In-vitro molecular docking analysis of microalgae extracted phycocyanin as an anti-diabetic candidate

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

Trott, O., & Olson, A. J. (2010) · Journal of Computational Chemistry · doi:10.1002/jcc.21334 · Cited by 38,412 · see citing works

PLIP: fully automated protein–ligand interaction profiler

Salentin, S., Schreiber, S., Haupt, V. J., Adasme, M. F., & Schroeder, M. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv315 · Cited by 2,375 · see citing works

The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives

Chen, L., Magliano, D. J., & Zimmet, P. Z. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.183 · Cited by 2,227 · see citing works

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

Kahn, S. E., Cooper, M. E., & Del Prato, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62154-6 · Cited by 1,743 · see citing works

Clinical review of antidiabetic drugs: implications for type 2 diabetes mellitus management

Chaudhury, A., Duvoor, C., Reddy Dendi, V. S., Kraleti, S., Chada, A., Ravilla, R., Marco, A., Shekhawat, N. S., Montales, M. T., Kuriakose, K., et al. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00006 · Cited by 1,500 · see citing works

Calculation of Protein-Ligand Binding Affinities

Gilson, M. K., & Zhou, H. (2007) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.36.040306.132550 · Cited by 966 · see citing works

Microalgae: A potential alternative to health supplementation for humans

Koyande, A. K., Chew, K. W., Rambabu, K., Tao, Y., Chu, D.-T., & Show, P.-L. (2019) · Food Science and Human Wellness · doi:10.1016/j.fshw.2019.03.001 · Cited by 908 · see citing works

Optimized Hydrophobic Interactions and Hydrogen Bonding at the Target-Ligand Interface Leads the Pathways of Drug-Designing

Patil, R., Das, S., Stanley, A., Yadav, L., Sudhakar, A., & Varma, A. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012029 · Cited by 766 · see citing works

α-glucosidase inhibitors from plants: A natural approach to treat diabetes

Kumar, V., Prakash, O., Kumar, S., & Narwal, S. (2011) · Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review · doi:10.4103/0973-7847.79096 · Cited by 731 · see citing works

A quantitative starch–iodine method for measuring alpha-amylase and glucoamylase activities

Xiao, Z., Storms, R. K., & Tsang, A. (2006) · Analytical Biochemistry · doi:10.1016/j.ab.2006.01.036 · Cited by 556 · see citing works

Flavonoids for Controlling Starch Digestion: Structural Requirements for Inhibiting Human α-Amylase

Piparo, E. L., Scheib, H., Frei, N., Williamson, G., Grigorov, M., & Chou, C. J. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm800115x · Cited by 475 · see citing works

The structure of human pancreatic α -amylase at 1.8 Å resolution and comparisons with related enzymes

Brayer, G. D., Luo, Y., & Withers, S. G. (1995) · Protein Science · doi:10.1002/pro.5560040908 · Cited by 411 · see citing works

Stability of phycocyanin extracted from Spirulina sp.: Influence of temperature, pH and preservatives

Chaiklahan, R., Chirasuwan, N., & Bunnag, B. (2012) · Process Biochemistry · doi:10.1016/j.procbio.2012.01.010 · Cited by 390 · see citing works

Current anti-diabetic agents and their molecular targets: A review

Kerru, N., Singh‐Pillay, A., Awolade, P., & Singh, P. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.04.061 · Cited by 370 · see citing works

Phycobiliprotein: Potential microalgae derived pharmaceutical and biological reagent

Manirafasha, E., Ndikubwimana, T., Zeng, X., Lu, Y., & Jing, K. (2016) · Biochemical Engineering Journal · doi:10.1016/j.bej.2016.01.025 · Cited by 321 · see citing works

In vitro antioxidant activity and in vivo anti-fatigue effect of loach (Misgurnus anguillicaudatus) peptides prepared by papain digestion

You, L., Zhao, M., Regenstein, J. M., & Ren, J. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.06.007 · Cited by 287 · see citing works

Phycocyanin and phycoerythrin: Strategies to improve production yield and chemical stability

Hsieh-Lo, M., Castillo-Herrera, G. A., Ochoa-Becerra, M. A., & Mojica, L. (2019) · Algal Research · doi:10.1016/j.algal.2019.101600 · Cited by 271 · see citing works

Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes

Ferrannini, E., & DeFronzo, R. A. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv239 · Cited by 256 · see citing works

Prediabetes and Lifestyle Modification: Time to Prevent a Preventable Disease

Tuso, P. (2014) · The Permanente Journal · doi:10.7812/tpp/14-002 · Cited by 252 · see citing works

The hydrophobic effect in protein folding

Lins, L., & Brasseur, R. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.7.7737462 · Cited by 218 · see citing works

