Mitochondrial dysfunction and oxidative damage cooperatively fuel axonal degeneration in X-linked adrenoleukodystrophy

The metabolic and molecular bases of inherited disease

Chen, Y.-T. (2001) · Medical Entomology and Zoology · Cited by 6,928 · see citing works

Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455 · see citing works

Reactive oxygen species in cell signaling

Thannickal, V. J., & Fanburg, B. L. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.6.l1005 · Cited by 2,936 · see citing works

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

Baines, C. P., Kaiser, R. A., Purcell, N. H., Blair, N. S., Osinska, H., Hambleton, M. A., Brunskill, E. W., Sayen, M. R., Gottlieb, R. A., Dorn, G. W., et al. (2005) · Nature · doi:10.1038/nature03434 · Cited by 2,280 · see citing works

Protein degradation and protection against misfolded or damaged proteins.

Goldberg, A. L. (2003) · Nature · doi:10.1038/nature02263 · Cited by 2,088 · see citing works

The ubiquitin-proteasome proteolytic pathway

Ciechanover, A. J. (1994) · Cell · doi:10.1016/0092-8674(94)90396-4 · Cited by 1,804 · see citing works

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

Nakagawa, T., Shimizu, S., Watanabe, T., Yamaguchi, O., Otsu, K., Yamagata, H., Inohara, H., Kubo, T., & Tsujimoto, Y. (2005) · Nature · doi:10.1038/nature03317 · Cited by 1,635 · see citing works

Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy

Cartier, N., Hacein-Bey-Abina, S., Bartholomae, C. C., Veres, G., Schmidt, M., Kutschera, I., Vidaud, M., Abel, U., Dal-Cortivo, L., Caccavelli, L., et al. (2009) · Science · doi:10.1126/science.1171242 · Cited by 1,508 · see citing works

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

Du, H., Guo, L., Fang, F., Chen, D., Sosunov, A. A., McKhann, G. M., Yan, Y., Wang, C., Zhang, H., Molkentin, J. D., et al. (2008) · Nature Medicine · doi:10.1038/nm.1868 · Cited by 935 · see citing works

Dimers of mitochondrial ATP synthase form the permeability transition pore

Giorgio, V., von Stockum, S., Antoniel, M., Fabbro, A., Fogolari, F., Forte, M. A., Glick, G. D., Petronilli, V., Zoratti, M., Szabó, I., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217823110 · Cited by 924 · see citing works

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.

Crompton, M., Ellinger, H., & COSTI, A. (1988) · PubMed Central · Cited by 841 · see citing works

Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

Schinzel, A. C., Takeuchi, O., Huang, Z., Fisher, J. K., Zhou, Z., Rubens, J., Hetz, C., Danial, N. N., Moskowitz, M. A., & Korsmeyer, S. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505294102 · Cited by 820 · see citing works

Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders

Calabrese, V., Cornelius, C., Dinkova‐Kostova, A. T., Calabrese, E. J., & Mattson, M. P. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3074 · Cited by 803 · see citing works

Peroxisomal and Mitochondrial Defects in the Cerebro-Hepato-Renal Syndrome

Goldfischer, S. L., Moore, C. L., Johnson, T., Spiro, A. J., Valsamis, M. P., Wisniewski, H. K., Ritch, R. H., Norton, W. T., Rapin, I., & Gartner, L. M. (1973) · Science · doi:10.1126/science.182.4107.62 · Cited by 791 · see citing works

Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase

Halestrap, A. P., & Davidson, A. M. (1990) · Biochemical Journal · doi:10.1042/bj2680153 · Cited by 753 · see citing works

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

Gandhi, S., Wood-Kaczmar, A., Yao, Z., Plun-Favreau, H., Deas, E., Klupsch, K., Downward, J., Latchman, D. S., Tabrizi, S. J., Wood, N. W., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.02.013 · Cited by 682 · see citing works

X-linked adrenoleukodystrophy

Moser, H. W., Mahmood, A., & Raymond, G. V. (2007) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0421 · Cited by 663 · see citing works

Role of peroxisomes in ros/rns-metabolism: Implications for human disease

Fransen, M., Nordgren, M., Wang, B., & Apanasets, O. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.12.001 · Cited by 644 · see citing works

X-linked adrenoleukodystrophy (X-ALD): clinical presentation and guidelines for diagnosis, follow-up and management

Engelen, M., Kemp, S., de Visser, M., van Geel, B. M., Wanders, R. J., Aubourg, P., & Poll-The, B. (2012) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-7-51 · Cited by 562 · see citing works

Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice

Hauptmann, S., Scherping, I., Dröse, S., Brandt, U., Schulz, K. L., Jendrach, M., Leuner, K., Eckert, A., & Müller, W. E. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.12.005 · Cited by 469 · see citing works

Oxidative Stress in Parkinson's Disease

Zhou, C. H., Huang, Y., & Przedborski, S. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.023 · Cited by 453 · see citing works

Cerebral X-linked adrenoleukodystrophy: the international hematopoietic cell transplantation experience from 1982 to 1999

Peters, C., Charnas, L. R., Tan, Y., Ziegler, R. S., Shapiro, E. G., DeFor, T., Grewal, S. S., Orchard, P. J., Abel, S. L., Goldman, A. I., et al. (2004) · Blood · doi:10.1182/blood-2003-10-3402 · Cited by 374 · see citing works

