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Cited by 548Wound Healing and TreatmentsHydrogels: synthesis, properties, applicationsSurgical Sutures and Adhesives

Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing

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Yang, Yutong, Liang, Yongping, Chen, Jueying, Duan, Xianglong, Guo, Baolin·2022·Bioactive Materials
DOI 10.1016/j.bioactmat.2021.06.014PMC PMC8427086
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Abstract

With the increasing prevalence of drug-resistant bacterial infections and the slow healing of chronically infected wounds, the development of new antibacterial and accelerated wound healing dressings has become a serious challenge. In order to solve this problem, we developed photo-crosslinked multifunctional antibacterial adhesive anti-oxidant hemostatic hydrogel dressings based on polyethylene glycol monomethyl ether modified glycidyl methacrylate functionalized chitosan (CSG-PEG), methacrylamide dopamine (DMA) and zinc ion for disinfection of drug-resistant bacteria and promoting wound healing. The mechanical properties, rheological properties and morphology of hydrogels were characterized, and the biocompatibility of these hydrogels was studied through cell compatibility and blood compatibility tests. These hydrogels were tested for the in vitro blood-clotting ability of whole blood and showed good hemostatic ability in the mouse liver hemorrhage model and the mouse-tail amputation model. In addition, it has been confirmed that the multifunctional hydrogels have good inherent antibacterial properties against Methicillin-resistant Staphylococcus aureus (MRSA). In the full-thickness skin defect model infected with MRSA, the wound closure ratio, thickness of granulation tissue, number of collagen deposition, regeneration of blood vessels and hair follicles were measured. The inflammation-related cytokines (CD68) and angiogenesis-related cytokines (CD31) expressed during skin regeneration were studied. All results indicate that these multifunctional antibacterial adhesive hemostatic hydrogels have better healing effects than commercially available Tegaderm™ Film, revealing that they have become promising alternative in the healing of infected wounds.

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  • Yang and coworkers utilized the coordination of Zn2+ with catechol to develop a composite injectable hydrogel (CSG-PEG/DMA/Zn); due to the inherent antibacterial property of Zn2+, the developed injectable hydrogel exhibited antimicrobial properties.

    “For example, Yang and coworkers utilized the coordination of Zn2+ with catechol to develop a composite injectable hydrogel (CSG-PEG/DMA/Zn). Due to the inherent antibacterial property of Zn2+, the developed injectable hydrogel exhibited antimicrobial properties [36].”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [36]

    Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

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  • The incorporation of DOPA or other catechol compounds endows hydrogels with enhanced adhesion and antimicrobial activity.

    “The incorporation of DOPA or other catechol compounds endows hydrogels with enhanced adhesion and antimicrobial activity [36,105,106,107].”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [36]

    The Morphology, adhesion, and antioxidation section reports that catechol groups improve hydrogel adhesion. But the Preparation section says zinc ions were introduced to improve antibacterial properties, and the Antibacterial property and cell compatibility section identifies zinc ions as the main antibacterial component. The paper therefore does not support attributing both effects to DOPA or other catechol compounds. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • The fascinating properties of mussel-inspired injectable hydrogels benefit their application in numerous biomedical fields, such as wound closure and healing, hemostasis, bone repair, drug delivery, smart sensors, and biological coatings.

    “Their fascinating properties benefit their application in numerous biomedical fields, such as wound closure and healing [36,37], hemostasis [38,39], bone repair [40,41], drug delivery [42,43], smart sensors [44], biological coatings [45], etc. (Figure 2).”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [36]

