Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047 · see citing works

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation.

Wang, C.-Y., Mayo, M., Korneluk, R., Goeddel, D., & Baldwin, A. (1998) · Science · doi:10.1126/science.281.5383.1680 · Cited by 2,950 · see citing works

Suppression of TNF-α-Induced Apoptosis by NF-κB

Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581 · see citing works

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

Wang, C.-Y., Mayo, M. W., & Baldwin, A. S. (1996) · Science · doi:10.1126/science.274.5288.784 · Cited by 2,581 · see citing works

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937 · see citing works

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

Sun, S., Ganchi, P. A., Ballard, D. W., & Greene, W. C. (1993) · Science · doi:10.1126/science.8096091 · Cited by 1,108 · see citing works

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.

Rudolph, D., Yeh, W., Wakeham, A. C., Rudolph, B., Nallainathan, D., Potter, J., Elia, A., & Mak, T. W. (2000) · PubMed Central · Cited by 518 · see citing works

Severe liver degeneration and lack of <i>NF</i>-κ<i>B</i> activation in <i>NEMO/IKKγ</i>-deficient mice

Rudolph, D., Yeh, W.-C., Wakeham, A., Rudolph, B., Nallainathan, D., Potter, J., Elia, A. J., & Mak, T. W. (2000) · Genes &amp; Development · doi:10.1101/gad.14.7.854 · Cited by 479 · see citing works

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.Preprint

Beg, A. A., Sha, W. C., Bronson, R. T., & Baltimore, D. (1995) · Genes & Development · doi:10.1101/gad.9.22.2736 · Cited by 473 · see citing works

Recruitment of the IKK Signalosome to the p55 TNF Receptor

Zhang, S. Q., Kovalenko, A., Cantarella, G., & Wallach, D. (2000) · Immunity · doi:10.1016/s1074-7613(00)80183-1 · Cited by 456 · see citing works

The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity.

Opipari, A. W., Hu, H., Yabkowitz, R., & Dixit, V. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42292-2 · Cited by 434 · see citing works

The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein.

Opipari, A. W., Boguski, M. S., & Dixit, V. M. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77165-2 · Cited by 419 · see citing works

The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation.

Song, H. Y., Rothe, M., & Goeddel, D. V. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6721 · Cited by 414 · see citing works

The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN

Heyninck, K., VALCK, D. D., Berghe, W. V., Criekinge, W. V., Contreras, R., Fiers, W., Haegeman, G., & Beyaert, R. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.7.1471 · Cited by 295 · see citing works

A20 Blocks Endothelial Cell Activation through a NF-κB-dependent Mechanism

Cooper, J. T., Stroka, D. M., Brostjan, C., Palmetshofer, A., Bach, F. H., & Ferran, C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.18068 · Cited by 247 · see citing works

A20 zinc finger protein inhibits TNF and IL-1 signaling

Jäättelä, M., Mouritzen, H., Elling, F., & Bastholm, L. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.3.1166 · Cited by 242 · see citing works

Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways.

Wong, G. H., & Goeddel, D. V. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.4.1751 · Cited by 196 · see citing works

Lymphoid expression and regulation of A20, an inhibitor of programmed cell death.

Tewari, M., Wolf, F. W., Seldin, M. F., O'Shea, K. S., Dixit, V. M., & Turka, L. A. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.4.1699 · Cited by 99 · see citing works

Constitutive synthesis of tumor necrosis factor in the thymus.

Giroir, B. P., Brown, T., & Beutler, B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.11.4864 · Cited by 95 · see citing works

Signaling to NF-κB

Hayden, M. S., & Ghosh, S. (2004) · Genes &amp; Development · doi:10.1101/gad.1228704 · Cited by 3,842 · see citing works

The TNF and TNF Receptor Superfamilies

Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650 · see citing works

Tumor necrosis factor signaling

Wajant, H., Pfizenmaier, K., & Scheurich, P. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401189 · Cited by 2,353 · see citing works

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

Yu, H., Lin, L., Zhang, Z., Zhang, H., & Hu, H. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00312-6 · Cited by 2,236 · see citing works

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

Bertheloot, D., Latz, E., & Franklin, B. S. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00630-3 · Cited by 2,198 · see citing works

Breaking the chains: structure and function of the deubiquitinases

Komander, D., Clague, M. J., & Urbé, S. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2731 · Cited by 2,106 · see citing works

