Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

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2. Synthesis of novel 7-azaindole derivatives containing pyridin-3-ylmethyl dithiocarbamate moiety as potent PKM2 activators and PKM2 nucleus translocation inhibitors
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5. MNX1-AS1, a c-Myc induced lncRNA, promotes the Warburg effect by regulating PKM2 nuclear translocation
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6. Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma
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8. Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma
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9. Differentially expressed proteins among normal cervix, cervical intraepithelial neoplasia and cervical squamous cell carcinoma
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10. Isoform Switch of Pyruvate Kinase M1 Indeed Occurs but Not to Pyruvate Kinase M2 in Human Tumorigenesis
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11. Aerobic Glycolysis as a Marker of Tumor Aggressiveness: Preliminary Data in High Grade Human Brain Tumors
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12. Warburg meets non-coding RNAs: the emerging role of ncRNA in regulating the glucose metabolism of cancer cells
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13. UCP2 and PRMT1 are key prognostic markers for lung carcinoma patients
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14. Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation
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15. PKM2 Involved in Neuronal Apoptosis on Hypoxic-ischemic Encephalopathy in Neonatal Rats
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16. Role of Pyruvate Kinase M2 (PKM2) in Cardiovascular Diseases
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17. Comprehensive analysis of FOXM1 immune infiltrates, m6a, glycolysis and ceRNA network in human hepatocellular carcinoma
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19. The Role of PKM2 in Multiple Signaling Pathways Related to Neurological Diseases
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20. Nuclear PKM2: a signal receiver, a gene programmer, and a metabolic modulator
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21. Ectopic expression of the TERE1 (UBIAD1) protein inhibits growth of renal clear cell carcinoma cells: Altered metabolic phenotype associated with reactive oxygen species, nitric oxide and SXR target genes involved in cholesterol and lipid metabolism
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22. Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation
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23. TEPP-46-Based AIE Fluorescent Probe for Detection and Bioimaging of PKM2 in Living Cells
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24. Molecular glues: enhanced protein-protein interactions and cell proteome editing
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25. Cancer metabolism control by natural products: Pyruvate kinase M2 targeting therapeutics
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26. High expression of PKM2 as a poor prognosis indicator is associated with radiation resistance in cervical cancer.
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27. Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis
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28. Targeting energy metabolism to eliminate cancer cells
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29. Versatile mechanisms of 2-substituted benzimidazoles in targeted cancer therapy
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30. Both high expression of pyruvate kinase M2 and vascular endothelial growth factor-C predicts poorer prognosis in human breast cancer.
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32. Glut1 expression is increased by p53 reduction to switch metabolism to glycolysis during osteoblast differentiation
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33. Metabolic Factors Affecting Tumor Immunogenicity: What Is Happening at the Cellular Level?
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34. A review on the emerging roles of pyruvate kinase M2 in anti-leukemia therapy
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36. Point-of-care testing in the diagnosis of gastrointestinal cancers: Current technology and future directions
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37. Vascular smooth muscle cell metabolic reprogramming and phenotypic remodeling in atherosclerosis
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38. Targeted Proteomics to Assess the Response to Anti-Angiogenic Treatment in Human Glioblastoma (GBM)
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39. Cancer‐associated mutations in human pyruvate kinase M2 impair enzyme activity
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40. A short review on cross-link between pyruvate kinase (PKM2) and Glioblastoma Multiforme
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41. HPV and Other Microbiota; Who’s Good and Who’s Bad: Effects of the Microbial Environment on the Development of Cervical Cancer—A Non-Systematic Review
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42. PKM2 is a potential prognostic biomarker and related to immune infiltration in lung cancer
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44. Carbon metabolism and the sign of control coefficients in metabolic adaptations underlying K-ras transformation
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45. Relationship between 18-F-fluoro-deoxy-d-glucose uptake and expression of glucose transporter 1 and pyruvate kinase M2 in intrahepatic cholangiocarcinoma
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46. The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation
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47. Knockdown of the M2 Isoform of Pyruvate Kinase (PKM2) with shRNA Enhances the Effect of Docetaxel in Human NSCLC Cell LinesIn Vitro
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48. Exploring targeted therapy of osteosarcoma using proteomics data
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49. STAT6 promotes bi-directional modulation of PKM2 in liver and adipose inflammatory cells in Rosiglitazone-treated mice
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50. Epithelial cancers in the post-genomic era: should we reconsider our lifestyle?
