Exploring the Potential of Nanotherapeutics in Targeting Tumor Microenvironment for Cancer Therapy

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Cancer stem cells: impact, heterogeneity, and uncertainty

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Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

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Recent progress in tumor pH targeting nanotechnology

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Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells

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Matrix Metalloproteinase- and pH-Sensitive Nanoparticle System Enhances Drug Retention and Penetration in Glioblastoma

Dosta, P., Dion, M. Z., Prado, M., Hurtado, P., Javelly, C. J. R., Cryer, A. M., Soria, Y., Interiano, N. A., Taboada, G. M., & Artzi, N. (2024) · ACS Nano · doi:10.1021/acsnano.3c03409 · Cited by 49 · see citing works

Targeting HER2-breast tumors with scFv-decorated bimodal nanoprobes

Alric, C., Hervé-Aubert, K., Aubrey, N., Melouk, S., Lajoie, L., Même, W., Même, S., Courbebaisse, Y., Ignatova, A. A., Feofanov, A. V., et al. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0341-6 · Cited by 44 · see citing works

Cabazitaxel and thymoquinone co-loaded lipospheres as a synergistic combination for breast cancer

Kommineni, N., Saka, R., Bulbake, U., & Khan, W. (2018) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2018.11.009 · Cited by 43 · see citing works

Recent progress on mitochondrial targeted cancer therapy based on inorganic nanomaterials

Xu, Z., Chen, X., Sun, Z., Li, C., & Jiang, B. (2019) · Materials Today Chemistry · doi:10.1016/j.mtchem.2019.02.004 · Cited by 43 · see citing works

Engineering metal‐phenolic networks for enhancing cancer therapy by tumor microenvironment modulation

Xie, L., Li, J., Wang, L., & Dai, Y. (2022) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1864 · Cited by 41 · see citing works

Preparation and Comparison of Oral Bioavailability for Different Nano-formulations of Olaparib

Pathade, A. D., Kommineni, N., Bulbake, U., Thummar, M. M., Samanthula, G., & Khan, W. (2019) · AAPS PharmSciTech · doi:10.1208/s12249-019-1468-y · Cited by 40 · see citing works

3D bioprinting technology to mimic the tumor microenvironment: tumor-on-a-chip concept

Samadian, H., Jafari, S., Sepand, M. R., Alaei, L., Malvajerd, S. S., Jaymand, M., Ghobadinezhad, F., Jahanshahi, F., Hamblin, M. R., Derakhshankhah, H., et al. (2021) · Materials Today Advances · doi:10.1016/j.mtadv.2021.100160 · Cited by 33 · see citing works

The Potential of Zebrafish as a Model Organism for Improving the Translation of Genetic Anticancer Nanomedicines

Gutiérrez-Lovera, C., Vázquez-Ríos, A. J., Guerra‐Varela, J., Sanchez, L. E., & la Fuente, M. D. (2017) · Genes · doi:10.3390/genes8120349 · Cited by 32 · see citing works

Nanoparticle-based immunotherapy of pancreatic cancer

Nzeteu, G. A. N., Gibbs, B. F., Kotnik, N., Troja, A., Bockhorn, M., & Meyer, N. H. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.948898 · Cited by 28 · see citing works

Molecular targeted treatment and drug delivery system for gastric cancer

Jiang, L., Gong, X., Liao, W., Lv, N., & Yan, R. (2021) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-021-03520-x · Cited by 27 · see citing works

Nanoengineering Branched Star Polymer‐Based Formulations: Scope, Strategies, and Advances

Yong, H. W., & Kakkar, A. K. (2021) · Macromolecular Bioscience · doi:10.1002/mabi.202100105 · Cited by 28 · see citing works

Interleukin 22 and its association with neurodegenerative disease activity

Chen, W., Wang, J., Yang, H., Sun, Y., Chen, B., Liu, Y., Han, Y., Shan, M., & Zhan, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.958022 · Cited by 25 · see citing works

Anticancer nanomedicines harnessing tumor microenvironmental components

Li, Y., Chen, Z., Gu, L., Duan, Z., Pan, D., Xu, Z., Gong, Q., Li, Y., Zhu, H., & Luo, K. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2050211 · Cited by 23 · see citing works

Trends in Nanotechnology to improve therapeutic efficacy across special structures