Phycocyanin and phycocyanobilin from <i>Spirulina platensis</i> protect against diabetic nephropathy by inhibiting oxidative stress

Zheng, J., Inoguchi, T., Sasaki, S., Maeda, Y., McCarty, M. F., Fujii, M., Ikeda, N., Kobayashi, K., Sonoda, N., & Takayanagi, R. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00648.2011 · Cited by 201 · see citing works

Statin inhibition of HMG-CoA reductase: a 3-dimensional view

Istvan, E. S. (2003) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(03)00003-5 · Cited by 196 · see citing works

Physicochemical factors affecting the stability of two pigments: R-phycoerythrin of Grateloupia turuturu and B-phycoerythrin of Porphyridium cruentum

Munier, M., Jubeau, S., Wijaya, A., Morançais, M., Dumay, J., Marchal, L., Jaouen, P., & Fleurence, J. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.10.113 · Cited by 187 · see citing works

Aqueous two phase extraction for purification of C-phycocyanin

Patil, G., & Raghavarao, K. S. M. S. (2006) · Biochemical Engineering Journal · doi:10.1016/j.bej.2006.11.026 · Cited by 183 · see citing works

Bio-assay guided isolation and identification of α-glucosidase inhibitors from the leaves of Aquilaria sinensis

Feng, J., Yang, X., & Wang, R. (2011) · Phytochemistry · doi:10.1016/j.phytochem.2010.11.025 · Cited by 179 · see citing works

Algal Biorefinery: An Integrated Approach

Das, D. (2015) · Springer eBooks · doi:10.1007/978-3-319-22813-6 · Cited by 177 · see citing works

Thermal degradation kinetics of the phycocyanin from Spirulina platensis

Antelo, F. S., Costa, J. A. V., & Kalil, S. J. (2008) · Biochemical Engineering Journal · doi:10.1016/j.bej.2008.03.012 · Cited by 150 · see citing works

Relative stabilities of microalgal carotenoids in microalgal extracts, biomass and fish feed: effect of storage conditions

Gouveia, L., & Empis, J. (2003) · Innovative Food Science & Emerging Technologies · doi:10.1016/s1466-8564(03)00002-x · Cited by 112 · see citing works

α-Glucosidase inhibitors from the seeds of Syagrus romanzoffiana

Lam, S.-H., Chen, J., Kang, C.-J., Chen, C.-H., & Lee, S. (2008) · Phytochemistry · doi:10.1016/j.phytochem.2007.12.004 · Cited by 112 · see citing works

Structure of C-phycocyanin fromSpirulina platensisat 2.2 Å resolution: a novel monoclinic crystal form for phycobiliproteins in phycobilisomes

Wang, X., Li, L.-N., Chang, W., Zhang, J.-P., Gui, L.-L., Guo, B.-J., & Liang, D. (2001) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444901004528 · Cited by 109 · see citing works

Preparation of phycocyanin microcapsules and its properties

Yan, M.-Y., Liu, B.-H., Jiao, X., & Qin, S. (2014) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2013.07.008 · Cited by 104 · see citing works

Analogues of xanthones——Chalcones and bis-chalcones as α-glucosidase inhibitors and anti-diabetes candidates

Cai, C., Rao, L., Rao, Y., Guo, J.-X., Xiao, Z.-Z., Cao, J., Huang, Z., & Wang, B. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.02.007 · Cited by 103 · see citing works

Preparation of nanofibers containing the microalga Spirulina (Arthrospira)

de Morais, M. G., Stillings, C., Dersch, R., Rudisile, M., Pranke, P. H. L., Costa, J. A. V., & Wendorff, J. (2009) · Bioresource Technology · doi:10.1016/j.biortech.2009.11.059 · Cited by 98 · see citing works

Discovery of potent α-glucosidase inhibitor flavonols: Insights into mechanism of action through inhibition kinetics and docking simulations

Şöhretoğlu, D., Sarı, S., Barut, B., & Özel, A. (2018) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2018.05.010 · Cited by 97 · see citing works

Molecular mechanism of the interaction between resveratrol and trypsin via spectroscopy and molecular docking

Ren, G., Sun, H. G., Guo, J., Fan, J., Li, G., & Xu, S. (2019) · Food & Function · doi:10.1039/c9fo00183b · Cited by 92 · see citing works

Antidiabetic potential of phycocyanin: Effects on KKAy mice

Ou, Y., Lin, L., Yang, X., Pan, Q., & Cheng, X. (2013) · Pharmaceutical Biology · doi:10.3109/13880209.2012.747545 · Cited by 85 · see citing works

Phycobiliproteins: Structure, functions and biotechnological applications

Stadnichuk, I. N., & Tropin, I. V. (2017) · Applied Biochemistry and Microbiology · doi:10.1134/s0003683817010185 · Cited by 77 · see citing works