Long-term effect of bone-marrow transplantation for childhood-onset cerebral X-linked adrenoleukodystrophy

Shapiro, E., Krivit, W., Lockman, L., Jambaqué, I., Peters, C., Cowan, M., Harris, R., Blanche, S., Bordigoni, P., Loes, D., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02629-5 · Cited by 329 · see citing works

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

Felice, F. G. D. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64595 · Cited by 328 · see citing works

Adrenoleukodystrophy: Incidence, new mutation rate, and results of extended family screening

Bezman, L., Moser, A. B., Raymond, G. V., Rinaldo, P., Watkins, P. A., Smith, K. D., Kass, N. E., & Moser, H. W. (2001) · Annals of Neurology · doi:10.1002/ana.101 · Cited by 324 · see citing works

Evidence of Oxidative Stress in Alzheimer's Disease Brain and Antioxidant Therapy

Praticò, D. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.010 · Cited by 315 · see citing works

A mouse model for X-linked adrenoleukodystrophy

Lu, J.-F., Lawler, A. M., Watkins, P. A., Powers, J. M., Moser, A. B., Moser, H. W., & Smith, K. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9366 · Cited by 293 · see citing works

Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation

Karbowski, M., & Youle, R. J. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.05.007 · Cited by 256 · see citing works

Adrenoleukodystrophy: Incidence, new mutation rate, and results of extended family screening

Bezman, L., Moser, A. B., Raymond, G. V., Watkins, P. A., Smith, K. D., KASS, N. E., & Moser, H. W. (2001) · Annals of Neurology · doi:10.1002/ana.101.abs · Cited by 237 · see citing works

Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta

Du, H., & Yan, S. S. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.07.005 · Cited by 235 · see citing works

Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis

Forte, M., Gold, B., Marracci, G., Chaudhary, P., Basso, E., Johnsen, D., Yu, X.-L., Fowlkes, J., Rahder, M., Stem, K., et al. (2007) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0702228104 · Cited by 222 · see citing works

Late onset neurological phenotype of the X-ALD gene inactivation in mice: a mouse model for adrenomyeloneuropathy

Pujol, A. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.5.499 · Cited by 214 · see citing works

Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy

Fourcade, S., Lopez-Erauskin, J., Galino, J., Duval, C., Naudi, A., Jove, M., Kemp, S., Villarroya, F., Ferrer, I., Pamplona, R., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn085 · Cited by 214 · see citing works

Protein Targets of Oxidative Damage in Human Neurodegenerative Diseases with Abnormal Protein Aggregates

Martínez, A., Portero‐Otín, M., Pamplona, R., & Ferrer, I. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00326.x · Cited by 213 · see citing works

Mitochondrial Alterations Caused by Defective Peroxisomal Biogenesis in a Mouse Model for Zellweger Syndrome (PEX5 Knockout Mouse)

Baumgart, E., Vanhorebeek, I., Grabenbauer, M., Borgers, M., Declercq, P. E., Fahimi, H. D., & Baes, M. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62534-5 · Cited by 210 · see citing works

Adrenomyeloneuropathy: A Neuropathologic Review Featuring Its Noninflammatory Myelopathy

Powers, J. M., DeCiero, D. P., Ito, M., Moser, A. B., & Moser, H. W. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.2.89 · Cited by 204 · see citing works

Functional overlap between ABCD1 (ALD) and ABCD2 (ALDR) transporters: a therapeutic target for X-adrenoleukodystrophy

Pujol, A., Ferrer, I., Camps, C., Metzger, E., Hindelang, C., Callizot, N., Ruiz, M., Pàmpols, T., Giròs, M., & Mandel, J. L. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh323 · Cited by 201 · see citing works

Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk

Ivashchenko, O., Veldhoven, P. P. V., Brees, C., Ho, Y.-S., Terlecky, S. R., & Fransen, M. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-11-0919 · Cited by 199 · see citing works

Interactions of a very long chain fatty acid with model membranes and serum albumin. Implications for the pathogenesis of adrenoleukodystrophy.

Ho, J. K., Moser, H., Kishimoto, Y., & Hamilton, J. A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118182 · Cited by 199 · see citing works

Adrenoleukodystrophy Protein-Deficient Mice Represent Abnormality of Very Long Chain Fatty Acid Metabolism

Kobayashi, T., Shinnoh, N., Kondo, A., & Yamada, T. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6340 · Cited by 197 · see citing works

Mitochondrial Dysfunction: The First Domino in Brain Aging and Alzheimer's Disease?

