Male Wistar rats are more susceptible to lasting social anxiety than Wild-type Groningen rats following social defeat stress during adolescence
Open accessAbstract
Adolescence is an important period for the development of adult social competences. Social stress during adolescence may contribute not only to an inadequate social development but also to adult vulnerability to social anxiety. There seems to be a clear individual differentiation, however, in the vulnerability to the long-term negative consequences of social stress. The current study further explores this individual vulnerability and is aimed at the influence of social stress during adolescence on adult social anxiety and its context specificity. Rats from different strains (Wistar and Wild-type Groningen rats) were exposed to the resident-intruder paradigm five times during 10 min each in the period between postnatal day 45 and 58. Three and 7 weeks later, the animals were re-exposed to the context in the presence of either a dominant male or an anestrous female behind a wire mesh screen. Wistar rats that were socially defeated spent less time exploring the social stimulus in comparison with socially defeated Wild-type rats and their non-defeated controls. We conclude that the stressed Wistar rat shows signs of generalized social anxiety indicating that the Wistar rat can be considered as a vulnerable phenotype to effects of adolescent social stress.
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- Authors
- Vidal, J., Buwalda, B., & Koolhaas, J. M.
- Affiliations
- University of Groningen (NL)
- Corresponding author
- Vidal, Jose
- Venue
- Behavioural Processes
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 88
- Issue
- 2
- Pages
- 76-80
- ISSN
- 0376-6357 (ISSN-L)
- OpenAlex
- W2001676546
- Cited by
- 50
- References
- 34
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 5 · 2019: 1 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 3 · 2012: 3
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- green
- research.rug.nl
- Licence
- Locations
- Behavioural Processes (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- Repository of Digital Objects for Teaching Research and Culture (University of Valencia) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- social anxiety, social defeat stress, adolescence, Wistar rats, resident-intruder paradigm, individual susceptibility, strain differences, context specificity, social stress, generalized social anxiety
- MeSH terms
- Adolescent, Psychology, Adolescent, Animals, Animals, Wild, Anxiety, Avoidance Learning, Disease Models, Animal, Female, Humans, Male, Phobic Disorders, Social Dominance, Social Environment, Rats, Wistar, Rats
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