Strong and weak hydrogen bonds in protein-ligand complexes of kinases: a comparative study

Panigrahi, S. K. (2008) · Amino Acids · doi:10.1007/s00726-007-0015-4 · Cited by 72 · see citing works

An Improved and Efficient Method for the Extraction of Phycocyanin from Spirulina sp

Doke, J. (2005) · International Journal of Food Engineering · doi:10.2202/1556-3758.1037 · Cited by 72 · see citing works

Molecular simulation of adsorption and its implications to protein chromatography: A review

Zhang, L., & Sun, Y. P. (2009) · Biochemical Engineering Journal · doi:10.1016/j.bej.2009.12.003 · Cited by 72 · see citing works

Design, synthesis, docking study, α-glucosidase inhibition, and cytotoxic activities of acridine linked to thioacetamides as novel agents in treatment of type 2 diabetes

Mohammadi‐Khanaposhtani, M., Rezaei, S., Khalifeh, R., Imanparast, S., Faramarzi, M. A., Bahadorikhalili, S., Safavi, M., Bandarian, F., Nasli‐Esfahani, E., Mahdavi, M., et al. (2018) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2018.06.035 · Cited by 71 · see citing works

Crystal structure of GH13 α‐glucosidase GSJ from one of the deepest sea bacteria

Shirai, T., Hung, V. S., Morinaka, K., Kobayashi, T., & Ito, S. (2008) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.22044 · Cited by 67 · see citing works

mtsslSuite:In silicospin labelling, trilateration and distance-constrained rigid body docking in PyMOL

Hagelueken, G., Abdullin, D., Ward, R., & Schiemann, O. (2013) · Molecular Physics · doi:10.1080/00268976.2013.809804 · Cited by 65 · see citing works

Inhibitory Potential of Five Traditionally Used Native Antidiabetic Medicinal Plants onα-Amylase,α-Glucosidase, Glucose Entrapment, and Amylolysis KineticsIn Vitro

Picot, C. M. N., Subratty, A. H., & Mahomoodally, M. F. (2014) · Advances in Pharmacological Sciences · doi:10.1155/2014/739834 · Cited by 52 · see citing works

The importance of synthetic drugs for type 2 diabetes drug discovery

Safavi, M., Foroumadi, A., & Abdollahi, M. R. (2013) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2013.837883 · Cited by 52 · see citing works

Response surface optimization of ultrasound-assisted protein extraction from Spirulina platensis: investigation of the effect of extraction conditions on techno-functional properties of protein concentrates

Yücetepe, A., Saroğlu, Ö., & Özçelik, B. (2019) · Journal of Food Science and Technology · doi:10.1007/s13197-019-03796-5 · Cited by 51 · see citing works

DOCKING MOLEKULAR POTENSI ANTI DIABETES MELITUS TIPE 2 TURUNAN ZERUMBON SEBAGAI INHIBITOR ALDOSA REDUKTASE DENGAN AUTODOCK-VINA

Saputri, K. E., Fakhmi, N., Kusumaningtyas, E., Priyatama, D., & Santoso, B. (2017) · Chimica et Natura Acta · doi:10.24198/cna.v4.n1.10443 · Cited by 49 · see citing works

Thermophilic C-phycocyanin: effect of temperature, monomer stability, and structure

Edwards, M. R., Hauer, C., Stack, R. F., Eisele, L. E., & MacColl, R. (1997) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(97)00056-x · Cited by 44 · see citing works

Relationship between color development and protein conformation in the phycocyanin molecule

FUKUI, K. (2004) · Dyes and Pigments · doi:10.1016/j.dyepig.2003.12.016 · Cited by 43 · see citing works

Actinoplanes utahensis ZJB-08196 fed-batch fermentation at elevated osmolality for enhancing acarbose production

Wang, Y., Liu, L.-L., Wang, Y.-S., Xue, Y., Zheng, Y., & Shen, Y. (2011) · Bioresource Technology · doi:10.1016/j.biortech.2011.09.121 · Cited by 39 · see citing works

Structural insights into the binding mode of d-sorbitol with sorbitol dehydrogenase using QM-polarized ligand docking and molecular dynamics simulations

Selvaraj, C., Gopinath, K., Jagtap, S. S., Patel, S. K. S., Dhiman, S. S., Kim, T., Singh, S. K., & Lee, J.-K. (2016) · Biochemical Engineering Journal · doi:10.1016/j.bej.2016.07.008 · Cited by 36 · see citing works

New tetrapeptide ligands designed for antibody purification with biomimetic chromatography: Molecular simulation and experimental validation

Wang, R., Lin, D., Chu, W., Zhang, Q., & Yao, S. (2016) · Biochemical Engineering Journal · doi:10.1016/j.bej.2016.06.030 · Cited by 31 · see citing works

