Cited by 173Prostate Cancer Treatment and ResearchHormonal and reproductive studiesSperm and Testicular Function

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Androgen biosynthetic pathways in the human prostate

Luu-The, Van, Bélanger, Alain, Labrie, Fernand·2008·Best Practice & Research Clinical Endocrinology & Metabolism

DOI 10.1016/j.beem.2008.01.008

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Abstract

It is well recognized that there are two androgens, namely testosterone (T) and dihydrotestosterone (DHT); T plays an important role in the testis and muscle, and DHT is crucial for the development, function and pathology of the prostate. It is generally thought that DHT is produced from the 5alpha-reduction of circulating T before being inactivated by 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) that converts DHT into 5alpha-androstane-3alpha,17beta-diol (3alpha-diol). However, the presence of various steroidogenic enzymes in the prostate as well as the availability at high levels of various steroid precursors such as dehydroepiandrosterone sulphate (DHEAS), dehydroepiandrosterone (DHEA) and 4-androstenedione (4-dione) strongly suggest the existence of additional pathways involved in the biosynthesis and metabolism of DHT. Because steroidogenesis could be different in different species, data from the literature obtained from various human, dog, rat and mouse prostate tissues, as well as primary cells and prostatic cancer cell lines, provide a somewhat confusing picture. In the present chapter, we review the data in order to provide a clearer picture of the pathways involved in DHT biosynthesis and metabolism in the human prostate.

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Cancer Statistics, 2004
Jemal, A., Tiwari, R. C., Murray, T., Ghafoor, A., Samuels, A., Ward, E., Feuer, E. J., & Thun, M. J. (2004) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.54.1.8 · Cited by 3,984
Progress in Clinical and Biological Research
Smyth, J. F. (1979) · Journal of Clinical Pathology · doi:10.1136/jcp.32.7.742-d · Cited by 1,558
Molecular and Cellular Endocrinology
Rainey, W. E., & Rodgers, R. J. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.10.007 · Cited by 1,340
Steroid 5α-reductase: two genes/two enzymes
Russell, D. W., & Wilson, J. D. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.000325 · Cited by 1,105
Important Advances in Oncology
DeVita, V. T., Hellman, S., & Rosenberg, S. A. (1991) · Anti-Cancer Drugs · doi:10.1097/00001813-199108000-00014 · Cited by 760
Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression.
Thigpen, A. E., Silver, R. I., Guileyardo, J. M., Casey, M. L., McConnell, J. D., & Russell, D. W. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116665 · Cited by 727
Intracrinology
Labrie, F. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90116-a · Cited by 685
Self-citation
Deletion of steroid 5α-reductase 2 gene in male pseudohermaphroditism
Andersson, S., Berman, D. M., Jenkins, E. P., & Russell, D. W. (1991) · Nature · doi:10.1038/354159a0 · Cited by 643
Molecular biology of the 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 –isomerase gene family
Simard, J., Ricketts, M.-L., Gingras, S., Soucy, P., Feltus, F. A., & Melner, M. H. (2005) · Endocrine Reviews · doi:10.1210/er.2002-0050 · Cited by 620
Male pseudohermaphroditism caused by mutations of testicular 17β-hydroxysteroid dehydrogenase 3
Geissler, W. M., Davis, D. L., Wu, L., Bradshaw, K. D., Patel, S., Mendonca, B. B., Elliston, K. O., Wilson, J. D., Russell, D. W., & Andersson, S. (1994) · Nature Genetics · doi:10.1038/ng0594-34 · Cited by 570

Show all 110 references

Research works printed but not linked: 3

Robert A, Rheault P, Labrie F, et al. Identification and characterization of an estrogen-activating and androgen-inactivating (EHAL) enzyme. In: Breast Cancer Research National Scientific Conference, Reasons for Hope Abstract: 82; 1999.
Robert A, Luu-The V. Cloning and characterization of a new form of human 3-keto-reductase specific for saturated steroid. In: CDA/CSEM Professional Conference and Annual Meetings, Ottawa; 1999.
Mendonca, 1999, 17Beta-hydroxysteroid dehydrogenase 3 deficiency in women, The Journal of Clinical Endocrinology and Metabolism, 84, 802

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Reprint of “In vitro and in vivo evaluation of a 3β-androsterone derivative as inhibitor of 17β-hydroxysteroid dehydrogenase type 3”
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Masiutin, M., & Yadav, M. (2023) · WikiJournal of Medicine · doi:10.15347/wjm/2023.003
Samples for analysis
Honour, J. W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-818124-9.00016-4
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BindingDB Entry 50031322: Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.
BindingDB (2010) · UC San Diego · doi:10.7270/q2kk9bxd
BindingDB Entry 8091: Synthesis and biological activity of progesterone derivatives as 5alpha-reductase inhibitors, and their effect on hamster prostate weight.
BindingDB (2017) · UC San Diego · doi:10.7270/q2g15zq6
BindingDB Entry 8164: Steroidal 5α-reductase inhibitors using 4-androstenedione as substrate.
BindingDB (2017) · UC San Diego · doi:10.7270/q25719xs
BindingDB Entry 50033731: Development of 3-substituted-androsterone derivatives as potent inhibitors of 17ß-hydroxysteroid dehydrogenase type 3.
BindingDB (2012) · UC San Diego · doi:10.7270/q2222v4t
Plasma Steroid Trajectories From Day‐of‐Surgery Baseline After Robot‐Assisted Radical Prostatectomy for Prostate Cancer
Heráček, J., Gaduš, L., Horenitzky, M., Novàkovâ, M., Škodová, T., Kolátorová, L., Varausova, A., Lukášková, A., & Vítků, J. (2026) · The Prostate · doi:10.1002/pros.70273

Authors: Luu-The, V., Bélanger, A., & Labrie, F.
Affiliations: Université Laval (CA)
Corresponding author: Luu-The, Van
Venue: Best Practice & Research Clinical Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2008-04
Volume: 22
Issue: 2
Pages: 207-221
ISSN: 1521-690X (ISSN-L)
DOI: 10.1016/j.beem.2008.01.008
OpenAlex: W2007245161
Cited by: 169
References: 110
Citations by year: 2026: 3 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 9 · 2021: 5 · 2020: 1 · 2019: 11 · 2018: 9 · 2017: 8 · 2016: 11 · 2015: 9 · 2014: 9 · 2013: 16 · 2012: 18
FWCI: 2.85
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords: androgen production, dihydrotestosterone, testosterone, human prostate, 5α-reduction, 3α-hydroxysteroid dehydrogenase, 3alpha-diol, dehydroepiandrosterone sulfate, dehydroepiandrosterone, 4-androstenedione, steroidogenic enzymes, prostate cancer
MeSH terms: Androgens, Animals, Humans, Hydroxysteroid Dehydrogenases, Male, Models, Biological, Oxidoreductases, Prostate, Dihydrotestosterone, Testosterone, Biosynthetic Pathways

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Androgen biosynthetic pathways in the human prostate

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