The role of TDP1 and APTX in mitochondrial DNA repair
Open accessAbstract
In recent years, our knowledge surrounding mammalian mitochondrial DNA (mtDNA) damage and repair has increased significantly. Greater insights into the factors that govern mtDNA repair are being elucidated, thus contributing to an increase in our understanding year on year. In this short review two enzymes, tyrosyl-DNA-phosphodiesterase 1 (TDP1) and aprataxin (APTX), involved in mitochondrial single strand break repair (SSBR) are discussed. The background into the identification of these enzymes in mtDNA repair is communicated with further deliberation into some of the specifics relating to the import of these enzymes into the mitochondrion. With the discovery of these enzymes in mitochondria comes the probability that other mechanisms underlying mtDNA repair are yet to be fully understood, suggesting there is much left to discover when shaping our understanding of this relatively undefined subject.
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TDP1 protects against oxidative DNA damage and has been implicated in single-strand break repair.
“TDP1 protects against oxidative DNA damage and has been implicated in SSBR [169].”
From Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress (2014) · cites this paper as [169]
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SURVEY AND SUMMARY The current state of eukaryotic DNA base damage and repair
Bauer, N. C., Corbett, A. H., & Doetsch, P. W. (2015)
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- Authors
- Meagher, M., & Lightowlers, R. N.
- Affiliations
- Wellcome Centre for Mitochondrial Research (GB)
- Corresponding author
- Meagher, Martin
- Venue
- Biochimie
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 100
- Pages
- 121-124
- ISSN
- 0037-9042 (ISSN-L)
- 0300-9084
- PMC
- PMC4356151
- OpenAlex
- W2005352968
- Cited by
- 21
- References
- 35
- Citations by year
- 2023: 4 · 2021: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 2
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Biochimie (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity) (cc-by)
- Funders
- Wellcome Trust (096919)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Keywords
- TDP1, aprataxin, mitochondrial DNA repair, single-strand break repair, mitochondrial DNA damage, mitochondrial protein import, tyrosyl-DNA phosphodiesterase, DNA repair enzymes
- MeSH terms
- Animals, Cell Nucleus, DNA Repair, DNA-Binding Proteins, DNA, Mitochondrial, Gene Expression Regulation, Humans, Mitochondria, Nuclear Proteins, Phosphoric Diester Hydrolases, Protein Transport, DNA Breaks, Single-Stranded
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