Cited by 267Wound Healing and TreatmentsHydrogels: synthesis, properties, applicationsElectrospun Nanofibers in Biomedical Applications

Progress in Hydrogels for Skin Wound Repair

Qi, Liangfa, Zhang, Chenlu, Wang, Bo, Yin, Jingbo, Yan, Shifeng·2022·Macromolecular Bioscience

Abstract

As the first defensive line between the human body and the outside world, the skin is vulnerable to damage from the external environment. Skin wounds can be divided into acute wounds (mechanical injuries, chemical injuries, and surgical wounds, etc.) and chronic wounds (burns, infections, diabetes, etc.). In order to manage skin wound, a variety of wound dressings have been developed, including gauze, films, foams, nanofibers, hydrocolloids, and hydrogels. Recently, hydrogels have received much attention because of their natural extracellular matrix (ECM)‐mimik structure, tunable mechanical properties, and facile bioactive substance delivery capability. They show great potential application in skin wound repair. This paper first introduces the anatomy and function of the skin, the process of wound healing and conventional wound dressings, and then introduces the composition and construction methods of hydrogels. Next, this paper introduces the necessary properties of hydrogels in skin wound repair and the latest research progress of hydrogel dressings for skin wound repair. Finally, the future development goals of hydrogel materials in the field of wound healing are proposed.

Integrity signals

Registry

Crossref · 10.1002/mabi.202100475

Cites

168 of 168 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The hydrophilic properties of PLCL materials can be significantly improved by adding collagen, fibroin, and chitosan to PLCL.

    “For example, the hydrophilic properties of PLCL materials can be significantly improved by adding collagen, fibroin and chitosan to PLCL.”
  • Incorporating electrospun PLCL fibers into hydrogels can significantly enhance the overall mechanical strength of the composite material.

    “Incorporating electrospun PLCL fibers into hydrogels can significantly enhance the overall mechanical strength of the composite material [143, 144].”

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Qi, L., Zhang, C., Wang, B., Yin, J., & Yan, S.
Affiliations
Shanghai University (CN)
Corresponding author
  • Yin, Jingbo
  • Yan, Shifeng
Venue
Macromolecular Bioscience
Publisher
Wiley
Published
2022-04-14
Volume
22
Issue
7
Pages
e2100475-e2100475
ISSN
  • 1616-5187 (ISSN-L)
  • 1616-5195
OpenAlex
W4223926804
Cited by
267
References
168
Citations by year
2026: 66 · 2025: 78 · 2024: 78 · 2023: 40 · 2022: 5
FWCI
5.97
Type
journal article
Language
en
Open access
closed
Locations
  • Macromolecular Bioscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (51873101, 52173131)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords
hydrogels, skin wound healing, wound dressings, hydrogel dressing, wound healing, extracellular matrix mimicry, chronic wounds, acute wounds, hydrogel properties
MeSH terms
Bandages, Burns, Humans, Skin, Wound Healing, Hydrogels

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review