ABINs: A20 binding inhibitors of NF-κB and apoptosis signaling

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A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

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Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

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Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice

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Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase

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The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

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A physical and functional map of the human TNF-α/NF-κB signal transduction pathway

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Nuclear factor-?B: its role in health and disease

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A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells

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New insights into the genetic etiology of Alzheimer’s disease and related dementias

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Crosstalk in NF-κB Signaling Pathways

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Neuroinflammation in Alzheimer disease

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Deubiquitinases in cancer: new functions and therapeutic options

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NF-κB in inflammation and renal diseases

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Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis

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Regulation of nuclear factor-κB in autoimmunity

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Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF‐κB regulation

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Oncogenic miR-210-3p promotes prostate cancer cell EMT and bone metastasis via NF-κB signaling pathway

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TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer

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Expression, biological activities and mechanisms of action of A20 (TNFAIP3)

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A20 inhibits LUBAC‐mediated NF‐κB activation by binding linear polyubiquitin chains via its zinc finger 7

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New Insights in the Immunologic Basis of Psoriasis

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Inhibitory feedback control of NF-κB signalling in health and disease

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Risk for myasthenia gravis maps to a 151 Pro→Ala change in TNIP1 and to human leukocyte antigen‐B*08

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Emerging Roles for Noncanonical NF-κB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology

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Transcriptomic signatures of attachment, NF-κB suppression and IFN stimulation in the catfish gill following columnaris bacterial infection

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IκB kinase regulation of the TPL‐2/ERK MAPK pathway

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Genetics of SLE: evidence from mouse models

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Protective effect of tetrahydrocoptisine against ethanol-induced gastric ulcer in mice

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A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease

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Genetic relationships betweenA20/TNFAIP3, chronic inflammation and autoimmune disease

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Limonin ameliorates acetaminophen-induced hepatotoxicity by activating Nrf2 antioxidative pathway and inhibiting NF-κB inflammatory response via upregulating Sirt1

Yang, R., Song, C., Chen, J., Zhou, L., Jiang, X., Cao, X., Sun, Y., & Zhang, Q. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153211 · Cited by 111

Oncogenetic landscape of lymphomagenesis in coeliac disease

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Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6

Jung, S. M., Lee, J.-H., Park, J., Oh, Y. S., Lee, S. K., Park, J. S., Lee, J. Y., Kim, J. H., Lee, J. Y., Bae, Y., et al. (2013) · Nature Communications · doi:10.1038/ncomms3562 · Cited by 104

Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease

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TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation

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miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops

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ABIN1 Protein Cooperates with TAX1BP1 and A20 Proteins to Inhibit Antiviral Signaling

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Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis

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Cot/tpl2 activity is required for TLR‐induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression

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Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study

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Negative regulation of NF-κB and its involvement in rheumatoid arthritis

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ABIN1 Dysfunction as a Genetic Basis for Lupus Nephritis

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Icariin alleviates murine lupus nephritis via inhibiting NF-κB activation pathway and NLRP3 inflammasome

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The paracaspase MALT1 mediates CARD14‐induced signaling in keratinocytes

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Genetics of human lupus nephritis

Iwamoto, T., & Niewold, T. B. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.09.012 · Cited by 75

Linear ubiquitination signals in adaptive immune responses

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Mantle cell lymphoma in the era of precision medicine-diagnosis, biomarkers and therapeutic agents

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The red coral (Corallium rubrum) transcriptome: a new resource for population genetics and local adaptation studies

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Regulation of TNF-induced NF-κB activation by different cytoplasmic ubiquitination events

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TAX1BP1, a ubiquitin-binding adaptor protein in innate immunity and beyond

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Coordinate Regulation of TPL-2 and NF-κB Signaling in Macrophages by NF-κB1 p105

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Regulation of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κβ) in Inflammatory Bowel Diseases

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Emerging roles for TNIP1 in regulating post-receptor signaling

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A20 , ABIN-1/2 , and CARD11 Mutations and Their Prognostic Value in Gastrointestinal Diffuse Large B-Cell Lymphoma

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Genetics of susceptibility and treatment response in psoriatic arthritis

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Genetic, Epigenetic and Pharmacogenetic Aspects of Psoriasis and Psoriatic Arthritis

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Transcriptome analysis illuminates the nature of the intracellular interaction in a vertebrate-algal symbiosis

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Review: A20‐Binding Inhibitor of NF‐κB Activation 1 Is a Physiologic Inhibitor of NF‐κB: A Molecular Switch for Inflammation and Autoimmunity

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Thymoquinone inhibits growth of human medulloblastoma cells by inducing oxidative stress and caspase-dependent apoptosis while suppressing NF-κB signaling and IL-8 expression

