Myalgic encephalomyelitis/chronic fatigue syndrome—metabolic disease or disturbed homeostasis due to focal inflammation in the hypothalamus?

Inflammation and Atherosclerosis

Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724 · see citing works

The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study

Fukuda, K., Straus, S. E., Hickie, I., Sharpe, M. C., Dobbins, J. G., Komaroff, A., & and International Chronic Fatigue Syndrome Study Group. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-12-199412150-00009 · Cited by 4,969 · see citing works

The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer

Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882 · see citing works

Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome

Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.683 · Cited by 4,760 · see citing works

Structural and functional features of central nervous system lymphatic vessels

Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., et al. (2015) · Nature · doi:10.1038/nature14432 · Cited by 4,413 · see citing works

The Metabolic Syndrome and Cardiovascular Risk

Mottillo, S., Filion, K. B., Genest, J., Joseph, L., Pilote, L., Poirier, P., Rinfret, S., Schiffrin, E. L., & Eisenberg, M. J. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.05.034 · Cited by 3,009 · see citing works

The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation

Chrousos, G. P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322008 · Cited by 2,579 · see citing works

The development of allergic inflammation

Galli, S. J., Tsai, M., & Piliponsky, A. M. (2008) · Nature · doi:10.1038/nature07204 · Cited by 1,839 · see citing works

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

Cantó, C., & Auwerx, J. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328328d0a4 · Cited by 1,624 · see citing works

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

Sun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W. E., Miller, D., & Zhang, H. (2010) · Molecular Therapy · doi:10.1038/mt.2010.105 · Cited by 1,579 · see citing works

The Isolation of a New Hypotensive Peptide, Neurotensin, from Bovine Hypothalami

Carraway, R. E., & Leeman, S. E. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43429-7 · Cited by 1,543 · see citing works

Myalgic encephalomyelitis: International Consensus Criteria

Carruthers, B. M., van de Sande, M. I., Meirleir, K. L. D., Klimas, N. G., Broderick, G., Mitchell, T., Staines, D., Powles, A. C. P., Speight, N., Vallings, R., et al. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02428.x · Cited by 1,234 · see citing works

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols

Carruthers, B. M., Jain, A. K., De Meirleir, K. L., Peterson, D. L., Klimas, N. G., Lerner, A. M., Bested, A. C., Flor-Henry, P., Joshi, P., Powles, A. C. P., et al. (2003) · Journal of Chronic Fatigue Syndrome · doi:10.1300/j092v11n01_02 · Cited by 1,180 · see citing works

Disease-associated functions of IL-33: the new kid in the IL-1 family

Liew, F. Y., Pitman, N. I., & McInnes, I. B. (2010) · Nature reviews. Immunology · doi:10.1038/nri2692 · Cited by 1,004 · see citing works

Mast cell secretory granules: armed for battle

Wernersson, S., & Pejler, G. (2014) · Nature reviews. Immunology · doi:10.1038/nri3690 · Cited by 968 · see citing works

A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties

Harwood, M., Danielewska-Nikiel, B., Borzelleca, J. F., Flamm, G., Williams, G. M., & Lines, T. C. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.05.015 · Cited by 890 · see citing works

Etiology of Insulin Resistance

Petersen, K. F., & Shulman, G. I. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.01.009 · Cited by 825 · cited 2× · see citing works

The role of substance P in inflammatory disease

O’Connor, T. M., O'Connell, J., O’Brien, D. I., Goode, T., Bredin, C. P., & Shanahan, F. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20061 · Cited by 789 · see citing works

Mast cells and inflammation

Theoharides, T. C., Alysandratos, K., Angelidou, A., Delivanis, D.-A., Sismanopoulos, N., Zhang, B., Asadi, S., Vasiadi, M., Weng, Z., Miniati, A., et al. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.014 · Cited by 759 · see citing works

Isolation of a Sialogogic Peptide from Bovine Hypothalamic Tissue and Its Characterization as Substance P

Chang, M. M., & Leeman, S. E. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62860-1 · Cited by 699 · see citing works

Mast cells as sources of cytokines, chemokines, and growth factors

Mukai, K., Tsai, M. M., Saito, H., & Galli, S. J. (2018) · Immunological Reviews · doi:10.1111/imr.12634 · Cited by 687 · see citing works

Metabolic Syndrome and 10-Year Cardiovascular Disease Risk in the Hoorn Study

Dekker, J. M., Girman, C. J., Rhodes, T., Nijpels, G., Stehouwer, C. D. A., Bouter, L. M., & Heine, R. J. (2005) · Circulation · doi:10.1161/circulationaha.104.516948 · Cited by 633 · see citing works

Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation

Petra, A. I., Panagiotidou, S., Hatziagelaki, E., Stewart, J. M., Conti, P., & Theoharides, T. C. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.04.002 · Cited by 592 · see citing works

Mast Cells, Mastocytosis, and Related Disorders

Theoharides, T. C., Valent, P., & Akin, C. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1409760 · Cited by 518 · see citing works

Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses

Collins, L. V., Hajizadeh, S., Holme, E., Jonsson, I., & Tarkowski, A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0703328 · Cited by 504 · see citing works

Neuropeptide substance P and the immune response

Mashaghi, A., Marmalidou, A., Tehrani, M., Grace, P. M., Pothoulakis, C., & Dana, R. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2293-z · Cited by 493 · see citing works

Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance

Davis, J. M., Murphy, E. A., Carmichael, M. D., & Davis, B. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90925.2008 · Cited by 486 · see citing works

Corticotropin-Releasing Hormone Induces Skin Mast Cell Degranulation and Increased Vascular Permeability, A Possible Explanation for Its Proinflammatory Effects

Theoharides, T. C., Singh, L. K., Boucher, W. S., Pang, X., Létourneau, R., Webster, E., & Chrousos, G. P. (1998) · Endocrinology · doi:10.1210/endo.139.1.5660 · Cited by 447 · see citing works

Critical role of mast cells in inflammatory diseases and the effect of acute stress

Theoharides, T. C., & Cochrane, D. E. (2003) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.10.041 · Cited by 437 · see citing works

Differential release of mast cell mediators and the pathogenesis of inflammation

Theoharides, T. C., Kempuraj, D., Tagen, M., Conti, P., & Kalogeromitros, D. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00519.x · Cited by 425 · see citing works

Metabolic features of chronic fatigue syndrome

Naviaux, R. K., Naviaux, J. C., Li, K., Bright, A. T., Alaynick, W. A., Wang, L., Baxter, A., Nathan, N., Anderson, W. H., & Gordon, E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607571113 · Cited by 393 · see citing works

Editorial (Thematic Issue: Mitochondrial Biogenesis: Pharmacological Approaches)

Valero, T. (2014) · Current Pharmaceutical Design · doi:10.2174/138161282035140911142118 · Cited by 369 · see citing works

Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An 11 C-( R )-PK11195 PET Study

Nakatomi, Y., Mizuno, K., Ishii, A., Wada, Y., Tanaka, M., Tazawa, S., Onoe, K., Fukuda, S., Kawabe, J., Takahashi, K., et al. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.113.131045 · Cited by 366 · see citing works

Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1

Jang, S., Kelley, K. W., & Johnson, R. W. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802865105 · Cited by 365 · see citing works

Substance P: a pioneer amongst neuropeptides

Hökfelt, T. G. M., Pernow, B., & Wahren, J. (2001) · Journal of Internal Medicine · doi:10.1046/j.0954-6820.2000.00773.x · Cited by 347 · see citing works

Human Mast Cells Express Corticotropin-Releasing Hormone (CRH) Receptors and CRH Leads to Selective Secretion of Vascular Endothelial Growth Factor

Cao, J., Papadopoulou, N., Kempuraj, D., Boucher, W. S., Sugimoto, K., Cetrulo, C. L., & Theoharides, T. C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.7665 · Cited by 337 · see citing works

Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells

Kempuraj, D., Madhappan, B., Christodoulou, S., Boucher, W. S., Cao, J., Papadopoulou, N., Cetrulo, C. L., & Theoharides, T. C. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706246 · Cited by 336 · see citing works

Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure

Marques, P. E., Amaral, S. S., Pires, D. A., Nogueira, L. L., Soriani, F. M., Lima, B. H. F., Lopes, G. A. O., Russo, R. C., Ávila, T. V., Melgaço, J. G., et al. (2012) · Hepatology · doi:10.1002/hep.25801 · Cited by 332 · see citing works

Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms

Kennedy, G., Spence, V. A., McLaren, M., Hill, A., Underwood, C., & Belch, J. J. F. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.04.020 · Cited by 325 · see citing works

IL-33 augments substance P–induced VEGF secretion from human mast cells and is increased in psoriatic skin

Theoharides, T. C., Zhang, B., Kempuraj, D., Tagen, M., Vasiadi, M., Angelidou, A., Alysandratos, K., Kalogeromitros, D., Asadi, S., Stavrianeas, N. G., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000803107 · Cited by 320 · see citing works

Mental stress--induced myocardial ischemia and cardiac events

Jiang, W. (1996) · JAMA · doi:10.1001/jama.275.21.1651 · Cited by 318 · see citing works

Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cells

Moulin, D., Donzé, O., Talabot‐Ayer, D., Mézin, F., Palmer, G., & Gabay, C. (2007) · Cytokine · doi:10.1016/j.cyto.2007.09.013 · Cited by 309 · see citing works

Mast cells as targets of corticotropin-releasing factor and related peptides

Theoharides, T. C., Donelan, J., Papadopoulou, N., Cao, J., Kempuraj, D., & Conti, P. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.09.007 · Cited by 301 · see citing works

Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats

Ishisaka, A., Ichikawa, S., Sakakibara, H., Piskula, M. K., Nakamura, T., Kato, Y., Ito, M., Miyamoto, K.-I., Tsuji, A., Kawai, Y., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.017 · Cited by 293 · see citing works

The Critical Role of Mast Cells in Allergy and Inflammation

Theoharides, T. C., & Kalogeromitros, D. C. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1366.025 · Cited by 291 · see citing works

Mast cells: The immune gate to the brain

Theoharides, T. C. (1990) · Life Sciences · doi:10.1016/0024-3205(90)90129-f · Cited by 274 · see citing works

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – Evidence for an autoimmune disease

Sotzny, F., Blanco, J., Capelli, E., Castro‐Marrero, J., Steiner, S., Murovska, M., & Scheibenbogen, C. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.01.009 · Cited by 272 · see citing works

Chronic fatigue syndrome and mitochondrial dysfunction.

Myhill, S., Booth, N. E., & McLaren-Howard, J. (2009) · PubMed Central · Cited by 262 · see citing works

Distinct plasma immune signatures in ME/CFS are present early in the course of illness

Hornig, M., Montoya, J. G., Klimas, N. G., Levine, S. M., Felsenstein, D., Bateman, L., Peterson, D. L., Gottschalk, C. G., Schultz, A. F., Che, X., et al. (2015) · Science Advances · doi:10.1126/sciadv.1400121 · Cited by 261 · see citing works

Case definitions for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): a systematic review

Brurberg, K. G., Fønhus, M. S., Larun, L., Flottorp, S. A., & Malterud, K. (2014) · BMJ Open · doi:10.1136/bmjopen-2013-003973 · Cited by 260 · see citing works

Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care

Nacul, L. C., Lacerda, E. M., Pheby, D., Campion, P., Molokhia, M., Fayyaz, S., Leite, J. C., Poland, F., Howe, A., & Drachler, M. L. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-91 · Cited by 255 · see citing works

Corticotropin-Releasing Hormone and Brain Mast Cells Regulate Blood-Brain-Barrier Permeability Induced by Acute Stress

Esposito, P., Chandler, N., Kandere, K., Basu, S., Jacobson, S., Connolly, R., Tutor, D., & Theoharides, T. C. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.038497 · Cited by 252 · see citing works

Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Brenu, E., van Driel, M., Staines, D., Ashton, K. J., Ramos, S. B., Keane, J., Klimas, N. G., & Marshall‐Gradisnik, S. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-81 · Cited by 252 · see citing works

Mental Stress—Induced Myocardial Ischemia and Cardiac Events

Jiang, W. (1996) · JAMA · doi:10.1001/jama.1996.03530450041030 · Cited by 248 · see citing works

An Open-Label Pilot Study of a Formulation Containing the Anti-Inflammatory Flavonoid Luteolin and Its Effects on Behavior in Children With Autism Spectrum Disorders

Taliou, A., Zintzaras, E., Lykouras, L., & Francis, K. (2013) · Clinical Therapeutics · doi:10.1016/j.clinthera.2013.04.006 · Cited by 235 · see citing works

Association of mitochondrial dysfunction and fatigue: A review of the literature

Filler, K., Lyon, D., Bennett, J. P., McCain, N. L., Elswick, R. K., Lukkahatai, N., & Saligan, L. N. (2014) · BBA Clinical · doi:10.1016/j.bbacli.2014.04.001 · Cited by 232 · see citing works

Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders

Theoharides, T. C., Tsilioni, I., Patel, A., & Doyle, R. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.77 · Cited by 231 · see citing works

Endotype-driven care pathways in patients with chronic rhinosinusitis

Bachert, C., Zhang, N., Hellings, P. W., & Bousquet, J. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.03.004 · Cited by 230 · see citing works

Sympathetic Nervous System Dysfunction in Fibromyalgia, Chronic Fatigue Syndrome, Irritable Bowel Syndrome, and Interstitial Cystitis: A Review of Case-Control Studies

Martínez-Martínez, L.-A., Mora, T., Vargas, A., Fuentes-Iniestra, M., & Martínez-Lavín, M. (2014) · JCR: Journal of Clinical Rheumatology · doi:10.1097/rhu.0000000000000089 · Cited by 224 · see citing works

Chronic fatigue syndrome after infectious mononucleosis in adolescents

Katz, B. Z., Shiraishi, Y., Mears, C. J., Binns, H. J., & Taylor, R. (2009) · PEDIATRICS · doi:10.1542/peds.2008-1879 · Cited by 221 · see citing works

Suppression of innate inflammation and immunity by interleukin‐37

Dinarello, C. A., Nold‐Petry, C. A., Nold, M. F., Fujita, M., Li, S., Kim, S., & Bufler, P. (2016) · European Journal of Immunology · doi:10.1002/eji.201545828 · Cited by 218 · see citing works

Mitochondrial DAMPs Increase Endothelial Permeability through Neutrophil Dependent and Independent Pathways

Sun, S., Sursal, T., Adibnia, Y., Zhao, C., Zheng, Y. Z., Li, H., Otterbein, L. E., Hauser, C. J., & Itagaki, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059989 · Cited by 216 · see citing works

Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: A systematic review

Meeus, M., Goubert, D., Backer, F. D., Struyf, F., Hermans, L., Coppieters, I., Wandele, I. D., Silva, H. D., & Calders, P. (2013) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2013.03.004 · Cited by 213 · see citing works

Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome

Fluge, Ø., Mella, O., Bruland, O., Risa, K., Dyrstad, S. E., Alme, K., Rekeland, I. G., Sapkota, D., Røsland, G. V., Fosså, A., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.89376 · Cited by 209 · see citing works

The role of reactive oxygen species and nitric oxide in mast cell‐dependent inflammatory processes

Swindle, E. J., & Metcalfe, D. D. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00513.x · Cited by 207 · see citing works

Our perception of the mast cell from Paul Ehrlich to now

Beaven, M. A. (2009) · European Journal of Immunology · doi:10.1002/eji.200838899 · Cited by 202 · see citing works

Neurokinin‐1 receptor: functional significance in the immune system in reference to selected infections and inflammation

Douglas, S. D., & Leeman, S. E. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05826.x · Cited by 200 · see citing works

Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6

Tsilioni, I., Taliou, A., Francis, K., & Theoharides, T. C. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.142 · Cited by 199 · see citing works

Flavonoids Health Benefits and Their Molecular Mechanism

Xiao, Z.-P., Peng, Z., Peng, M., Yan, W.-B., Ouyang, Y.-Z., & Zhu, H.-L. (2011) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955711794519546 · Cited by 198 · see citing works

