Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

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1. PKM2 promotes cell migration and inhibits autophagy by mediating PI3K/AKT activation and contributes to the malignant development of gastric cancer
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2. PKM2, STAT3 and HIF-1α
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3. Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence
   Yinsheng Wu, Lixu Tang, Han Huang, Qi Yu, Bicheng Hu, Gang Wang, Feng Ge, Tailang Yin, Shanshan Li, Xilan Yu · 2023 · Nature Communications
4. Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs OXPHOS and prostate cancer metastatic spread
   Elisa Giannoni, Maria Letizia Taddei, Andrea Morandi, Giuseppina Comito, Maura Calvani, Francesca Bianchini, Barbara Richichi, Giovanni Raugei, Nicholas Wong, Damu Tang et al. · 2015 · Oncotarget
5. Molecular Responses to Hypoxia-Inducible Factor 1α and Beyond
   Jason Brocato, Yana Chervona, Max Costa · 2014 · Molecular Pharmacology
6. Cancer Usurps Skeletal Muscle as an Energy Repository
   Yi Luo, Junya Yoneda, Hitoshi Ohmori, Takamitsu Sasaki, Kazutaka Shimbo, Sachise Eto, Yumiko O. KATO, Hiroshi Miyano, Tsuyoshi Kobayashi, Tomonori Sasahira et al. · 2013 · Cancer Research
7. Glutamine‐fueled mitochondrial metabolism is decoupled from glycolysis in melanoma
   Fabian V. Filipp, Boris I. Ratnikov, Jessica De Ingeniis, Jeffrey W. Smith, Andrei L. Osterman, David A. Scott · 2012 · Pigment Cell & Melanoma Research
8. Cancer‐like metabolism of the mammalian retina
   Soo Khai Ng, John PM Wood, Glyn Chidlow, Guoge Han, Thaksaon Kittipassorn, Daniel J. Peet, Robert James Casson · 2014 · Clinical and Experimental Ophthalmology
9. MiR‐133b inhibits growth of human gastric cancer cells by silencing pyruvate kinase muscle‐splicer polypyrimidine tract‐binding protein 1
   Taro Sugiyama, Kohei Taniguchi, Nobuhisa Matsuhashi, Toshihiro Tajirika, Manabu Futamura, Tomoaki Takai, Yukihiro Akao, Kazuhiro Yoshida · 2016 · Cancer Science
10. Epigenetics and cancer metabolism
    Christelle Johnson, Marc O. Warmoes, Xiling Shen, Jason W. Locasale · 2013 · Cancer Letters
11. PKM2, a potential target for regulating cancer
    Yuhuan Li, Xiaofeng Li, Jiatao Liu, Hua Wang, Lulu Fan, Jun Li, Guoping Sun · 2018 · Gene
12. Metabolic control of the cell cycle
    Joanna Maria Kalucka, Rindert Missiaen, Μαρία Γεωργιάδου, Sandra Schoors, Christian M. Lange, Katrien De Bock, Mieke A. Dewerchin, Peter Carmeliet · 2015 · Cell Cycle
13. The Warburg Effect in Diabetic Kidney Disease
    Guanshi Zhang, Manjula Darshi, Kumar Sharma · 2018 · Seminars in Nephrology
14. Linking vitamin B1 with cancer cell metabolism
    Jason A. Zastre, Rebecca L. Sweet, Bradley S. Hanberry, Star Ye · 2013 · Cancer & Metabolism
15. L-lactic acidosis: pathophysiology, classification, and causes; emphasis on biochemical and metabolic basis
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16. Impacts and mechanisms of alternative mRNA splicing in cancer metabolism, immune response, and therapeutics
    Peng Qiu, Yujuan Zhou, Linda Oyang, Nayiyuan Wu, Yanyan Tang, Min Su, Xia Luo, Ying Wang, Xiaowu Sheng, Jian Ma et al. · 2021 · Molecular Therapy
17. Inhibition of Pyruvate Kinase M2 Markedly Reduces Chemoresistance of Advanced Bladder Cancer to Cisplatin
    Xing Wang, Fenglin Zhang, Xue‐Ru Wu · 2017 · Scientific Reports
18. The Key Role of the WNT/β-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions
    Alexandre Vallée, Yves Lecarpentier, Jean-Noël Vallée · 2021 · Cancers
19. SRSF3, a Splicer of the PKM Gene, Regulates Cell Growth and Maintenance of Cancer-Specific Energy Metabolism in Colon Cancer Cells
    Yuki Kuranaga, Nobuhiko Sugito, Haruka Shinohara, Takuya Tsujino, Kohei Taniguchi, Kazumasa Komura, Yuko Ito, Tomoyoshi Soga, Yukihiro Akao · 2018 · International Journal of Molecular Sciences
20. Down‐regulation of PKM2 decreases FASN expression in bladder cancer cells through AKT/mTOR/SREBP‐1c axis
    Ting Tao, Qiongli Su, Simeng Xu, Jun Deng, Sichun Zhou, Zhuang Yu, Yanjun Huang, Caimei He, Shanping He, Mei Peng et al. · 2018 · Journal of Cellular Physiology
21. MiR-let-7a inhibits cell proliferation, migration, and invasion by down-regulating PKM2 in gastric cancer
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22. Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity
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23. Modulation of dysregulated cancer metabolism by plant secondary metabolites: A mechanistic review
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24. Pyruvate uptake is increased in highly invasive ovarian cancer cells under anoikis conditions for anaplerosis, mitochondrial function, and migration
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25. Alternative RNA splicing and cancer
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26. Endothelial pyruvate kinase M2 maintains vascular integrity
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27. Aerobic glycolysis: a novel target in kidney cancer
    Brian M. Shuch, William Marston Linehan, Ramaprasad Srinivasan · 2013 · Expert Review of Anticancer Therapy
