Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells
Mazurek, Sybille·2011·The International Journal of Biochemistry & Cell Biology
Cited by (707)
Items 201–300 of 707
- Organ-specific PTB1-associated microRNAs determine expression of pyruvate kinase isoformsKohei Taniguchi, Yuko Ito, Nobuhiko Sugito, Minami Kumazaki, Haruka Shinohara, Nami O. Yamada, Yoshihito Nakagawa, Tarou Sugiyama, Manabu Futamura, Yoshinori Otsuki et al. · 2015 · Scientific Reports
- Vitamin K3 and K5 are inhibitors of tumor pyruvate kinase M2Jing Chen, Zheng Jiang, Beibei Wang, Yanguang Wang, Xun Hu · 2011 · Cancer Letters
- Faecal pyruvate kinase isoenzyme type M2 for colorectal cancer screening: A meta-analysisCarolin Tonus · 2012 · World Journal of Gastroenterology
- GLUT3 and PKM2 regulate OCT4 expression and support the hypoxic culture of human embryonic stem cellsDavid R. Christensen, Philip C. Calder, Franchesca D. Houghton · 2015 · Scientific Reports
- The Glycogen Shunt Maintains Glycolytic Homeostasis and the Warburg Effect in CancerRobert G. Shulman, Douglas L. Rothman · 2017 · Trends in cancer
- Nutrient Sensing via mTOR in T Cells Maintains a Tolerogenic MicroenvironmentDuncan Howie, Herman Waldmann, Stephen Paul Cobbold · 2014 · Frontiers in Immunology
- Extracellular Vesicle Transmission of Chemoresistance to Ovarian Cancer Cells Is Associated with Hypoxia-Induced Expression of Glycolytic Pathway Proteins, and Prediction of Epithelial Ovarian Cancer Disease RecurrenceMona Ghazi Alharbi, Andrew Lai, Shayna Sharma, Priyakshi Kalita‐de Croft, Nihar Godbole, America V. Campos, Dominic Guanzon, Alexis Salas-Burgos, Flavio Carrión, Felipe Andrés Zuñiga et al. · 2021 · Cancers
- Activators of PKM2 in Cancer MetabolismSteven L. Warner, Kent J. Carpenter, David J. Bearss · 2014 · Future Medicinal Chemistry
- M-Type Pyruvate Kinase Isoforms and Lactate Dehydrogenase A in the Mammalian Retina: Metabolic ImplicationsRobert James Casson, John P. M. Wood, Guoge Han, Thaksaon Kittipassorn, Daniel J. Peet, Glyn Chidlow · 2016 · Investigative Ophthalmology & Visual Science
- PKM2 depletion induces the compensation of glutaminolysis through β-catenin/c-Myc pathway in tumor cellsHaili Wu, Zongwei Li, Peng Yang, Lichao Zhang, Yongsheng Fan, Zhuoyu Li · 2014 · Cellular Signalling
- Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1α and Bcl-xL in cultureTianfu Dong, Youde Yan, Hao Chai, Shenglin Chen, Xinkui Xiong, Daoyi Sun, Yue Yu, Lei Deng, Feng Cheng · 2014 · Biomedicine & Pharmacotherapy
- Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathwaysChunmei Wang, Salvatore Delogu, Coral Ho, Susie A. Lee, Bing Gui, Lijie Jiang, Sara Ladu, Antonio Cigliano, Frank Dombrowski, Matthias Evert et al. · 2012 · Journal of Hepatology
- Posttranslational modification of pyruvate kinase type M2 (PKM2): novel regulation of its biological roles to be further discoveredShutao Zheng, Qing Liu, Tao Liu, Xiaomei Lu · 2021 · Journal of Physiology and Biochemistry
- Inhibition of tumour cell growth by carnosine: some possible mechanismsAlan R. Hipkiss, Frank Gaunitz · 2013 · Amino Acids
- Glycolytic Enzyme PKM2 Mediates Autophagic Activation to Promote Cell Survival in NPM1-Mutated LeukemiaLu Wang, Liyuan Yang, Zailin Yang, Yuting Tang, Yao Tao, Qian Zhan, Lei Li, Yipei Jing, Xueke Jiang, Hongjun Jin et al. · 2019 · International Journal of Biological Sciences