Developing a physiological model for type II diabetes mellitus

Vahidi, O., Kwok, K. E., Gopaluni, R. B., & Sun, L. (2011) · Biochemical Engineering Journal · doi:10.1016/j.bej.2011.02.019 · Cited by 26 · see citing works

Potentially Antihyperglycemic from Biomass and Phycocyanin of Spirulina Fusiformis Voronikhin by in Vivo Test

Setyaningsih, I., Bintang, M., & Madina, N. (2015) · Procedia Chemistry · doi:10.1016/j.proche.2015.03.030 · Cited by 25 · see citing works

A comprehensive compartmental model of blood glucose regulation for healthy and type 2 diabetic subjects

Vahidi, O., Kwok, K. E., Gopaluni, R. B., & Knop, F. K. (2015) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-015-1406-4 · Cited by 23 · see citing works

An optimized industrial fermentation processes for acarbose production by Actinoplanes sp. A56

Li, K., Zhou, J. N., Wei, S., & Cheng, X. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.05.013 · Cited by 20 · see citing works

Characterization of phycocyanin fromSpirulina fusiformisand its thermal stability

Munawaroh, H. S. H., Darojatun, K., Gumilar, G. G., Aisyah, S., & Wulandari, A. P. (2018) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1013/1/012205 · Cited by 18 · see citing works

Application of ion exchange to purify acarbose from fermentation broths

Rodríguez, J. F., Lucas, A. D., Carmona, M., & Cañas, F. (2007) · Biochemical Engineering Journal · doi:10.1016/j.bej.2007.11.025 · Cited by 11 · see citing works

Plants and Fluxes

Nobel, P. S. (2005) · Elsevier eBooks · doi:10.1016/b978-012520026-4/50010-x · Cited by 6 · see citing works

Isolation, improvement and characterization of an ammonium excreting mutant strain of the heterocytous cyanobacterium, Anabaena variabilis PCC 7937

Bui, L. A., Dupré, C., Legrand, J., & Grizeau, D. (2014) · Biochemical Engineering Journal · doi:10.1016/j.bej.2014.06.016 · Cited by 6 · see citing works

Biologically-mediated carbon capture and utilization by microalgae towards sustainable CO2 biofixation and biomass valorization – A review

Daneshvar, E., Wicker, R. J., Show, P.-L., & Bhatnagar, A. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.130884 · Cited by 493 · see citing works

Exploring the Benefits of Phycocyanin: From Spirulina Cultivation to Its Widespread Applications

Fernandes, R., Campos, J., Serra, M., Fidalgo, J., Almeida, H., Casas, A., Toubarro, D., & Barros, A. (2023) · Pharmaceuticals · doi:10.3390/ph16040592 · Cited by 255 · see citing works

Phycocyanin, a super functional ingredient from algae; properties, purification characterization, and applications

Ashaolu, T. J., Samborska, K., Lee, C. C., Tomas, M., Capanoglu, E., Tarhan, Ö., Taze, B., & Jafari, S. M. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.11.064 · Cited by 184 · see citing works

Edible Microalgae and Their Bioactive Compounds in the Prevention and Treatment of Metabolic Alterations

Ramos-Romero, S., Torrella, J. R., Pagès, T., Viscor, G., & Torres, J. L. (2021) · Nutrients · doi:10.3390/nu13020563 · Cited by 134 · see citing works

Phycobiliproteins—A Family of Algae-Derived Biliproteins: Productions, Characterization and Pharmaceutical Potentials

Chen, H., Qi, H., & Xiong, P. (2022) · Marine Drugs · doi:10.3390/md20070450 · Cited by 129 · see citing works

Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature

Gentscheva, G., Nikolova, K., Panayotova, V., Peycheva, K., Makedonski, L., Slavov, P., Radusheva, P., Petrova, P., & Yotkovska, I. (2023) · Life · doi:10.3390/life13030845 · Cited by 106 · see citing works

Phycocyanin from Spirulina: A comprehensive review on cultivation, extraction, purification, and its application in food and allied industries

Athiyappan, K. D., Routray, W., & Balasubramanian, P. (2024) · Food and Humanity · doi:10.1016/j.foohum.2024.100235 · Cited by 80 · see citing works

Microalgae: A Promising Source of Bioactive Phycobiliproteins

Tounsi, L., Hlima, H. B., Hentati, F., Hentati, O., Derbel, H., Michaud, P., & Abdelkafi, S. (2023) · Marine Drugs · doi:10.3390/md21080440 · Cited by 54 · see citing works

Protein extracts from microalgae and Cyanobacteria biomass. Techno-functional properties and bioactivity: a review

Nunes, E., Odenthal, K., Nunes, N., Fernandes, T., Fernandes, I. A., & Pinheiro de Carvalho, M. A. A. (2024) · Algal Research · doi:10.1016/j.algal.2024.103638 · Cited by 53 · see citing works