NF-κB, Inflammation, and Metabolic Disease

Baker, R. G., Hayden, M. S., & Ghosh, S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2010.12.008 · Cited by 1,952 · see citing works

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

Wertz, I. E., O’Rourke, K. M., Zhou, H., Eby, M. T., Aravind, L., Seshagiri, S., Wu, P., Wiesmann, C., Baker, R. T., Boone, D. L., et al. (2004) · Nature · doi:10.1038/nature02794 · Cited by 1,852 · see citing works

Inflammatory bowel disease

Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806 · see citing works

The immunological and genetic basis of inflammatory bowel disease

Bouma, G., & Strober, W. (2003) · Nature reviews. Immunology · doi:10.1038/nri1132 · Cited by 1,882 · see citing works

Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways

Tedgui, A., & Mallat, Z. (2006) · Physiological Reviews · doi:10.1152/physrev.00024.2005 · Cited by 1,701 · see citing works

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

Nair, R. P., Duffin, K. C., Helms, C. A., Ding, J., Stuart, P. E., Goldgar, D. E., Gudjonsson, J. E., Li, Y., Tejasvi, T., Feng, B., et al. (2009) · Nature Genetics · doi:10.1038/ng.311 · Cited by 1,414 · see citing works

The Immunology of Mucosal Models of Inflammation

Strober, W., Fuss, I. J., & Blumberg, R. S. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064816 · Cited by 1,300 · see citing works

Ubiquitin signalling in the NF-κB pathway

Chen, Z. J. (2005) · Nature Cell Biology · doi:10.1038/ncb0805-758 · Cited by 1,184 · see citing works

Regulation of NF-κB by TNF family cytokines

Hayden, M. S., & Ghosh, S. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.05.004 · Cited by 1,116 · see citing works

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

Boone, D. L., Turer, E. E., Lee, E. G., Ahmad, R., Wheeler, M. T., Tsui, C., Hurley, P. J., Chien, M., Chai, S., Hitotsumatsu, O., et al. (2004) · Nature Immunology · doi:10.1038/ni1110 · Cited by 1,091 · see citing works

Mutations of multiple genes cause deregulation of NF-kB in diffuse large B-cell lymphoma

Compagno, M., Lim, W., Grunn, A., Nandula, S., Brahmachary, M., Shen, Q., Bertoni, F., Ponzoni, M., Scandurra, M., Califano, A., et al. (2009) · Nature · doi:10.1038/nature07968 · Cited by 1,116 · see citing works

Cell death

Newton, K., Strasser, A., Kayagaki, N., & Dixit, V. M. (2024) · Cell · doi:10.1016/j.cell.2023.11.044 · Cited by 1,029 · see citing works

Mechanism and function of deubiquitinating enzymes

Amerik, A. Y., & Hochstrasser, M. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.10.003 · Cited by 978 · see citing works

Death by TNF: a road to inflammation

Loo, G., & Bertrand, M. J. M. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00792-3 · Cited by 977 · see citing works

Nonproteolytic Functions of Ubiquitin in Cell Signaling

Chen, Z. J., & Sun, L. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.01.014 · Cited by 921 · see citing works

Function of Nod‐like receptors in microbial recognition and host defense

Franchi, L., Warner, N. E., Viani, K. L., & Núñez, G. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00734.x · Cited by 900 · see citing works

Breaking the chains: deubiquitylating enzyme specificity begets function

Clague, M. J., Urbé, S., & Komander, D. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0099-1 · Cited by 839 · see citing works

Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway

Riewald, M., Petrovan, R. J., Donner, A. J., Mueller, B. M., & Ruf, W. (2002) · Science · doi:10.1126/science.1071699 · Cited by 832 · see citing works

Single-cell NF-κB dynamics reveal digital activation and analogue information processing

Tay, S., Hughey, J., Lee, T. K., Lipniacki, T., Quake, S. R., & Covert, M. W. (2010) · Nature · doi:10.1038/nature09145 · Cited by 790 · see citing works

Homeostasis and Inflammation in the Intestine

Garrett, W. S., Gordon, J. I., & Glimcher, L. H. (2010) · Cell · doi:10.1016/j.cell.2010.01.023 · Cited by 784 · see citing works