- Common Responses of Tumors and Wounds to HypoxiaValéry L. Payen, Lucie Brisson, Mark W. Dewhirst, Pierre Sonveaux · 2015 · The Cancer Journal
- Cutting off the fuel supply to calcium pumps in pancreatic cancer cells: role of pyruvate kinase-M2 (PKM2)Andrew D. James, Daniel A. Richardson, In-Whan Oh, Pishyaporn Sritangos, Thomas Attard, Lisa Barrett, Jason I.E. Bruce · 2019 · British Journal of Cancer
- Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 SignalingWenjing Guo, Zhishuai Zhang, Guihuan Li, Xiaoju Lai, Ruonan Gu, Wanfu Xu, Hua Chen, Zhe Xing, Liping Chen, Jiabi Qian et al. · 2020 · Frontiers in Oncology
- Targeting Glucose Metabolism in Cancer Cells as an Approach to Overcoming Drug ResistanceAndrea Cunha, Patrícia M. A. Silva, Bruno Filipe Carmelino Cardoso Sarmento, Odília Queirós · 2023 · Pharmaceutics
- High Expression of Pyruvate Kinase M2 is Associated with Chemosensitivity to Epirubicin and 5-Fluorouracil in Breast CancerLin Yang, Feng Lv, Fangfang Liu, Xiaojing Guo, Yu Fan, Feng Gu, Jun Gu, Li Fu · 2015 · Journal of Cancer
- Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinaseInbal Mor, Rodrigo Carlessi, Tslil Ast, Elena Feinstein, Adi Kimchi · 2011 · Oncogene
- Discovery of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamide activators of the M2 isoform of pyruvate kinase (PKM2)Yong Xu, Xiaohui Liu, Michael Saunders, Scott Pearce, Jason M. Foulks, K. Mark Parnell, Adrianne Clifford, Rebecca N. Nix, Jeremy Bullough, Thomas F. Hendrickson et al. · 2013 · Bioorganic & Medicinal Chemistry Letters
- Heterogeneity of glycolysis in cancers and therapeutic opportunitiesMarc O. Warmoes, Jason W. Locasale · 2014 · Biochemical Pharmacology
- Cosilencing of PKM-2 and MDR-1 Sensitizes Multidrug-Resistant Ovarian Cancer Cells to Paclitaxel in a Murine Model of Ovarian CancerMeghna Talekar, Qijun Ouyang, Michael S. Goldberg, Mansoor M. Amiji · 2015 · Molecular Cancer Therapeutics
- Linc RNA ‐p21 suppresses development of human prostate cancer through inhibition of PKM 2Xiaohai Wang, Yongzhi Xu, Xingjie Wang, Chenyi Jiang, Sha Han, Kai Dong, Mengjun Shen, Dongliang Xu · 2017 · Cell Proliferation
- Cachexia as Evidence of the Mechanisms of Resistance and Tolerance during the Evolution of Cancer DiseaseAntonio Macciò, Elisabetta Sanna, Manuela Neri, Sara Oppi, Clelia Madeddu · 2021 · International Journal of Molecular Sciences
- The Role of Ovarian Sex Steroids in Metabolic Homeostasis, Obesity, and Postmenopausal Breast Cancer: Molecular Mechanisms and Therapeutic ImplicationsViroj Boonyaratanakornkit, Prangwan Pateetin · 2015 · BioMed Research International
- Aberrant role of pyruvate kinase M2 in the regulation of gamma-secretase and memory deficits in Alzheimer’s diseaseJonghee Han, Junho Hyun, Jaesang Park, Sunmin Jung, Yoonseo Oh, Youbin Kim, Shin-Hyeon Ryu, Seohyun Kim, Eun Il Jeong, Dong‐Gyu Jo et al. · 2021 · Cell Reports
- Reactive Oxygen Species and Metabolism in Leukemia: A Dangerous LiaisonMarta Romo-González, Carla Ijurko, Ángel Hernández‐Hernández · 2022 · Frontiers in Immunology
- New pyridin-3-ylmethyl carbamodithioic esters activate pyruvate kinase M2 and potential anticancer lead compoundsYu Zhang, Bin Liu, Xingyu Wu, Ridong Li, Xianling Ning, Yu Liu, Zhenming Liu, Zemei Ge, Runtao Li, Yuxin Yin · 2015 · Bioorganic & Medicinal Chemistry