Microalgae as a Potential Functional Ingredient: Evaluation of the Phytochemical Profile, Antioxidant Activity and In-Vitro Enzymatic Inhibitory Effect of Different Species

Vieira, M. V., Turkiewicz, I. P., Tkacz, K., Fuentes-Grünewald, C., Pastrana, L. M., Fuciños, P., Wojdyło, A., & Nowicka, P. (2021) · Molecules · doi:10.3390/molecules26247593 · Cited by 50 · see citing works

Phycocyanin as a nature-inspired antidiabetic agent: A systematic review

Ziyaei, K., Abdi, F., Mokhtari, M., Daneshmehr, M. A., & Ataie, Z. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154964 · Cited by 46 · see citing works

Dietary natural products as inhibitors of α-amylase and α-glucosidase: An updated review of ligand-receptor correlations validated by docking studies

Rangel‐Galván, M., Pacheco‐Hernández, Y., Lozoya‐Gloria, E., & Villa‐Ruano, N. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105456 · Cited by 42 · see citing works

Synthesis, modification and application of fish skin gelatin-based hydrogel as sustainable and versatile bioresource of antidiabetic peptide

Munawaroh, H. S. H., Pratiwi, R. N., Gumilar, G. G., Aisyah, S., Rohilah, S., Nurjanah, A., Ningrum, A., Susanto, E., Pratiwi, A., Arindita, N. P. Y., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123248 · Cited by 40 · see citing works

Nitrate and ammonia: two key nitrogen sources for biomass and phycocyanin production by Arthrospira (Spirulina) platensis

Mousavi, M., Mehrzad, J., Najafi, M. F., Zhiani, R., & Shamsian, S. A. A. (2022) · Journal of Applied Phycology · doi:10.1007/s10811-021-02664-0 · Cited by 35 · see citing works

Preparation and characterization of protein-antioxidant complex pickering particles for high internal phase emulsions

Ding, J., Qiu, X., Li, Y., Wang, Y., Mao, Y., Yang, C., & Sun, Y. (2024) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2024.109861 · Cited by 33 · see citing works

Therapeutic Potentials of Microalgae and Their Bioactive Compounds on Diabetes Mellitus

Tamel Selvan, K., Goon, J. A., Makpol, S., & Tan, J. K. (2023) · Marine Drugs · doi:10.3390/md21090462 · Cited by 32 · see citing works

Innovative Bioactive Products with Medicinal Value from Microalgae and Their Overall Process Optimization through the Implementation of Life Cycle Analysis—An Overview

Papadaki, S., Tricha, N., Panagiotopoulou, M., & Krokida, M. K. (2024) · Marine Drugs · doi:10.3390/md22040152 · Cited by 32 · see citing works

Next-Generation Carbazole-Linked 1,2,4-Triazole-Thione Derivatives: Strategic Design, Synthesis, Molecular Docking, and Evaluation of Antidiabetic Potential

Çapan, İ., Hawash, M., Qaoud, M. T., & Jaradat, N. A. (2024) · ACS Omega · doi:10.1021/acsomega.4c07896 · Cited by 28 · see citing works

Effects and interaction mechanism of soybean 7S and 11S globulins on anthocyanin stability and antioxidant activity during in vitro simulated digestion

Zheng, J., Zheng, X., Zhao, L., Yi, J., & Cai, S. (2021) · Current Research in Food Science · doi:10.1016/j.crfs.2021.08.003 · Cited by 27 · see citing works

Impact of licochalcone A on the progression of diabetic nephropathy in type 2 diabetes mellitus of C57BL/6 mice

Luo, Z., Li, T., Gao, Q., Chen, Y., Su, G., & Zhao, Y. (2021) · Food & Function · doi:10.1039/d1fo01630j · Cited by 27 · see citing works

Bacterial cellulose nanocrystal as drug delivery system for overcoming the biological barrier of cyano-phycocyanin: a biomedical application of microbial product

Munawaroh, H. S. H., Anwar, B., Yuliani, G., Murni, I. C., Arindita, N. P. Y., Maulidah, G. S., Martha, L., Hidayati, N. A., Chew, K. W., & Show, P. L. (2023) · Bioengineered · doi:10.1080/21655979.2023.2252226 · Cited by 27 · see citing works

Phycocyanin Protects against High Glucose High Fat Diet Induced Diabetes in Mice and Participates in AKT and AMPK Signaling

Hao, S., Li, F., Li, Q., Yang, Q. E., & Zhang, W. (2022) · Foods · doi:10.3390/foods11203183 · Cited by 26 · see citing works

Physicochemical characterization of C-phycocyanin from Plectonema sp. and elucidation of its bioactive potential through in silico approach

