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Diphenyl diselenide protects endothelial cells against oxidized low density lipoprotein-induced injury: Involvement of mitochondrial function

Hort, Mariana Appel, Straliotto, Marcos Raniel, de Oliveira, Jade, Amoêdo, Nívea Dias, da Rocha, João Batista Teixeira, Galina, Antônio, Ribeiro-do-Valle, Rosa Maria, de Bem, Andreza Fabro·2014·Biochimie
DOI 10.1016/j.biochi.2014.07.004
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Abstract

Elevated levels of oxidized low density lipoprotein (oxLDL) are considered to be one of the major risk factors for atherosclerosis and cardiovascular morbidity. The early stages of atherosclerosis are initiated by the accumulation of oxLDL and the induction of toxic effects on endothelial cells, resulting in endothelial dysfunction. The aim of this study was to investigate how diphenyl diselenide (DD), an organoselenium compound, protect vascular endothelial cells against the toxic effects of oxLDL in vitro. Our data showed that the treatment of bovine endothelial aortic cells (BAEC) with DD (0.1-1 μM) for 24 h protected from oxLDL-induced reactive species (RS) production and reduced glutathione (GSH) depletion. Moreover, DD (1 μM) per se improved the maximal mitochondrial respiratory capacity and prevented oxLDL-induced mitochondrial damage. In addition, DD could prevent apoptosis induced by oxLDL in BAEC. Results from this study may provide insight into a possible molecular mechanism underlying DD suppression of oxLDL-mediated vascular endothelial dysfunction.

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  • In vitro studies previously published by our group using endothelial cells and macrophages demonstrated increased reactive species generation after 1 h of exposure to oxidized LDL.

    “In vitro studies previously published by our group using endothelial cells (Hort et al. 2014) and macrophages (Straliotto et al. 2013) also demonstrated increased reactive species generation after 1 h of exposure to oxidized LDL.”

    From LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models (2026) · cites this paper as Hort et al. 2014

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Metadata

Authors
Hort, M. A., Straliotto, M. R., de Oliveira, J., Amoêdo, N. D., da Rocha, J. B. T., Galina, A., Ribeiro-do-Valle, R. M., & de Bem, A. F.
Venue
Biochimie
Publisher
Elsevier BV
Published
2014-10
Volume
105
Pages
172-181
ISSN
0300-9084
DOI
10.1016/j.biochi.2014.07.004
Cited by
27
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
  • Coordenacão de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
  • Fundação de Apoio a Pesquisa do Estado de Santa Catarina (FAPESC)

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