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51. PK-M2 Makes Cells Sweeter on HIF1
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52. M2 isoform of pyruvate kinase (PKM2) is upregulated in Kazakh’s ESCC and promotes proliferation and migration of ESCC cells
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53. De novo transcriptome sequencing and analysis of male, pseudo-male and female yellow perch, Perca flavescens
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54. Evaluation of tumor M2-pyruvate kinase (Tumor M2-PK) as a biomarker for pancreatic cancer
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55. Vacuolar H+-ATPase Subunit V0C Regulates Aerobic Glycolysis of Esophageal Cancer Cells via PKM2 Signaling
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56. PKM2 Knockdown Induces Autophagic Cell Death via the AKT/mTOR Pathway in Human Prostate Cancer Cells
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58. Proteomic analysis of meat exudates to discriminate fresh and freeze-thawed porcine longissimus thoracis muscle
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60. Metabolic, autophagic, and mitophagic activities in cancer initiation and progression
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61. Identification of a new pyruvate kinase M2 isoform ( PKM 2) activator for the treatment of non‐small‐cell lung cancer ( NSCLC )
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62. The contribution of uncoupling protein 2 to mitochondrial Ca2+ homeostasis in health and disease – A short revisit
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63. LC–MS Based Metabolomics Study of the Effects of EGCG on A549 Cells
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64. Targeting the Interplay between Cancer Metabolic Reprogramming and Cell Death Pathways as a Viable Therapeutic Path
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65. Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma
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66. Multifaceted roles of aerobic glycolysis and oxidative phosphorylation in hepatocellular carcinoma
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67. Interpretable attention-based deep learning ensemble for personalized ovarian cancer treatment without manual annotations
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68. A proteomic approach to identification of plutonium-binding proteins in mammalian cells
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69. Aucklandiae radix targeted PKM2 to alleviate ulcerative colitis: Insights from the photocrosslinking target fishing technique
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70. SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling
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71. Targeting Cancer Metabolism and Current Anti-Cancer Drugs
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72. Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis
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73. Native Mass Spectrometry Gives Insight into the Allosteric Binding Mechanism of M2 Pyruvate Kinase to Fructose-1,6-Bisphosphate
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74. Evaluating the diagnostic and prognostic value of serum TuM2‐PK , NSE, and ProGRP in small cell lung cancer
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75. Homeostasis and the glycogen shunt explains aerobic ethanol production in yeast
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76. A novel approach to the discovery of anti-tumor pharmaceuticals: searching for activators of liponecrosis
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77. Alterations in glucose metabolism proteins responsible for the Warburg effect in esophageal squamous cell carcinoma
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78. MiR-106b-mediated Mfn2 suppression is critical for PKM2 induced mitochondrial fusion.
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79. Epigenetic silencing of miR-338 facilitates glioblastoma progression by de-repressing the pyruvate kinase M2-β-catenin axis
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80. Pyruvate kinase type M2 contributes to the development of pancreatic ductal adenocarcinoma by regulating the production of metabolites and reactive oxygen species
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81. Gastric Carcinogenesis
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82. Nanomedicine-driven tumor glucose metabolic reprogramming for enhanced cancer immunotherapy
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83. An iTRAQ based quantitative proteomic strategy to explore novel secreted proteins in metastatic hepatocellular carcinoma cell lines
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84. Modern Perspective on Metabolic Reprogramming in Malignant Neoplasms
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85. Biomarkers to Detect Early-Stage Colorectal Cancer
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86. GCN2, an old dog with new tricks
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87. Effects of PKM2 Gene Silencing on the Proliferation and Apoptosis of Colorectal Cancer LS-147T and SW620 Cells
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88. The Krebs Cycle Connection: Reciprocal Influence Between Alternative Splicing Programs and Cell Metabolism
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91. Significant association of PKM2 and NQO1 proteins with poor prognosis in breast cancer
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92. High Expression of PKM2 Was Associated with the Poor Prognosis of Acute Leukemia
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94. Pyruvate Kinase M2 Mediates Glycolysis in the Lymphatic Endothelial Cells and Promotes the Progression of Lymphatic Malformations
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96. Serum tumour M2‐pyruvate kinase as a biomarker for diagnosis and prognosis of early‐stage non–small cell lung cancer
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97. Like Brothers in Arms: How Hormonal Stimuli and Changes in the Metabolism Signaling Cooperate, Leading HPV Infection to Drive the Onset of Cervical Cancer
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98. Metabolic Regulation of Cardiac Regeneration
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99. Recent Advances on PKM2 Inhibitors and Activators in Cancer Applications
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