Husain, A., Farooqui, A., Khanam, A., Sharma, S., Mahfooz, S., Shamim, A., Akhter, F., Alatar, A. A., Faisal, M., & Ahmad, S. (2022) · Cellular and Molecular Biology · doi:10.14715/cmb/2021.67.4.8 · Cited by 21 · see citing works

Algal metabolites: Paving the way towards new generation antidiabetic therapeutics

Kaushik, A., Sangtani, R., Parmar, H. S., & Bala, K. (2022) · Algal Research · doi:10.1016/j.algal.2022.102904 · Cited by 20 · see citing works

Spirulina Platensis Microalgae as High Protein-Based Products for Diabetes Treatment

Ahda, M., Suhendra, S., & Permadi, A. (2023) · Food Reviews International · doi:10.1080/87559129.2023.2238050 · Cited by 21 · see citing works

Microalgae and cyanobacteria as natural sources of antioxidant enzymes and enzyme inhibitors for Alzheimer's and diabetes

Odenthal, K., Nunes, E. B., Nunes, N., Fernandes, T., Fernandes, I. A., & de Carvalho, M. Â. A. P. (2024) · Algal Research · doi:10.1016/j.algal.2024.103610 · Cited by 19 · see citing works

Modeling and optimizing the phycocyanins extraction from Arthrospira platensis ( Spirulina ) algae and preliminary supplementation assays in soft beverage as natural colorants and antioxidants

Benchikh, Y., Filali, A., & Rebai, S. (2020) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.15170 · Cited by 13 · see citing works

Glucosidase Inhibitors Screening in Microalgae and Cyanobacteria Isolated from the Amazon and Proteomic Analysis of Inhibitor Producing Synechococcus sp. GFB01

Gradíssimo, D. G., da Silva, V. C. O., Xavier, L. P., do Nascimento, S. V., Valadares, R. B. D. S., Faustino, S. M. M., Schneider, M. P. C., & Santos, A. V. (2021) · Microorganisms · doi:10.3390/microorganisms9081593 · Cited by 13 · see citing works

Therapeutic potential of Phycocyanin in gastrointestinal cancers and related disorders

Motamedzadeh, A., Rahmati‐Dehkordi, F., Heydari, H., Behnam, M., Noshabad, F. Z. R., Tamtaji, Z., Taheri, A. T., Nabavizadeh, F., Aschner, M., Mirzaei, H., et al. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09675-3 · Cited by 12 · see citing works

Recent advances on anti-diabetic potential of pigmented phytochemicals in foods and medicinal plants

Kamiloğlu, S., Günal‐Köroğlu, D., Özdal, T., Tomaş, M., & Çapanoğlu, E. (2024) · Phytochemistry Reviews · doi:10.1007/s11101-024-10014-4 · Cited by 10 · see citing works

“C-phycocyanin from cyanobacteria: a therapeutic journey from antioxidant defence to diabetes management and beyond”

Husain, A., Khanam, A., Alouffi, S., Shahab, U., Alharazi, T. H., Maarfi, F., Khan, S. A., Hasan, Z., Akasha, R., Farooqui, A., et al. (2024) · Phytochemistry Reviews · doi:10.1007/s11101-024-10045-x · Cited by 8 · see citing works

Valorization of Salmo salar Skin Waste for the Synthesis of Angiotensin Converting Enzyme-1 (ACE1) Inhibitory Peptides

Munawaroh, H. S. H., Gumilar, G. G., Khoiriah, S. F., Nindya, F. S., Berliana, N., Aisyah, S., Nuraini, V. A., Ningrum, A., Susanto, E., Martha, L., et al. (2023) · Waste and Biomass Valorization · doi:10.1007/s12649-023-02141-4 · Cited by 8 · see citing works

Molecular docking approaches of biomolecules extracted from red seaweed Kappaphycus alvarezii against hemolysin protein of bioluminescence disease-causing bacteria Vibrio harveyi

Sivakumar, K., Kannappan, S., & Balakrishnan, V. (2023) · Algal Research · doi:10.1016/j.algal.2023.103207 · Cited by 6 · see citing works

In silico Study of Essential Oil of Bambusa vulgaris Leaves as an Anti Beta-lactamase Compound

Anggini, P. W., Amanina, S. A., Asyura, S. R., & Dion, R. (2022) · Molecular and Cellular Biomedical Sciences · doi:10.21705/mcbs.v6i3.278 · Cited by 5 · see citing works

Identification of potential anti‐Alzheimer agents from Pistacia atlantica Desf. galls using UPLC fingerprinting, chemometrics, and molecular docking analyses

Ahmed, Z. B., Hefied, F., Mahammed, T. H., Seidel, V., & Yousfi, M. (2022) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.16916 · Cited by 5 · see citing works