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  1. [1]Annabi N. Rana D. Shirzaei Sani E. Portillo-Lara R. Gifford J.L. Fares M.M. Mithieux S.M. Weiss A.S. Engineering a sprayable and elastic hydrogel adhesive with antimicrobial properties for wound healing Biomaterials 139 2017 229 243 28579065 PMC11110881
  2. [5]Hu C. Zhang F. Kong Q. Lu Y. Zhang B. Wu C. Luo R. Wang Y. Synergistic chemical and photodynamic antimicrobial therapy for enhanced wound healing mediated by multifunctional light-responsive nanoparticles Biomacromolecules 20 2019 4581 4592 31697486
  3. [6]Li S. Pei M. Wan T. Yang H. Gu S. Tao Y. Liu X. Zhou Y. Xu W. Xiao P. Self-healing hyaluronic acid hydrogels based on dynamic Schiff base linkages as biomaterials Carbohydr. Polym. 250 2020 116922 33049836
  4. [7]Li Z. Zhou F. Li Z. Lin S. Chen L. Liu L. Chen Y. Hydrogel cross-linked with dynamic covalent bonding and micellization for promoting burn wound healing ACS Appl. Mater. Interfaces 10 2018 25194 25202 29986126
  5. [8]Liang Y. Chen B. Li M. He J. Yin Z. Guo B. Injectable Antimicrobial conductive hydrogels for wound disinfection and infectious wound healing Biomacromolecules 21 2020 1841 1852 32388998
  6. [9]Qi C. Xu L. Deng Y. Wang G. Wang Z. Wang L. Sericin hydrogels promote skin wound healing with effective regeneration of hair follicles and sebaceous glands after complete loss of epidermis and dermis Biomater. Sci. 6 2018 2859 2870 30259043
  7. [10]Zhao X. Zhang M. Guo B. Ma P.X. Mussel-inspired injectable supramolecular and covalent bond crosslinked hydrogels with rapid self-healing and recovery properties via a facile approach under metal-free conditions J. Mater. Chem. B 4 2016 6644 6651 32263519
  8. [11]Currie J. Lin W. Zhang W. Patient knowledge and antibiotic abuse: evidence from an audit study in China J. Health Econ. 30 2011 933 949 21733587
  9. [12]Zhang J. Ge J. Xu Y. Chen J. Zhou A. Sun L. Gao Y. Zhang Y. Gu T. Ning X. Bioactive multi-engineered hydrogel offers simultaneous promise against antibiotic resistance and wound damage Int. J. Biol. Macromol. 164 2020 4466 4474 32890556
  10. [15]Chen H. Cheng J. Ran L. Yu K. Lu B. Lan G. Dai F. Lu F. An injectable self-healing hydrogel with adhesive and antibacterial properties effectively promotes wound healing Carbohydr. Polym. 201 2018 522 531 30241849
  11. [16]Du X. Hou Y. Wu L. Li S. Yu A. Kong D. Wang L. Niu G. An anti-infective hydrogel adhesive with non-swelling and robust mechanical properties for sutureless wound closure J. Mater. Chem. B 8 2020 5682 5693 32500887
  12. [17]Gao Y. Han Y. Cui M. Tey H.L. Wang L. Xu C. ZnO nanoparticles as an antimicrobial tissue adhesive for skin wound closure J. Mater. Chem. B 5 2017 4535 4541 32263980
  13. [18]Han W. Zhou B. Yang K. Xiong X. Luan S. Wang Y. Xu Z. Lei P. Luo Z. Gao J. Zhan Y. Chen G. Liang L. Wang R. Li S. Xu H. Biofilm-inspired adhesive and antibacterial hydrogel with tough tissue integration performance for sealing hemostasis and wound healing Bioactive Mater. 5 2020 768 778 PMC7317234 32637741
  14. [19]Cheng H. Yue K. Kazemzadeh-Narbat M. Liu Y. Khalilpour A. Li B. Zhang Y.S. Annabi N. Khademhosseini A. Mussel-Inspired multifunctional hydrogel coating for prevention of infections and enhanced osteogenesis ACS Appl. Mater. Interfaces 9 2017 11428 11439 28140564 PMC5844698
  15. [22]Du X. Liu Y. Yan H. Rafique M. Li S. Shan X. Wu L. Qiao M. Kong D. Wang L. Anti-Infective and pro-coagulant chitosan-based hydrogel tissue adhesive for sutureless wound closure Biomacromolecules 21 2020 1243 1253 32045224
  16. [23]Bhattarai N. Gunn J. Zhang M. Chitosan-based hydrogels for controlled, localized drug delivery Adv. Drug Deliv. Rev. 62 2010 83 99 19799949