Regional distribution of mast cells containing histamine, dopamine, or 5‐hydroxytryptamine in the mammalian brain

Edvinsson, L. I., Cervós‐Navarro, J., Larsson, L., Owman, C., & Rönnberg, A. L. (1977) · Neurology · doi:10.1212/wnl.27.9.878 · Cited by 192 · see citing works

Dietary Polyphenols, Inflammation, and Cancer

Guo, W., Kong, E., & Meydani, M. (2009) · Nutrition and Cancer · doi:10.1080/01635580903285098 · Cited by 191 · see citing works

Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008-2012

Bakken, I. J., Tveito, K., Gunnes, N., Ghaderi, S., Stoltenberg, C., Trogstad, L., åberg, S. E. H., & Magnus, P. M. (2014) · BMC Medicine · doi:10.1186/s12916-014-0167-5 · Cited by 185 · see citing works

Markers of oxidative and nitrosative stress in systemic lupus erythematosus: Correlation with disease activity

Wang, G., Pierangeli, S. S., Papalardo, E., Ansari, G. A. S., & Khan, M. F. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27442 · Cited by 182 · see citing works

Corticotropin-Releasing Hormone and Its Structurally Related Urocortin Are Synthesized and Secreted by Human Mast Cells

Kempuraj, D., Papadopoulou, N., Lytinas, M., Huang, M., Kandere‐Grzybowska, K., Madhappan, B., Boucher, W. S., Christodoulou, S., Athanassiou, A., & Theoharides, T. C. (2003) · Endocrinology · doi:10.1210/en.2003-0805 · Cited by 181 · see citing works

Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology

Shungu, D. C., Weiduschat, N., Murrough, J. W., Mao, X., Pillemer, S., Dyke, J. P., Medow, M. S., Natelson, B. H., Stewart, J. M., & Mathew, S. J. (2012) · NMR in Biomedicine · doi:10.1002/nbm.2772 · Cited by 179 · see citing works

The Economic impact of ME/CFS: Individual and societal costs

Jason, L. A., Benton, M. C., Valentine, L., Johnson, A., & Torres‐Harding, S. (2008) · Dynamic Medicine · doi:10.1186/1476-5918-7-6 · Cited by 173 · see citing works

Cellular bioenergetics is impaired in patients with chronic fatigue syndrome

Tomas, C., Brown, A. E., Strassheim, V., Elson, J. L., Newton, J. L., & Manning, P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186802 · Cited by 169 · see citing works

Magnesium and muscle performance in older persons: the InCHIANTI study

Dominguez, L. J., Barbagallo, M., Lauretani, F., Bandinelli, S., Bós, Â. J. G., Corsi, A. M., Simonsick, E. M., & Ferrucci, L. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.419 · Cited by 166 · see citing works

Mitochondrial dysfunctions in Myalgic Encephalomyelitis / chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways

Morris, G., & Maes, M. H. J. (2013) · Metabolic Brain Disease · doi:10.1007/s11011-013-9435-x · Cited by 164 · see citing works

Adolescent Chronic Fatigue Syndrome: Prevalence, Incidence, and Morbidity

Nijhof, S. L., Maijer, K., Bleijenberg, G., Uiterwaal, C. S. P. M., Kimpen, J. L. L., & van de Putte, E. M. (2011) · Pediatrics · doi:10.1542/peds.2010-1147 · Cited by 162 · see citing works

Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease

Johri, A., Calingasan, N. Y., Hennessey, T., Sharma, A., Yang, L., Wille, E. J., Chandra, A., & Beal, M. F. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr541 · Cited by 161 · see citing works

Metabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism

Germain, A., Ruppert, D., Levine, S. M., & Hanson, M. R. (2016) · Molecular BioSystems · doi:10.1039/c6mb00600k · Cited by 161 · see citing works

Biomarkers for chronic fatigue

Klimas, N. G., Broderick, G., & FLETCHER, M. A. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.06.006 · Cited by 156 · see citing works

Brain “fog,” inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin

Theoharides, T. C. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00225 · Cited by 154 · see citing works

Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Increased interleukin-1, tumor necrosis factor-α, PMN-elastase, lysozyme and neopterin

Maes, M. H. J., Twisk, F., Kubera, M., & Ringel, K. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.09.004 · Cited by 154 · see citing works

Evaluation for Safety of Antioxidant Chemopreventive Agents

Kawanishi, S., Oikawa, S., & Murata, M. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1728 · Cited by 152 · see citing works

Corticotropin-releasing hormone and the blood-brain-barrier

Theoharis, C. (2006) · Frontiers in bioscience · doi:10.2741/2174 · Cited by 148 · see citing works

Human mast cell degranulation and preformed TNF secretion require mitochondrial translocation to exocytosis sites: Relevance to atopic dermatitis

Zhang, B., Alysandratos, K., Angelidou, A., Asadi, S., Sismanopoulos, N., Delivanis, D.-A., Weng, Z., Miniati, A., Vasiadi, M., Katsarou‐Katsari, A., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.02.005 · Cited by 142 · see citing works

Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process

Donelan, J., Boucher, W. S., Papadopoulou, N., Lytinas, M., Papaliodis, D., Dobner, P. R., & Theoharides, T. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602210103 · Cited by 142 · see citing works

Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity

Vermeulen, R. C., Kurk, R. M., Visser, F. C., Sluiter, W. J., & Scholte, H. R. (2010) · Journal of Translational Medicine · doi:10.1186/1479-5876-8-93 · Cited by 142 · see citing works

Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Rome

Castro‐Marrero, J., Sáez‐Francàs, N., Santillo, D., & Alegre, J. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13702 · Cited by 142 · see citing works

Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics

Morris, G., & Maes, M. H. J. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-205 · Cited by 141 · see citing works

The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells

Weng, Z., Patel, A., Panagiotidou, S., & Theoharides, T. C. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.10.032 · Cited by 141 · see citing works

Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Booth, N. E., Myhill, S., & McLaren-Howard, J. (2012) · Europe PMC (PubMed Central) · Cited by 136 · see citing works

Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?

de Cavanagh, E. M. V., Inserra, F., & Ferder, L. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq285 · Cited by 136 · see citing works

The role of neurotensin in physiologic and pathologic processes

Mustain, W. C., Rychahou, P. G., & Evers, B. M. (2011) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3283419052 · Cited by 136 · see citing works

Magnesium and muscle performance in older persons: The InCHIANTI study

Dominguez, L. J., Barbagallo, M., Lauretani, F., Bandinelli, S., Bos, A., Corsi, A. M., Simonsick, E. M., & Ferrucci, L. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.2.419 · Cited by 136 · see citing works

Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients

Armstrong, C. W., McGregor, N., Lewis, D. P., Butt, H. L., & Gooley, P. R. (2015) · Metabolomics · doi:10.1007/s11306-015-0816-5 · Cited by 135 · see citing works

Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder.

Maes, M. H. J., Mihaylova, I., Kubera, M., Uytterhoeven, M., Vrydags, N., & Bosmans, E. (2009) · PubMed · Cited by 134 · see citing works

IL-33 synergizes with IgE-dependent and IgE-independent agents to promote mast cell and basophil activation

Silver, M. R., Margulis, A. R., Wood, N. L., Goldman, S. J., Kasaian, M. T., & Chaudhary, D. (2009) · Inflammation Research · doi:10.1007/s00011-009-0088-5 · Cited by 130 · see citing works

SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors

Taracanova, A., Alevizos, M., Karagkouni, A., Weng, Z., Norwitz, E. R., Conti, P., Leeman, S. E., & Theoharides, T. C. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524845114 · Cited by 128 · see citing works

Neurotensin: Role in psychiatric and neurological diseases

Cáceda, R., Kinkead, B. L., & Nemeroff, C. B. (2006) · Peptides · doi:10.1016/j.peptides.2006.04.024 · Cited by 127 · see citing works

Metabolic syndrome in women with chronic pain

Loevinger, B. L., Muller, D., Alonso, C. M., & Coe, C. L. (2006) · Metabolism · doi:10.1016/j.metabol.2006.09.001 · Cited by 124 · see citing works

Hypothalamo-Pituitary-Adrenal Axis Dysfunction in Chronic Fatigue Syndrome, and the Effects of Low-Dose Hydrocortisone Therapy

