Cited by 173Prostate Cancer Treatment and ResearchHormonal and reproductive studiesSperm and Testicular Function

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Androgen biosynthetic pathways in the human prostate

Luu-The, Van, Bélanger, Alain, Labrie, Fernand·2008·Best Practice & Research Clinical Endocrinology & Metabolism

DOI 10.1016/j.beem.2008.01.008

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Abstract

It is well recognized that there are two androgens, namely testosterone (T) and dihydrotestosterone (DHT); T plays an important role in the testis and muscle, and DHT is crucial for the development, function and pathology of the prostate. It is generally thought that DHT is produced from the 5alpha-reduction of circulating T before being inactivated by 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) that converts DHT into 5alpha-androstane-3alpha,17beta-diol (3alpha-diol). However, the presence of various steroidogenic enzymes in the prostate as well as the availability at high levels of various steroid precursors such as dehydroepiandrosterone sulphate (DHEAS), dehydroepiandrosterone (DHEA) and 4-androstenedione (4-dione) strongly suggest the existence of additional pathways involved in the biosynthesis and metabolism of DHT. Because steroidogenesis could be different in different species, data from the literature obtained from various human, dog, rat and mouse prostate tissues, as well as primary cells and prostatic cancer cell lines, provide a somewhat confusing picture. In the present chapter, we review the data in order to provide a clearer picture of the pathways involved in DHT biosynthesis and metabolism in the human prostate.

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Authors: Luu-The, V., Bélanger, A., & Labrie, F.
Affiliations: Université Laval (CA)
Corresponding author: Luu-The, Van
Venue: Best Practice & Research Clinical Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2008-04
Volume: 22
Issue: 2
Pages: 207-221
ISSN: 1521-690X (ISSN-L)
DOI: 10.1016/j.beem.2008.01.008
OpenAlex: W2007245161
Cited by: 169
References: 110
Citations by year: 2026: 3 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 9 · 2021: 5 · 2020: 1 · 2019: 11 · 2018: 9 · 2017: 8 · 2016: 11 · 2015: 9 · 2014: 9 · 2013: 16 · 2012: 18
FWCI: 2.85
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords: androgen production, dihydrotestosterone, testosterone, human prostate, 5α-reduction, 3α-hydroxysteroid dehydrogenase, 3alpha-diol, dehydroepiandrosterone sulfate, dehydroepiandrosterone, 4-androstenedione, steroidogenic enzymes, prostate cancer
MeSH terms: Androgens, Animals, Humans, Hydroxysteroid Dehydrogenases, Male, Models, Biological, Oxidoreductases, Prostate, Dihydrotestosterone, Testosterone, Biosynthetic Pathways

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Androgen biosynthetic pathways in the human prostate

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