent for liver diseases: A comprehensive descriptive review of the molecular mechanism
Zhao, X., Wang, J., Deng, Y., Liao, L., Zhou, M., Peng, C. Y., & Li, Y. (2021) · Phytotherapy Research · doi:10.1002/ptr.7104 · Cited by 126 · see citing works
Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer
Oršolić, N., & Jembrek, M. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810479 · Cited by 132 · see citing works
Celastrol exerts anti‐inflammatory effect in liver fibrosis via activation of AMPK‐SIRT3 signalling
Wang, Y., Li, M., Gu, J., Chen, C., Duanmu, J., Miao, J., Yao, W., Tao, J., Tu, M., Xiong, B., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14805 · Cited by 106 · see citing works
Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice
Dungan, C. M., Murach, K. A., Zdunek, C. J., Tang, Z. J., Nolt, G. L., Brightwell, C. R., Hettinger, Z. R., Englund, D. A., Liu, Z., Fry, C. S., et al. (2021) · Aging Cell · doi:10.1111/acel.13528 · Cited by 105 · see citing works
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Septembre‐Malaterre, A., Boumendjel, A., Seteyen, A.-L. S., Boina, C., Gasque, P., Guiraud, P., & Sélambarom, J. (2022) · Phytomedicine Plus · doi:10.1016/j.phyplu.2022.100220 · Cited by 104 · see citing works
Luteolin: A flavone with myriads of bioactivities and food applications
Bangar, S. P., Kajla, P., Chaudhary, V., Sharma, N. N., & Özoğul, F. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.102366 · Cited by 101 · see citing works
Effects of Sorafenib and Quercetin Alone or in Combination in Treating Hepatocellular Carcinoma: In Vitro and In Vivo Approaches
Abdu, S. B. S., Juaid, N., Amin, A., Moulay, M., & Miled, N. (2022) · Molecules · doi:10.3390/molecules27228082 · Cited by 98 · see citing works
Antitumor Effects of Quercetin in Hepatocarcinoma In Vitro and In Vivo Models: A Systematic Review
Fernández‐Palanca, P., Fondevila, F., Méndez‐Blanco, C., Tuñón, M. J., González‐Gallego, J., & Mauriz, J. L. (2019) · Nutrients · doi:10.3390/nu11122875 · Cited by 93 · see citing works
The microglial innate immune receptors TREM-1 and TREM-2 in the anterior cingulate cortex (ACC) drive visceral hypersensitivity and depressive-like behaviors following DSS-induced colitis
Wu, K., Liu, Y.-Y., Shao, S., Song, W., Chen, X.-H., Dong, Y.-T., & Zhang, Y.-M. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.06.003 · Cited by 83 · see citing works
Flavonoids-mediated SIRT1 signaling activation in hepatic disorders
Sayed, A. M. M., Hassanein, E. H. M., Salem, S. H., Hussein, O. E., & Mahmoud, A. M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118173 · Cited by 75 · see citing works
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Lim, H.-J., Kang, S.-H., Song, Y.-J., Jeon, Y., & Jin, J. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107557 · Cited by 75 · see citing works
Myricetin modulates macrophage polarization and mitigates liver inflammation and fibrosis in a murine model of nonalcoholic steatohepatitis
Yao, Q., Li, S., Li, X., Wang, F., & Tu, C. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00071 · Cited by 71 · see citing works
Self-citation
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Sun, H., Feng, J., & Tang, L. (2020) · Cells · doi:10.3390/cells9122626 · Cited by 71 · see citing works
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Lim, H. A., Heo, M. Y., & Kim, H. P. (2019) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2019.034 · Cited by 71 · see citing works
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Wu, B., Wang, R., Li, S., Wang, Y., Song, F., Gu, Y., & Yuan, Y. (2019) · Pharmacological Reports · doi:10.1016/j.pharep.2019.01.008 · Cited by 49 · see citing works
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Wang, T., Liu, L., Deng, J., Jiang, Y., Yan, X., & Liu, W. (2023) · Food & Function · doi:10.1039/d2fo03509j · Cited by 39 · see citing works