- Splicing Programs and CancerSophie Germann, Lise Gratadou, Martin Dutertre, Didier Auboeuf · 2011 · Journal of Nucleic Acids
- Noninvasive assessment of mitochondrial organization in three-dimensional tissues reveals changes associated with cancer developmentJoanna F. Xylas, Antonio Varone, Kyle P. Quinn, Dimitra Pouli, Margaret E. McLaughlin-Drubin, Hong-Thao N. Thieu, Maria Garcia-Moliner, Michael D. House, Martin Hunter, Karl Münger et al. · 2014 · International Journal of Cancer
- HPV – A different view on Head and Neck CancerC. Wittekindt, S. Wagner, S. J. Sharma, N. Würdemann, Jennifer Knuth, Henrike Reder, J. Klussmann · 2018 · Laryngo-Rhino-Otologie
- Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulationJamie A. Macpherson, Alina Theisen, Laura Masino, Louise Fets, Paul C. Driscoll, Vesela Encheva, Ambrosius P. Snijders, Stephen R. Martin, Jens Kleinjung, Perdita E. Barran et al. · 2019 · eLife
- Pyruvate Kinase M2 Promotes Expression of Proinflammatory Mediators in House Dust Mite–Induced Allergic Airways DiseaseCheryl van de Wetering, Reem Aboushousha, Allison M. Manuel, Shi Biao Chia, Cuixia Shi Erickson, Maximilian B. MacPherson, Jos L. J. van der Velden, Vikas Anathy, Anne E. Dixon, Charles G. Irvin et al. · 2020 · The Journal of Immunology
- Tumor pyruvate kinase M2 modulators: a comprehensive account of activators and inhibitors as anticancer agentsBhagyashri Rathod, Shivam Chak, Sagarkumar Patel, Amit Shard · 2021 · RSC Medicinal Chemistry
- The Role of Pyruvate Kinase M2 in Cancer MetabolismVivian M. Liu, Matthew G. Vander Heiden · 2015 · Brain Pathology
- Knockdown of PKM2 induces apoptosis and autophagy in human A549 alveolar adenocarcinoma cellsBei‐Bei Chu, Jiang Wang, Yueying Wang, Guo‐Yu Yang · 2015 · Molecular Medicine Reports
- In vitro effects of some flavonoids and phenolic acids on human pyruvate kinase isoenzyme M2Erdem Aslan, Çağlar Güler, Şevki Adem · 2015 · Journal of Enzyme Inhibition and Medicinal Chemistry
- Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activatorsChuangxing Guo, Angelica Linton, Mehran Jalaie, Susan E. Kephart, Martha A. Ornelas, Mason Pairish, Samantha E. Greasley, Paul Richardson, Karen A. Maegley, Michael Hickey et al. · 2013 · Bioorganic & Medicinal Chemistry Letters
- Enhanced expression of the M2 isoform of pyruvate kinase is involved in gastric cancer development by regulating cancer‐specific metabolismTakeharu Shiroki, Misa Yokoyama, Nobuhiro Tanuma, Ryuhei Maejima, Keiichi Tamai, Kazunori Yamaguchi, Tomoyuki Oikawa, Tetsuya Noguchi, Koh Miura, Tsuneaki Fujiya et al. · 2017 · Cancer Science
- PKM2 and HIF-1α regulation in prostate cancer cell linesDiya Hasan, Elisabetta Gamen, Nafez Abu Tarboush, Y. Hussein Mohamed Ismail, Oleg Pak, Belal Azab · 2018 · PLoS ONE
- Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2Cheryl van de Wetering, Allison M. Manuel, Mona Sharafi, Reem Aboushousha, Xi Qian, Cuixia Shi Erickson, Maximilian B. MacPherson, Garrett J. Chan, Ian Michael Adcock, Nazanin Zounemat Kermani et al. · 2021 · Redox Biology
- A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2Sahil Arora, Gaurav Joshi, Anuhar Chaturvedi, Michael Heuser, Santoshkumar N. Patil, Raj Kumar · 2021 · Journal of Medicinal Chemistry
