Receptor-independent actions of PPAR thiazolidinedione agonists: Is mitochondrial function the key?

Feinstein, D.L., Spagnolo, A., Akar, C., Weinberg, G., Murphy, P., Gavrilyuk, V., Russo, C. Dello·2005·Biochemical Pharmacology

Cited by (278)

Items 101–200 of 278

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  2. Deuterium‐Stabilized (R)‐Pioglitazone (PXL065) Is Responsible for Pioglitazone Efficacy in NASH yet Exhibits Little to No PPARγ Activity
    Vincent Jacques, Sébastien Bolze, Sophie Hallakou‐Bozec, Anthony W. Czarnik, Ajit S. Divakaruni, Pascale Fouqueray, Anne N. Murphy, Lex H.T. Van der Ploeg, Sheila Hobbs DeWitt · 2021 · Hepatology Communications
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  4. Nutrient-Deprivation Autophagy Factor-1 (NAF-1): Biochemical Properties of a Novel Cellular Target for Anti-Diabetic Drugs
    Sagi Tamir, John A. Zuris, Lily Agranat-Tamir, Colin H. Lipper, Andrea R. Conlan, Dorit Michaeli, Yael Harir, Mark L. Paddock, Ron Mittler, Zvi Ioav Cabantchik et al. · 2013 · PLoS ONE
  5. The potential of antidiabetic thiazolidinediones for anticancer therapy
    Andrea Galli, Tommaso Mello, Elisabetta Ceni, Elisabetta Surrenti, C. Surrenti · 2006 · Expert Opinion on Investigational Drugs
  6. Mitochondrial dysfunction and delayed hepatotoxicity: another lesson from troglitazone
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  7. Pioglitazone Inhibits the Development of Hyperalgesia and Sensitization of Spinal Nociresponsive Neurons in Type 2 Diabetes
    Ryan B. Griggs, Renée R. Donahue, Braxton G. Adkins, Katie L. Anderson, Olivier Thibault, Bradley Kenneth Taylor · 2015 · Journal of Pain
  8. Glitazones Induce Astroglioma Cell Death by Releasing Reactive Oxygen Species from Mitochondria: Modulation of Cytotoxicity by Nitric Oxide
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  9. The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells
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  10. New Mechanism of Rosiglitazone to Reduce Neointimal Hyperplasia
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  11. Activation of Peroxisome Proliferator-Activated Receptor-γ Decreases Pancreatic Cancer Cell Invasion through Modulation of the Plasminogen Activator System
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  12. Peroxisome Proliferator-Activated Receptor γ Agonists Accelerate Oligodendrocyte Maturation and Influence Mitochondrial Functions and Oscillatory Ca2+Waves
    Chiara De Nuccio, Antonietta Bernardo, Roberta De Simone, Enrico Mancuso, Valerio Magnaghi, Sergio Visentin, Luisa Minghetti · 2011 · Journal of Neuropathology & Experimental Neurology
  13. An Insulin-Sensitizing Thiazolidinedione, Which Minimally Activates PPARγ, Does Not Cause Bone Loss
    Tomohiro Fukunaga, Wei Zou, Nidhi Rohatgi, Jerry R. Colca, Steven L. Teitelbaum · 2014 · Journal of Bone and Mineral Research
  14. Troglitazone, a peroxisome proliferator‐activated receptor‐γ agonist, decreases tau phosphorylation in CHOtau4R cells
    Cristina d’Abramo, Roberta Ricciarelli, Maria Adelaide Pronzato, Peter Davies · 2006 · Journal of Neurochemistry
  15. A Novel MitoNEET Ligand, TT01001, Improves Diabetes and Ameliorates Mitochondrial Function in db/db Mice
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  16. PPAR-γ activation enhances myelination and neurological recovery in premature rabbits with intraventricular hemorrhage
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  17. Mitochondria, PPARs, and Cancer: Is Receptor‐Independent Action of PPAR Agonists a Key?
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  18. Rosiglitazone Affects Nitric Oxide Synthases and Improves Renal Outcome in a Rat Model of Severe Ischemia/Reperfusion Injury
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  19. Rosiglitazone reduces tau phosphorylation via JNK inhibition in the hippocampus of rats with type 2 diabetes and tau transfected SH-SY5Y cells
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  20. Glutaminolysis and glycolysis regulation by troglitazone in breast cancer cells: Relationship to mitochondrial membrane potential
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  21. Chemical Proteomics-Based Analysis of Off-Target Binding Profiles for Rosiglitazone and Pioglitazone: Clues for Assessing Potential for Cardiotoxicity
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  23. Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor
    Delphine Gras, Pascal Chanez, Valérie Urbach, Isabelle Vachier, Philippe Godard, Caroline Bonnans · 2009 · American Journal of Physiology-Lung Cellular and Molecular Physiology
  24. Heme oxygenase-1 induction by rosiglitazone via PKCα/AMPKα/p38 MAPKα/SIRT1/PPARγ pathway suppresses lipopolysaccharide-mediated pulmonary inflammation
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  25. Insulin Sensitizing Pharmacology of Thiazolidinediones Correlates with Mitochondrial Gene Expression rather than Activation of PPARγ
    Charles W. Bolten, Patrick M. Blanner, William G. McDonald, Nicholas R. Staten, Richard A. Mazzarella, Graciela B. Arhancet, Martin F. Meier, David J. Weiss, Patrick M. Sullivan, Alexander E. Hromockyj et al. · 2007 · Gene Regulation and Systems Biology