Corilagin alleviates liver fibrosis in zebrafish and mice by repressing IDO1-mediated M2 macrophage repolarization
Wang, Y., Huang, S., Kong, W., Wu, C., Zeng, T., Xie, S., Chen, Q., Kuang, S., Zheng, R., Wang, F., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155016 · Cited by 36 · see citing works
RETRACTED: Melatonin modulates mitophagy, innate immunity and circadian clocks in a model of viral‐induced fulminant hepatic failure
Crespo, I., Fernández‐Palanca, P., San‐Miguel, B., Alvarez, M., González‐Gallego, J., & Tuñón, M. J. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15398 · Cited by 36 · see citing works
Retracted
Quercetin Attenuates d-GaLN-Induced L02 Cell Damage by Suppressing Oxidative Stress and Mitochondrial Apoptosis via Inhibition of HMGB1
Fang, P., Liang, J., Jiang, X., Fang, X., Wu, M., Wei, X., Yang, W., Hou, W., & Zhang, Q. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00608 · Cited by 34 · see citing works
Plant‐derived flavonoids are a potential source of drugs for the treatment of liver fibrosis
Zhao, B., Liu, K., Liu, X., Li, Q., Li, Z., Xi, J., Xie, F., & Li, X. (2024) · Phytotherapy Research · doi:10.1002/ptr.8193 · Cited by 32 · see citing works
Self-citation
Evaluation of the toxicity and anti-inflammatory activities of the infusion of leaves of Campomanesia guazumifolia (Cambess.) O. Berg
Catelan, T. B. S., Radai, J. A. S., Leitão, M. M., Branquinho, L. S., Vasconcelos, P. C. D. P., Vieira, S. C. H., Kassuya, C. A. L., & Cardoso, C. A. L. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.08.015 · Cited by 31 · see citing works
Multifunctional Extracellular Matrix Hydrogel with Self-Healing Properties and Promoting Angiogenesis as an Immunoregulation Platform for Diabetic Wound Healing
Sun, Z., Xiong, H., Lou, T., Liu, W., Xu, Y., Yu, S., Wang, H., Liu, W., Yang, L., Zhou, C., et al. (2023) · Gels · doi:10.3390/gels9050381 · Cited by 29 · see citing works
Protective effect of acrocarpus fraxinifolius extract against hepatic fibrosis induced by Gamma irradiation and carbon tetrachloride in albino rats
Elshawi, O. E., El‐Nashar, H. A. S., El‐Rahman, S. S. A., Eldahshan, O. A., & Singab, A. N. B. (2022) · International Journal of Radiation Biology · doi:10.1080/09553002.2022.2087926 · Cited by 29 · see citing works
Polyphenol-based targeted therapy for oral submucous fibrosis
Mehta, C. H., Paliwal, S., Muttigi, M. S., Seetharam, R. N., Prasad, A. S. B., Nayak, Y., Acharya, S., & Nayak, U. Y. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01212-1 · Cited by 28 · see citing works
Quercetin reduces tendon adhesion in rat through suppression of oxidative stress
Liang, Y., Xu, K., Zhang, P., Zhang, J., Chen, P., He, J., Fang, Y., Zhou, Y., Wang, J., & Bai, J. (2020) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-020-03618-2 · Cited by 27 · see citing works
Schisandrin B regulates macrophage polarization and alleviates liver fibrosis via activation of PPARγ
Chen, Q., Bao, L., Lv, L., Xie, F., Zhou, X., Zhang, H., & Zhang, G. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-4602 · Cited by 27 · see citing works
Wuling capsule modulates macrophage polarization by inhibiting the TLR4-NF-κB signaling pathway to relieve liver fibrosis
Ren, S., Zhou, R., Tang, Z., Song, Z., Li, N., Shi, X., Liu, Y., & Chu, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111598 · Cited by 26 · see citing works
Wild Bitter Melon Extract Regulates LPS-Induced Hepatic Stellate Cell Activation, Inflammation, Endoplasmic Reticulum Stress, and Ferroptosis
Ho, C.-H., Huang, J.-H., Sun, M.-S., Tzeng, I., Hsu, Y., & Kuo, C. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/6671129 · Cited by 26 · see citing works
Neuroprotective Effect of Morin Hydrate against Attention-Deficit/Hyperactivity Disorder (ADHD) Induced by MSG and/or Protein Malnutrition in Rat Pups: Effect on Oxidative/Monoamines/Inflammatory Balance and Apoptosis