  17. [24]Sarwar M.S. Ghaffar A. Huang Q. Zafar M.S. Usman M. Latif M. Controlled-release behavior of ciprofloxacin from a biocompatible polymeric system based on sodium alginate/poly(ethylene glycol) mono methyl ether Int. J. Biol. Macromol. 165 2020 1047 1054 33002535
  18. [25]Ito T. Yoshida C. Murakami Y. Design of novel sheet-shaped chitosan hydrogel for wound healing: a hybrid biomaterial consisting of both PEG-grafted chitosan and crosslinkable polymeric micelles acting as drug containers Mater. Sci. Eng. C 33 2013 3697 3703 23910266
  19. [27]Zhu J. Li F. Wang X. Yu J. Wu D. Hyaluronic acid and polyethylene glycol hybrid hydrogel encapsulating nanogel with hemostasis and sustainable antibacterial property for wound healing ACS Appl. Mater. Interfaces 10 2018 13304 13316 29607644
  20. [28]Mouriño V. Cattalini J.P. Boccaccini A.R. Metallic ions as therapeutic agents in tissue engineering scaffolds: an overview of their biological applications and strategies for new developments J. R. Soc. Interface 9 2012 401 419 22158843 PMC3262432
  21. [29]Shi Y. Liu M. Deng F. Zeng G. Wan Q. Zhang X. Wei Y. Recent progress and development on polymeric nanomaterials for photothermal therapy: a brief overview J. Mater. Chem. B 5 2017 194 206 32263539
  22. [30]Sirelkhatim A. Mahmud S. Seeni A. Kaus N.H.M. Ann L.C. Bakhori S.K.M. Hasan H. Mohamad D. Review on zinc oxide nanoparticles: antibacterial activity and toxicity mechanism Nano-Micro Lett. 7 2015 219 242 PMC6223899 30464967
  23. [31]Mao C. Xiang Y. Liu X. Cui Z. Yang X. Yeung K.W.K. Pan H. Wang X. Chu P.K. Wu S. Photo-Inspired antibacterial activity and wound healing acceleration by hydrogel embedded with Ag/Ag@AgCl/ZnO nanostructures ACS Nano 11 2017 9010 9021 28825807
  24. [34]Brun N.R. Lenz M. Wehrli B. Fent K. Comparative effects of zinc oxide nanoparticles and dissolved zinc on zebrafish embryos and eleuthero-embryos: importance of zinc ions Sci. Total Environ. 476–477 2014 657 666 24508854
  25. [36]Fullenkamp D.E. Rivera J.G. Gong Y.-k. Lau K.H.A. He L. Varshney R. Messersmith P.B. Mussel-inspired silver-releasing antibacterial hydrogels Biomaterials 33 2012 3783 3791 22374454 PMC3367767
  26. [38]He X. Liu X. Yang J. Du H. Chai N. Sha Z. Geng M. Zhou X. He C. Tannic acid-reinforced methacrylated chitosan/methacrylated silk fibroin hydrogels with multifunctionality for accelerating wound healing Carbohydr. Polym. 247 2020 116689 32829817
  27. [39]Liang Y. Li Z. Huang Y. Yu R. Guo B. Dual-Dynamic-bond cross-linked antibacterial adhesive hydrogel sealants with on-demand removability for post-wound-closure and infected wound healing ACS Nano 15 2021 7078 7093 33764740
  28. [40]Puertas-Bartolomé M. Benito-Garzón L. Fung S. Kohn J. Vázquez-Lasa B. J. San Román, Bioadhesive functional hydrogels: controlled release of catechol species with antioxidant and antiinflammatory behavior Mater. Sci. Eng. C 105 2019 110040 31546368
  29. [41]Wang T. Mu X.Y. Li H.B. Wu W.L. Nie J. Yang D.Z. The photocrosslinkable tissue adhesive based on copolymeric dextran/HEMA Carbohydr. Polym. 92 2013 1423 1431 23399173
  30. [42]Hu J. Hou Y. Park H. Choi B. Hou S. Chung A. Lee M. Visible light crosslinkable chitosan hydrogels for tissue engineering Acta Biomater. 8 2012 1730 1738 22330279
  31. [43]Mathiyalagan R. Kim Y.J. Wang C. Jin Y. Subramaniyam S. Singh P. Wang D. Yang D.C. Protopanaxadiol aglycone ginsenoside-polyethylene glycol conjugates: synthesis, physicochemical characterizations, and in vitro studies Artif. Cell Nanomed. B 44 2016 1803 1809 26539976
  32. [44]Hou S. Ma P.X. Stimuli-Responsive supramolecular hydrogels with high extensibility and fast self-healing via precoordinated mussel-inspired chemistry Chem. Mater. 27 2015 7627 7635 26834315 PMC4729395