Khan, M. I., Zahra, Q. U. A., Batool, F., Kalsoom, F., Gao, S., Ali, R., Wang, W., Kazmi, A., Lianliang, L., Wang, G., et al. (2022) · OpenNano · doi:10.1016/j.onano.2022.100049 · Cited by 23 · see citing works

Nanotherapy Targeting the Tumor Microenvironment

Gong, B., Wang, R., Xu, H., Miao, M., & Yao, Z. (2018) · Current Cancer Drug Targets · doi:10.2174/1568009619666181220103714 · Cited by 22 · see citing works

Thiophene Derivatives as Anticancer Agents and Their Delivery to Tumor Cells Using Albumin Nanoparticles

Cai, G., Wang, S., Zhao, L., Sun, Y., Yang, D., Lee, R. J., Zhao, M., Zhang, H., & Zhou, Y. (2019) · Molecules · doi:10.3390/molecules24010192 · Cited by 19 · see citing works

Coating a Self-Assembly Nanoconstruct with a Neutrophil Cell Membrane Enables High Specificity for Triple Negative Breast Cancer Treatment

Chowdhury, P., Nagesh, P. K. B., Hollingsworth, T., Jaggi, M., Chauhan, S. C., & Yallapu, M. M. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00614 · Cited by 20 · see citing works

Nanomedicine for Immunotherapy Targeting Hematological Malignancies: Current Approaches and Perspective

Allegra, A., Gioacchino, M. D., Tonacci, A., Petrarca, C., & Gangemi, S. (2021) · Nanomaterials · doi:10.3390/nano11112792 · Cited by 19 · see citing works

Plant‐Derived Extracellular Vesicles as Potential Emerging Tools for Cancer Therapeutics

Ding, L., Chang, C., Liang, M., Dong, K., & Li, F. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202400256 · Cited by 19 · see citing works

Anti-tumour effects of a xenogeneic fibroblast activation protein-based whole cell tumour vaccine in murine tumour models

Chen, M., Xu, G., Fan, M., Jia, H., Xiao, L., & Lang, J. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1687498 · Cited by 19 · see citing works

Curcumin-shellac nanoparticle-loaded GelMA/SilMA hydrogel for colorectal cancer therapy

Zhang, B., Yan, J., Jin, Y. C., Yang, Y., & Zhao, X. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114409 · Cited by 17 · see citing works

Nanotherapeutics to Modulate the Compromised Micro-Environment for Lung Cancers and Chronic Obstructive Pulmonary Disease

Seshadri, D. R., & Ramamurthi, A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00759 · Cited by 16 · see citing works

Development of a novel Cu-Mn hydroxide layered nanosheet-loaded drug modulating the tumour microenvironment and enhancing antitumor effects

Shi, X., Shen, T., Gu, M., Guan, Y., Aimaiti, G., Yu, W., Zhang, X., Yuan, W., & Su, J. (2025) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2025.137904 · Cited by 14 · see citing works

Recent advances in matrix metalloproteinases-responsive nanoprobes for cancer diagnosis and therapy

Wang, Q., Cui, H., Gan, N., Ma, X., Ren, W., & Wu, A. (2022) · Reviews in Analytical Chemistry · doi:10.1515/revac-2022-0044 · Cited by 14 · see citing works

Nanotechnology for Biomedical Applications

Pasika, S. R., Bulusu, R., Rao, B. V. K., Kommineni, N., Bolla, P. K., Kala, S. G., & Godugu, C. (2023) · Springer eBooks · doi:10.1007/978-981-19-7963-7_11 · Cited by 14 · see citing works

Advanced Drug Delivery Strategies for Overcoming Biological Barriers: Tumor Microenvironment and Blood–Brain Barrier

Lei, Y., Xiao, T., Hu, X., & Lin, H. (2026) · Drugs in R&D · doi:10.1007/s40268-026-00538-9 · Cited by 14 · see citing works

Patient-derived xenografts or organoids in the discovery of traditional and self-assembled drug for tumor immunotherapy

Zhang, W. J., & Zheng, X. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1122322 · Cited by 14 · see citing works

Recent advances in the extraction technology and bioactivity of lentinan

Ren, S., Xie, C., Liu, H., Li, L., Han, X., & Chen, W. (2025) · Journal of Functional Foods · doi:10.1016/j.jff.2025.106680 · Cited by 13 · see citing works