Limiting inflammation—the negative regulation of NF-κB and the NLRP3 inflammasome

Afonina, I. S., Zhong, Z., Karin, M., & Beyaert, R. (2017) · Nature Immunology · doi:10.1038/ni.3772 · Cited by 772 · see citing works

Regulation of cytokine signaling and inflammation

Hanada, T., & Yoshimura, A. (2002) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(02)00026-6 · Cited by 748 · see citing works

Role of TNF-α in vascular dysfunction

Zhang, H., Park, Y., Wu, J., Chen, X. P., Lee, S., Yang, J., Dellsperger, K. C., & Zhang, C. (2009) · Clinical Science · doi:10.1042/cs20080196 · Cited by 683 · see citing works

IκB kinase complexes: gateways to NF-κB activation and transcription

Scheidereit, C. (2006) · Oncogene · doi:10.1038/sj.onc.1209934 · Cited by 652 · see citing works

Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis

Joyce, D. E., Gelbert, L., Ciaccia, A., DeHoff, B., & Grinnell, B. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100017200 · Cited by 649 · see citing works

Activation‐induced cell death in T cells

Green, D. R., Droin, N. M., & Pinkoski, M. J. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00051.x · Cited by 645 · see citing works

Inhibition of NF-κB Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

Shembade, N., Ma, A. I., & Harhaj, E. W. (2010) · Science · doi:10.1126/science.1182364 · Cited by 644 · see citing works

Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease

Zhou, Q., Wang, H., Schwartz, D. M., Stoffels, M., Park, Y. H., Zhang, Y., Yang, D., Demirkaya, E., Takeuchi, M., Tsai, W. L., et al. (2015) · Nature Genetics · doi:10.1038/ng.3459 · Cited by 643 · see citing works

Ubiquitylation in innate and adaptive immunity

Bhoj, V. G., & Chen, Z. J. (2009) · Nature · doi:10.1038/nature07959 · Cited by 639 · see citing works

Transcriptional regulation via the NF-κB signaling module

Hoffmann, A., Natoli, G., & Ghosh, G. (2006) · Oncogene · doi:10.1038/sj.onc.1209933 · Cited by 629 · see citing works

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

Ofengeim, D., & Yuan, J. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3683 · Cited by 615 · see citing works

Lipopolysaccharide signaling in endothelial cells

Dauphinee, S. M., & Karsan, A. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700366 · Cited by 618 · see citing works

NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ

Greten, F. R., Arkan, M. C., Bollrath, J., Hsu, L.-C., Goode, J., Miething, C., Göktuna, S. I., Neuenhahn, M., Fierer, J., Paxian, S., et al. (2007) · Cell · doi:10.1016/j.cell.2007.07.009 · Cited by 616 · see citing works

All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction

Chung, J. Y., Park, Y. C., Ye, H., & Wu, H. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.4.679 · Cited by 613 · see citing works

Functions of NF-κB1 and NF-κB2 in immune cell biology

Beinke, S., & Ley, S. C. (2004) · Biochemical Journal · doi:10.1042/bj20040544 · Cited by 611 · see citing works

NF‐κB signaling in inflammation and cancer

Zhang, T., Ma, C., Zhang, Z., Zhang, H., & Hu, H. (2021) · MedComm · doi:10.1002/mco2.104 · Cited by 615 · see citing works

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

Schuijs, M. J., Willart, M. A., Vergote, K., Gras, D., Deswarte, K., Ege, M. J., Madeira, F. B., Beyaert, R., van Loo, G., Bracher, F., et al. (2015) · Science · doi:10.1126/science.aac6623 · Cited by 576 · see citing works

Nuclear Factor κB Signaling in Atherogenesis

de Winther, M. P. J., Kanters, E., Kraal, G., & Hofker, M. H. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000160340.72641.87 · Cited by 586 · see citing works

Frequent inactivation of A20 in B-cell lymphomas

Kato, M., Sanada, M., Kato, I., Sato, Y., Takita, J., Takeuchi, K., Niwa, A., Chen, Y., Nakazaki, K., Nomoto, J., et al. (2009) · Nature · doi:10.1038/nature07969 · Cited by 553 · see citing works

The Genetics of Inflammatory Bowel Disease

Cho, J. H., & Weaver, C. T. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.032 · Cited by 550 · see citing works