Salem, H. A., Elsherbiny, N. M., Alzahrani, S., Alshareef, H. M., Elmageed, Z. Y. A., Ajwah, S. M., Hamdan, A. M., Abdou, Y. S., Galal, O., Azazy, M. K. A.-E. E., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15081012 · Cited by 30 · see citing works
Turmeronol A and turmeronol B from Curcuma longa prevent inflammatory mediator production by lipopolysaccharide-stimulated RAW264.7 macrophages, partially via reduced NF-κB signaling
Okuda-Hanafusa, C., Uchio, R., Fuwa, A., Kawasaki, K., Muroyama, K., Yamamoto, Y., & Murosaki, S. (2019) · Food & Function · doi:10.1039/c9fo00336c · Cited by 26 · see citing works
Alantolactone mitigates renal injury induced by diabetes via inhibition of high glucose-mediated inflammatory response and macrophage infiltration
Zhu, Y., Ling, Y., & Wang, X. (2020) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2020.1725039 · Cited by 26 · see citing works
Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome
Cano-Martı́nez, A., Bautista‐Pérez, R., Castrejón-Téllez, V., Carreón‐Torres, E., Pérez-Torres, I., Díaz‐Díaz, E., Flores‐Estrada, J., Guarner‐Lans, V., & Rubio-Ruiz, M. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168939 · Cited by 25 · see citing works
Dietary calcium regulates the insulin sensitivity by altering the adipokine secretion in high fat diet induced obese rats
Das, S. R., & Choudhuri, D. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117560 · Cited by 25 · see citing works
Effect of Isoquercitrin on Free Fatty Acid-Induced Lipid Accumulation in HepG2 Cells
Kim, S. H., Yun, C., Kwon, D., Lee, Y., Kwak, J., & Jung, Y. (2023) · Molecules · doi:10.3390/molecules28031476 · Cited by 24 · see citing works
Sphingosine Kinase 1 Aggravates Liver Fibrosis by Mediating Macrophage Recruitment and Polarization
Ding, X., Zhang, X., Cao, J., Chen, S., Chen, Y., Yuan, K., Chen, B., Yang, G., Li, S., Yang, J., et al. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.101406 · Cited by 23 · see citing works
Human diet‐derived polyphenolic compounds and hepatic diseases: From therapeutic mechanisms to clinical utilization
Hu, Q., Zhang, W., Wei, F., Huang, M., Shu, M., Song, D., Wen, J., Wang, J.-D., Nian, Q., Ma, X., et al. (2023) · Phytotherapy Research · doi:10.1002/ptr.8043 · Cited by 23 · see citing works
Medicinal Plants As Natural Polarizers of Macrophages: Phytochemicals and Pharmacological Effects
Davoodvandi, A., Sahebnasagh, R., Mardanshah, O., Asemi, Z., Nejati, M., Shahrzad, M. K., Mirzaei, H. R., & Mirzaei, H. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190829154934 · Cited by 24 · see citing works
Quercetin inhibits mitophagy-mediated apoptosis and inflammatory response by targeting the PPARγ/PGC-1α/NF-κB axis to improve acute liver failure
Wu, H., Wu, L., Luo, L., Wu, Y., Zhang, Q., Li, H., & Zhang, B.-F. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113444 · Cited by 22 · see citing works
The Application of Exosomes From Different Sources Loaded with Natural Small-Molecule Compounds in Disease
Zhang, L., Shi, C., Lan, Y., Zhang, X., Ji, X., Li, L., He, X., Tan, Y., Zhao, N., & Lu, C. C. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s542641 · Cited by 26 · see citing works
Self-citation
Selective suppression of M1 macrophages is involved in zinc inhibition of liver fibrosis in mice
Xie, C., Wan, L., Li, C., Feng, Y., & Kang, Y. J. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108802 · Cited by 22 · see citing works
Dihydromyricetin-Encapsulated Liposomes Inhibit Exhaustive Exercise-Induced Liver Inflammation by Orchestrating M1/M2 Macrophage Polarization
Zhou, X., Yi, L., Lang, H., Zhang, J., Zhang, Q., Yu, L., Zhu, J., & Mi, M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.887263 · Cited by 23 · see citing works
