Luteolin Inhibits Inflammatory Response and Improves Insulin Sensitivity in the Endothelium

Deqiu, Zhu; Kang, Liu; Jiali, Yi; Baolin, Liu; Gaolin, Liu

doi:10.1016/j.biochi.2010.11.002

Cited by 65Flavonoids in Medical ResearchNitric Oxide and Endothelin EffectsNatural Antidiabetic Agents Studies

Luteolin Inhibits Inflammatory Response and Improves Insulin Sensitivity in the Endothelium

Deqiu, Zhu, Kang, Liu, Jiali, Yi, Baolin, Liu, Gaolin, Liu·2011·Biochimie

DOI 10.1016/j.biochi.2010.11.002

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Abstract

Endothelial insulin resistance is tightly associated with diabetic cardiovascular complication, and it is well known that inflammation plays an important role in the development of insulin resistance. Luteolin, a flavonoid abundant in some medical and eatable plants, is a potent inhibitor of inflammation. It is also reported that luteolin exhibited some chemoprotection capability to the endothelial integrity. This study aims to clarify whether the anti-inflammatory potency of luteolin contributes to amelioration of insulin resistance in the endothelium. Palmitate (PA) stimulation markedly reduced insulin-mediated endothelium-dependent relaxation in rat aorta, while luteolin pretreatment effectively reversed the effects of palmitate in a concentration-dependent manner. PA stimulation also evoked inflammatory response in endothelial cells. When the cells were pretreated with luteolin, IKKβ phosphorylation were reduced, which, in turn, blocked the NF-κB activation through attenuating P65 phosphorylation. At the same time, it was also found that the gene over-expressions for TNF-α and IL-6 were also reduced by luteolin pretreatment. When endothelial cells were stimulated with PA, the insulin signaling cascades were impaired with reduced insulin-dependent production of NO. Again, pretreatment of luteolin could effectively reverse the effects of PA. Luteolin modulated the Ser/Thr phosphorylation of insulin receptor substrates-1 and restored downstream Akt/eNOS activation, resulting in increased NO production in the presence of insulin. In conclusion, these results suggested that luteolin ameliorated inflammation related endothelial insulin resistance in an IKKβ/IRS-1/Akt/eNOS-dependent pathway.

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Luteolin improves insulin sensitivity in many cell types, including adipocytes and endothelial cells.
“luteolin has been shown to improve insulin sensitivity in many cell types, including adipocytes and endothelial cells (Ding et al., 2010; Deqiu et al., 2011)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Deqiu et al., 2011

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Authors: Deqiu, Z., Kang, L., Jiali, Y., Baolin, L., & Gaolin, L.
Affiliations: Tongji University (CN)
China Pharmaceutical University (CN)
Venue: Biochimie
Publisher: Elsevier BV
Published: 2011-03
Volume: 93
Issue: 3
Pages: 506-512
ISSN: 0037-9042 (ISSN-L)
0300-9084
DOI: 10.1016/j.biochi.2010.11.002
OpenAlex: W2081998540
Cited by: 65
References: 31
Citations by year: 2026: 1 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 8 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 7 · 2013: 4 · 2012: 7
FWCI: 3.29
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biochimie (publishedVersion)
PubMed (publishedVersion)
Funders: Fundamental Research Funds for the Central Universities
Ministry of Education of the People's Republic of China (ZJ10041)
Topics: Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords: luteolin, endothelial insulin resistance, inflammation, palmitate, NF-κB signaling, IKKβ phosphorylation, IRS-1, Akt/eNOS pathway, nitric oxide, TNF-α, interleukin-6, endothelial dysfunction, flavonoids, cardiovascular complications of diabetes
MeSH terms: Animals, Aorta, Endothelium, Vascular, Gene Expression Regulation, Inflammation, Insulin, Nitric Oxide, Palmitates, Phosphorylation, RNA, Messenger, Serine, Vasodilation, Signal Transduction, Cytokines, NF-kappa B, Rats, Sprague-Dawley, Luteolin, Proto-Oncogene Proteins c-akt, Rats, I-kappa B Kinase, Nitric Oxide Synthase Type III, Insulin Receptor Substrate Proteins, In Vitro Techniques

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Luteolin Inhibits Inflammatory Response and Improves Insulin Sensitivity in the Endothelium

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