Kinase RIP3 Is Dispensable for Normal NF-κBs, Signaling by the B-Cell and T-Cell Receptors, Tumor Necrosis Factor Receptor 1, and Toll-Like Receptors 2 and 4

Newton, K., Sun, X., & Dixit, V. M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.4.1464-1469.2004 · Cited by 544 · see citing works

A20: linking a complex regulator of ubiquitylation to immunity and human disease

Ma, A. I., & Malynn, B. A. (2012) · Nature reviews. Immunology · doi:10.1038/nri3313 · Cited by 550 · see citing works

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis

Plenge, R. M., Cotsapas, C. J., Davies, L. R. L., Price, A. L., de Bakker, P. I. W., Maller, J., Pe’er, I., Burtt, N. P., Blumenstiel, B. S., DeFelice, M., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.27 · Cited by 550 · see citing works

Information Transduction Capacity of Noisy Biochemical Signaling Networks

Cheong, R., Rhee, A., Wang, C. J., Nemenman, I. M., & Levchenko, A. (2011) · Science · doi:10.1126/science.1204553 · Cited by 524 · see citing works

Interactions Between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease

Abraham, C., & Medzhitov, R. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.012 · Cited by 537 · see citing works

The NF-κB Regulatory Network

Brasier, A. R. (2006) · Cardiovascular Toxicology · doi:10.1385/ct:6:2:111 · Cited by 528 · see citing works

A critical role of RICK/RIP2 polyubiquitination in Nod‐induced NF‐κB activation

Hasegawa, M., Fujimoto, Y., Lucas, P. C., Nakano, H., Fukase, K., Núñez, G., & Inohara, N. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601962 · Cited by 520 · see citing works

Regulation of tissue homeostasis by NF-κB signalling: implications for inflammatory diseases

Pasparakis, M. (2009) · Nature reviews. Immunology · doi:10.1038/nri2655 · Cited by 523 · see citing works

Ubiquitination in the regulation of inflammatory cell death and cancer

Cockram, P. E., Kist, M., Prakash, S., Chen, S., Wertz, I. E., & Vucic, D. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-020-00708-5 · Cited by 519 · see citing works

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

Walle, L., Opdenbosch, N. V., Jacques, P., Fossoul, A., Verheugen, E., Vogel, P., Beyaert, R., Elewaut, D., Kanneganti, T., van Loo, G., et al. (2014) · Nature · doi:10.1038/nature13322 · Cited by 499 · see citing works

Mouse models of inflammatory bowel disease☆

Wirtz, S. J., & Neurath, M. F. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.07.003 · Cited by 508 · see citing works

Stimulus Specificity of Gene Expression Programs Determined by Temporal Control of IKK Activity

Werner, S. L., Barken, D. M., & Hoffmann, A. (2005) · Science · doi:10.1126/science.1113319 · Cited by 506 · see citing works

Tumor Necrosis Factor

Varfolomeev, E. E., & Ashkenazi, A. (2004) · Cell · doi:10.1016/s0092-8674(04)00166-7 · Cited by 498 · see citing works

A20 in inflammation and autoimmunity

Catrysse, L., Vereecke, L., Beyaert, R., & Loo, G. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.10.005 · Cited by 494 · see citing works

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

Vereecke, L., Beyaert, R., & Loo, G. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.05.007 · Cited by 482 · see citing works

The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules

Hao, S., & Baltimore, D. (2009) · Nature Immunology · doi:10.1038/ni.1699 · Cited by 480 · see citing works

TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma

Schmitz, R., Hansmann, M., Bohle, V., Martín-Subero, J. I., Hartmann, S., Mechtersheimer, G., Klapper, W., Vater, I., Giefing, M., Gesk, S., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090528 · Cited by 480 · see citing works

Structural identifiability of systems biology models: a critical comparison of methods

Chis, O.-T., Banga, J. R., & Balsa-Canto, E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027755 · Cited by 448 · see citing works

TRAF6 and A20 Regulate Lysine 63–Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy

Shi, C.-S., & Kehrl, J. H. (2010) · Science Signaling · doi:10.1126/scisignal.2000751 · Cited by 472 · see citing works

The Role of Ubiquitin in NF-κB Regulatory Pathways

Skaug, B. A., Jiang, X., & Chen, Z. J. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.070907.102750 · Cited by 471 · see citing works