  33. [45]Qu J. Zhao X. Ma P.X. Guo B. Injectable antibacterial conductive hydrogels with dual response to an electric field and pH for localized “smart” drug release Acta Biomater. 72 2018 55 69 29555459
  34. [47]Shirzaei Sani E. Portillo Lara R. Aldawood Z. Bassir S.H. Nguyen D. Kantarci A. Intini G. Annabi N. An antimicrobial dental light curable bioadhesive hydrogel for treatment of peri-implant diseases Matter 1 2019 926 944 31663080 PMC6818244
  35. [48]Liang Y. Zhao X. Hu T. Chen B. Yin Z. Ma P.X. Guo B. Adhesive hemostatic conducting injectable composite hydrogels with sustained drug release and photothermal antibacterial activity to promote full-thickness skin regeneration during wound healing Small 15 2019 1900046 30786150
  36. [50]Zhao X. Li P. Guo B. Ma P.X. Antibacterial and conductive injectable hydrogels based on quaternized chitosan-graft-polyaniline/oxidized dextran for tissue engineering Acta Biomater. 26 2015 236 248 26272777
  37. [51]Zhang M. Chen S. Zhong L. Wang B. Wang H. Hong F. Zn2+-loaded TOBC nanofiber-reinforced biomimetic calcium alginate hydrogel for antibacterial wound dressing Int. J. Biol. Macromol. 143 2020 235 242 31816370
  38. [52]Shu M. Long S. Huang Y. Li D. Li H. Li X. High strength and antibacterial polyelectrolyte complex CS/HS hydrogel films for wound healing Soft Matter 15 2019 7686 7694 31498364
  39. [53]Dai T. Tanaka M. Huang Y.-Y. Hamblin M.R. Chitosan preparations for wounds and burns: antimicrobial and wound-healing effects Expert Rev. Anti Infect. Ther. 9 2011 857 879 21810057 PMC3188448
  40. [54]Huang X. Sun Y. Nie J. Lu W. Yang L. Zhang Z. Yin H. Wang Z. Hu Q. Using absorbable chitosan hemostatic sponges as a promising surgical dressing Int. J. Biol. Macromol. 75 2015 322 329 25661881
  41. [55]Verlee A. Mincke S. Stevens C.V. Recent developments in antibacterial and antifungal chitosan and its derivatives Carbohydr. Polym. 164 2017 268 283 28325326
  42. [56]Furuike T. Komoto D. Hashimoto H. Tamura H. Preparation of chitosan hydrogel and its solubility in organic acids Int. J. Biol. Macromol. 104 2017 1620 1625 28258006
  43. [59]Jeong Y.-I. Kim D.-G. Jang M.-K. Nah J.-W. Preparation and spectroscopic characterization of methoxy poly(ethylene glycol)-grafted water-soluble chitosan Carbohydr. Res. 343 2008 282 289 18035341
  44. [61]Hong Y. Xi Y. Zhang J. Wang D. Zhang H. Yan N. He S. Du J. Polymersome–hydrogel composites with combined quick and long-term antibacterial activities J. Mater. Chem. B 6 2018 6311 6321 32254621
  45. [64]Zhang Z. Wang X. Wang Y. Hao J. Rapid-forming and self-healing agarose-based hydrogels for tissue adhesives and potential wound dressings Biomacromolecules 19 2018 980 988 29451778
  46. [65]Liang Y.P. Zhao X. Hu T.L. Han Y. Guo B.L. Mussel-inspired, antibacterial, conductive, antioxidant, injectable composite hydrogel wound dressing to promote the regeneration of infected skin J. Colloid Interface Sci. 556 2019 514 528 31473541
  47. [66]Tang Q. Chen C. Jiang Y. Huang J. Liu Y. Nthumba P.M. Gu G. Wu X. Zhao Y. Ren J. Engineering an adhesive based on photosensitive polymer hydrogels and silver nanoparticles for wound healing J. Mater. Chem. B 8 2020 5756 5764 32519734
  48. [68]Zhang W. Wang R. Sun Z. Zhu X. Zhao Q. Zhang T. Cholewinski A. Yang F. Zhao B. Pinnaratip R. Forooshani P.K. Lee B.P. Catechol-functionalized hydrogels: biomimetic design, adhesion mechanism, and biomedical applications Chem. Soc. Rev. 49 2020 433 464 31939475 PMC7208057
  49. [69]Qu J. Zhao X. Liang Y. Zhang T. Ma P.X. Guo B. Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing Biomaterials 183 2018 185 199 30172244