Leuner, K., Hauptmann, S., Abdel-Kader, R. M., Scherping, I., Keil, U., Strosznajder, J. B., Eckert, A., & Müller, W. E. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1763 · Cited by 194 · see citing works

Mitochondria as a central sensor for axonal degenerative stimuli

Court, F. A., & Coleman, M. P. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.04.001 · Cited by 193 · see citing works

Redox Sensing by Proteins: Oxidative Modifications on Cysteines and the Consequent Events

Wang, Y., Yang, J., & Yi, J. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4313 · Cited by 188 · see citing works

The mitochondrial permeability transition pore in motor neurons: Involvement in the pathobiology of ALS mice

Martin, L. J., Gertz, B., Pan, Y. H., Price, A. C., Molkentin, J. D., & Chang, Q. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.02.015 · Cited by 181 · see citing works

Toxic effects of X-linked adrenoleukodystrophy-associated, very long chain fatty acids on glial cells and neurons from rat hippocampus in culture

Hein, S., Schonfeld, P., Kahlert, S., & Reiser, G. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn066 · Cited by 180 · see citing works

Absence of peroxisomes in mouse hepatocytes causes mitochondrial and ER abnormalities†

Dirkx, R., Vanhorebeek, I., Martens, K., Schad, A., Grabenbauer, M., Fahimi, D., Declercq, P., Van Veldhoven, P. P., & Baes, M. (2005) · Hepatology · doi:10.1002/hep.20628 · Cited by 174 · see citing works

Effects of long-chain, saturated fatty acids on membrane microviscosity and adrenocorticotropin responsiveness of human adrenocortical cells in vitro.

Whitcomb, R. W., Linehan, W. M., & Knazek, R. A. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113292 · Cited by 168 · see citing works

Evidence of Oxidant Damage in Huntington's Disease: Translational Strategies Using Antioxidants

Stack, E. C., Matson, W. R., & Ferrante, R. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.008 · Cited by 167 · see citing works

Pathomechanisms underlying X-adrenoleukodystrophy: A three-hit hypothesis

Singh, I., & Pujol, A. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2010.00392.x · Cited by 148 · see citing works

RNA oxidation in Alzheimer disease and related neurodegenerative disorders

Nunomura, A., Hofer, T., Moreira, P. I., Castellani, R. J., Smith, M. A., & Perry, G. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0508-1 · Cited by 148 · see citing works

Role of ALDP (ABCD1) and Mitochondria in X-Linked Adrenoleukodystrophy

McGuinness, M. C., Lu, J.-F., Zhang, H.-P., Dong, G.-X., Heinzer, A. K., Watkins, P. A., Powers, J., & Smith, K. D. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.2.744-753.2003 · Cited by 147 · see citing works

General aspects and neuropathology of X-linked adrenoleukodystrophy

Ferrer, I., Aubourg, P., & Pujol, A. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2010.00390.x · Cited by 139 · see citing works

Antioxidants halt axonal degeneration in a mouse model of X‐adrenoleukodystrophy

López‐Erauskin, J., Fourcade, S., Galino, J., Ruíz, M., Schlüter, A., Naudí, A., Jové, M., Portero‐Otín, M., Pamplona, R., Ferrer, I., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22363 · Cited by 135 · see citing works

Adreno-leukodystrophy: Oxidative Stress of Mice and Men

Powers, J. M., Pei, Z., Heinzer, A. K., Brose, R. D., Moser, A. B., Moser, H. W., Watkins, P. A., & Smith, K. D. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000190064.28559.a4 · Cited by 131 · see citing works

Highly resistant macromolecular components and low rate of generation of endogenous damage: Two key traits of longevity

Pamplona, R., & Barja, G. (2007) · Ageing Research Reviews · doi:10.1016/j.arr.2007.06.002 · Cited by 126 · see citing works

Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy

López-Erauskin, J., Galino, J., Ruiz, M., Cuezva, J. M., Fabregat, I., Cacabelos, D., Boada, J., Martínez, J., Ferrer, I., Pamplona, R., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt186 · Cited by 125 · see citing works

The ubiquitin proteasome system in neurodegenerative diseases: Culprit, accomplice or victim?

Dennissen, F. J. A., Kholod, N., & van Leeuwen, F. W. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.01.003 · Cited by 124 · see citing works

Evidence of oxidative stress in very long chain fatty acid – Treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins

Baarine, M., Andreoletti, P., Athias, A., Nury, T., Zarrouk, A., Ragot, K., Véjux, A., Riedinger, J., Kattan, Z., Bessède, G., et al. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.058 · Cited by 119 · see citing works

Evidence that oxidative stress is increased in patients with X-linked adrenoleukodystrophy

Vargas, C. R., Wajner, M., Sirtori, L. R., Goulart, L. D. S., Chiochetta, M., Coelho, D. M., Latini, A., Llesuy, S., Belló‐Klein, A., Giugliani, R., et al. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2003.10.004 · Cited by 114 · see citing works

Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: A paradigm for multifactorial neurodegenerative diseases?

Galea, E., Launay, N., Portero-Otin, M., Ruiz, M., Pamplona, R., Aubourg, P., Ferrer, I., & Pujol, A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.02.005 · Cited by 108 · see citing works

Inactivation of the peroxisomal ABCD2 transporter in the mouse leads to late-onset ataxia involving mitochondria, Golgi and endoplasmic reticulum damage

Ferrer, I., Kapfhammer, J. P., Hindelang, C., Kemp, S., Troffer-Charlier, N., Broccoli, V., Callyzot, N., Mooyer, P., Selhorst, J., Vreken, P., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi384 · Cited by 106 · see citing works

A key role for the peroxisomal<i>ABCD2</i>transporter in fatty acid homeostasis

Fourcade, S., Ruiz, M., Camps, C., Schlüter, A., Houten, S. M., Mooyer, P. A. W., Pàmpols, T., Dacremont, G., Wanders, R. J. A., Giròs, M., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90736.2008 · Cited by 104 · see citing works

X-linked adrenoleukodystrophy is a frequent cause of idiopathic Addison's disease in young adult male patients.