Novel Dual Strategy Based on EPR/AT for Optimizing Therapeutic Effect by Improving Drug Delivery System Physicochemical Properties and Regulating TME

Chen, L., Deng, X., Shen, Q., Chen, M., Li, C., & Wang, S. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s559763 · Cited by 13 · see citing works

Exploring lung cancer microenvironment: pathways and nanoparticle-based therapies

Arandhara, A., Bhuyan, P., & Das, B. K. (2025) · Discover Oncology · doi:10.1007/s12672-025-01902-y · Cited by 12 · see citing works

Multistage Self-Assembled Nanomaterials for Cancer Immunotherapy

Guo, L., Yang, J., Wang, H., & Yi, Y. (2023) · Molecules · doi:10.3390/molecules28237750 · Cited by 12 · see citing works

High efficiency loading of micellar nanoparticles with a light switch for enzyme-induced rapid release of cargo

Choi, W., Battistella, C., & Gianneschi, N. C. (2020) · Biomaterials Science · doi:10.1039/d0bm01713b · Cited by 8 · see citing works

Nanoparticles targeting tumor-associated macrophages: A novel anti-tumor therapy

Chen, S., Qin, F., Wang, M., Wei, Y., Qian, Z., & Wei, X. (2021) · Nano Research · doi:10.1007/s12274-021-3781-5 · Cited by 8 · see citing works

Research Progress of Chitosan-based Multifunctional Nanoparticles in Cancer Targeted Therapy

Lai, C., Lin, S., Liu, W., & Jin, Y. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867330666230416153352 · Cited by 7 · see citing works

Promises and challenges for targeting the immunological players in the tumor micro-environment – Critical determinants for NP-based therapy

Suresh, P. K., Banerjee, A., & Singh, P. (2023) · OpenNano · doi:10.1016/j.onano.2023.100134 · Cited by 7 · see citing works

Challenges of enzyme therapy: Why two players are better than one

Cuoghi, S., Caraffi, R., Anderlini, A., Baraldi, C., Enzo, E., Vandelli, M. A., Tosi, G., Ruozi, B., Duskey, J. T., & Ottonelli, I. (2024) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1979 · Cited by 9 · see citing works

Molecular scale study on the interactions of biocompatible nanoparticles with macrophage membrane and blood proteins

Khedri, M., Afsharchi, F., Souderjani, A. H., Rezvantalab, S., Didandeh, M., Maleki, R., Musaie, K., Santos, H. A., & Shahbazi, M. (2022) · Nano Select · doi:10.1002/nano.202200043 · Cited by 7 · see citing works

Biomaterial-based strategy for bone tumor therapy and bone defect regeneration: An innovative application option

Zhang, Y., Wu, Y., Qiao, X., Lin, T., Wang, Y., & Wang, M. (2022) · Frontiers in Materials · doi:10.3389/fmats.2022.990931 · Cited by 7 · see citing works

Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy

Grapa, C. M., MOCAN, L. C., Crișan, D., Florea, M., & Mocan, T. (2021) · Materials · doi:10.3390/ma14113083 · Cited by 7 · see citing works

Phage therapy in oncology: opportunities for cancer prevention and treatment

Mutalik, V. K., Inman, J. L., Chang, H., Arkin, A., & Mao, J.-H. (2026) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2026.02.001 · Cited by 5 · see citing works

Nanomedicine: future therapy for brain cancers

Haque, S., Norbert, C. C., & Patra, C. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819793-6.00003-5 · Cited by 4 · see citing works

Targeting tumor microenvironment for breast cancer treatment

Mir, M. A., & Haq, B. U. (2022) · Elsevier eBooks · doi:10.1016/b978-0-443-18696-7.00008-7 · Cited by 4 · see citing works

Biophysical Characterization of cubosomal nanoparticles intended for drug delivery applications and its interaction with a model drug: the miltefosine case

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Challenges and Emerging Problems in Nanomedicine Mediated Gene Therapy

Bhatt, S., Faridi, N., Pathak, R., Punetha, V. D., & Punetha, M. (2023) · doi:10.1002/9781394175635.ch13 · Cited by 2 · see citing works