Cleare, A. J., MIELL, J. P., Heap, E., Sookdeo, S. D., Young, L. S., Malhi, G. S., & O’Keane, V. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7735 · Cited by 123 · see citing works

NEUROTENSIN: DISCOVERY, ISOLATION, CHARACTERIZATION, SYNTHESIS AND POSSIBLE PHYSIOLOGICAL ROLES*

Leeman, S. E., & Carraway, R. E. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb31557.x · Cited by 123 · see citing works

Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles

Yamano, E., Sugimoto, M., Hirayama, A., Kume, S., Yamato, M., Jin, G., Tajima, S., Goda, N., Iwaï, K., Fukuda, S., et al. (2016) · Scientific Reports · doi:10.1038/srep34990 · Cited by 123 · see citing works

Effects of Mental Stress in Patients With Coronary Artery Disease

Krantz, D. S., Sheps, D. S., Carney, R. M., & Natelson, B. H. (2000) · JAMA · doi:10.1001/jama.283.14.1800 · Cited by 122 · see citing works

The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis

Morris, G., Stubbs, B., Köhler, C. A., Walder, K. R., Slyepchenko, A., Berk, M., & Carvalho, A. F. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.03.007 · Cited by 122 · see citing works

Stimulated Human Mast Cells Secrete Mitochondrial Components That Have Autocrine and Paracrine Inflammatory Actions

Zhang, B., Asadi, S., Weng, Z., Sismanopoulos, N., & Theoharides, T. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049767 · Cited by 121 · see citing works

Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism

Patel, A., Tsilioni, I., Leeman, S. E., & Theoharides, T. C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604992113 · Cited by 121 · see citing works

Hypothalamic-Pituitary-Adrenal Hypofunction in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) as a Consequence of Activated Immune-Inflammatory and Oxidative and Nitrosative Pathways

Morris, G., Anderson, G., & Maes, M. H. J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0170-2 · Cited by 120 · see citing works

Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics

Nagy-Szakal, D., Barupal, D. K., Lee, B., Che, X., Williams, B. L., Kahn, E. J. R., Ukaigwe, J. E., Bateman, L., Klimas, N. G., Komaroff, A. L., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-28477-9 · Cited by 120 · see citing works

Comparative Study of Anxiety, Depression, Somatization, Functional Disability, and Illness Attribution in Adolescents With Chronic Fatigue or Migraine

Smith, M. S., Martin-Herz, S. P., Womack, W. M., & Marsigan, J. L. (2003) · PEDIATRICS · doi:10.1542/peds.111.4.e376 · Cited by 118 · see citing works

Neuroendocrinology of mast cells: Challenges and controversies

Theoharides, T. C. (2017) · Experimental Dermatology · doi:10.1111/exd.13288 · Cited by 117 · see citing works

Chronic fatigue syndrome: diagnosis and treatment.

Yancey, J. R., & Thomas, S. M. (2012) · PubMed · Cited by 117 · see citing works

A Pediatric Case Definition for Myalgic Encephalomyelitis and Chronic Fatigue Syndrome

Jason, L. A., Jordan, K. M., Miike, T., Bell, D. S., Lapp, C. W., Torres‐Harding, S., Rowe, K., Gurwitt, A., Meirleir, K. D., & Hoof, E. V. (2006) · Journal of Chronic Fatigue Syndrome · doi:10.1300/j092v13n02_01 · Cited by 113 · see citing works

The role of the IL-33/IL-1RL1 axis in mast cell and basophil activation in allergic disorders

Saluja, R., Ketelaar, M. E., Hawro, T., Church, M. K., Maurer, M., & Nawijn, M. C. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.06.018 · Cited by 108 · see citing works

The Emerging Role of Autoimmunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/cfs)

Morris, G., Berk, M., Gałecki, P., & Maes, M. H. J. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8553-0 · Cited by 105 · see citing works

Can Magnesium Enhance Exercise Performance?

Zhang, Y., Xun, P., Wang, R., Mao, L., & He, K. (2017) · Nutrients · doi:10.3390/nu9090946 · Cited by 104 · see citing works

Perceived fatigue is highly prevalent and debilitating in patients with mitochondrial disease

Gorman, G. S., Elson, J. L., Newman, J. H., Payne, B. A. I., McFarland, R., Newton, J. L., & Turnbull, D. M. (2015) · Neuromuscular Disorders · doi:10.1016/j.nmd.2015.03.001 · Cited by 103 · see citing works

Inability of myalgic encephalomyelitis/chronic fatigue syndrome patients to reproduce VO2peak indicates functional impairment

Keller, B. A., Pryor, J. L., & Giloteaux, L. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-104 · Cited by 102 · see citing works

Chronic fatigue syndrome: understanding a complex illness

Holgate, S. T., Komaroff, A. L., Mangan, D. F., & Wessely, S. C. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3087 · Cited by 101 · see citing works

Definitions and aetiology of myalgic encephalomyelitis: how the Canadian consensus clinical definition of myalgic encephalomyelitis works

Carruthers, B. M. (2006) · Journal of Clinical Pathology · doi:10.1136/jcp.2006.042754 · Cited by 101 · see citing works

Chronic fatigue syndrome: diagnosis and treatment

Revelas, A., & Baltaretsou, E. (2013) · South African Family Practice · doi:10.1080/20786204.2013.10874302 · Cited by 100 · see citing works

Neurotensin and CRH Interactions Augment Human Mast Cell Activation

Alysandratos, K., Asadi, S., Angelidou, A., Zhang, B., Sismanopoulos, N., Yang, H., Critchfield, A. S., & Theoharides, T. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048934 · Cited by 99 · see citing works

Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: A systematic literature review

Nijs, J., Nees, A., Paul, L., Kooning, M. D., Ickmans, K., Meeus, M., & Oosterwijck, J. V. (2026) · PubMed · doi:10.22029/eir.2014.1690 · Cited by 98 · see citing works

Neuropeptide-Induced Secretion from Human Skin Mast Cells

Church, M. K., El-Lati, S., & CAULFIELD, J. P. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000235393 · Cited by 98 · see citing works

Targeting IL-33 in Autoimmunity and Inflammation

Theoharides, T. C., Petra, A. I., Taracanova, A., Panagiotidou, S., & Conti, P. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.222505 · Cited by 94 · see citing works

Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome

Hornig, M., Gottschalk, G., Peterson, D. L., Knox, K. K., Schultz, A. F., Eddy, M. L., Che, X., & Lipkin, W. I. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.29 · Cited by 93 · see citing works

The role of corticotropin‐releasing hormone in immune‐mediated cutaneous inflammatory disease

Kane, M. O., Murphy, E. P., & Kirby, B. (2006) · Experimental Dermatology · doi:10.1111/j.1600-0625.2006.00382.x · Cited by 93 · see citing works

Mitochondrial DNA and anti-mitochondrial antibodies in serum of autistic children

Zhang, B., Angelidou, A., Alysandratos, K., Vasiadi, M., Francis, K., Asadi, S., Theoharides, A., Sideri, K., Lykouras, L., Kalogeromitros, D. C., et al. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-80 · Cited by 93 · see citing works

Corticotropin-Releasing Hormone Causes Vasodilation in Human Skin via Mast Cell-Dependent Pathways

Crompton, R., Clifton, V. L., Bisits, A., Read, M. A., Smith, R., & Wright, I. M. R. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030377 · Cited by 91 · see citing works

The effects of magnesium supplementation on exercise performance

Newhouse, I. J., & Finstad, E. W. (2000) · Clinical Journal of Sport Medicine · doi:10.1097/00042752-200007000-00008 · Cited by 90 · see citing works

Induction of Microglial Activation by Mediators Released from Mast Cells

Zhang, X., Wang, Y., Dong, H., Xu, Y. X., & Zhang, S. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000443093 · Cited by 90 · see citing works

A Preliminary Placebo-Controlled Crossover Trial of Fludrocortisone for Chronic Fatigue Syndrome

Peterson, P. K., Pheley, A. M., Schroeppel, J., Schenck, C. H., Marshall, P., Kind, A., Haugland, J. M., Lambrecht, L. J., Swan, S. K., & Goldsmith, S. R. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.8.908 · Cited by 88 · see citing works