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

Musone, S. L., Taylor, K. E., Lu, T. T., Nititham, J., Ferreira, R. C., Ortmann, W. A., Shifrin, N. T., Petri, M., Kamboh, M. I., Manzi, S., et al. (2008) · Nature Genetics · doi:10.1038/ng.202 · Cited by 470 · see citing works

Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota

Elson, C. O., Cong, Y., McCracken, V. J., Dimmitt, R. A., Lorenz, R. G., & Weaver, C. T. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00291.x · Cited by 469 · see citing works

Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology

Rossin, E. J., Lage, K., Raychaudhuri, S., Xavier, R. J., Tatar, D., Benita, Y., Constortium, I. I. B. D. G., Cotsapas, C., & Daly, M. J. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001273 · Cited by 438 · see citing works

TRAF molecules in cell signaling and in human diseases

Xie, P. (2013) · Journal of Molecular Signaling · doi:10.1186/1750-2187-8-7 · Cited by 467 · see citing works

Detecting shared pathogenesis from the shared genetics of immune-related diseases

Zhernakova, A., van Diemen, C. C., & Wijmenga, C. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2489 · Cited by 551 · see citing works

Ubiquitin-mediated activation of TAK1 and IKK

Adhikari, A., Xu, M., & Chen, Z. J. (2007) · Oncogene · doi:10.1038/sj.onc.1210413 · Cited by 455 · see citing works

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

Vucic, D., Dixit, V. M., & Wertz, I. E. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3143 · Cited by 451 · see citing works

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

Newton, K., Dugger, D. L., Maltzman, A., Greve, J. M., Hedehus, M., Martin-McNulty, B., Carano, R. A. D., Cao, T. C., van Bruggen, N., Bernstein, L., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.46 · Cited by 442 · see citing works

The ‘cytokine storm’: molecular mechanisms and therapeutic prospects

Karki, R., & Kanneganti, T. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.06.001 · Cited by 445 · see citing works

T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

Coornaert, B., Baens, M., Heyninck, K., Bekaert, T., Haegman, M., Staal, J., Sun, L., Chen, Z. J., Marynen, P., & Beyaert, R. (2008) · Nature Immunology · doi:10.1038/ni1561 · Cited by 437 · see citing works

Immune Responses to the Microbiota at the Intestinal Mucosal Surface

Duerkop, B. A., Vaishnava, S., & Hooper, L. V. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.009 · Cited by 424 · see citing works

Anti-Inflammatory Mechanisms in the Vascular Wall

Tedgui, A., & Mallat, Z. (2001) · Circulation Research · doi:10.1161/hh0901.090440 · Cited by 418 · see citing works

The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis

Zaki, H., Vogel, P., Malireddi, R. K. S., Body–Malapel, M., Anand, P., Bertin, J., Green, D. R., Lamkanfi, M., & Kanneganti, T. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.10.022 · Cited by 410 · see citing works

CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes

Sun, S.-C. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.43 · Cited by 401 · see citing works

Differential gene expression during capillary morphogenesis in 3D collagen matrices

Bell, S. E., Mavila, A., Salazar, R., Bayless, K. J., Kanagala, S., Maxwell, S. A., & Davis, G. E. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.15.2755 · Cited by 394 · see citing works

Raf Kinase Inhibitor Protein Interacts with NF-κB-Inducing Kinase and TAK1 and Inhibits NF-κB Activation

Yeung, K. C., Rose, D. W., Dhillon, A. S., Yaros, D., Gustafsson, M. K., Chatterjee, D., McFerran, B. W., Wyche, J. H., Kölch, W., & Sedivy, J. M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.21.7207-7217.2001 · Cited by 387 · see citing works

The RIP kinases: crucial integrators of cellular stress

Meylan, E., & Tschopp, J. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.01.003 · Cited by 383 · see citing works

Rheumatoid arthritis association at 6q23

Thomson, W., Barton, A. C., Ke, X., Eyre, S., Hinks, A., Bowes, J., Donn, R. P., Symmons, D. P. M., Hider, S., Bruce, I. N., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.32 · Cited by 381 · see citing works

Identification of a Novel Homotypic Interaction Motif Required for the Phosphorylation of Receptor-interacting Protein (RIP) by RIP3

Sun, X., Yin, J., Starovasnik, M. A., Fairbrother, W. J., & Dixit, V. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109488200 · Cited by 371 · see citing works

Toll-Like Receptors and RNA Helicases: Two Parallel Ways to Trigger Antiviral Responses

Meylan, E., & Tschopp, J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.012 · Cited by 371 · see citing works

Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol

Lam, L. T., Pickeral, O. K., Peng, A. C., Rosenwald, A., Hurt, E. M., Giltnane, J. M., Averett, L., Zhao, H. G., Davis, R. E., Sathyamoorthy, M., et al. (2001) · Genome biology · doi:10.1186/gb-2001-2-10-research0041 · Cited by 371 · see citing works

Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years?