Ashour, A. E., Ahmed, A. F., Kumar, A., Zoheir, K. M. A., Aboul‐Soud, M. A. M., Ahmad, S. F., Attia, S. M., Abd‐Allah, A. R. A., Cheriyan, V. T., & Rishi, A. K. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2703-4 · Cited by 54

A20 inactivation in ocular adnexal MALT lymphoma

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Psoriatic Arthritis: An Update

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Activation of an immune-regulatory macrophage response and inhibition of lung inflammation in a mouse model of COPD using heat-shock protein alpha B-crystallin-loaded PLGA microparticles

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Genetics of psoriatic arthritis

O’Rielly, D. D., & Rahman, P. (2014) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2014.10.010 · Cited by 48

A20 Regulation of Nuclear Factor–κB

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Alpha-B-Crystallin Induces an Immune-Regulatory and Antiviral Microglial Response in Preactive Multiple Sclerosis Lesions

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Liquiritin protects PC12 cells from corticosterone-induced neurotoxicity via regulation of metabolic disorders, attenuation ERK1/2-NF-κB pathway, activation Nrf2-Keap1 pathway, and inhibition mitochondrial apoptosis pathway

Xiao, L., Qin, X., Tian, J., Gao, X., Wu, X., Du, G., & Zhou, Y. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111801 · Cited by 40

Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells

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TNIP1 Regulates Cutibacterium acnes-Induced Innate Immune Functions in Epidermal Keratinocytes

Erdei, L., Bolla, B. S., Bozó, R., Tax, G., Urbán, E. Z., Kemény, L. V., & Szabó, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02155 · Cited by 40

Regulation of Toll-Like Receptors-Mediated Inflammation by Immunobiotics in Bovine Intestinal Epitheliocytes: Role of Signaling Pathways and Negative Regulators

Villena, J., Aso, H., & Kitazawa, H. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00421 · Cited by 40

Sex-specific variation in signaling pathways and gene expression patterns in human leukocytes in response to endotoxin and exercise

Abbasi, A., Vieira, R. P., Bischof, F., Walter, M. J., Movassaghi, M., Berchtold, N. C., Niess, A. M., Cotman, C. W., & Northoff, H. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0758-5 · Cited by 40

TNF Tolerance in Monocytes and Macrophages: Characteristics and Molecular Mechanisms

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Downregulation of TNIP1 Expression Leads to Increased Proliferation of Human Keratinocytes and Severer Psoriasis-Like Conditions in an Imiquimod-Induced Mouse Model of Dermatitis

Chen, Y., Yan, H., Song, Z., Chen, F., Wang, H., Niu, J., Shi, X., Zhang, D., Zhang, N., Zhai, Z., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127957 · Cited by 37

Novel molecular changes induced by Nrg1 hypomorphism and Nrg1-cannabinoid interaction in adolescence: a hippocampal proteomic study in mice

Spencer, J. R., Darbyshire, K. M. E., Boucher, A. A., Kashem, M. A., Long, L. E., McGregor, I. S., Karl, T., & Arnold, J. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00015 · Cited by 35

“Without Ub I am nothing”: NEMO as a multifunctional player in ubiquitin-mediated control of NF-κB activation

Gautheron, J., & Courtois, G. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0404-9 · Cited by 35

TNIP1, a Retinoic Acid Receptor Corepressor and A20-binding Inhibitor of NF-κB, Distributes to Both Nuclear and Cytoplasmic Locations

Gurevich, I., Zhang, C., Francis, N., & Aneskievich, B. J. (2011) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155411427728 · Cited by 34

Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκΒ signaling by stabilizing IκBα

Hu, Y., O’Boyle, K. C., Auer, J., Raju, S. M., You, F., Wang, P., Fikrig, E., & Sutton, R. E. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006187 · Cited by 33

TNIP1‐mediated TNF‐α/NF‐κB signalling cascade sustains glioma cell proliferation

Lei, Q., Gu, H., Li, L., Wu, T., Xie, W., Li, M., & Zhao, N. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14760 · Cited by 35

The Functional Role of Prostate Cancer Metastasis-related Micro-RNAs

Weidle, U. H., Epp, A., Birzele, F., & Brinkmann, U. (2018) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20108 · Cited by 32

ABIN-1 negatively regulates NF-κB by inhibiting processing of the p105 precursor

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MiR-1180 promoted the proliferation of hepatocellular carcinoma cells by repressing TNIP2 expression

Zhou, X., Zhu, H., Ma, C., Li, H.-G., Liu, F., Chang, H., & Lu, J. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.02.025 · Cited by 31

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions

Banks, C. A. S., Boanca, G., Lee, Z. T., Kempf, C. G., Hattem, G. L., Peak, A., Weems, L., Conkright, J. J., Florens, L. A., & Washburn, M. P. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m116.060509 · Cited by 32

Loss of CNFY toxin-induced inflammation drives Yersinia pseudotuberculosis into persistency