Effect of magnesium supplementation on strength training in humans

Brilla, L. R., & Haley, T. F. (1992) · Journal of the American College of Nutrition · doi:10.1080/07315724.1992.10718233 · Cited by 86 · see citing works

Fibromyalgia Syndrome in Need of Effective Treatments

Theoharides, T. C., Tsilioni, I., Arbetman, L., Panagiotidou, S., Stewart, J. M., Gleason, R. M., & Russell, I. J. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.227298 · Cited by 86 · see citing works

Myalgic Encephalomyelitis (ME), Chronic Fatigue Syndrome (CFS), and Chronic Fatigue (CF) are distinguished accurately: Results of supervised learning techniques applied on clinical and inflammatory data

Maes, M. H. J., Twisk, F., & Johnson, C. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.03.031 · Cited by 85 · see citing works

Impaired oxygen delivery to muscle in chronic fatigue syndrome

McCully, K. K., & Natelson, B. H. (1999) · Clinical Science · doi:10.1042/cs0970603 · Cited by 84 · see citing works

Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder

Murrough, J. W., Mao, X., Collins, K. A., Kelly, C. A., Andrade, G., Nestadt, P. S., Levine, S. M., Mathew, S. J., & Shungu, D. C. (2010) · NMR in Biomedicine · doi:10.1002/nbm.1512 · Cited by 83 · see citing works

Astragalus membranaceus flavonoids (AMF) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming

Kuo, Y., Tsai, W., Loke, S.-H., Wu, T.-S., & Chiou, W.-F. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.11.025 · Cited by 83 · see citing works

Stress triggers coronary mast cells leading to cardiac events

Alevizos, M., Karagkouni, A., Panagiotidou, S., Vasiadi, M., & Theoharides, T. C. (2013) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2013.09.017 · Cited by 83 · see citing works

Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model

Gupta, A. K., Vij, G., Sharma, S., Tirkey, N., Rishi, P., & Chopra, K. (2008) · Immunobiology · doi:10.1016/j.imbio.2008.04.003 · Cited by 81 · see citing works

Definitive characterization of rat hypothalamic mast cells

Pang, X., Létourneau, R., Rózniecki, J., Wang, L., & Theoharides, T. C. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00606-0 · Cited by 81 · see citing works

Luteolin, a food‐derived flavonoid, suppresses adipocyte‐dependent activation of macrophages by inhibiting JNK activation

Ando, C., Takahashi, N., Hirai, S., Nishimura, K., Lin, S., Uemura, T., Goto, T., Yu, R., Nakagami, J., Murakami, S., et al. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.10.045 · Cited by 80 · see citing works

Diagnostic Methods for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systematic Review for a National Institutes of Health Pathways to Prevention Workshop

Haney, E. M., Smith, M. E. B., McDonagh, M. S., Pappas, M., Daeges, M., Wasson, N., & Nelson, H. D. (2015) · Annals of Internal Medicine · doi:10.7326/m15-0443 · Cited by 79 · see citing works

Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review

Campagnolo, N., Johnston, S. C., Collatz, A., Staines, D., & Marshall‐Gradisnik, S. (2017) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12435 · Cited by 77 · see citing works

NMR metabolic profiling of serum identifies amino acid disturbances in chronic fatigue syndrome

Armstrong, C. W., McGregor, N., Sheedy, J. R., Buttfield, I. H., Butt, H. L., & Gooley, P. R. (2012) · Clinica Chimica Acta · doi:10.1016/j.cca.2012.06.022 · Cited by 76 · see citing works

The influence of aerobic fitness and fibromyalgia on cardiorespiratory and perceptual responses to exercise in patients with chronic fatigue syndrome

Cook, D. B., Nagelkirk, P. R., Poluri, A., Mores, J., & Natelson, B. H. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22124 · Cited by 75 · see citing works

Mechanisms Explaining Muscle Fatigue and Muscle Pain in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a Review of Recent Findings

Morris, G., & Maes, M. H. J. (2017) · Current Rheumatology Reports · doi:10.1007/s11926-017-0628-x · Cited by 75 · see citing works

On the role of the corticotropin-releasing hormone signalling system in the aetiology of inflammatory skin disorders

Slominski, A. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08958.x · Cited by 74 · see citing works

Angiotensin II Reduces Mitochondrial Content in Skeletal Muscle and Affects Glycemic Control

Mitsuishi, M., Miyashita, K., Muraki, A., & Itoh, H. (2008) · Diabetes · doi:10.2337/db08-0949 · Cited by 74 · see citing works

Association of metabolic syndrome and insulin resistance with congestive heart failure: findings from the Third National Health and Nutrition Examination Survey

Li, C., Ford, E. S., McGuire, L., & Mokdad, A. H. (2006) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2006.048173 · Cited by 72 · see citing works

Mitochondrial enzymes discriminate between mitochondrial disorders and chronic fatigue syndrome

Smits, B. W., van den Heuvel, L., Knoop, H., Küsters, B., Janssen, A. J. M., Borm, G. F., Bleijenberg, G., Rodenburg, R. J., & van Engelen, B. G. M. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.05.005 · Cited by 69 · see citing works

Trends in the incidence of chronic fatigue syndrome and fibromyalgia in the UK, 2001–2013: a Clinical Practice Research Datalink study

Collin, S. M., Bakken, I. J., Nazareth, I., Crawley, E. M., & White, P. D. (2017) · Journal of the Royal Society of Medicine · doi:10.1177/0141076817702530 · Cited by 69 · see citing works

The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Glassford, J. A. G. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00088 · Cited by 68 · see citing works

Metabolism in Chronic Fatigue Syndrome

Armstrong, C. W., McGregor, N., Butt, H. L., & Gooley, P. R. (2014) · Advances in clinical chemistry · doi:10.1016/b978-0-12-801401-1.00005-0 · Cited by 66 · see citing works

Abnormalities of AMPK Activation and Glucose Uptake in Cultured Skeletal Muscle Cells from Individuals with Chronic Fatigue Syndrome

Brown, A. E., Jones, D. E., Walker, M., & Newton, J. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122982 · Cited by 65 · see citing works

Luteolin Inhibits Inflammatory Response and Improves Insulin Sensitivity in the Endothelium

Deqiu, Z., Kang, L., Jiali, Y., Baolin, L., & Gaolin, L. (2011) · Biochimie · doi:10.1016/j.biochi.2010.11.002 · Cited by 65 · see citing works

Pharmacological treatment of chronic fatigue syndrome: focusing on the role of antidepressants

Pae, C., Marks, D. M., Patkar, A. A., Masand, P. S., Luyten, P., & Serretti, A. (2009) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560902988510 · Cited by 64 · see citing works

Impaired cardiovascular response to standing in Chronic Fatigue Syndrome

Hollingsworth, K. G., Jones, D. E., Taylor, R., Blamire, A. M., & Newton, J. L. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2010.02310.x · Cited by 64 · see citing works

Sympathetic cardiovascular control during orthostatic stress and isometric exercise in adolescent chronic fatigue syndrome

Wyller, V. B., Saul, J. P., Walløe, L., & Thaulow, E. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0634-1 · Cited by 63 · see citing works

Decreased oxygen extraction during cardiopulmonary exercise test in patients with chronic fatigue syndrome

Vermeulen, R. C., & van Eck, I. W. V. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-20 · Cited by 61 · see citing works

Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome

Billing-Ross, P., Germain, A., Ye, K., Keinan, A., Gu, Z., & Hanson, M. R. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0771-6 · Cited by 61 · see citing works

Increased nuclear factor-κB and loss of p53 are key mechanisms in Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS)

Morris, G., & Maes, M. H. J. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.07.034 · Cited by 60 · see citing works

Identification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-associated DNA methylation patterns

Trivedi, M. S., Oltra, E., Sarría, L., Rose, N., Beljanski, V., FLETCHER, M. A., Klimas, N. G., & Nathanson, L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201066 · Cited by 59 · see citing works

Cytokines in the Cerebrospinal Fluids of Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Peterson, D. L., Brenu, E., Gottschalk, G., Ramos, S., Nguyen, T. H. P., Staines, D., & Marshall-Gradisnik, S. (2015) · Mediators of Inflammation · doi:10.1155/2015/929720 · Cited by 58 · see citing works

Metabolic abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a mini-review

Tomas, C., & Newton, J. L. (2018) · Biochemical Society Transactions · doi:10.1042/bst20170503 · Cited by 58 · see citing works

Chronic Fatigue Syndrome : diagnosis and treatment.