28. The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs
    Dexter L. Puckett, Mohammed Ibrahim Alquraishi, Winyoo Chowanadisai, Ahmed Bettaieb · 2021 · International Journal of Molecular Sciences
29. Clinical significance of T cell metabolic reprogramming in cancer
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30. Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome
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31. Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth
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32. Overexpression of the M2 isoform of pyruvate kinase is an adverse prognostic factor for signet ring cell gastric cancer
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33. Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities
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34. Phosphotyrosine recognition domains: the typical, the atypical and the versatile
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35. Dual roles of PKM2 in cancer metabolism
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36. Activated lymphocytes as a metabolic model for carcinogenesis
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37. Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene‐induced senescent cells
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38. Serine Biosynthesis with One Carbon Catabolism and the Glycine Cleavage System Represents a Novel Pathway for ATP Generation
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39. Bisphenol S exposure modulate macrophage phenotype as defined by cytokines profiling, global metabolomics and lipidomics analysis
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40. Aerobic glycolysis fuels platelet activation: small-molecule modulators of platelet metabolism as anti-thrombotic agents
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41. PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis
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42. Direct Measurements of Oscillatory Glycolysis in Pancreatic Islet β-Cells Using Novel Fluorescence Resonance Energy Transfer (FRET) Biosensors for Pyruvate Kinase M2 Activity
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43. Emerging Metabolic Targets in Cancer Therapy
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44. Pyruvate Kinase M2 Tetramerization Protects against Hepatic Stellate Cell Activation and Liver Fibrosis
    Dandan Zheng, Yuchuan Jiang, Chen Qu, Hui Yuan, Kaishun Hu, Lu He, Peng Chen, Jinying Li, Mengxian Tu, Lehang Lin et al. · 2020 · American Journal Of Pathology
45. Pyruvate kinase M knockdown–induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survival
    Gopinath Prakasam, Rajnish Kumar Singh, Mohammad Askandar Iqbal, Sunil Kumar Saini, Ashu Bhan Tiku, Ramesh N K Bamezai · 2017 · Journal of Biological Chemistry
46. The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis
    Manasa K. Nayak, Madankumar Ghatge, Gagan D. Flora, Nirav Dhanesha, Manish Kumar Jain, Kathleen R. Markan, Matthew J. Potthoff, Steven R. Lentz, Anil Kumar Chauhan · 2020 · Blood
47. Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2
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48. Nur77-activated lncRNA WFDC21P attenuates hepatocarcinogenesis via modulating glycolysis
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49. Phosphoglyceric acid mutase-1 contributes to oncogenic mTOR-mediated tumor growth and confers non-small cell lung cancer patients with poor prognosis
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50. Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level
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51. Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma
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52. Links between cancer metabolism and cisplatin resistance
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53. PKM2-dependent metabolic reprogramming in CD4+ T cells is crucial for hyperhomocysteinemia-accelerated atherosclerosis
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54. FOXM1D potentiates PKM2‐mediated tumor glycolysis and angiogenesis
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55. Metabolomic Characterizations of Liver Injury Caused by Acute Arsenic Toxicity in Zebrafish
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56. Astrocyte-neuron crosstalk regulates the expression and subcellular localization of carbohydrate metabolism enzymes
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57. Tumor Metabolism of Malignant Gliomas
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58. Regulation of Cellular Metabolism by High-Risk Human Papillomaviruses
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59. Centromere protein F (CENPF), a microtubule binding protein, modulates cancer metabolism by regulating pyruvate kinase M2 phosphorylation signaling
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60. Mechanism of PKM2 affecting cancer immunity and metabolism in Tumor Microenvironment
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61. Knockdown of Pyruvate Kinase M Inhibits Cell Growth and Migration by Reducing NF-kB Activity in Triple-Negative Breast Cancer Cells.