Phycocyanin: A Natural Antioxidant to Combat Free Radicals

Zhuang, D., Tang, D. Y. Y., Chew, K. W., & Ling, T. C. (2021) · Current Nutrition & Food Science · doi:10.2174/1573401318666211221160338 · Cited by 5 · see citing works

Microalgae as a potential sustainable solution to environment health

Munawaroh, H. S. H., Hazmatulhaq, F., Gumilar, G. G., Pratiwi, R. N., Kurniawan, I., Ningrum, A., Hidayati, N. A., Koyande, A. K., Kumar, P. S., & Show, P. L. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.133740 · Cited by 5 · see citing works

Recent updates on the pharmacological and nutritional properties of Spirulina platensis: A comprehensive review

Ketu, K. V., Akwo, A. U., Innocent, M., & Aphrodite, C. T. (2026) · Food Chemistry Advances · doi:10.1016/j.focha.2026.101235 · Cited by 4 · see citing works

Docking Studies on Biomolecules from Marine Microalga Skeletonema costatum Against Hemolysin Protein of Bioluminescence Disease-Causing Vibrio harveyi

Sivakumar, K., Kannappan, S., & Balakrishnan, V. (2023) · Current Microbiology · doi:10.1007/s00284-023-03372-3 · Cited by 4 · see citing works

UVB irradiation improved the gel properties of phycocyanin‐ undaria pinnatifida hydrogel

Sun, Y., Ren, J., Li, X., Sun, K., Feng, D., Dong, X., & Qi, H. (2024) · International Journal of Food Science & Technology · doi:10.1111/ijfs.16926 · Cited by 4 · see citing works

Simulasi Inhibisi Aktivitas Enzim α-Amilase dan α-Glukosidase oleh Senyawa Bioaktif Mikroalga Spirulina platensis

Syafrizayanti, S., Putri, A., Salim, M., & Kusnanda, A. J. (2023) · ALCHEMY Jurnal Penelitian Kimia · doi:10.20961/alchemy.19.2.73120.223-233 · Cited by 3 · see citing works

Study on the extraction of Phycocyanin and the impact of in vitro simulated digestion on its anti-diabetic ability

Chen, Y., Yi, H., & Pan, S. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105211 · Cited by 3 · see citing works

Safety issues on microalgae based products

Lemos, A. C., & Scaglioni, P. T. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-22080-7.00004-1 · Cited by 2 · see citing works

In vitro and in silico approaches to the antidiabetic potential of brown seaweed Spatoglossum asperum by targeting α-amylase and α-glucosidase enzymes

Roshni, T. R., Divya, P. V., & Sanilkumar, M. G. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107296 · Cited by 2 · see citing works

Fluorescence quenching and docking insights into fucoidan-C-phycocyanin interactions

Alavi, N., & Golmakani, M. (2025) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2025.128303 · Cited by 2 · see citing works

Phytoconstituents of Endiandra kingiana ; antidiabetic effects and molecular docking studies on alpha-amylase and alpha-glucosidase

Tanazi, N. N. H., Aziz, A. N., Azmi, M. N., Bakar, M. H. A., Hassim, M. F. N., Wahab, N. H. A., Rasol, N. E., Ghani, N. A., Maulidiani, M., & Awang, K. (2023) · Natural Product Research · doi:10.1080/14786419.2023.2283759 · Cited by 2 · see citing works

In-silico molecular investigation of Nannochloropsis microalgae cellulose synthase under salinity conditions and in-vitro evaluation of the proportionate effects on cellulose production

Haghayeghi, S. M. H., Irani, M. A., Askari, H. G., Rasa, M. S., & Shariatmadari, Z. (2025) · 3 Biotech · doi:10.1007/s13205-025-04329-y · Cited by 1 · see citing works

Antidiabetic Properties of Microalgae Compounds

Machado, R. L. S., Dutra, D. A., Schneider, A. T., Dias, R. R., Deprá, M. C., Zepka, L. Q., & Jacob-Lopes, E. (2025) · Springer eBooks · doi:10.1007/978-981-95-0571-5_4 · Cited by 1 · see citing works

COMBINING LIQUID CHROMATOGRAPHY WITH TANDEM MASS SPECTROMETRY (LC-MS/MS) TECHNIQUE, SPECTROPHOTOMETERVALIDATION AND AN IN SILICO STUDY OF 96% ETHANOL EXTRACT OF SPIRULINA PLATENSIS

Susantiningsih, T., Fadilah, F., Prijanti, A. R., & Hardiany, N. S. (2024) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2024v16i5.51339 · Cited by 1 · see citing works

Phycocyanin—Technical Aspects and Current Prospects

Rex, K., Vijayambika, B., & Singh, M. V. P. (2025) · Sustainable landscape planning and natural resources management · doi:10.1007/978-3-031-85550-4_15 · Cited by 1 · see citing works