Phillygenin Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis: Suppression of Inflammation and Wnt/β-Catenin Signaling Pathway
Wang, C., Liu, Y., Gong, L., Xue, X., Fu, K., Ma, C., & Li, Y. (2023) · Inflammation · doi:10.1007/s10753-023-01826-1 · Cited by 22 · see citing works
Moringa oleifera Improves MAFLD by Inducing Epigenetic Modifications
Monraz-Méndez, C. A., Escutia-Gutiérrez, R., Rodríguez-Sanabria, J. S., Galicia‐Moreno, M., Monroy-Ramírez, H. C., Sánchez-Orozco, L. V., Garcia-Bañuelos, J. J., la Rosa-Bibiano, R. D., Santos, A., Armendáriz‐Borunda, J., et al. (2022) · Nutrients · doi:10.3390/nu14204225 · Cited by 21 · see citing works
The protective effect of quercetin in the alcohol-induced liver and lymphoid tissue injuries in newborns
Ince, E. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-05148-0 · Cited by 21 · see citing works
The Preventive and Therapeutic Potential of the Flavonoids in Liver Cirrhosis: Current and Future Perspectives
Sahu, R., Goswami, S., Sastry, G. N., & Rawal, R. K. (2023) · Chemistry & Biodiversity · doi:10.1002/cbdv.202201029 · Cited by 20 · see citing works
The potential of flavonoids in hepatic fibrosis: A comprehensive review
Wenbo, Z., Jianwei, H., Hua, L., Tang, L., Guijuan, C., & Mengfei, T. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155932 · Cited by 20 · see citing works
The Effect of Quercetin on Non-Alcoholic Fatty Liver Disease (NAFLD) and the Role of Beclin1, P62, and LC3: An Experimental Study
Katsaros, I., Sotiropoulou, M. G., Vailas, M. G., Papachristou, F., Papakyriakopoulou, P., Grigoriou, M. E., Kostomitsopoulos, N. G., Giatromanolaki, A. N., Valsami, G. N., Tsaroucha, A. K., et al. (2024) · Nutrients · doi:10.3390/nu16244282 · Cited by 19 · see citing works
Pathological and immunological characterization of bluetongue virus serotype 1 infection in type I interferons blocked immunocompetent adult mice
Saminathan, M., Singh, K. P., Maity, M., Vineetha, S., Manjunathareddy, G. B., Dhama, K., Malik, Y. S., Ramakrishnan, M. A., Misri, J., & Gupta, V. K. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.01.007 · Cited by 19 · see citing works
The combination of Lonicerae Japonicae Flos and Forsythiae Fructus herb-pair alleviated inflammation in liver fibrosis
Zhang, J.-B., Jin, H., Feng, X., Feng, S., Zhu, W., Nan, H.-M., & Yuan, Z. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.984611 · Cited by 19 · see citing works
A review of edible plant-derived natural compounds for the therapy of liver fibrosis
Xu, W., Wang, L., Niu, Y., Mao, L., Du, X., Zhang, P., Li, Z., Li, H., & Li, N. (2022) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002483 · Cited by 19 · see citing works
Maternal quercetin intake during lactation attenuates renal inflammation and modulates autophagy flux in high-fructose-diet-fed female rat offspring exposed to maternal malnutrition
Sato, S., Norikura, T., & Mukai, Y. (2019) · Food & Function · doi:10.1039/c9fo01134j · Cited by 19 · see citing works
Quercetin confers protection of murine sepsis by inducing macrophage M2 polarization via the TRPM2 dependent calcium influx and AMPK/ATF3 activation
Zhu, Y., Fan, S., Lu, Y., Yan, W., Tang, J., Yang, Y., Li, F., Chen, Q., Zheng, J., & Liu, X. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.03.001 · Cited by 19 · see citing works
Quercetin Reduces Hepatic Fibrogenesis by Inhibiting TGF-β/Smad3 Signaling Pathway in LX-2 Cell Line
Shakerian, E., Akbari, R., Mohammadtaghvaei, N., Gahrooie, M. M., & Afarin, R. (2021) · Jundishapur Journal of Natural Pharmaceutical Products · doi:10.5812/jjnpp.113484 · Cited by 17 · see citing works
Research progress on antitumor effects of sea buckthorn, a traditional Chinese medicine homologous to food and medicine
Xu, D., Yuan, L., Meng, F., Lu, D., Che, M., Yang, Y., Liu, W., & Nan, Y. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1430768 · Cited by 17 · see citing works