Laureti, S., Casucci, G., Santeusanio, F., Angeletti, G., Aubourg, P., & Brunetti, P. (1996) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.81.2.8636252 · Cited by 101 · see citing works

Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy

Fourcade, S., Ruíz, M., Guilera, C., Hahnen, E., Brichta, L., Naudí, A., Portero‐Otín, M., Dacremont, G., Cartier, N., Wanders, R. J. A., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq082 · Cited by 100 · see citing works

Oxidative Stress and Altered Mitochondrial Function in Neurodegenerative Diseases: Lessons From Mouse Models

Fernández-Checa, J. C., Fernandez, A., Morales, A., Marı́, M., García‐Ruiz, C., & Colell, A. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791556113 · Cited by 98 · see citing works

The Dorsal Root Ganglia in Adrenomyeloneuropathy: Neuronal Atrophy and Abnormal Mitochondria

Powers, J. M., Deciero, D. P., Cox, C., Richfield, E. K., Ito, M., Moser, A. B., & Moser, H. W. (2001) · Journal of Neuropathology &amp; Experimental Neurology · doi:10.1093/jnen/60.5.493 · Cited by 96 · see citing works

Induction of Mitochondrial Changes Associated with Oxidative Stress on Very Long Chain Fatty Acids (C22:0, C24:0, or C26:0)-Treated Human Neuronal Cells (SK-NB-E)

Zarrouk, A., Véjux, A., Nury, T., Hajj, H. I. E., Haddad, M., Cherkaoui‐Malki, M., Riedinger, J., Hammami, M., & Lizard, G. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/623257 · Cited by 90 · see citing works

Current and Future Pharmacological Treatment Strategies in X‐Linked Adrenoleukodystrophy

Berger, J., Pujol, A., Aubourg, P. R., & Forss‐Petter, S. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2010.00393.x · Cited by 90 · see citing works

Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy

López‐Erauskin, J., Galino, J., Bianchi, P., Fourcade, S., Andreu, A. L., Ferrer, I., Muñoz‐Pinedo, C., & Pujol, A. (2012) · Brain · doi:10.1093/brain/aws292 · Cited by 87 · see citing works

Oxidative Damage Compromises Energy Metabolism in the Axonal Degeneration Mouse Model of X-Adrenoleukodystrophy

Galino, J., Ruíz, M., Fourcade, S., Schlüter, A., López‐Erauskin, J., Guilera, C., Jové, M., Naudí, A., García‐Arumí, E., Andreu, A. L., et al. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3877 · Cited by 85 · see citing works

Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy

Morató, L., Galino, J., Ruíz, M., Calingasan, N. Y., Starkov, A. A., Dumont, M., Naudí, A., Martínez, J. J., Aubourg, P. R., Portero‐Otín, M., et al. (2013) · Brain · doi:10.1093/brain/awt143 · Cited by 82 · see citing works

Brain gangliosides in adrenoleukodystrophy1

Igarashi, M., Belchjs, D., & Suzuki, K. (1976) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1976.tb01593.x · Cited by 81 · see citing works

Untitled work

Menkes (1977) · doi:10.1212/wnl.27.10.928 · Cited by 78 · see citing works

The mitochondrial permeability transition pore: A molecular target for amyotrophic lateral sclerosis therapy

Martin, L. J. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.07.009 · Cited by 76 · see citing works

Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophy

Schlüter, A., Espinosa, L., Fourcade, S., Galino, J., López, E., Ilieva, E., Morató, L., Asheuer, M., Cook, T., McLaren, A., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/ddr536 · Cited by 72 · see citing works

Fibrate induction of the adrenoleukodystrophy‐related gene (<i>ABCD2</i>): Promoter analysis and role of the peroxisome proliferator‐activated receptor PPARα

Fourcade, S., Savary, S., Albet, S., Gauthé, D., Gondcaille, C., Pineau, T., Bellenger, J., Bentejac, M., Holzinger, A., Berger, J., et al. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02249.x · Cited by 70 · see citing works

Fatty Acid Composition of Human Myelin Proteolipid Protein in Peroxisomal Disorders

Bizzozero, O. A., Zuñiga, G., & Lees, M. B. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb02003.x · Cited by 61 · see citing works

Life span extension and reduced neuronal death after weekly intraventricular cyclosporin injections in the G93A transgenic mouse model of amyotrophic lateral sclerosis

Karlsson, J., Fong, K. S. K., Hansson, M. J., Elmàr, E., Csiszár, K., & Keep, M. F. (2004) · Journal of neurosurgery · doi:10.3171/jns.2004.101.1.0128 · Cited by 59 · see citing works

Mitochondrial Permeability Transition Pore Component Cyclophilin D Distinguishes Nigrostriatal Dopaminergic Death Paradigms in the MPTP Mouse Model of Parkinson's Disease

Thomas, B., Banerjee, R., Starkova, N. N., Zhang, S. F., Calingasan, N. Y., Yang, L., Wille, E. J., Lorenzo, B. J., Ho, D. J., Beal, M. F., et al. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3849 · Cited by 57 · see citing works

Mitochondria unite to survive

Blackstone, C. D., & Chang, C. (2011) · Nature Cell Biology · doi:10.1038/ncb0511-521 · Cited by 53 · see citing works