  26. Neuroprotective and anti-inflammatory properties of a novel non-thiazolidinedione PPARγ agonist in vitro and in MPTP-treated mice
    Daniele Lecca, Daniel K. Nevin, Giovanna Mulas, M.A. Casu, Andrea Diana, D. Rossi, G. Sacchetti, Anna Rosa Carta · 2015 · Neuroscience
  27. Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis
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  32. Pioglitazone inhibits mitochondrial pyruvate metabolism and glucose production in hepatocytes
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  33. Novel ligands that target the mitochondrial membrane protein mitoNEET
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  36. Rosiglitazone enhances learning, place cell activity, and synaptic plasticity in middle-aged rats
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  37. BNIP3 is essential for mitochondrial bioenergetics during adipocyte remodelling in mice
    Jin Woo Choi, Anna Jo, Min Kim, Ho Seon Park, Sung Soo Chung, Shinae Kang, Kyong Soo Park · 2015 · Diabetologia
  38. Troglitazone and pioglitazone interactions via PPAR-γ-independent and -dependent pathways in regulating physiological responses in renal tubule-derived cell lines
    Francesco Turturro, Robert Oliver, Ellen Friday, Itzhak Nissim, Tomas Welbourne · 2006 · American Journal of Physiology-Cell Physiology
  39. Rosiglitazone Prevents Amyloid-β Oligomer-Induced Impairment of Synapse Formation and Plasticity via Increasing Dendrite and Spine Mitochondrial Number
    Shujun Xu, Liu Guilan, Xiaoming Bao, Jie Wu, Shaomin Li, Bangxu Zheng, Roger Anwyl, Qinwen Wang · 2014 · Journal of Alzheimer s Disease
  40. Neuroprotective mechanisms of peroxisome proliferator-activated receptor agonists in Alzheimer’s disease
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  41. 15‐Deoxy‐Δ12,14‐prostaglandin J2 (15d‐ PGJ 2) protects neurons from oxidative death via an Nrf2 astrocyte‐specific mechanism independent of PPAR γ
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  42. PEROXISOME PROLIFERATOR‐ACTIVATED RECEPTOR γ‐INDEPENDENT EFFECTS OF THIAZOLIDINEDIONES ON HUMAN CARDIAC MYOFIBROBLAST FUNCTION
    Romana S. Mughal, Philip Warburton, David John O'Regan, Stephen G. Ball, Neil A. Turner, Karen E. Porter · 2008 · Clinical and Experimental Pharmacology and Physiology
  43. Troglitazone, a thiazolidinedione, decreases tau phosphorylation through the inhibition of cyclin‐dependent kinase 5 activity in SH‐SY5Y neuroblastoma cells and primary neurons
    Du‐Hyong Cho, Eun Joo Lee, Kyoung Ja Kwon, Chan Young Shin, Kee‐Ho Song, Jung‐Hyun Park, Inho Jo, Seol‐Heui Han · 2013 · Journal of Neurochemistry
  44. Acute Mitochondrial Actions of Glitazones on the Liver: a Crucial Parameter for their Antidiabetic Properties
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  45. Antinociceptive and antidiarrheal effects of pioglitazone in a rat model of diarrhoea‐predominant irritable bowel syndrome: Role of nitric oxide
    Pedram Paragomi, Reza Rahimian, Mohammad Hossein Kazemi, Mohammad Hadi Gharedaghi, Amin Khalifeh‐Soltani, Saeedeh Azary, Abbas Norouzi‐Javidan, Kamran Moradi, Stephen Sakuma, Ahmad Reza Dehpour · 2013 · Clinical and Experimental Pharmacology and Physiology
  46. The Role of PPAR‐γ and Its Interaction with COX‐2 in Pancreatic Cancer
    Guido Eibl · 2008 · PPAR Research
  47. Drug-induced mitochondrial dysfunction in cardiac and skeletal muscle injury
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  48. 15‐deoxy‐Δ12,14‐prostaglandin J2 (15d‐PGJ2) and ciglitazone modulate Staphylococcus aureus‐dependent astrocyte activation primarily through a PPAR‐γ‐independent pathway
    Nirmal K. Phulwani, Douglas L. Feinstein, Vitaliy Gavrilyuk, Candan A Akar, Tammy Kielian · 2006 · Journal of Neurochemistry
  49. Thiazolidinediones: novel treatments for cognitive deficits in mood disorders?
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  50. A rapid, PPAR-γ-dependent effect of pioglitazone on the phosphorylation of MYPT
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  51. Curcumin protects neurons against oxygen‐glucose deprivation/reoxygenation‐induced injury through activation of peroxisome proliferator‐activated receptor‐γ function
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  52. Tesaglitazar, a PPARα/γ Agonist, Induces Interstitial Mesenchymal Cell DNA Synthesis and Fibrosarcomas in Subcutaneous Tissues in Rats
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  53. Pioglitazone-induced AMPK-Glutaminase-1 prevents high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system
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  54. Mitochondrial target of thiazolidinediones
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  55. CISD2 plays a role in age-related diseases and cancer
    Hai-Yang Liao, Bei Liao, Haihong Zhang · 2021 · Biomedicine & Pharmacotherapy
  56. Peroxisome proliferator-activated receptor-γ ligands as investigational modulators of angiogenesis
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  57. Neuroprotective Properties of a Novel Non-Thiazoledinedione Partial PPAR-γAgonist against MPTP
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  58. PPAR-γ signaling pathway in placental development and function: A potential therapeutic target in the treatment of gestational diseases
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