Hold, G. L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i5.1192 · Cited by 365 · see citing works

Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization

Iyengar, P., Combs, T. P., Shah, S. J., Gouon–Evans, V., Pollard, J. W., Albanese, C., Flanagan, L., Tenniswood, M., Guha, C., Lisanti, M. P., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206737 · Cited by 364 · see citing works

Deubiquitylation and regulation of the immune response

Sun, S. (2008) · Nature reviews. Immunology · doi:10.1038/nri2337 · Cited by 357 · see citing works

Ankylosing spondylitis: an autoimmune or autoinflammatory disease?

Mauro, D., Thomas, R., Guggino, G., Lories, R. J. U., Brown, M. A., & Ciccia, F. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00625-y · Cited by 358 · see citing works

The TNF-receptor-associated factor family

Wajant, H., Henkler, F., & Scheurich, P. (2001) · Cellular Signalling · doi:10.1016/s0898-6568(01)00160-7 · Cited by 353 · see citing works

The Ubiquitin-Editing Enzyme A20 Restricts Nucleotide-Binding Oligomerization Domain Containing 2-Triggered Signals

Hitotsumatsu, O., Ahmad, R., Tavares, R. M., Wang, M., Philpott, D. J., Turer, E. E., Lee, B. L., Shiffin, N., Advincula, R., Malynn, B. A., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.002 · Cited by 349 · see citing works

NF-κB signaling and bone resorption

Abu‐Amer, Y. (2013) · Osteoporosis International · doi:10.1007/s00198-013-2313-x · Cited by 341 · see citing works

Inflammatory bowel disease

Teitelbaum, D. H., & Coran, A. G. (2006) · CRC Press eBooks · doi:10.1201/b13237-67 · Cited by 341 · see citing works

Recent Advances in the Genetics of Autoimmune Disease

Gregersen, P. K., & Olsson, L. M. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132653 · Cited by 337 · see citing works

Life And Death Decisions

Muppidi, J. R., Tschopp, J., & Siegel, R. M. (2004) · Immunity · doi:10.1016/j.immuni.2004.10.001 · Cited by 339 · see citing works

Return to homeostasis: downregulation of NF-κB responses

Ruland, J. (2011) · Nature Immunology · doi:10.1038/ni.2055 · Cited by 321 · see citing works

New insights into NF-κB regulation and function

Sun, S., & Ley, S. C. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.07.003 · Cited by 320 · see citing works

The Balance of TNF Mediated Pathways Regulates Inflammatory Cell Death Signaling in Healthy and Diseased Tissues

Webster, J. D., & Vucic, D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00365 · Cited by 315 · see citing works

A20 and cell death-driven inflammation

Priem, D., van Loo, G., & Bertrand, M. J. M. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.03.001 · Cited by 139 · see citing works

A20 at the Crossroads of Cell Death, Inflammation, and AutoimmunityPreprint

Martens, A., & Loo, G. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a036418 · Cited by 138 · see citing works

A20 contribution to NF-κB regulation, Ripoptosome formation and TNF-induced cell death in keratinocytes

Panayotova‐Dimitrova, D., & Feoktistova, M. (2019) · doi:10.26226/morressier.5d4980cf8fb7e44098e72fd2

A20 and A20-binding proteins as cellular inhibitors of nuclear factor-κB-dependent gene expression and apoptosis

Beyaert, R., Heyninck, K., & Huffel, S. V. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00404-4 · Cited by 301 · see citing works

The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN

Heyninck, K., VALCK, D. D., Berghe, W. V., Criekinge, W. V., Contreras, R., Fiers, W., Haegeman, G., & Beyaert, R. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.7.1471 · Cited by 295 · see citing works