Development of Poly(lipoic acid) Nanoparticles with Improved Oral Bioavailability and Hepatoprotective Effects of Quercetin
Banik, S., Yamada, K., Sato, H., & Onoue, S. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00009 · Cited by 17 · see citing works
Investigating the Molecular Mechanism of Quercetin Protecting against Podocyte Injury to Attenuate Diabetic Nephropathy through Network Pharmacology, MicroarrayData Analysis, and Molecular Docking
Ma, X., Hao, C., Yu, M., Zhang, Z., Huang, J., & Yang, W. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/7291434 · Cited by 16 · see citing works
Effects of Micellar Quercetin Supplementation on Growth Performance, Nutrient Digestibility, Fecal Microbiota, Meat Quality, and Physiological Status in Broiler Chickens
Ahammad, G. S., & Kim, I. H. (2024) · Animals · doi:10.3390/ani14131918 · Cited by 16 · see citing works
Mechanism of action of quercetin in regulating cellular autophagy in multiple organs of Goto-Kakizaki rats through the PI3K/Akt/mTOR pathway
Guo, Z., Zhang, J., Li, M., Xing, Z., Li, X., Qing, J., Zhang, Y., Zhu, L., Qi, M., & Zou, X. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1442071 · Cited by 15 · see citing works
Self-citation
Combined quercetin and simvastatin attenuate hepatic fibrosis in rats by modulating SphK1/NLRP3 pathways
Salama, Y., Hassan, H. M., El-Gayar, A. M., & Abdel‐Rahman, N. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122349 · Cited by 15 · see citing works
Recent Progress in Nano-TCM Active Ingredient Co-Delivery Systems for Inflammation-Mediated Diseases
Sun, C., Chen, J., Bai, S., Liao, W., Chen, J., Guo, W., Zeng, L., & Yu, L. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s526731 · Cited by 14 · see citing works
Flavonoids as modulators of gut-liver axis: emerging therapeutic strategies for MAFLD
Hao, M., Wang, Z., Wang, L., Yimamu, A., Su, X., Zhang, M., Li, X., Zhang, Q., & Sun, Z. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1657751 · Cited by 15 · see citing works
Self-citation
Mechanisms of Xiaochaihu Decoction on Treating Hepatic Fibrosis Explored by Network Pharmacology
Qiang, R., Zhang, Y., & Wang, Y. (2022) · Disease Markers · doi:10.1155/2022/8925637 · Cited by 14 · see citing works
Legumain‐Guided Ferulate‐Peptide Self‐Assembly Enhances Macrophage‐Endotheliocyte Partnership to Promote Therapeutic Angiogenesis After Myocardial Infarction
Xu, D., Bi, S., Li, J., Ma, S., Yu, Z., Wang, Y., Chen, H.-M., Zhan, J., Song, X., & Cai, Y. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202402056 · Cited by 14 · see citing works
Quercetin-Loaded Melanin Nanoparticles Decorated with Collagenase Mediates Synergistic Immunomodulation and Restores Extracellular Matrix Homeostasis in Liver Fibrosis
Li, T., Fu, W., Li, X., Huo, Y., Ji, H., Liang, T., & Zhang, R. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c15494 · Cited by 14 · see citing works
Self-citation
Herbal medicines for the liver: from bench to bedside
Vargas-Pozada, E. E., & Muriel, P. (2019) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000001485 · Cited by 14 · see citing works
Oxyberberine suppressed the carbon tetrachloride-induced liver fibrosis by inhibiting liver inflammation in a sirtuin 3-dependent manner in mice
Zhao, S., Li, J., Xing, X., Chen, J., Zhou, Q., & Sun, J. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109876 · Cited by 13 · see citing works
Ziziphus spina-christi L. extract attenuates bleomycin-induced lung fibrosis in mice via regulating TGF-β1/SMAD pathway: LC-MS/MS Metabolic profiling, chemical composition, and histology studies
Elhady, S. S., Goda, M. S., Mehanna, E. T., El-Sayed, N. M., Hazem, R. M., Elfaky, M. A., Almalki, A. J., Mohamed, M. S., & Abdelhameed, R. F. A. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116823 · Cited by 13 · see citing works