- Mitoplasticity: Adaptation Biology of the Mitochondrion to the Cellular Redox State in Physiology and CarcinogenesisCaroline José, Su Melser, Giovanni Bénard, Rodrigue Rossignol · 2012 · Antioxidants and Redox Signaling
- Elevation of serum pyruvate kinase M2 (PKM2) in IBD and its relationship to IBD indicesAhmed A. Almousa, Marc W Morris, Sharyle A. Fowler, Jennifer Jones, Jane Alcorn · 2017 · Clinical Biochemistry
- PHGDH as a mechanism for resistance in metabolically-driven cancersRicha Rathore, Charles R. Schutt, Brian Andrew Van Tine · 2020 · Cancer Drug Resistance
- Hydrogen sulfide coordinates glucose metabolism switch through destabilizing tetrameric pyruvate kinase M2Rong‐Hsuan Wang, Pin‐Ru Chen, Yue-Ting Chen, Yi‐Chang Chen, Yu-Hsin Chu, Chia-Chen Chien, Po-Chen Chien, Shao-Yun Lo, Zhongliang Wang, Min-Chen Tsou et al. · 2024 · Nature Communications
- Pyruvate Kinase M2 Modulates Esophageal Squamous Cell Carcinoma Chemotherapy Response by Regulating the Pentose Phosphate PathwayShuichi Fukuda, Hiroshi Miyata, Yasuhiro Miyazaki, Tomoki Makino, Tsuyoshi Takahashi, Yukinori Kurokawa, Makoto Yamasaki, Kiyokazu Nakajima, Shuji Takiguchi, Masaki Mori et al. · 2015 · Annals of Surgical Oncology
- PKM2: The Thread Linking Energy Metabolism Reprogramming with Epigenetics in CancerLing Chen, Ying Shi, Shuang Liu, Ya Cao, Xiang Wang, Yongguang Tao · 2014 · International Journal of Molecular Sciences
- PKM2 and ACVR 1C are prognostic markers for poor prognosis of gallbladder cancerJunfei Li, Zhuanyi Yang, Qiong Zou, Yanchun Yuan, Junfei Li, Lian Liang, G. Zeng, S. Chen · 2013 · Clinical & Translational Oncology
- PKM2 Knockdown Induces Autophagic Cell Death via AKT/mTOR Pathway in Human Prostate Cancer CellsPrasanta Kumar Dey, Amit B. Kundu, Richa Sachan, Jae Hyeon Park, Mee Young Ahn, Kyungsil Yoon, Jaewon Lee, Nam Deuk Kim, In Su Kim, Byung Mu Lee et al. · 2019 · Cellular Physiology and Biochemistry
- Interplay Between Metabolism and Oncogenic Process: Role of microRNAsAastha Arora, Saurabh Pratap Singh, Anant Narayan Bhatt, Sanjay Pandey, Rajat Sandhir, Bilikere Srinivasa Rao Dwarakanath · 2015 · Translational Oncogenomics
- Action at a Distance: Allostery and the Development of Drugs to Target Cancer Cell MetabolismByron DeLaBarre, Jonathan Hurov, Giovanni Cianchetta, Stuart Murray, Lenny Dang · 2014 · Chemistry & Biology
- Estradiol-17β Upregulates Pyruvate Kinase M2 Expression to Coactivate Estrogen Receptor-α and to Integrate Metabolic Reprogramming With the Mitogenic Response in Endometrial CellsSalama A. Salama, Mahmoud Ali Mohammad, Concepcion Diaz‐Arrastia, Marwa Kamel, Gokhan Sami Kilic, Bih T. Ndofor, Mohamed Shebl Abdelbaki, Stefan Theiler · 2014 · The Journal of Clinical Endocrinology & Metabolism
- Pyruvate Kinase M2 Regulates Apoptosis of Intestinal Epithelial Cells in Crohn’s DiseaseQiyun Tang, Qianqian Ji, Weiwei Xia, Li Li, Jian’an Bai, Runzhou Ni, Yongwei Qin · 2014 · Digestive Diseases and Sciences
- Insights into the Regulatory Role of Non-coding RNAs in Cancer MetabolismFredy Omar Beltrán‐Anaya, Alberto Cedro‐Tanda, Alfredo Hidalgo‐Miranda, Sandra Lorena Romero-Cordoba · 2016 · Frontiers in Physiology
- Targeting metabolic pathways for head and neck cancers therapeuticsMasashi Yamamoto, Hidenori Inohara, Takashi Nakagawa · 2017 · Cancer and Metastasis Reviews