Meirleir, K. D. (2008) · VUBIR (Vrije Universiteit Brussel) · Cited by 58 · see citing works

Mast cells squeeze the heart and stretch the gird: Their role in atherosclerosis and obesity

Theoharides, T. C., Sismanopoulos, N., Delivanis, D.-A., Zhang, B., Hatziagelaki, E. E., & Kalogeromitros, D. C. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.05.005 · Cited by 57 · see citing works

Chronic fatigue syndrome: new evidence for a central fatigue disorder

Georgiades, E., Behan, W. M. H., Kilduff, L. P., Hadjicharalambous, M., Mackie, E. E., Wilson, J., Ward, S. A., & Pitsiladis, Y. P. (2003) · Clinical Science · doi:10.1042/cs20020354 · Cited by 57 · see citing works

Cytokines across the Night in Chronic Fatigue Syndrome with and without Fibromyalgia

Nakamura, T., Schwander, S., DONNELLY, R. J., Ortega, F. Z., Togo, F., Broderick, G., Yamamoto, Y., Cherniack, N. S., Rapoport, D. M., & Natelson, B. H. (2010) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00379-09 · Cited by 57 · see citing works

A Systematic Review of Drug Therapies for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Collatz, A., Johnston, S., Staines, D., & Marshall‐Gradisnik, S. (2016) · Clinical Therapeutics · doi:10.1016/j.clinthera.2016.04.038 · Cited by 57 · see citing works

Mast cell activation disorders

Akin, C. (2014) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2014.03.007 · Cited by 56 · see citing works

Cytotoxic lymphocyte microRNAs as prospective biomarkers for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Brenu, E., Ashton, K. J., van Driel, M., Staines, D., Peterson, D. L., Atkinson, G. M., & Marshall‐Gradisnik, S. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.03.037 · Cited by 56 · see citing works

Brain cytokines and neuropsychiatric disorders

Theoharides, T. C., Weinkauf, C., & Conti, P. (2004) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000148026.86483.4f · Cited by 56 · see citing works

Migraine headaches in Chronic Fatigue Syndrome (CFS): Comparison of two prospective cross-sectional studies

Ravindran, M. K., Zheng, Y., Timbol, C. R., Merck, S. J., & Baraniuk, J. N. (2011) · BMC Neurology · doi:10.1186/1471-2377-11-30 · Cited by 56 · see citing works

Is chronic fatigue syndrome the same illness as fibromyalgia: evaluating the 'single syndrome' hypothesis

Abbi, B., & Natelson, B. H. (2012) · QJM · doi:10.1093/qjmed/hcs156 · Cited by 56 · see citing works

The epidemiology of chronic fatigue syndrome/myalgic encephalitis in children

Crawley, E. M. (2013) · Archives of Disease in Childhood · doi:10.1136/archdischild-2012-302156 · Cited by 56 · see citing works

Roles of Microglial Phagocytosis and Inflammatory Mediators in the Pathophysiology of Sleep Disorders

Nadjar, A., Wigren, H., & Tremblay, M. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00250 · Cited by 56 · see citing works

Advances in Biomarker-Guided Therapy for Pediatric- and Adult-Onset Neuroinflammatory Disorders: Targeting Chemokines/Cytokines

Pranzatelli, M. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00557 · Cited by 56 · see citing works

Muscle metabolism with blood flow restriction in chronic fatigue syndrome

McCully, K. K., Smith, S. A., Rajaei, S., LEIGH, J. S. J., & Natelson, B. H. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00141.2003 · Cited by 55 · see citing works

Do mast cells link obesity and asthma?

Sismanopoulos, N., Delivanis, D. A., Mavrommati, D., Hatziagelaki, E. E., Conti, P., & Theoharides, T. C. (2012) · Allergy · doi:10.1111/all.12043 · Cited by 54 · see citing works

Metabolic Syndrome and Health‐related Quality of Life in Obese Individuals Seeking Weight Reduction

Tsai, A. G., Wadden, T. A., Sarwer, D. B., Berkowitz, R. I., Womble, L. G., Hesson, L. A., Phelan, S., & Rothman, R. A. (2008) · Obesity · doi:10.1038/oby.2007.8 · Cited by 54 · see citing works

Methoxyluteolin Inhibits Neuropeptide-stimulated Proinflammatory Mediator Release via mTOR Activation from Human Mast Cells

Patel, A., & Theoharides, T. C. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.240564 · Cited by 54 · see citing works

Epigallocatechin gallate ameliorates behavioral and biochemical deficits in rat model of load-induced chronic fatigue syndrome

Sachdeva, A. K., Kuhad, A., & Chopra, K. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.06.007 · Cited by 53 · see citing works

Impaired blood pressure variability in chronic fatigue syndrome--a potential biomarker

Frith, J., Zalewski, P., Klawe, J. J., Pairman, J., Bitner, A., Tafil‐Klawe, M., & Newton, J. L. (2012) · QJM · doi:10.1093/qjmed/hcs085 · Cited by 53 · see citing works

Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome

FLETCHER, M. A., Rosenthal, M., Antoni, M. H., Ironson, G. H., Zeng, X. R., Barnes, Z. M., Harvey, J. M., Hurwitz, B. E., Levis, S., Broderick, G., et al. (2010) · Behavioral and Brain Functions · doi:10.1186/1744-9081-6-76 · Cited by 52 · see citing works

Lower Ambulatory Blood Pressure in Chronic Fatigue Syndrome

Newton, J. L., Sheth, A., Shin, J., Pairman, J., Wilton, K., Burt, J. A., & Jones, D. E. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31819ccd2a · Cited by 50 · see citing works

CDC Grand Rounds: Chronic Fatigue Syndrome — Advancing Research and Clinical Education

Unger, E. R., Lin, J.-M. S., Brimmer, D. J., Lapp, C. W., Komaroff, A. L., Nath, A., Laird, S., & Iskander, J. K. (2016) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm655051a4 · Cited by 50 · see citing works

Human mast cells express leptin and leptin receptors

Taildeman, J., Perez-Novo, C. A., Rottiers, I., Ferdinande, L., Waeytens, A., Colvenaer, V. D., Bachert, C., Demetter, P., Waelput, W., Braet, K., et al. (2009) · Histochemistry and Cell Biology · doi:10.1007/s00418-009-0575-3 · Cited by 49 · see citing works

Diverse exocytic pathways for mast cell mediators

Xu, H., Bin, N., & Sugita, S. (2018) · Biochemical Society Transactions · doi:10.1042/bst20170450 · Cited by 49 · see citing works

Low-grade chronic inflammation mediated by mast cells in fibromyalgia: role of IL-37.

Mastrangelo, F., Frydas, I., Ronconi, G., Kritas, S. K., Tettamanti, L., Caraffa, A., Ovidio, C. D., Younes, A., Gallenga, C. E., & Conti, P. (2018) · PubMed · Cited by 49 · see citing works

Murine Mast Cells Secrete and Respond to Interleukin-33

Tung, H.-Y., Plunkett, B., Huang, S.-K., & Zhou, Y. (2013) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2012.0066 · Cited by 48 · see citing works

Chronic Fatigue Syndrome

Natelson, B. H. (2001) · JAMA · doi:10.1001/jama.285.20.2557 · Cited by 48 · see citing works

The “missing link” in autoimmunity and autism: Extracellular mitochondrial components secreted from activated live mast cells

Theoharides, T. C., Asadi, S., Panagiotidou, S., & Weng, Z. (2013) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.06.018 · Cited by 48 · see citing works

Do we know enough about the immune pathogenesis of acute coronary syndromes to improve clinical practice?