Advancements in Plant-Based Therapeutics for Hepatic Fibrosis: Molecular Mechanisms and Nanoparticulate Drug Delivery Systems
Ciceu, A., Fenyvesi, F., Hermenean, A. O., Ardelean, S., Dumitra, S., & Puticiu, M. I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179346 · Cited by 13 · see citing works
Use quercetin for pulmonary fibrosis: a preclinical systematic review and meta-analysis
Wu, X., Xiao, X., Su, Y., Zhang, Y., Li, G., Wang, F., Du, Q., & Yang, H. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01678-1 · Cited by 13 · see citing works
Protective effect of quercetin on weight drop injury model-induced neuroinflammation alterations in brain of mice
Kom, H., Nageshwar, M., Srilatha, K., & Karnati, P. R. (2019) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2019.90412 · Cited by 15 · see citing works
Characterization and gastroprotective effects of Rosa brunonii Lindl. fruit on gastric mucosal injury in experimental rats – A preliminary study
Ahmad, E., Jahangeer, M., Akhtar, Z. M., Aziz, T. A., Alharbi, M., Alshammari, A., Alasmari, A. F., & Bukhari, N. I. (2023) · Acta Biochimica Polonica · doi:10.18388/abp.2020_6772 · Cited by 12 · see citing works
Lead compounds with the potentials for the treatment of chronic liver diseases
Ezhilarasan, D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817890-4.00012-3 · Cited by 12 · see citing works
Quercetin Nanocrystals Prepared by A Novel Technique Improve The Dissolution Rate and Antifibrotic Activity of Quercetin
Cheshmehnoor, P., Rabbani, S., & Haeri, A. (2023) · Nanomedicine · doi:10.2217/nnm-2022-0032 · Cited by 12 · see citing works
Gossypetin Prevents the Progression of Nonalcoholic Steatohepatitis by Regulating Oxidative Stress and AMP-Activated Protein Kinase
Oh, E.-J., Lee, J., Cho, S., Kim, S. W., Jo, K. W., Shin, W., Gwak, S. H., Ha, J., Jeon, S. Y., Park, J.-H., et al. (2023) · Molecular Pharmacology · doi:10.1124/molpharm.123.000675 · Cited by 12 · see citing works
A review of Phyllanthus urinaria L. in the treatment of liver disease: viral hepatitis, liver fibrosis/cirrhosis and hepatocellular carcinoma
Liu, L., Wang, B., Ma, Y., Sun, K., Wang, P., Li, M., Dong, J., Qin, M., Li, M., Wei, C., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1443667 · Cited by 11 · see citing works
A Genetically Engineered Biomimetic Nanodecoy for the Treatment of Liver Fibrosis
Du, Y., Ding, H., Chen, Y., Gao, B., Mao, Z., Wang, W., & Ding, Y. (2024) · Advanced Science · doi:10.1002/advs.202405026 · Cited by 11 · see citing works
The NF-κB signalling pathway and TM7SF3 contribute to liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis
Wu, Y., He, Q., Shang, M., Yin, Y.-X., Li, Y., Du, X., & Li, X.-R. (2021) · Parasites & Vectors · doi:10.1186/s13071-021-04663-z · Cited by 11 · see citing works
Self-citation
Quercetin ameliorates acute lung injury in a rat model of hepatopulmonary syndrome
Nassef, N. A., Hamid, M. S. A.-E., Abusikkien, S. A., & Ahmed, A. I. (2022) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-022-03785-w · Cited by 11 · see citing works
Mechanistic Insights into the Regio‐ and Stereoselectivities of Testosterone and Dihydrotestosterone Hydroxylation Catalyzed by CYP3A4 and CYP19A1
Li, J., Tang, Y., Li, W., & Tu, Y. (2020) · Chemistry - A European Journal · doi:10.1002/chem.201905272 · Cited by 11 · see citing works
Macrophage-tregs crosstalk: the “hub” of the immune network in MASLD
Zhao, H., Wang, W., Zhu, P., & Shi, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1680878 · Cited by 10 · see citing works
Mechanisms of main components in Curcuma longa L. on hepatic fibrosis based on network pharmacology and molecular docking: A review
Han, Q., Zhu, J., & Zhang, P. (2023) · Medicine · doi:10.1097/md.0000000000034353 · Cited by 10 · see citing works