Oxidative Damage in Rat Brain During Aging: Interplay Between Energy and Metabolic Key Target Proteins

Domenico, F. D., Marzia Perluigi, A., Butterfield, D. A., Cornelius, C., & Calabrese, V. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0295-z · Cited by 48 · see citing works

Oxidative stress regulates the ubiquitin–proteasome system and immunoproteasome functioning in a mouse model of X-adrenoleukodystrophy

Launay, N., Ruíz, M., Fourcade, S., Schlüter, A., Guilera, C., Ferrer, I., Knecht, E., & Pujol, A. (2013) · Brain · doi:10.1093/brain/aws370 · Cited by 48 · see citing works

Incidence of Abcd1 level on the induction of cell death and organelle dysfunctions triggered by very long chain fatty acids and TNF-α on oligodendrocytes and astrocytes

Baarine, M., Ragot, K., Athias, A., Nury, T., Kattan, Z., Genin, E. C., Andreoletti, P., Ménétrier, F., Riedinger, J.-M., Bardou, M., et al. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2011.10.007 · Cited by 43 · see citing works

Thyroid Hormone Induction of the Adrenoleukodystrophy-Related Gene (ABCD2)

Fourcade, S., Savary, S., Gondcaille, C., Berger, J., Netik, A., Cadepond, F., El‐Etr, M., Molzer, B., & Bugaut, M. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.6.1296 · Cited by 41 · see citing works

ABCD2 is abundant in adipose tissue and opposes the accumulation of dietary erucic acid (C22:1) in fat

Liu, J., Sabeva, N. S., Bhatnagar, S., Li, X., Pujol, A., & Graf, G. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m900237-jlr200 · Cited by 36 · see citing works

Insulin‐like growth factor‐1 and neurotrophin‐3 gene therapy prevents motor decline in an X‐linked adrenoleukodystrophy mouse model

Mastroeni, R., Bensadoun, J., Charvin, D., Aebischer, P., Pujol, A., & Raoul, C. (2009) · Annals of Neurology · doi:10.1002/ana.21677 · Cited by 27 · see citing works

Mitochondrial abnormalities and intrafamilial variability of sural nerve biopsy findings in adrenomyeloneuropathy

Schröder, J. M., Mayer, M., & Weis, J. (1996) · Acta Neuropathologica · doi:10.1007/s004010050490 · Cited by 23 · see citing works

Characterization of the Adrenoleukodystrophy-Related (ALDR, ABCD2) Gene Promoter: Inductibility by Retinoic Acid and Forskolin

Pujol, A., Troffer-Charlier, N., Metzger, E., Chimini, G., & Mandel, J. (2000) · Genomics · doi:10.1006/geno.2000.6367 · Cited by 23 · see citing works

The absence of ABCD2 sensitizes mice to disruptions in lipid metabolism by dietary erucic acid

Liu, J., Liang, S., Liu, X., Brown, J. A., Newman, K. E., Sunkara, M., Morris, A. J., Bhatnagar, S., Li, X., Pujol, A., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m022160 · Cited by 23 · see citing works

Caffeic acid phenethyl ester induces adrenoleukodystrophy (Abcd2) gene in human X-ALD fibroblasts and inhibits the proinflammatory response in Abcd1/2 silenced mouse primary astrocytes

Singh, J., Khan, M., & Singh, I. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.01.004 · Cited by 21 · see citing works

ABCD2 Is a Direct Target of β-Catenin and TCF-4: Implications for X-Linked Adrenoleukodystrophy Therapy

Park, C., Kim, H.-S., Jang, J., Lee, H., Lee, J. S., Yoo, J., Lee, D. R., & Kim, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056242 · Cited by 14 · see citing works

Dehydroepiandrosterone up-regulates the Adrenoleukodystrophy-related gene (ABCD2) independently of PPARalpha in rodents.

Gueugnon, F., Gondcaille, C., Leclercq, S., Bellenger, J., Bellenger, S., Narce, M., Pineau, T., Bonnetain, F., & Savary, S. (2007) · Biochimie · doi:10.1016/j.biochi.2007.06.013 · Cited by 11 · see citing works

Cyclophilin D: a therapeutic target to counteract reactive oxygen species-mediated damage in neurodegenerative disease?

Fransen, M. (2012) · Brain · doi:10.1093/brain/aws304 · Cited by 6 · see citing works

Untitled work

Forss-Petter, S. (1997) · doi:10.1002/(sici)1097-4547(19971201)50:5

The peroxisome: an update on mysteries 2.0

Islinger, M., Völkl, A., Fahimi, H. D., & Schrader, M. (2018) · Histochemistry and Cell Biology · doi:10.1007/s00418-018-1722-5 · Cited by 287 · see citing works

Peroxisome‐mitochondria interplay and disease

Schrader, M., Costello, J. L., Godinho, L. F., & Islinger, M. (2015) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-015-9819-7 · Cited by 217 · see citing works

X‐linked adrenoleukodystrophy: Pathology, pathophysiology, diagnostic testing, newborn screening and therapies

Turk, B. R., Theda, C., Fatemi, A. S., & Moser, A. B. (2020) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10003 · Cited by 206 · see citing works

Peroxisomes in brain development and function

Berger, J., Dorninger, F., Forss-Petter, S., & Kunze, M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.12.005 · Cited by 194 · see citing works

Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction

van Zutphen, T., Čiapaitė, J., Bloks, V. W., Ackereley, C., Gerding, A., Jurdzinski, A., de Moraes, R. A., Zhang, L., Wolters, J. C., Bischoff, R., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.05.046 · Cited by 190 · see citing works

Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies

Pagano, G., Talamanca, A. A., Castello, G., Cordero, M. D., d’Ischia, M., Gadaleta, M. N., Pallardó, F. V., Petrović, S. Ž., Tiano, L., & Zatterale, A. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/541230 · Cited by 137 · see citing works

N-acetylcysteine Pharmacology and Applications in Rare Diseases—Repurposing an Old Antioxidant

Sahasrabudhe, S. A., Terluk, M. R., & Kartha, R. V. (2023) · Antioxidants · doi:10.3390/antiox12071316 · Cited by 102 · see citing works

Brain energy metabolism spurns fatty acids as fuel due to their inherent mitotoxicity and potential capacity to unleash neurodegeneration

Schönfeld, P., & Reiser, G. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.03.018 · Cited by 99 · see citing works

Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: A paradigm for axonal degeneration

Fourcade, S., Ferrer, I., & Pujol, A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.041 · Cited by 77 · see citing works

Mitochondrial dysfunction in central nervous system white matter disorders

Morató, L., Bertini, E., Verrigni, D., Ardissone, A., Ruíz, M., Ferrer, I., Uziel, G., & Pujol, A. (2014) · Glia · doi:10.1002/glia.22670 · Cited by 75 · see citing works

How the brain fights fatty acids’ toxicity

Schönfeld, P., & Reiser, G. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105050 · Cited by 70 · see citing works

Brain Lipotoxicity of Phytanic Acid and Very Long-chain Fatty Acids. Harmful Cellular/Mitochondrial Activities in Refsum Disease and X-Linked Adrenoleukodystrophy

Schönfeld, P., & Reiser, G. (2016) · Aging and Disease · doi:10.14336/ad.2015.0823 · Cited by 69 · see citing works

Astrocytes and mitochondria from adrenoleukodystrophy protein (ABCD1)-deficient mice reveal that the adrenoleukodystrophy-associated very long-chain fatty acids target several cellular energy-dependent functions

Kruska, N., Schönfeld, P., Pujol, A., & Reiser, G. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.01.005 · Cited by 56 · see citing works

CRISPR/Cas9-mediated knockout of Abcd1 and Abcd2 genes in BV-2 cells: novel microglial models for X-linked Adrenoleukodystrophy

Raas, Q., Gondcaille, C., Hamon, Y., Leoni, V., Caccia, C., Ménétrier, F., Lizard, G., Trompier, D., & Savary, S. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.02.006 · Cited by 53 · see citing works

Autophagy induction halts axonal degeneration in a mouse model of X-adrenoleukodystrophy

Launay, N., Aguado, C., Fourcade, S., Ruíz, M., Grau, L., Riera, J., Guilera, C., Girós, M., Ferrer, I., Knecht, E., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1378-8 · Cited by 51 · see citing works

Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy

Ruíz, M., Jové, M., Schlüter, A., Casasnovas, C., Villarroya, F., Guilera, C., Ortega, F. J., Naudí, A., Pamplona, R., Gimeno, R., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv375 · Cited by 45 · see citing works

The brain penetrant PPARγ agonist leriglitazone restores multiple altered pathways in models of X-linked adrenoleukodystrophy

Rodríguez-Pascau, L., Vilalta, A., Cerrada, M., Traver, E., Forss-Petter, S., Weinhofer, I., Bauer, J., Kemp, S., Pina, G., Pascual, S., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abc0555 · Cited by 40 · see citing works

Functional Characterization of IPSC-Derived Brain Cells as a Model for X-Linked Adrenoleukodystrophy

Baarine, M., Khan, M., Singh, A., & Singh, I. (2015) · PLOS ONE · doi:10.1371/journal.pone.0143238 · Cited by 38 · see citing works

Epigenomic signature of adrenoleukodystrophy predicts compromised oligodendrocyte differentiation

Schlüter, A., Sandoval, J., Fourcade, S., Díaz‐Lagares, Á., Ruíz, M., Casaccia, P., Esteller, M., & Pujol, A. (2018) · Brain Pathology · doi:10.1111/bpa.12595 · Cited by 35 · see citing works

Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy

Morató, L., Ruíz, M., Boada, J., Calingasan, N. Y., Galino, J., Guilera, C., Jové, M., Naudí, A., Ferrer, I., Pamplona, R., et al. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.20 · Cited by 33 · see citing works

ABCD1 and X‐linked adrenoleukodystrophy: A disease with a markedly variable phenotype showing conserved neurobiology in animal models

Manor, J., Chung, H.-L., Bhagwat, P., & Wangler, M. F. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24953 · Cited by 32 · see citing works

N-Acetylcysteine Reverses the Mitochondrial Dysfunction Induced by Very Long-Chain Fatty Acids in Murine Oligodendrocyte Model of Adrenoleukodystrophy

Zhou, J., Terluk, M. R., Orchard, P. J., Cloyd, J. C., & Kartha, R. V. (2021) · Biomedicines · doi:10.3390/biomedicines9121826 · Cited by 30 · see citing works

