Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia
Open accessAbstract
Mitochondrial permeability transition (PT) is a phenomenon induced by high levels of matrix calcium and is characterized by the opening of the PT pore (PTP). Activation of the PTP results in loss of mitochondrial membrane potential, expansion of the matrix, and rupture of the mitochondrial outer membrane. Consequently, PT has been implicated in both apoptotic and necrotic cell death. Cyclophilin D (CypD) appears to be a critical component of the PTP. To investigate the role of CypD in cell death, we created a CypD-deficient mouse. In vitro , CypD-deficient mitochondria showed an increased capacity to retain calcium and were no longer susceptible to PT induced by the addition of calcium. CypD-deficient primary mouse embryonic fibroblasts (MEFs) were as susceptible to classical apoptotic stimuli as the WT, suggesting that CypD is not a central component of cell death in response to these specific death stimuli. However, CypD-deficient MEFs were significantly less susceptible than their WT counterparts to cell death induced by hydrogen peroxide, implicating CypD in oxidative stress-induced cell death. Importantly, CypD-deficient mice displayed a dramatic reduction in brain infarct size after acute middle cerebral artery occlusion and reperfusion, strongly supporting an essential role for CypD in an ischemic injury model in which calcium overload and oxidative stress have been implicated.
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To date, PPIF (CYPD) is the only protein whose in vivo requirement for MPT induction has been formally validated with robust genetic tools.
“To date, peptidylprolyl isomerase F (PPIF; best known as cyclophilin D, CYPD) is the only protein whose in vivo requirement for MPT induction has been formally validated with robust genetic tools (although there is consensus around the notion that CYPD does not constitute the pore-forming unit of the PTPC) [376–379].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [379]
There is consensus that CYPD does not constitute the pore-forming unit of PTPC.
“although there is consensus around the notion that CYPD does not constitute the pore-forming unit of the PTPC) [376–379].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [379]
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- Authors
- Schinzel, A. C., Takeuchi, O., Huang, Z., Fisher, J. K., Zhou, Z., Rubens, J., Hetz, C., Danial, N. N., Moskowitz, M. A., & Korsmeyer, S. J.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2005-08-15
- Volume
- 102
- Issue
- 34
- Pages
- 12005-12010
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1189333
- OpenAlex
- W2088629175
- Cited by
- 820
- References
- 55
- Citations by year
- 2026: 15 · 2025: 10 · 2024: 14 · 2023: 21 · 2022: 31 · 2021: 36 · 2020: 34 · 2019: 33 · 2018: 30 · 2017: 42 · 2016: 45 · 2015: 50 · 2014: 63 · 2013: 41 · 2012: 53
- FWCI
- 15.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Damon Runyon Cancer Research Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Institutes of Health
- National Cancer Institute (R01CA050239, CA50239, R37CA050239)
- National Institute of Neurological Disorders and Stroke (R01NS037141, NS10828, F32NS010828, P50NS010828, P01NS010828, NS 37141)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- cyclophilin D, mitochondrial permeability transition, mitochondrial permeability transition pore, focal cerebral ischemia, neuronal cell death, oxidative stress-induced cell death, hydrogen peroxide, middle cerebral artery occlusion, ischemia-reperfusion injury, brain infarct size, apoptosis, necrosis
- MeSH terms
- Peptidyl-Prolyl Isomerase F, Animals, Calcium, Brain Ischemia, Hydrogen Peroxide, Intracellular Membranes, Mice, Transgenic, Mitochondria, Mitochondrial Swelling, Neurons, Permeability, Spectrophotometry, Apoptosis, Cyclophilins, Microscopy, Electron, Transmission, Voltage-Dependent Anion Channels, Mice
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