  50. [70]Li H. Xu Q. Chen Y. Wan A. Effect of concentration and molecular weight of chitosan and its derivative on the free radical scavenging ability J. Biomed. Mater. Res. 102 2014 911 916 23589358
  51. [71]Liu C. Liu C. Yu S. Wang N. Yao W. Liu X. Sun G. Song Q. Qiao W. Efficient antibacterial dextran-montmorillonite composite sponge for rapid hemostasis with wound healing Int. J. Biol. Macromol. 160 2020 1130 1143 32446893
  52. [73]Zhao X. Guo B.L. Wu H. Liang Y.P. Ma P.X. Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing Nat. Commun. 9 2018 1 17 30018305 PMC6050275
  53. [74]Li D. Ye Y. Li D. Li X. Mu C. Biological properties of dialdehyde carboxymethyl cellulose crosslinked gelatin–PEG composite hydrogel fibers for wound dressings Carbohydr. Polym. 137 2016 508 514 26686157
  54. [75]Zhang D. Xu Z. Li H. Fan C. Cui C. Wu T. Xiao M. Yang Y. Yang J. Liu W. Fabrication of strong hydrogen-bonding induced coacervate adhesive hydrogels with antibacterial and hemostatic activities Biomater. Sci. 8 2020 1455 1463 31960840
  55. [76]Zhu Y. Zhang J. Song J. Yang J. Xu T. Pan C. Zhang L. One-step synthesis of an antibacterial and pro-healing wound dressing that can treat wound infections J. Mater. Chem. B 5 2017 8451 8458 32264512
  56. [78]Zhang Y. Chang M. Bao F. Xing M. Wang E. Xu Q. Huan Z. Guo F. Chang J. Multifunctional Zn doped hollow mesoporous silica/polycaprolactone electrospun membranes with enhanced hair follicle regeneration and antibacterial activity for wound healing Nanoscale 11 2019 6315 6333 30882821
  57. [80]Song Y. Wu H. Gao Y. Li J. Lin K. Liu B. Lei X. Cheng P. Zhang S. Wang Y. Sun J. Bi L. Pei G. Zinc silicate/nano-hydroxyapatite/collagen scaffolds promote angiogenesis and bone regeneration via the p38 MAPK pathway in activated monocytes ACS Appl. Mater. Interfaces 12 2020 16058 16075 32182418
  58. [81]Hoque J. Prakash R.G. Paramanandham K. Shome B.R. Haldar J. Biocompatible injectable hydrogel with potent wound healing and antibacterial properties Mol. Pharm. 14 2017 1218 1230 28207269
  59. [82]Hou C. He W. Wang Z. Yi B. Hu Z. Wang W. Deng X. Yao X. Particulate-aggregated adhesives with exudate-sensitive properties and sustained bacteria disinfection to facilitate wound healing ACS Appl. Mater. Interfaces 12 2020 31090 31098 32613825
  60. [83]Li M. Zhang Z. Liang Y. He J. Guo B. Multifunctional tissue-adhesive cryogel wound dressing for rapid nonpressing surface hemorrhage and wound repair ACS Appl. Mater. Interfaces 12 2020 35856 35872 32805786
  61. [84]Sharma S. Kumar R. Kumari P. Kharwar R.N. Yadav A.K. Saripella S. Mechanically magnified chitosan-based hydrogel as tissue adhesive and antimicrobial candidate Int. J. Biol. Macromol. 125 2019 109 115 30521916
  62. [85]Huang L. Zhu Z. Wu D. Gan W. Zhu S. Li W. Tian J. Li L. Zhou C. Lu L. Antibacterial poly (ethylene glycol) diacrylate/chitosan hydrogels enhance mechanical adhesiveness and promote skin regeneration Carbohydr. Polym. 225 2019 115110 31521272
  63. [86]Song A. Rane A.A. Christman K.L. Antibacterial and cell-adhesive polypeptide and poly(ethylene glycol) hydrogel as a potential scaffold for wound healing Acta Biomater. 8 2012 41 50 22023748 PMC3226862
  64. [87]Leu J.-G. Chen S.-A. Chen H.-M. Wu W.-M. Hung C.-F. Yao Y.-D. Tu C.-S. Liang Y.-J. The effects of gold nanoparticles in wound healing with antioxidant epigallocatechin gallate and α-lipoic acid Nanomedicine 8 2012 767 775 21906577
  65. [88]Shao Y. Dang M. Lin Y. Xue F. Evaluation of wound healing activity of plumbagin in diabetic rats Life Sci. 231 2019 116422 31059689
  66. [89]Yin G. Wang Z. Wang Z. Wang X. Topical application of quercetin improves wound healing in pressure ulcer lesions Exp. Dermatol. 27 2018 779 786 29733461