Thymoquinone and quercetin protect against hepatic steatosis in association with SIRT1/AMPK stimulation and regulation of autophagy, perilipin-2, and cytosolic lipases
Ashour, H., Rashed, L. A., Hassanein, R. T. M., Aboulhoda, B. E., Ebrahim, H. A., Elsayed, M. H., Elkordy, M. A., & Abdelwahed, O. M. (2022) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2022.2134423 · Cited by 9 · see citing works
Insight into the Regulation of Nrf2/Keap 1 Pathway by Flavonoids as an Approach for Treatment of Liver Diseases: A Review
Sharma, R., Majee, C., Mazumder, R., Padhi, S., Khan, F., & Pal, R. S. (2024) · Indian Journal of Pharmaceutical Education and Research · doi:10.5530/ijper.58.1s.4 · Cited by 9 · see citing works
Arctium lappa L. polysaccharides enhanced the therapeutic effects of nasal ectomesenchymal stem cells against liver fibrosis by inhibiting the Wnt/β-catenin pathway
Xiang, W., Yin, G., Liu, H., Wei, J., Yu, X., Xie, Y., Zhang, L., XueTang, Jiang, W., & Lu, N. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129670 · Cited by 9 · see citing works

Quercetin Promotes the M1-to-M2 Macrophage Phenotypic Switch During Liver Fibrosis Treatment by Modulating the JAK2/STAT3 Signaling Pathway
Sun, D., Zhou, X., Wu, T., Li, Z., Huang, S., & Peng, Z. (2026) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/0115748928318948240920044716 · Cited by 13 · see citing works
Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-κB signaling pathways
Li, X., Jin, Q., Yao, Q., Xu, B., Li, Z., & Tu, C. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2016.09.002 · Cited by 75 · see citing works
Self-citation
Quercetin-driven M2 polarization of macrophages via ALOX5 inhibition in kupffer cells: A strategy for mouse liver fibrosis treatment
Chen, C., Cui, D., Yang, S., Yuan, W., & Yang, L. (2026) · Gene · doi:10.1016/j.gene.2026.150143 · Cited by 1 · see citing works
Inhibitory effects of quercetin on the progression of liver fibrosis through the regulation of NF-кB/IкBα, p38 MAPK, and Bcl-2/Bax signaling
Wang, R., Zhang, H., Wang, Y., Song, F., & Yuan, Y. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.03.029 · Cited by 145 · see citing works
Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro‐fibrogenic/anti‐fibrogenic molecules balance
Hernández‐Ortega, L. D., Alcántar‐Díaz, B. E., Ruiz-Corro, L., Sandoval-Rodriguez, A. S., Bueno‐Topete, M. R., Armendáriz‐Borunda, J., & Salazar-Montes, A. M. (2012) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2012.07262.x · Cited by 106 · see citing works

Authors: Li, X., Jin, Q., Yao, Q., Xu, B., Li, L., Zhang, S., & Tu, C.
Affiliations: Fudan University (CN)
Corresponding author: Zhang, Shuncai
Tu, Chuantao
ORCID: Li, Xi
Yao, Qunyan
Xu, Beili
Li, Lixin
Zhang, Shuncai
Tu, Chuantao
Venue: Frontiers in Pharmacology
Publisher: Frontiers Media SA
Published: 2018-02-09
Volume: 9
Pages: 72-72
ISSN: 1663-9812 (ISSN-L)
DOI: 10.3389/fphar.2018.00072
PMC: PMC5819566
OpenAlex: W2793967975
Cited by: 171
References: 43
Citations by year: 2026: 16 · 2025: 21 · 2024: 24 · 2023: 23 · 2022: 19 · 2021: 26 · 2020: 25 · 2019: 14 · 2018: 2
FWCI: 10.50
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Frontiers in Pharmacology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (81170398)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
Keywords: quercetin, liver fibrosis, liver inflammation, hepatic macrophages, M1 macrophage polarization, Notch1 signaling, hepatic stellate cell activation, carbon tetrachloride-induced liver injury, antifibrotic therapy, chronic liver disease, inflammatory cytokines, nitric oxide synthase 2, macrophage infiltration, flavonoids

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The Flavonoid Quercetin Ameliorates Liver Inflammation and Fibrosis by Regulating Hepatic Macrophages Activation and Polarization in Mice

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