- OGA activated glycopeptide-based nano-activator to activate PKM2 tetramerization for switching catabolic pathways and sensitizing chemotherapy resistanceDa‐Yong Hou, Wuyi Xiao, Jiaqi Wang, Yaseen Muhammad, Zhijia Wang, Yue Fei, Man‐Di Wang, Lu Wang, Hui Wang, Xinghua Shi et al. · 2022 · Biomaterials
- Improved Clearance during Treatment of HPV-Positive Head and Neck Cancer through mTOR InhibitionJoseph D. Coppock, Bryant G. Wieking, Alfredo Molinolo, Jorge Silvio Gutkind, W. Keith Miskimins, John H. Lee · 2013 · Neoplasia
- Evidence That Does Not Support Pyruvate Kinase M2 (PKM2)-catalyzed Reaction as a Rate-limiting Step in Cancer Cell GlycolysisJiansheng Xie, Chunyan Dai, Xun Hu · 2016 · Journal of Biological Chemistry
- Analysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinomaEdward B. Sanders, Svenja Diehl · 2015 · Oncoscience
- Research progress on the role of PKM2 in the immune responseChunyan Liu, Chenchen Liu, Rong Fu · 2022 · Frontiers in Immunology
- Tumor aerobic glycolysis: new insights into therapeutic strategies with targeted deliveryMeghna Talekar, Srinivas Reddy Boreddy, Amit Singh, Mansoor M. Amiji · 2014 · Expert Opinion on Biological Therapy
- MicroRNA regulation and analytical methods in cancer cell metabolismLing-Fei Zhang, Shuai Jiang, Mo‐Fang Liu · 2017 · Cellular and Molecular Life Sciences
- Overexpression of PKM2 promotes mitochondrial fusion through attenuated p53 stabilityHaili Wu, Peng Yang, Wanglai Hu, Yingying Wang, Yangxu Lu, Lichao Zhang, Yongsheng Fan, Hong Xiao, Zhuoyu Li · 2016 · Oncotarget
- Oxidative stress stimulates invasive potential in rat C6 and human U-87 MG glioblastoma cells via activation and cross-talk between PKM2, ENPP2 and APE1 enzymesRavi P. Cholia, Monisha Dhiman, Raj Kumar, Anil Kumar Mantha · 2018 · Metabolic Brain Disease
- PKM2 promotes reductive glutamine metabolismLiu Miao, Wang Yuanyuan, Ruan Yuxia, Bai Changsen, Qiu Li, Cui Yanfen, Ying Guoguang, Li Binghui · 2018 · Cancer Biology and Medicine
- Role of Glycolytic and Glutamine Metabolism Reprogramming on the Proliferation, Invasion, and Apoptosis Resistance through Modulation of Signaling Pathways in GlioblastomaCristina Trejo‐Solís, Daniela Silva‐Adaya, Norma Serrano-García, Roxana Magaña-Maldonado, Dolores Jiménez‐Farfán, Elizabeth Ferreira-Guerrero, Arturo Cruz-Salgado, Rosa Angélica Castillo‐Rodríguez · 2023 · International Journal of Molecular Sciences
- Pyruvate kinase M2 is a novel diagnostic marker and predicts tumor progression in human biliary tract cancerDipok Kumar Dhar, Steven W.M. Olde Damink, James Hallimond Brindley, Andrew Robert Godfrey, Michael Huw Chapman, Neomal S. Sandanayake, Fausto Andreola, Sybille Mazurek, Tayyaba G. Hasan, Massimo Malagó et al. · 2012 · Cancer
- Inhibitors of glucose transport and glycolysis as novel anticancer therapeuticsYanrong Qian · 2014 · World Journal of Translational Medicine
- The role of pyruvate kinase M2 in anticancer therapeutic treatments (Review)Qiongli Su, Shengping Luo, Qiuhong Tan, Jun Deng, Sichun Zhou, Mei Peng, Ting Tao, Xiaoping Yang · 2019 · Oncology Letters
- Glucose transporter‑1 inhibition overcomes imatinib resistance in gastrointestinal stromal tumor cellsTakafumi Shima, Kohei Taniguchi, Yoshihisa Tokumaru, Yosuke Inomata, Jun Arima, Sang‐Woong Lee, Kazuaki Takabe, Kazuhiro Yoshida, Kazuhisa Uchiyama · 2021 · Oncology Reports