Matusik, P. T., Guzik, B., Weber, C., & Guzik, T. J. (2012) · Thrombosis and Haemostasis · doi:10.1160/th12-05-0341 · Cited by 48 · see citing works

Urinary and plasma organic acids and amino acids in chronic fatigue syndrome

Jones, M. G., Cooper, E., Amjad, S., Goodwin, C. S., BARRON, J. L., & CHALMERS, R. A. (2005) · Clinica Chimica Acta · doi:10.1016/j.cccn.2005.05.023 · Cited by 48 · see citing works

Detection of herpesviruses and parvovirus B19 in gastric and intestinal mucosa of chronic fatigue syndrome patients.

Frémont, M., Metzger, K., Rady, H. F., Hulstaert, J., & Meirleir, K. D. (2009) · PubMed · Cited by 48 · see citing works

Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue

Theoharides, T. C., Cholevas, C., Polyzoidis, K. S., & Politis, A. M. (2021) · BioFactors · doi:10.1002/biof.1726 · Cited by 219 · see citing works

A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against ß2-adrenergic receptors

WIRTH, K. J., & Scheibenbogen, C. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102527 · Cited by 137 · see citing works

Molecular Mechanisms of Neuroinflammation in ME/CFS and Long COVID to Sustain Disease and Promote Relapses

Tate, W. P., Walker, M., Sweetman, E., Helliwell, A., Peppercorn, K., Edgar, C. D., Blair, A., & Chatterjee, A. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.877772 · Cited by 128 · see citing works

Recent advances in our understanding of mast cell activation – or should it be mast cell mediator disorders?

Theoharides, T. C., Tsilioni, I., & Ren, H. L. (2019) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2019.1596800 · Cited by 124 · see citing works

How Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Progresses: The Natural History of ME/CFS

Nacul, L., O’Boyle, S., Palla, L., Nácul, F. E., Mudie, K., Kingdon, C. C., Cliff, J. M., Clark, T. G., Dockrell, H. M., & Lacerda, E. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00826 · Cited by 104 · see citing works

Astragalus polysaccharide ameliorated complex factor-induced chronic fatigue syndrome by modulating the gut microbiota and metabolites in mice

Wei, X., Xin, J., Chen, W., Wang, J., Lv, Y., Wei, Y., Li, Z., Ding, Q., Shen, Y., Xu, X., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114862 · Cited by 87 · see citing works

Role of SARS-CoV-2 Spike-Protein-Induced Activation of Microglia and Mast Cells in the Pathogenesis of Neuro-COVID

Theoharides, T. C., & Kempuraj, D. (2023) · Cells · doi:10.3390/cells12050688 · Cited by 81 · see citing works

The relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome

Ghali, A., Lacombe, V., Ravaiau, C., Delattre, E., Ghali, M., Urbanski, G., & Lavigne, C. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04229-w · Cited by 73 · see citing works

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Where will the drugs come from?

Toogood, P. L., Clauw, D. J., Phadke, S., & Hoffman, D. L. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105465 · Cited by 68 · see citing works

The underlying sex differences in neuroendocrine adaptations relevant to Myalgic Encephalomyelitis Chronic Fatigue Syndrome

Thomas, N., Gurvich, C., Huang, K., Gooley, P. R., & Armstrong, C. W. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.100995 · Cited by 68 · see citing works

Neuroimmunology: What Role for Autoimmunity, Neuroinflammation, and Small Fiber Neuropathy in Fibromyalgia, Chronic Fatigue Syndrome, and Adverse Events after Human Papillomavirus Vaccination?

Ryabkova, V. A., Churilov, L. P., & Shoenfeld, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205164 · Cited by 69 · see citing works

Mitochondria and immunity in chronic fatigue syndrome

Anderson, G., & Maes, M. H. J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109976 · Cited by 64 · see citing works

Mast cells in the autonomic nervous system and potential role in disorders with dysautonomia and neuroinflammation

Theoharides, T. C., Twahir, A., & Kempuraj, D. (2023) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2023.10.032 · Cited by 54 · see citing works

Glial Activation and Expression of the Serotonin Transporter in Chronic Fatigue Syndrome

Noda, M., Ifuku, M., Hossain, M. S., & Katafuchi, T. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00589 · Cited by 46 · see citing works

Exploring the Pathophysiology of Long COVID: The Central Role of Low-Grade Inflammation and Multisystem Involvement

Gusev, E., & Sarapultsev, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126389 · Cited by 39 · see citing works

Factors Influencing the Prognosis of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Ghali, A., Lacout, C., Fortrat, J., Depres, K., Ghali, M., & Lavigne, C. (2022) · Diagnostics · doi:10.3390/diagnostics12102540 · Cited by 35 · see citing works

Ways to Address Perinatal Mast Cell Activation and Focal Brain Inflammation, including Response to SARS-CoV-2, in Autism Spectrum Disorder

Theoharides, T. C. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11090860 · Cited by 29 · see citing works

Differential diagnosis between “chronic fatigue” and “chronic fatigue syndrome”

Son, C. (2019) · Integrative Medicine Research · doi:10.1016/j.imr.2019.04.005 · Cited by 28 · see citing works

Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Stanculescu, D., Larsson, L., & Bergquist, J. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.628029 · Cited by 25 · see citing works

Acupuncture and moxibustion for chronic fatigue syndrome: A systematic review and network meta-analysis

Fang, Y., Yue, B.-W., Ma, H., & Yuan, Y.-P. (2022) · Medicine · doi:10.1097/md.0000000000029310 · Cited by 24 · see citing works

Herpesviruses Serology Distinguishes Different Subgroups of Patients From the United Kingdom Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Biobank

Domingues, T. D., Grabowska, A. D., Lee, J., Ameijeiras‐Alonso, J., Westermeier, F., Scheibenbogen, C., Cliff, J. M., Nacul, L., Lacerda, E., Mouriño, H., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.686736 · Cited by 20 · see citing works

Exosome‐associated mitochondrial DNA from patients with myalgic encephalomyelitis/chronic fatigue syndrome stimulates human microglia to release IL‐1β

Tsilioni, I., Natelson, B. H., & Theoharides, T. C. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15828 · Cited by 20 · see citing works

Converging Evidence of Similar Symptomatology of ME/CFS and PASC Indicating Multisystemic Dyshomeostasis

Marks, D. F. (2023) · Biomedicines · doi:10.3390/biomedicines11010180 · Cited by 20 · see citing works

A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for Long COVID

Jurek, J. M., & Castro‐Marrero, J. (2024) · Nutrients · doi:10.3390/nu16111545 · Cited by 20 · see citing works

A description of the current status of chronic fatigue syndrome and associated factors among university students in Wuhan, China

Luo, L., Zhang, Y., Huang, T., Zhou, F., Xiong, C., Liu, Y. S., Zhai, P., Wang, G., Tan, J., Jiao, C., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1047014 · Cited by 19 · see citing works

Genetics of COVID‐19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review

Tziastoudi, M., Cholevas, C., Stefanidis, I., & Theoharides, T. (2022) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51631 · Cited by 16 · see citing works

Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically-relevant Phenotyping of Women with Chronic Fatigue Syndrome

Morris, M. C., Cooney, K. E., Sedghamiz, H., Abreu, M., Collado, F., Balbin, E. G., Craddock, T. J. A., Klimas, N. G., Broderick, G., & Fletcher, M. A. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.03.002 · Cited by 14 · see citing works

Chronic Fatigue Exhibits Heterogeneous Autoimmunity Characteristics Which Reflect Etiology

Даниленко, О. И., Gavrilova, N., & Churilov, L. P. (2022) · Pathophysiology · doi:10.3390/pathophysiology29020016 · Cited by 15 · see citing works

Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Stanculescu, D., Sepúlveda, N., Lim, C. L., & Bergquist, J. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.789784 · Cited by 12 · see citing works

Mast Cells in Autism Spectrum Disorder—The Enigma to Be Solved?

Kovacheva, E., Gevezova, M., Maes, M. H. J., & Sarafian, V. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052651 · Cited by 12 · see citing works

Oxytocin, the panacea for long-COVID? a review

Diep, P.-T., Chaudry, M., Dixon, A., Chaudry, F., & Kasabri, V. N. (2022) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2021-0034 · Cited by 10 · see citing works

[Asthenia, mental fatigue and cognitive dysfunction].

