Progress in Hydrogels for Skin Wound Repair
Abstract
As the first defensive line between the human body and the outside world, the skin is vulnerable to damage from the external environment. Skin wounds can be divided into acute wounds (mechanical injuries, chemical injuries, and surgical wounds, etc.) and chronic wounds (burns, infections, diabetes, etc.). In order to manage skin wound, a variety of wound dressings have been developed, including gauze, films, foams, nanofibers, hydrocolloids, and hydrogels. Recently, hydrogels have received much attention because of their natural extracellular matrix (ECM)‐mimik structure, tunable mechanical properties, and facile bioactive substance delivery capability. They show great potential application in skin wound repair. This paper first introduces the anatomy and function of the skin, the process of wound healing and conventional wound dressings, and then introduces the composition and construction methods of hydrogels. Next, this paper introduces the necessary properties of hydrogels in skin wound repair and the latest research progress of hydrogel dressings for skin wound repair. Finally, the future development goals of hydrogel materials in the field of wound healing are proposed.
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The hydrophilic properties of PLCL materials can be significantly improved by adding collagen, fibroin, and chitosan to PLCL.
“For example, the hydrophilic properties of PLCL materials can be significantly improved by adding collagen, fibroin and chitosan to PLCL.”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [143]
Incorporating electrospun PLCL fibers into hydrogels can significantly enhance the overall mechanical strength of the composite material.
“Incorporating electrospun PLCL fibers into hydrogels can significantly enhance the overall mechanical strength of the composite material [143, 144].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [143]
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Application of PLCL as a biodegradable polymer in biomedical engineering
Zhao, Y., & Liu, H. (2026) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-026-07016-3 · Cited by 7 · see citing works
“For example, the hydrophilic properties of PLCL materials can be signi fi cantly improved by adding collagen, fi broin and chitosan to PLCL. Incorporating electrospun PLCL fi bers into hydrogels can signi fi cantly enhance the overall mechanical strength of the composite material [143, 144].”
- Authors
- Qi, L., Zhang, C., Wang, B., Yin, J., & Yan, S.
- Affiliations
- Shanghai University (CN)
- Corresponding author
- Yin, Jingbo
- Yan, Shifeng
- Venue
- Macromolecular Bioscience
- Publisher
- Wiley
- Published
- 2022-04-14
- Volume
- 22
- Issue
- 7
- Pages
- e2100475-e2100475
- ISSN
- 1616-5187 (ISSN-L)
- 1616-5195
- OpenAlex
- W4223926804
- Cited by
- 267
- References
- 168
- Citations by year
- 2026: 66 · 2025: 78 · 2024: 78 · 2023: 40 · 2022: 5
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Macromolecular Bioscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (51873101, 52173131)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- hydrogels, skin wound healing, wound dressings, hydrogel dressing, wound healing, extracellular matrix mimicry, chronic wounds, acute wounds, hydrogel properties
- MeSH terms
- Bandages, Burns, Humans, Skin, Wound Healing, Hydrogels
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