- PKM2 functions as a histidine kinase to phosphorylate PGAM1 and increase glycolysis shunts in cancerYang Wang, Hengyao Shu, Yanzhao Qu, Xin Jin, Jia Liu, Wanting Peng, Lihua Wang, Miao Hao, Mingjie Xia, Zhexuan Zhao et al. · 2024 · The EMBO Journal
- Nuclear PKM2 promotes the progression of oral squamous cell carcinoma by inducing EMT and post-translationally repressing TGIF2Fumie Tanaka, Shohei Yoshimoto, Kazuhiko Okamura, Tetsuro Ikebe, Shuichi Hashimoto · 2018 · Oncotarget
- ARHGAP4 mediates the Warburg effect in pancreatic cancer through the mTOR and HIF-1α signaling pathwaysYehua Shen, Gang Chen, Liping Zhuang, Litao Xu, Junhua Lin, Luming Liu · 2019 · OncoTargets and Therapy
- Antitumor Effect of Shikonin, a PKM2 Inhibitor, in Cholangiocarcinoma Cell LinesUnchalee Thonsri, Wunchana Seubwai, Sakda Waraasawapati, Sopit Wongkham, Thidarat Boonmars, Ubon Cha’on, Chaisiri Wongkham · 2020 · Anticancer Research
- Defining the Molecular Basis of Tumor Metabolism: a Continuing Challenge Since Warburg’s DiscoveryAna Carolina Santos de Souza, Giselle Zenker Justo, Daniele Ribeiro de Araújo, Alexandre Donizeti Martins Cavagis · 2011 · Cellular Physiology and Biochemistry
- Homocysteine induces energy imbalance in rat skeletal muscle: Is creatine a protector?Janaína Kolling, Emilene B. S. Scherer, Cassiana Siebert, Fernanda Hansen, Felipe Vasconcelos Torres, Giselli Scaini, Gabriela Kozuchovski Ferreira, Rodrigo B. de Andrade, Carlos Alberto Gonçalves, Emilio Luiz STRECK et al. · 2012 · Cell Biochemistry and Function
- Alteration of O-GlcNAcylation affects serine phosphorylation and regulates gene expression and activity of pyruvate kinase M2 in colorectal cancer cellsParunya Chaiyawat, Daranee Chokchaichamnankit, Kriengsak Lirdprapamongkol, Chantragan Srisomsap, Jisnuson Svasti, Voraratt Champattanachai · 2015 · Oncology Reports
- 1-(sulfonyl)-5-(arylsulfonyl)indoline as activators of the tumor cell specific M2 isoform of pyruvate kinaseAvihai Yacovan, Rachel Ozeri, Tzofit Kehat, Sima Mirilashvili, Daniel Sherman, Alexander Aizikovich, Alina Shitrit, Efrat Ben‐Zeev, Nili C. Schutz, Osnat Bohana‐Kashtan et al. · 2012 · Bioorganic & Medicinal Chemistry Letters
- RhoC GTPase Is a Potent Regulator of Glutamine Metabolism and N-Acetylaspartate Production in Inflammatory Breast Cancer CellsMichelle L. Wynn, Joel A. Yates, Charles R. Evans, Lauren D. Van Wassenhove, Zhi-Fen Wu, Sydney Bridges, Liwei Bao, Chelsea L. Fournier, Sepideh Ashrafzadeh, Matthew J. Merrins et al. · 2016 · Journal of Biological Chemistry
- Pyruvate Kinase M2: a Metabolic Bug in Re-Wiring the Tumor MicroenvironmentMohd Rihan, Lakshmi Vineela Nalla, Anil Dharavath, Amit Shard, Kiran Kalia, Amit Khairnar · 2019 · Cancer Microenvironment
- Tissue-based metabolomics reveals potential biomarkers for cervical carcinoma and HPV infectionAbulizi Abudula, Nuermanguli Rouzi, Lixiu Xu, Yun Yang, Axiangu Hasimu · 2019 · Bosnian Journal of Basic Medical Sciences
- The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinaseNan Chen, Oliver Rinner, Dominika Czernik, Katarzyna J. Nytko, Dan Zheng, Daniel P. Stiehl, Nicola Zamboni, Matthias Gstaiger, Christian Frei · 2011 · Cell Research