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Loading of doxorubicin and thymoquinone with F2 gel nanofibers improves the antitumor activity and ameliorates doxorubicin-associated nephrotoxicity

Zidan, A. A., El‐Ashmawy, N. E., Khedr, E. G., Ebeid, E. M., Salem, M. L., & Mosalam, E. M. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.06.008 · Cited by 30

IL-17 Signaling Triggers Degradation of the Constitutive NF-κB Inhibitor ABIN-1

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A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells

Yin, H., Karayel, Ö., Chao, Y.-Y., Seeholzer, T., Hamp, I., Plettenburg, O., Gehring, T., Zielinski, C. E., Mann, M., & Krappmann, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04154-z · Cited by 29

A20-binding Inhibitor of Nuclear Factor-κB (NF-κB)-2 (ABIN-2) Is an Activator of Inhibitor of NF-κB (IκB) Kinase α (IKKα)-mediated NF-κB Transcriptional Activity

Léotoing, L., Chéreau, F., Baron, S., Hubé, F., Valencia, H. J., Bordereaux, D., Demmers, J., Strouboulis, J., & Baud, V. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.236448 · Cited by 28

A TRAF and TNF receptor-associated protein (TTRAP) in mollusk with endonuclease activity

Yang, J., Qiu, L., Wang, L., Huang, M., Wang, L., Zhang, H., & Song, L. (2011) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2011.02.013 · Cited by 25

Modulation of Toll-like receptor-mediated innate immunity in bovine intestinal epithelial cells by lactic acid bacteria isolated from feedlot cattle

Mansilla, F. I., Takagi, M., García-Castillo, V., Aso, H., Nader-Macı́as, M. E., Vignolo, G. M., Kitazawa, H., & Villena, J. (2020) · Beneficial Microbes · doi:10.3920/bm2019.0189 · Cited by 23

Differential gene expression in human tissue resident regulatory T cells from lung, colon, and blood

Niedzielska, M., Israelsson, E., Angermann, B., Sidders, B. S., Clausen, M., Catley, M. C., Malhotra, R., & Dumont, C. (2018) · Oncotarget · doi:10.18632/oncotarget.26322 · Cited by 23

NLRP10 Affects the Stability of Abin-1 To Control Inflammatory Responses

Mirza, N., Sowa, A. S., Lautz, K., & Kufer, T. A. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800334 · Cited by 22

Association of genetic polymorphism of interleukin-17A & interleukin-17F with susceptibility of psoriasis

Kaur, R., Rawat, A. K., Kumar, S., Wani, A., Akhtar, T., Narang, T. K., & Chopra, D. (2018) · The Indian Journal of Medical Research · doi:10.4103/ijmr.ijmr_1859_16 · Cited by 22

TNF receptor–activated factor 2 mediates cardiac protection through noncanonical NF-κB signaling

Evans, S., Tzeng, H.-P., Novack, D. V., Matkovich, S. J., Weinheimer, C. J., Kovács, A., Barger, P. M., & Mann, D. L. (2018) · JCI Insight · doi:10.1172/jci.insight.98278 · Cited by 22

The bacterial pathogen-ubiquitin interface: lessons learned fromShigella

Tanner, K., Brzović, P. S., & Rohde, J. R. (2014) · Cellular Microbiology · doi:10.1111/cmi.12390 · Cited by 22

CARP-1 Functional Mimetics: A Novel Class of Small Molecule Inhibitors of Medulloblastoma Cell Growth

Ashour, A. E., Jamal, S., Cheriyan, V. T., Muthu, M., Zoheir, K. M. A., Alafeefy, A. M., Abd‐Allah, A. R. A., Levi, E., Tarca, A. L., Polin, L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066733 · Cited by 21

Emergence of the A20/ABIN-mediated inhibition of NF-κB signaling via modifying the ubiquitinated proteins in a basal chordate

Yuan, S., Dong, X., Tao, X., Xu, L., Ruan, J., Peng, J., & Xu, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321187111 · Cited by 21

Association between TNIP1, MPHOSPH6 and ZNF208 genetic polymorphisms and the coronary artery disease risk in Chinese Han population

Song, Y., Yan, M., Li, J., Li, J., Jin, T., & Chen, C. (2017) · Oncotarget · doi:10.18632/oncotarget.20432 · Cited by 21

Potential probiotic Lactiplantibacillus plantarum strains alleviate TNF-α by regulating ADAM17 protein and ameliorate gut integrity through tight junction protein expression in in vitro model

Devi, M. B., Bhattacharya, A., Kumar, A., Singh, C. T., Das, S., Sarma, H. K., Mukherjee, A. K., & Khan, M. R. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01900-7 · Cited by 22

