The DOI matches its Crossref record; 159 of the 159 references it cites were found in a registry or an index.
Cancer stem cells
Open accessAbstract
Cancer Stem Cells (CSCs) are a small subpopulation of cells within tumors with capabilities of self-renewal, differentiation, and tumorigenicity when transplanted into an animal host. A number of cell surface markers such as CD44, CD24, and CD133 are often used to identify and enrich CSCs. A regulatory network consisting of microRNAs and Wnt/β-catenin, Notch, and Hedgehog signaling pathways controls the CSC properties. The clinical relevance of CSCs has been strengthened by emerging evidence, demonstrating that CSCs are resistant to conventional chemotherapy and radiation treatment and that CSCs are very likely to be the origin of cancer metastasis. CSCs are believed to be an important target for novel anti-cancer drug discovery. Herein we summarize the current understanding of CSCs, with a focus on the role of miRNA and epithelial mesenchymal transition (EMT), and discuss the clinical application of targeting CSCs for cancer treatment.
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1 retracted
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“They are resistant to standard chemotherapies and are thought to be one of the main contributors to cancer development, drug resistance and clinical relapse (Yu et al., 2012).”
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Metadata
- Authors
- Yu, Z., Pestell, T. G., Lisanti, M. P., & Pestell, R. G.
- Venue
- The International Journal of Biochemistry & Cell Biology
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 44
- Issue
- 12
- Pages
- 2144-2151
- ISSN
- 1357-2725 (ISSN-L)
- OpenAlex
- W2116504531
- Cited by
- 647
- References
- 159
- FWCI
- 9.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Yu, Z., Pestell, T. G., Lisanti, M. P., & Pestell, R. G. (2012). Cancer stem cells. The International Journal of Biochemistry & Cell Biology. https://doi.org/10.1016/j.biocel.2012.08.022
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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