Titova, N., Bezdolny, Y. N., & Katunina, E. (2023) · Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova · doi:10.17116/jnevro202312305138 · Cited by 9 · see citing works

The Rise and Fall of the Psychosomatic Approach to Medically Unexplained Symptoms, Myalgic Encephalomyelitis and Chronic Fatigue Syndrome

Marks, D. F. (2022) · Archives of Epidemiology & Public Health Research · doi:10.33140/aephr.01.02.06 · Cited by 13 · see citing works

Perspective: Drawing on Findings From Critical Illness to Explain Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Stanculescu, D., & Bergquist, J. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.818728 · Cited by 9 · see citing works

Hypothalamus Connectivity in Adolescent Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Byrne, H. R., Knight, S., Josev, E. K., Scheinberg, A. M., Beare, R. J., Yang, J. Y., Oldham, S., Rowe, K., & Seal, M. L. (2024) · Journal of Neuroscience Research · doi:10.1002/jnr.25392 · Cited by 6 · see citing works

NANOENCAPSULATION OF LUTEOLIN: ENHANCING BIOAVAILABILITY AND MEDICINAL BENEFITS

Raksha, B., Vaishnavi, M., Durga, M., B., B. B., & Deepikaa, R. (2023) · International Journal of Pharmacy and Pharmaceutical Sciences · doi:10.22159/ijpps.2023v15i12.49440 · Cited by 6 · see citing works

Hypothalamus volumes in adolescent Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): impact of self-reported fatigue and illness duration

Byrne, H. R., Josev, E. K., Knight, S., Scheinberg, A. M., Rowe, K., Lubitz, L., & Seal, M. L. (2023) · Brain Structure and Function · doi:10.1007/s00429-023-02682-3 · Cited by 5 · see citing works

Editorial: Current Insights Into Complex Post-infection Fatigue Syndromes With Unknown Aetiology: The Case of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Beyond

Westermeier, F., Lacerda, E., Scheibenbogen, C., & Sepúlveda, N. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.862953 · Cited by 5 · see citing works

The duality of asthenia and cognitive impairments in cerebral diseases

Борисовна, Л. А., & Zakharov, V. V. (2023) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2023-401 · Cited by 4 · see citing works

Chronic fatigue syndrome against the background of the COVID-19 pandemic

Nikitina, A. Y., & Levin, O. S. (2021) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202112110292 · Cited by 3 · see citing works

A Timely Multidisciplinary Update on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Theoharides, T. C. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.03.004 · Cited by 3 · see citing works

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Rowe, P. C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-75608-2.00200-7 · Cited by 2 · see citing works

Myalgic encephalomyelitis / chronic fatigue syndrome as a breakdown of homeostasisPreprint

Marks, D. F. (2021) · Qeios · doi:10.32388/fz1y68.2 · Cited by 1 · see citing works

An integrative review on the orexin system and hypothalamic dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome: implications for precision medicine

López‐Amador, N. (2025) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2025.1004112 · Cited by 1 · see citing works

Myalgic encephalomyelitis - enigma at the medicine’s crossroads

Pavlović, D. M., Djordjević, J., Pavlovic, A. M., Stjepanovic, M., & Baralić, M. (2020) · Srpski arhiv za celokupno lekarstvo · doi:10.2298/sarh200628091p · Cited by 1 · see citing works

Myalgic encephalomyelitis /chronic fatigue syndrome as a breakdown of homeostasisPreprint

Marks, D. F. (2021) · doi:10.32388/fz1y68 · Cited by 1 · see citing works

Myalgic encephalomyelitis / chronic fatigue syndrome as a breakdown of homeostasisPreprint

Marks, D. F. (2022) · Qeios · doi:10.32388/fz1y68.3 · Cited by 1 · see citing works

Orexinergic and Hypothalamic Dysfunction in Chronic Fatigue Syndrome: A Mechanistic Framework for Biomarker Discovery and Targeted TherapiesPreprint

López‐Amador, N. (2025) · Qeios · doi:10.32388/zozbh7 · Cited by 1 · see citing works

In Search of Effective Treatments for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Theoharides, T. C. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.04.011

The preclinical studies of the stress-protective activity of “Tonus-aktiv” homeopathic granules

Gaidukova, O. O., Nikolenko, Y. Y., Kvitchata, G. I., Олійник, С. В., & Belyaeva, L. V. (2020) · News of pharmacy · doi:10.24959/nphj.20.36

Mast Cells and their Role in Health and Disease

Faustino, A., & Oliveira, P. A. (2022) · Nova Science Publishers eBooks · doi:10.52305/gpjw5150

Psychoneurological disorders in the stage of post-COVID syndrome

Soldatenko, A. A., Николаевна, Г. Л., & Bobrik, Y. V. (2024) · Medical alphabet · doi:10.33667/2078-5631-2024-21-47-52

Orexinergic and Hypothalamic Dysfunction: An Integrative Review with a Focus on Precision Medicine in Chronic Fatigue SyndromePreprint

López‐Amador, N. (2025) · Qeios · doi:10.32388/zozbh7.3

Additional file 2 of The relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome

Ghali, A., Lacombe, V., Ravaiau, C., Delattre, E., Ghali, M., Urbanski, G., & Lavigne, C. (2024) · Figshare · doi:10.6084/m9.figshare.26595716

Additional file 3 of The relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome

Ghali, A., Lacombe, V., Ravaiau, C., Delattre, E., Ghali, M., Urbanski, G., & Lavigne, C. (2024) · Figshare · doi:10.6084/m9.figshare.26595719

Additional file 1 of The relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome

Ghali, A., Lacombe, V., Ravaiau, C., Delattre, E., Ghali, M., Urbanski, G., & Lavigne, C. (2024) · Figshare · doi:10.6084/m9.figshare.26595713

Chronic fatigue syndrome induced by environmental toxic exposure: Effects of polyhexamethyleneguanidine phosphate exposure on mitochondrial function and neural health

Yang, H.-S., Lee, J.-S., Kang, M.-H., Song, M.-K., Kang, J.-Y., Kim, H., Kim, H., Jong‐Han, L., Son, C.-G., & Lee, K. (2026) · Environmental Research · doi:10.1016/j.envres.2026.123874

Systems neuroendocrinology in ME/CFS and long COVID: a chronobiological framework for hormone-based research

Thomas, N., Huang, K., Schneider‐Futschik, E. K., Pollack, B., Tal, M. C., Fineberg, D., Wang, X. Y., Gurvich, C., Pretorius, R., Bergquist, J., et al. (2026) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2026.101268

Tryptophan Metabolism and Aryl‐Hydrocarbon Receptor Agonists in the Gut Microbiome of People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Esteban, D. J., Conrad, B., Cullinan, A., Luong, S., Albaum, J. A., & WILK, V. (2026) · MicrobiologyOpen · doi:10.1002/mbo3.70333

Mast cell activation disorders: mechanisms, comorbidities and look-alike

Theoharides, T. C., Kempuraj, D., & Maitland, A. L. (2026) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2026.2699311

Pathogen effects on the brain: the case of SARS-CoV-2 spike protein and neuro COVID

Theoharides, T. C., & Papadopoulou, P. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1853951

In Search of Effective Treatments for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Theoharides, T. C. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.04.011

Metabolic abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a mini-review

Tomas, C., & Newton, J. L. (2018) · Biochemical Society Transactions · doi:10.1042/bst20170503 · Cited by 58 · see citing works

Pathological Mechanisms Underlying Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Missailidis, D., Annesley, S. J., & Fisher, P. (2019) · La Trobe University · doi:10.26181/15511845

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (Me/Cfs): The Biology of a Neglected DiseasePreprint

Arron, H. E., Marsh, B., Khan, A., Jaeger, B. R., Kell, D. B., & Pretorius, E. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4622074

Insights into the Complex Biological Network Underlying Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Dudova, D., Bozhkova, M., Петров, С. В., Nikolova, R., Kalfova, T., Ivanovska, M., Vaseva, K., Nikolova, M., & Ivanov, I. N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010268 · Cited by 9 · see citing works