The deubiquitinase A20 in immunopathology of autoimmune diseases

Majumdar, I., & Paul, J. (2014) · Autoimmunity · doi:10.3109/08916934.2014.900756 · Cited by 20

Pharmacogenetics and pharmacogenomics in psoriasis treatment: current challenges and future prospects

Sutherland, A. M. S., Power, R. J., Rahman, P., & O’Rielly, D. D. (2016) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2016.1194394 · Cited by 20

CARP-1 Functional Mimetics Are a Novel Class of Small Molecule Inhibitors of Malignant Pleural Mesothelioma Cells

Jamal, S., Cheriyan, V. T., Muthu, M., Munie, S., Levi, E., Ashour, A. E., Pass, H. I., Wali, A., Singh, M. S., & Rishi, A. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089146 · Cited by 19

Linear ubiquitination in NF-κB signaling and inflammation: What we do understand and what we do not

Verhelst, K., Verstrepen, L., Carpentier, I., & Beyaert, R. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.066 · Cited by 19

TNF alpha signaling is associated with therapeutic responsiveness to vascular disrupting agents in endocrine tumors

Hantel, C., Ozimek, A., Lira, R. C. P., Ragazzon, B., Jäckel, C., Frantsev, R. S., Reincke, M., Bertherat, J. Y., Mussack, T., & Beuschlein, F. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.12.009 · Cited by 19

The Role of Pharmacogenetics in Chronic Plaque Psoriasis: Update of the Literature

Talamonti, M., D’Adamio, S., Bianchi, L., & Galluzzo, M. (2017) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-017-0274-z · Cited by 19

TNF phase III signalling in tolerant cells is tightly controlled by A20 and CYLD

Bikker, R., Christmann, M., Preuß, K., Welz, B., Friesenhagen, J., Dittrich‐Breiholz, O., Huber, R., & Brand, K. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.06.009 · Cited by 18

ABIN1 Determines Severity of Glomerulonephritis via Activation of Intrinsic Glomerular Inflammation

Korte, E. A., Caster, D. J., Barati, M. T., Tan, M., Zheng, S., Berthier, C. C., Brosius, F. C., Vieyra, M. B., Sheehan, R. M., Kosiewicz, M. M., et al. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.08.018 · Cited by 19

Activation of Adenosine A2A Receptor Attenuates Inflammatory Response in a Rat Model of Small-for-Size Liver Transplantation

Tang, L., Zhu, J.-F., Wang, F., Qian, J., Zhu, J., Mo, Q., Lu, H., Li, G.-Q., & Wang, X.-H. (2010) · Transplantation Proceedings · doi:10.1016/j.transproceed.2010.02.084 · Cited by 19

Naf1 Regulates HIV-1 Latency by Suppressing Viral Promoter-Driven Gene Expression in Primary CD4 + T Cells

Li, C., Wang, H., Kuang, W.-D., Ren, X., Song, S.-T., Zhu, H.-Z., Li, Q., Xu, L.-R., Guo, H.-J., Wu, L. J., et al. (2016) · Journal of Virology · doi:10.1128/jvi.01830-16 · Cited by 18

Knockdown of NF-κB p65 subunit expression suppresses growth of nude mouse lung tumor cell xenografts by activation of Bax apoptotic pathway

Qu, Y., ZHANG, X., & Wu, R. (2015) · Neoplasma · doi:10.4149/neo_2015_005 · Cited by 18

596 POSTER Complexity of constitutive NF-kappaB activity as a therapeutic target in breast cancer cells

Moiseeva, E. V., Heukers, R., & Manson, M. M. (2006) · European Journal of Cancer Supplements · doi:10.1016/s1359-6349(06)70601-2 · Cited by 1

597 POSTER MDM2 309T>G polymorphism in human sarcomas

Biason, P., Masier, S., Serra, M., Scotlandi, K., Cecchin, E., Sartor, F., Biscontin, G., & Toffoli, G. (2006) · European Journal of Cancer Supplements · doi:10.1016/s1359-6349(06)70602-4

765 An intron 8 polymorphism G/T of NFKB2 gene is associated with NSCLC

Dimitrakopoulos, F.-I. D., Antonacopoulou, A. G., Marousi, S., Kottorou, A. E., Scopa, C., & Kalofonos, H. P. (2010) · European Journal of Cancer Supplements · doi:10.1016/s1359-6349(10)71561-5

F.53. The Receptor for Advanced Glycation End Products (RAGE)Regulates Nuclear Transcription Factor κB (NF-κB) Activation

Tang, D., Kang, R., Loux, T., Cheh, C.-W., Zeh, H. J., & Lotze, M. T. (2009) · Clinical Immunology · doi:10.1016/j.clim.2009.03.316

The Biology of A20-Binding Inhibitors of NF-κB Activation (ABINS)

Verstrepen, L., Carpentier, I., & Beyaert, R. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0398-6_2 · Cited by 44