Hyaluronic Acid Conjugated Geraniol for Targeted Breast Cancer Therapy

Yu, H., Jiang, L., Bai, Y., Wu, J., Ning, N., Duan, S., & Zhao, Y. (2025) · Natural Product Communications · doi:10.1177/1934578x251344985 · Cited by 1 · see citing works

Curcumin-conjugated Nanoparticles: An Approach to Target Mitochondria

Suvarna, V., Sawant, N. D., & Desai, N. D. (2023) · The Natural Products Journal · doi:10.2174/2210315513666230515143651 · Cited by 1 · see citing works

Potential application of nanotechnology in the treatment and overcoming of pancreatic cancer resistance

Dash, S., Sahoo, S., & Sahoo, S. K. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-19142-8.00017-6 · Cited by 1 · see citing works

Stromal reprogramming in solid tumors by nanoparticles: A review

Altalbawy, F. M. A., Hussein, U. A., Ballal, S., Chahar, M., Darwish, N. S. A., Saini, S., Prasad, G. V. S., Rizaev, J. A., Al-Anbari, H. H. A., Saud, M. J., et al. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108794 · Cited by 1 · see citing works

Introduction to cancer nanotherapeutics

Zarif, M.-E., Florea, D. A., & Grumezescu, A. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816506-5.00001-2

Suppression of cancer stem cells

García-Mazás, C., Barrios-Esteban, S., Csaba, N., & García-Fuentes, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-102983-1.00013-2

Tumoral delivery of nanotherapeutics

Prabhu, P. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821013-0.00024-6

Estudo da eficácia de encapsulação da Cinarizina em cubossomos não-iônicos: caracterização estrutural e citotóxica

Lotierzo, M. C. G. (2021) · doi:10.11606/d.9.2021.tde-17122021-104433

Recent advances in nanocarrier-based targeted drug delivery: For lung, colon, and breast cancers

Sabouri, P., Bahadori, S., Mohsennejadesaniyani, A., Hosseini, S. M. R., Khodamorovati, M., Yazdani, E., Mohammadi, D., Nejadkoorki, D., Sulashvili, M., Tavamaishvili, K., et al. (2023) · Journal of Composites and Compounds · doi:10.61186/jcc.5.2.3

Remodeling the Tumor Microenvironment: Targeted Metal-Based Nanomaterials for Precision Theranostics of Pancreatic Ductal Adenocarcinoma

Luo, P., Zhang, P., Tang, F., Wu, M., Yang, G., Luo, L., Lin, J., Ma, X., Gao, C., Li, G., et al. (2026) · ACS Materials Letters · doi:10.1021/acsmaterialslett.5c01559

Comparison of the effects of nano, micro silver particles, and silver nitrate on glioblastoma multiforme (CRL-1690)

PEHLİVAN, S., Şimşek, İ., Akdağ, E., Yıltırak, A. F., Arslan, P., Kuzukıran, Ö., & Filazı, A. (2026) · Journal of Advances in VetBio Science and Techniques · doi:10.31797/vetbio.1863533

Polymeric Nanomedicines for Comprehensive Regulation of Tumor Microenvironment

Li, H., Wu, R.-Y., Mao, X.-T., Zhou, X.-R., Hao, K., & Tian, H.-Y. (2026) · Chinese Journal of Polymer Science · doi:10.1007/s10118-026-3678-6

Emerging nano-strategies against tumour microenvironment (TME): a review

Mandal, D., Kushwaha, K., & Gupta, J. (2022) · OpenNano · doi:10.1016/j.onano.2022.100112 · Cited by 11 · see citing works

Nanoparticle-Mediated Targeted Drug Delivery to Remodel Tumor Microenvironment for Cancer Therapy

Tang, L., Mei, Y., Shen, Y., He, S., Xiao, Q., Yin, Y., Xu, Y., Shao, J., Wang, W., & Cai, Z. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s321416 · Cited by 100 · see citing works

Nanoparticles Targeting and Remodeling Tumor Microenvironment for Cancer Theranostics

Lin, G., Chen, S., & Mi, P. (2018) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2018.2546 · Cited by 35 · see citing works

Nanoparticles for modulating tumor microenvironment to improve drug delivery and tumor therapy

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Revolutionizing cancer treatment: Nanotherapeutics targeting the tumor micro-environment

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