    Chaobing Ma, Xueyin Zu, Kangdong Liu, Ann M. Bode, Zigang Dong, Zhenzhen Liu, Dong Joon Kim · 2019 · Europe PMC (PubMed Central)
62. Pharmacologic Activation of PKM2 Slows Lung Tumor Xenograft Growth
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63. Homocysteine Activates B Cells via Regulating PKM2-Dependent Metabolic Reprogramming
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64. Exosomal Long Non-coding RNAs: Emerging Players in the Tumor Microenvironment
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65. Tanshinone ⅡA inhibits human esophageal cancer cell growth through miR-122-mediated PKM2 down-regulation
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66. Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein
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67. Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells
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68. The role of interleukin-6 in the evolution of ovarian cancer: clinical and prognostic implications—a review
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69. l -cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2
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70. Overview: Cellular plasticity, cancer stem cells and metastasis
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71. The metabolic cooperation between cells in solid cancer tumors
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72. PKM2-dependent glycolysis promotes the proliferation and migration of vascular smooth muscle cells during atherosclerosis
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73. Enzymatic features of the glucose metabolism in tumor cells
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74. PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2
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75. Cancer stem cells, microRNAs, and therapeutic strategies including natural products
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76. Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect
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77. Metabolic changes in triple negative breast cancer-focus on aerobic glycolysis
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78. The function of alternative splicing in the proteome: rewiring protein interactomes to put old functions into new contexts
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79. Metabolic reprogramming of fibro/adipogenic progenitors facilitates muscle regeneration
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80. The role of mitochondrial electron transport in tumorigenesis and metastasis
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81. Deciphering metabolic rewiring in breast cancer subtypes
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82. Site-specific characterization and quantitation of N -glycopeptides in PKM2 knockout breast cancer cells using DiLeu isobaric tags enabled by electron-transfer/higher-energy collision dissociation (EThcD)
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83. The strategic roles of four enzymes in the interconnection between metabolism and oncogene activation in non-small cell lung cancer: Therapeutic implications
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84. MicroRNAs in obesity-associated disorders
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85. Bioenergetic Impairment in Animal and Cellular Models of Alzheimer’s Disease: PARP-1 Inhibition Rescues Metabolic Dysfunctions
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86. PKM2 in carcinogenesis and oncotherapy
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87. Contemporary Perspectives on the Warburg Effect Inhibition in Cancer Therapy
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88. Mitochondria-Mediated Energy Adaption in Cancer: The H + -ATP Synthase-Geared Switch of Metabolism in Human Tumors
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89. Natural Compounds as Regulators of the Cancer Cell Metabolism
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90. Aspirin acetylates multiple cellular proteins in HCT-116 colon cancer cells: Identification of novel targets
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91. Lin28A promotes IRF6-regulated aerobic glycolysis in glioma cells by stabilizing SNHG14
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92. 2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase
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93. PKM2 as a biomarker for chemosensitivity to front-line platinum-based chemotherapy in patients with metastatic non-small-cell lung cancer
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94. PTBP1 ‐targeting microRNAs regulate cancer‐specific energy metabolism through the modulation of PKM1/M2 splicing
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95. Jmjd4 Facilitates Pkm2 Degradation in Cardiomyocytes and Is Protective Against Dilated Cardiomyopathy
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96. The proliferating cell hypothesis: a metabolic framework for Plasmodium growth and development
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97. An Update on Novel Quantitative Techniques in the Context of Evolving Whole-Body PET Imaging
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98. Metabolic reprogramming: a hallmark of viral oncogenesis
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99. PKM2 regulates endothelial cell junction dynamics and angiogenesis via ATP production
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100. Inhibiting the Pkm2/b-catenin axis drives in vivo replication of adult cardiomyocytes following experimental MI
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