Pengaruh Paparan Radiasi Dental Panoramik Digital Terhadap Aktivitas Kerja Enzim Amilase Pada Air Liur

Amatulhaq, S., Milvita, D., & Adrial, R. (2022) · Jurnal Fisika Unand · doi:10.25077/jfu.12.1.63-69.2023 · Cited by 1 · see citing works

Extraction, purification, characterization, and α-amylase inhibition of C- Phycocyanin from Dolichospermum spiroidesPreprint

Sanniyasi, E., Jayachandran, S., Gopal, R. K., & Damodharan, R. (2023) · Research Square · doi:10.21203/rs.3.rs-2250746/v2 · Cited by 1 · see citing works

Extraction, purification, characterization, and α-amylase inhibition of C- Phycocyanin from Dolichospermum spiroidesPreprint

Sanniyasi, E., Jayachandran, S., Gopal, R. K., & Damodharan, R. (2022) · Research Square · doi:10.21203/rs.3.rs-2250746/v1

The Impact of Radiation Dose Variation in Panoramic Dental Examination on Salivary Amylase Enzyme Activity

Yusuf, K., Milvita, D., & Utami, H. T. (2023) · JURNAL ILMU FISIKA | UNIVERSITAS ANDALAS · doi:10.25077/jif.16.1.34-45.2024

MOLECULAR DOCKING STUDIES OF NEW ANTIHYPERTENSIVE DRUG BASED ON DELPHINIDIN-3-SAMBUBIOSIDE ANALOGUES USING ANTIOGENSIN I–CONVERTING ENZYME AS THE TARGET

PEETHAMBARAN, H., C, D. A., GEORGE, N., & HARISH, A. (2025) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2025v18i6.54657

Glycemic Index and Organoleptic Test of Gluten-Free Chips Made from Composite Flour Enriched with Spirulina Platensis

Rahma, A. N., Supriatiningrum, D. N., Prayitno, S. A., Mulyani, E., & Ariestiningsih, E. S. (2025) · Amerta Nutrition · doi:10.20473/amnt.v9i2.2025.310-318

Studi In Silico Potensi Senyawa Jambu Biji (Psidium guajava) sebagai Inhibitor α-Amilase dan α-Glukosidase

Febbiana, A. P., Moerbi, T. R. T., Savita, W. D., Natashya, D., Heldestasia, D. R., Nurnahari, N., & Yusuf, M. S. (2025) · Jurnal Sains dan Kesehatan · doi:10.30872/jsk.v6i2.736

Computational Insights into Algal Compounds for Diabetes Mellitus Management

Satravada, B. A., Jayavarshini, V., Ravichandiran, S., Rajamanikandan, S., & Prabhu, D. (2025) · Springer eBooks · doi:10.1007/978-981-95-0571-5_17

Computational Bioprospection of Therapeutic Agents from Algae: Evidence from Molecular Docking and Molecular Dynamics Studies

Ayodele, O. M., & Sabiu, S. (2026) · Reference series in phytochemistry · doi:10.1007/978-3-031-80866-1_36-1

Identification Of Putative Inhibitors Of Human Pancreatic ?-Amylase From Phytochemicals Using Molecular Docking And Computational Analysis

Jalal, M. (2026) · Pakistan Journal of Pharmaceutical Sciences · doi:10.36721/pjps.2026.39.7.198.1

Molecular Docking and Molecular Dynamics Simulation Studies of Human Pancreatic α-Amylase with Phytochemicals from Corydalis chaerophylla D.C.

Maharjan, B., Parajuli, N., Shrestha, T., Bharati, S., Neupane, P., Dhital, S., Mali, S., Chhantyal, D., Marasini, B. P., Subin, J. A., et al. (2026) · Amrit Research Journal · doi:10.3126/arj.v7i1.101335

Molecular Docking and Molecular Dynamics Study of Phlorotannin-Derived Metabolites from Brown Macroalgae (Sargassum sp.) as Potential α-Amylase Inhibitors

Asnawi, A., Silviana, L., Andriansyah, I., Kurnia, D., Febrina, E., & Dinata, D. I. (2025) · Jurnal Kimia Riset · doi:10.20473/jkimris.v10i2.75900

In-silico screening of Alpha Amylase Enzyme Inhibitors from Siddha Formulation Pungampoo Chooranam by Molecular docking analysis for the management of Type II Diabetes mellitus

Nisha, J. (2017) · International Journal of Current Research in Medical Sciences · doi:10.22192/ijcrms.2017.03.10.006

Phytochemical profiling and evaluation of the antidiabetic potential of Ichnocarpus frutescens (Krishna Sariva): kinetic study, molecular modelling, and free energy approach

Kumari, S., Saini, R. P., & Mishra, A. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2248265 · Cited by 3 · see citing works