Cited by

Sorted by citations

Authors
Yang, Y., Liang, Y., Chen, J., Duan, X., & Guo, B.
Affiliations
  • Shaanxi Provincial People's Hospital (CN)
  • Xi'an Jiaotong University (CN)
Corresponding author
  • Duan, Xianglong
  • Guo, Baolin
ORCID
Venue
Bioactive Materials
Publisher
Elsevier BV
Published
2022-02
Volume
8
Pages
341-354
ISSN
  • 2097-1192 (ISSN-L)
  • 2452-199X
DOI
10.1016/j.bioactmat.2021.06.014
PMC
PMC8427086
OpenAlex
W3174641118
Cited by
548
References
0
Citations by year
2026: 34 · 2025: 98 · 2024: 140 · 2023: 149 · 2022: 118 · 2021: 9
FWCI
54.60
Type
journal article
Language
en
Open access
Licence
Locations
  • Bioactive Materials (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Education Department of Shaanxi Province (18JC027)
  • State Key Laboratory for Mechanical Behavior of Materials
  • Fundamental Research Funds for the Central Universities
  • National Natural Science Foundation of China (51673155, 51973172)
  • Xi’an Jiaotong University (2019LHM-KFKT008)
  • Natural Science Foundation of Shaanxi Province (2019TD-020, 2020JC-03)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
Keywords
mussel-inspired adhesives, hydrogel dressing, antibacterial hydrogel, antioxidant hydrogel, hemostatic hydrogel, infected wound healing, methicillin-resistant Staphylococcus aureus, photo-crosslinked hydrogel, chitosan, glycidyl methacrylate, dopamine, zinc ions, drug-resistant bacterial infections, skin regeneration, angiogenesis, inflammation, hemocompatibility, biocompatibility

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