Combination therapy of lovastatin and AMP ‐activated protein kinase activator improves mitochondrial and peroxisomal functions and clinical disease in experimental autoimmune encephalomyelitis model

Singh, I., Samuvel, D. J., Choi, S., Saxena, N., Singh, A. K., & Won, J. (2018) · Immunology · doi:10.1111/imm.12893 · Cited by 29 · see citing works

Molecular Biomarkers for Adrenoleukodystrophy: An Unmet Need

Honey, M. I. J., Jaspers, Y. R. J., Engelen, M., Kemp, S., & Huffnagel, I. C. (2021) · Cells · doi:10.3390/cells10123427 · Cited by 27 · see citing works

Oxidative Stress in Patients with X-Linked Adrenoleukodystrophy

Deon, M., Marchetti, D. P., Donida, B., Wajner, M., & Vargas, C. R. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0234-2 · Cited by 26 · see citing works

Serum very long-chain fatty acids (VLCFA) levels as predictive biomarkers of diseases severity and probability of survival in peroxisomal disorders

Stradomska, T. J., Syczewska, M., Jamroz, E., Pleskaczyńska, A., Kruczek, P., Ciara, E., & Tylki‐Szymańska, A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0238796 · Cited by 25 · see citing works

The peroxisomal fatty acid transporter ABCD1/PMP-4 is required in the C. elegans hypodermis for axonal maintenance: A worm model for adrenoleukodystrophy

Coppa, A., Guha, S., Fourcade, S., Parameswaran, J., Ruiz, M., Moser, A. B., Schlüter, A., Murphy, M. P., Lizcano, J. M., Miranda-Vizuete, A., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.01.177 · Cited by 23 · see citing works

Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities

Wang, X. M., Yik, W. Y., Zhang, P., Lu, W., Huang, N., Kim, B. R., Shibata, D. K., Zitting, M., Chow, R. H.-P., Moser, A. B., et al. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0149-3 · Cited by 22 · see citing works

Biogenesis and Function of Peroxisomes in Human Disease with a Focus on the ABC Transporter

Imanaka, T. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00723 · Cited by 21 · see citing works

Novel Therapeutic Targets and Drug Candidates for Modifying Disease Progression in Adrenoleukodystrophy

Pujol, A. (2015) · Endocrine development · doi:10.1159/000439340 · Cited by 18 · see citing works

Therapeutic potential of deuterium‐stabilized (R)‐pioglitazone— PXL065 —for X‐linked adrenoleukodystrophy

Monternier, P., Singh, J., Parasar, P., Theurey, P., DeWitt, S. H., Jacques, V., Klett, E. L., Kaur, N., Nagaraja, T. N., Moller, D. E., et al. (2022) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12510 · Cited by 17 · see citing works

X-linked Adrenoleukodystrophy: Pathology, Pathophysiology, Diagnostic Testing, Newborn Screening, and Therapies

Turk, B. R., Theda, C., Fatemi, A. S., & Moser, A. B. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2019.11.002 · Cited by 17 · see citing works

Imbalanced mitochondrial dynamics contributes to the pathogenesis of X-linked adrenoleukodystrophy

Launay, N., Lopez-Erauskin, J., Bianchi, P., Guha, S., Parameswaran, J., Coppa, A., Torreni, L., Schlüter, A., Fourcade, S., Paredes-Fuentes, A. J., et al. (2024) · Brain · doi:10.1093/brain/awae038 · Cited by 14 · see citing works

Loss of AMP‐Activated Protein Kinase Induces Mitochondrial Dysfunction and Proinflammatory Response in Unstimulated Abcd1‐Knockout Mice Mixed Glial Cells

Singh, J., Suhail, H., & Giri, S. (2015) · Mediators of Inflammation · doi:10.1155/2015/176983 · Cited by 14 · see citing works

OXPHOS deficiencies affect peroxisome proliferation by downregulating genes controlled by the SNF1 signaling pathway

Farré, J., Carolino, K., Devanneaux, L., & Subramani, S. E. (2022) · eLife · doi:10.7554/elife.75143 · Cited by 12 · see citing works

Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy

Bougnères, P., & Le Stunff, C. (2025) · Genes · doi:10.3390/genes16050590 · Cited by 11 · see citing works

Peroxisomal disorders

Dasouki, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802896-4.00007-9 · Cited by 10 · see citing works

Beneficial Effects of the Direct AMP-Kinase Activator PXL770 in In Vitro and In Vivo Models of X-Linked Adrenoleukodystrophy

Monternier, P., Parasar, P., Theurey, P., Dagorn, P. G., Kaur, N., Nagaraja, T. N., Fouqueray, P., Bolze, S., Moller, D. E., Singh, J., et al. (2022) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.122.001208 · Cited by 8 · see citing works

Human Disorders of Peroxisome Biogenesis: Zellweger Spectrum and Rhizomelic Chondrodysplasia Punctata

Braverman, N., Argyriou, C., & Moser, A. B. (2014) · Springer eBooks · doi:10.1007/978-3-7091-1788-0_4 · Cited by 7 · see citing works

Nervonic acid, a long chain monounsaturated fatty acid, improves mitochondrial function in adrenomyeloneuropathy fibroblasts

