The DOI matches its Crossref record; 154 of the 172 references it cites were found in a registry or an index, and 6 are not checked yet.
Molecular cell biology of androgen receptor signalling
Abstract
The classical action of androgen receptor (AR) is to regulate gene transcriptional processes via AR nuclear translocation, response element binding and recruitment of, or crosstalk with, transcription factors. AR also utilises non-classical, non-genomic mechanisms of signal transduction. These precede gene transcription or protein synthesis, and involve steroid-induced modulation of cytoplasmic or cell membrane-bound regulatory proteins. Despite many decades of investigation, the role of AR in gene regulation of cells and tissues remains only partially characterised. AR exerts most of its effects in sex hormone-dependent tissues of the body, but the receptor is also expressed in many tissues not previously thought to be androgen sensitive. Thus it is likely that a complex, more over-arching, role for AR exists. Each AR domain co-ordinates a multitude of individual and vital roles via a diverse array of interacting partner molecules that are necessary for cellular and tissue development and maintenance. Aberrant AR activity, promoted by mutations or binding partner misregulation, can present as many clinical manifestations including androgen insensitivity syndrome and prostate cancer. In the case of malignant prostate cancer, treatment generally revolves around androgen deprivation therapies designed to interfere with AR action and the androgen signalling axis. Androgen therapies for prostate cancer often fail, highlighting a real need for increased research into AR function.
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“Androgen transmits signals via cell membrane receptors [19], which are distinct from the androgen nuclear receptors [20].”
From G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone (2020) · cites this paper as [20]
Citations
Cites
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Heck, A., & Handa, R. J. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0167-9 · Cited by 567
Sex differences in anxiety and depression: Role of testosterone
McHenry, J. A., Carrier, N., Hull, E. M., & Kabbaj, M. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.09.001 · Cited by 526
“More detailed information regarding the molecular mechanisms of androgens and estrogens at their receptors can be found in Bennett et al. (2010).”
BackgroundSex differences and sex steroids in lung health and disease
Townsend, E. A., Miller, V. M., & Prakash, Y. S. (2012) · Endocrine Reviews · doi:10.1210/er.2010-0031 · Cited by 395
Androgen-Induced Immunosuppression
Bupp, M. G., & Jørgensen, T. N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00794 · Cited by 404
“Activation of non-classical (NC) AR rapidly affects the regulation of other nuclear receptors, transcription factors, and cytoplasmic signaling events including the release of intracellular calcium and the formation of inositol 1,4,5-triphosphate (15).”
BackgroundSex, the aging immune system, and chronic disease
Bupp, M. G. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.02.002 · Cited by 333
“Peripheral T and B cells, thymocytes, bone marrow stromal cells, thymic epithelial cells, macrophages, monocytes, dendritic cells, and mast cells express intracellular androgen receptors and peripheral T cells and circulating monocytes also express membrane-bound ARs [45–48].”
Background
Metadata
- Authors
- Bennett, N. C., Gardiner, R. A., Hooper, J. D., Johnson, D. W., & Gobe, G. C.
- Affiliations
- The University of Queensland (AU)
- Queensland University of Technology (AU)
- Princess Alexandra Hospital (AU)
- Corresponding author
- Gobe, Glenda C.
- Venue
- The International Journal of Biochemistry & Cell Biology
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 42
- Issue
- 6
- Pages
- 813-827
- ISSN
- 1357-2725 (ISSN-L)
- OpenAlex
- W1546185806
- Cited by
- 292
- References
- 172
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 16 · 2023: 18 · 2022: 24 · 2021: 22 · 2020: 23 · 2019: 17 · 2018: 22 · 2017: 15 · 2016: 13 · 2015: 30 · 2014: 15 · 2013: 22 · 2012: 18
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- The International Journal of Biochemistry & Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Faculty of Health; Institute of Health and Biomedical Innovation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- androgen receptor, androgen signaling, nuclear translocation, transcriptional regulation, transcription factor crosstalk, androgen insensitivity syndrome, prostate cancer, androgen deprivation therapy, androgen receptor mutations
- MeSH terms
- Animals, Humans, Male, Polymorphism, Genetic, Prostatic Neoplasms, Receptors, Androgen, Gonadal Steroid Hormones, Androgen-Insensitivity Syndrome, Transcription Factors, Signal Transduction, Transcriptional Activation, Genetic Predisposition to Disease, Multiprotein Complexes
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