- Pivotal Role of Pervasive Neoplastic and Stromal Cells Reprogramming in Circulating Tumor Cells Dissemination and Metastatic ColonizationDidier Meseure, Kinan Drak Alsibai, Andre Nicolas · 2014 · Cancer Microenvironment
- Inhibition of Proliferation, Migration, and Invasion by Knockdown of Pyruvate Kinase-M2 (PKM2) in Ovarian Cancer SKOV3 and OVCAR3 CellsYi Miao, Meng Lü, Qin Yan, Shuangdi Li, You-Ji Feng · 2016 · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · Retracted
- Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responsesJessica F. Walls, Jeffrey J. Subleski, Erika Mariana Palmieri, Marieli Gonzalez-Cotto, Clair M. Gardiner, Daniel W. McVicar, David K. Finlay · 2020 · eLife
- Structures of pyruvate kinases display evolutionarily divergent allosteric strategiesHugh P. Morgan, Wenhe Zhong, Iain W. McNae, Paul A.M. Michels, Linda A. Fothergill‐Gilmore, Malcolm D. Walkinshaw · 2014 · Royal Society Open Science
- Lapatinib Inhibits Breast Cancer Cell Proliferation by Influencing PKM2 ExpressionMingxiu Guan, Yingna Tong, Minghua Guan, Xiaobin Liu, Meng Wang, Ruifang Niu, Fei Zhang, Dong Dong, Jie Shao, Yunli Zhou · 2018 · Technology in Cancer Research & Treatment
- Proteomic analysis of rat serum revealed the effects of chronic sleep deprivation on metabolic, cardiovascular and nervous systemBo Ma, Jincheng Chen, Yongying Mu, Bingjie Xue, Aimei Zhao, Daoping Wang, Dennis Chang, Yinghong Pan, Jianxun Liu · 2018 · PLoS ONE
- PKM2 upregulation promotes malignancy and indicates poor prognosis for intrahepatic cholangiocarcinomaZe Qian, Wendi Hu, Zhen Lv, Hua Liu, Diyu Chen, Yacong Wang, Jian Wu, Shusen Zheng · 2019 · Clinics and Research in Hepatology and Gastroenterology
- A pan-cancer analysis of alternative splicing of splicing factors in 6904 patientsRui Cheng, Lixing Xiao, Wenyang Zhou, Xiyun Jin, Zhaochun Xu, Chang Xu, Pingping Wang, Meng Luo, Mengyun Wang, Kexin Ma et al. · 2021 · Oncogene
- Metabolic perturbation, proliferation and reactive oxygen species jointly contribute to cytotoxicity of human breast cancer cell induced by tetrabromo and tetrachloro bisphenol AChao Zhao, Zhi Tang, Arthur C.K. Chung, Hailin Wang, Zongwei Cai · 2018 · Ecotoxicology and Environmental Safety
- Sepsis-induced changes in pyruvate metabolism: insights and potential therapeutic approachesLouise Nuyttens, Jolien Vandewalle, Claude Libert · 2024 · EMBO Molecular Medicine
- The laforin/malin E3-ubiquitin ligase complex ubiquitinates pyruvate kinase M1/M2Rosa Viana, Pablo Luján, Pascual Sanz · 2015 · BMC Biochemistry
- Cryptanshinone Inhibits the Glycolysis and Inhibits Cell Migration Through PKM2/β-Catenin Axis in Breast CancerJiefeng Zhou, Chih-Ming Su, Hsin-An Chen, Shicong Du, Chang‐Wei Li, Haoran Wu, Shin‐Han Tsai, Yu-Ting Yeh · 2020 · OncoTargets and Therapy
- Cell metabolism-based therapy for liver fibrosis, repair, and hepatocellular carcinomaHélène Gilgenkrantz, Valérie Paradis, Sophie Lotersztajn · 2023 · Hepatology
- Pyruvate Kinase M2 Plays a Dual Role on Regulation of the EGF/EGFR Signaling via E-Cadherin-Dependent Manner in Gastric Cancer CellsLeyi Wang, Yunpeng Liu, Ligang Chen, Yanling Chen, Li Tan, Jingjing Liu, Amarsanaa Jazag, Jianlin Ren, Bayasi Guleng · 2013 · PLoS ONE
- Metabolic modulation of cancer: a new frontier with great translational potentialAdam S. Kinnaird, Evangelos D. Michelakis · 2015 · Journal of Molecular Medicine