Li, C., Terluk, M. R., & Kartha, R. V. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70044 · Cited by 6 · see citing works

Nutritional status of children affected by X‐linked adrenoleukodystrophy

Moroni, I., Amicis, R. S. D., Ardissone, A., Ravella, S., & Bertoli, S. (2023) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.13173 · Cited by 2 · see citing works

Therapeutic Strategies for X-Linked Adrenoleukodystrophy, a Representative Peroxisomal Disorder

Morita, M. (2019) · Springer eBooks · doi:10.1007/978-981-15-1169-1_8 · Cited by 2 · see citing works

Organellar crosstalk as a potential therapeutic target for rare neurodegenerative diseases

Lam, J., Li, C., Terluk, M. R., & Kartha, R. V. (2025) · Rare Disease and Orphan Drugs Journal · doi:10.20517/rdodj.2024.55 · Cited by 1 · see citing works

Peroxisomal ABCD1 deficiency in mice drives Th1 bias through 25-HC–LXR signaling in CD4+ T cells

Maeda, R., Oishi, M., Nagamori, R., Hikosaka‐Kuniishi, M., Watanabe, S., Lee, J., Morita, M., & So, T. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1722647 · Cited by 1 · see citing works

X-linked adrenoleukodystrophy; Recent Advances in Classification, Diagnosis and Management

정을식, 강훈철, & 고아라 (2016) · Annals of Child Neurology · doi:10.26815/jkcns.2016.24.3.71 · Cited by 1 · see citing works

X-linked adrenoleukodystrophy in Norway Clinical and epidemiological aspects

Horn, M. A. (2016) · NORA - Norwegian Open Research Archives · Cited by 1 · see citing works

网络新技术及其在国外外语教学中的应用——从“网志”到“维基”再到“播客”

王湘云, & 戴丽华 (2007) · Shandong Foreign Language Teaching Journal

Quantitative Myelinbildgebung bei Erkrankungen der weißen Hirnsubstanz im Kindes- und Jugendalter

Preuße, M. (2021) · doi:10.53846/goediss-8458

X-Linked Adrenoleukodystrophy/Adrenomyeloneuropathy

Rizzo, W. B. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.99427-3

The brain penetrant PPARγ agonist leriglitazone restores multiple altered pathways in models of X-linked adrenoleukodystrophy

Rodríguez‐Pascau, L., Vilalta, A., Cerrada, M., Traver, E., Forss‐Petter, S., Weinhofer, I., Bauer, J., Kemp, S., Pina, G., Pascual, S., et al. (2022) · Yearbook of pediatric endocrinology · doi:10.1530/ey.19.8.10

X-linked adrenoleukodystrophy/adrenomyeloneuropathy

Rizzo, W. B., & Baker, C. V. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00109-6

Inactivation génique des transporteurs ABC peroxysomaux ABCD1 et ABCD2 dans les cellules microgliales BV-2 : étude de la physiopathogenèse de l’adrénoleucodystrophie liée à l’X.

Raas, Q. (2018) · theses.fr (ABES) · doi:10.70675/21dd2b17z388az4373z866az5229716abfb1

Preclinical gene therapy using recombinant AAV vectors in mouse models of two human diseases

Günes, Y. Ö. (2022) · theses.fr (ABES) · doi:10.70675/52c9a808z1652z42c4zae82zc812b95f1723

Plasma Very‐Long‐Chain Fatty Acids in X‐Linked Adrenoleukodystrophy: Diagnostic Insights From a Clinical Laboratory Cohort

Molina-Blas, S., Pujalte, S. P., Álvarez, A. M., Álvarez‐Ríos, A. I., Cabello, B. M., Moreno, C. N., Gómez-Gila, A. L., Fuentes, E., Venegas-Moreno, E. M., & Delgado‐Pecellín, C. (2026) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.70269

Mitigating Oxidative Stress in Childhood Cerebral Adrenoleukodystrophy -An Investigation of N-acetylcysteine Pharmacology

Zhou, J. (2014) · University of Minnesota Digital Conservancy (University of Minnesota)

Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy

López-Erauskin, J., Galino, J., Ruiz, M., Cuezva, J. M., Fabregat, I., Cacabelos, D., Boada, J., Martínez, J., Ferrer, I., Pamplona, R., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt186 · Cited by 125 · see citing works

Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: A paradigm for multifactorial neurodegenerative diseases?

Galea, E., Launay, N., Portero-Otin, M., Ruiz, M., Pamplona, R., Aubourg, P., Ferrer, I., & Pujol, A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.02.005 · Cited by 108 · see citing works

Novel Therapeutic Targets and Drug Candidates for Modifying Disease Progression in Adrenoleukodystrophy

Pujol, A. (2015) · Endocrine development · doi:10.1159/000439340 · Cited by 18 · see citing works

Oxidative Damage Compromises Energy Metabolism in the Axonal Degeneration Mouse Model of X-Adrenoleukodystrophy

Galino, J., Ruíz, M., Fourcade, S., Schlüter, A., López‐Erauskin, J., Guilera, C., Jové, M., Naudí, A., García‐Arumí, E., Andreu, A. L., et al. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3877 · Cited by 85 · see citing works

Regulation of lipid and redox metabolism in X-linked Adrenoleukodystrophy (X-ALD): therapeutic implications

Barrenechea, L. G. (2021) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)