Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
Open accessAbstract
The PGC-1 family of regulated coactivators, consisting of PGC-1α, PGC-1β and PRC, plays a central role in a regulatory network governing the transcriptional control of mitochondrial biogenesis and respiratory function. These coactivators target multiple transcription factors including NRF-1, NRF-2 and the orphan nuclear hormone receptor, ERRα, among others. In addition, they themselves are the targets of coactivator and co-repressor complexes that regulate gene expression through chromatin remodeling. The expression of PGC-1 family members is modulated by extracellular signals controlling metabolism, differentiation or cell growth and in some cases their activities are known to be regulated by post-translational modification by the energy sensors, AMPK and SIRT1. Recent gene knockout and silencing studies of many members of the PGC-1 network have revealed phenotypes of wide ranging severity suggestive of complex compensatory interactions or broadly integrative functions that are not exclusive to mitochondrial biogenesis. The results point to a central role for the PGC-1 family in integrating mitochondrial biogenesis and energy production with many diverse cellular functions. This article is part of a Special Issue entitled: Mitochondria and Cardioprotection.
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PGC-1α and NCoR1 oppositely regulate several transcription factors, including nuclear respiratory factors, estrogen-related receptors and PPARs.
“In fact, PGC-1α and NCoR1 oppositely regulate several transcription factors, including nuclear respiratory factors, estrogen-related receptors and PPARs (Scarpulla, 2011; Andreux et al, 2013; Mottis et al, 2013).”
From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Scarpulla, 2011
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1 retracted
Wenz, T., Diaz, F., Spiegelman, B. M., & Moraes, C. T. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.006 · Cited by 297 · see citing works
RetractedBrown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139 · see citing works
Self-citationA Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864 · see citing works
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300 · see citing works
Wallace, D. C. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095751 · Cited by 3,185 · see citing works
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546 · see citing works
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491 · see citing works
Gray, M. W., Burger, G., & Lang, B. F. (1999) · Science · doi:10.1126/science.283.5407.1476 · Cited by 1,710 · see citing works
Transcriptional paradigms in mammalian mitochondrial biogenesis and function
Scarpulla, R. C. (2008) · Physiological Reviews · doi:10.1152/physrev.00025.2007 · Cited by 1,666 · see citing works
Self-citationLee, S. S. T., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernández‐Salguero, P. M., Westphal, H., & Gonzalez, F. J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3012 · Cited by 1,655 · see citing works
THE MITOCHONDRIAL ELECTRON TRANSPORT AND OXIDATIVE PHOSPHORYLATION SYSTEM
Hatefi, Y. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.005055 · Cited by 1,650 · see citing works
The mitochondrial genome: structure, transcription, translation and replication
Taanman, J.-W. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00161-3 · Cited by 1,635 · see citing works
Steinberg, G. R., & Kemp, B. E. (2009) · Physiological Reviews · doi:10.1152/physrev.00011.2008 · Cited by 1,633 · see citing works
Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice
Larsson, N.-G., Wang, J., Wilhelmsson, H., Oldfors, A., Rustin, P., Lewandoski, M., Barsh, G. S., & Clayton, D. A. (1998) · Nature Genetics · doi:10.1038/ng0398-231 · Cited by 1,594 · see citing works
Biochemical Adaptations in Muscle
Holloszy, J. O. (1967) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96046-1 · Cited by 1,517 · see citing works
PGC-1 coactivators: inducible regulators of energy metabolism in health and disease
Finck, B. N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27794 · Cited by 1,427 · see citing works
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
Gerhart‐Hines, Z., Rodgers, J. T., Bare, O., Lerin, C., Kim, S., Mostoslavsky, R., Alt, F. W., Wu, Z., & Puigserver, P. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601633 · Cited by 1,294 · see citing works
Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis
Lehman, J. J., Barger, P. M., Kovacs, A., Saffitz, J. E., Medeiros, D. M., & Kelly, D. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10268 · Cited by 1,285 · see citing works
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
Kelly, D. P., & Scarpulla, R. C. (2004) · Genes & Development · doi:10.1101/gad.1177604 · Cited by 1,243 · see citing works
Self-citationDefects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice
Lin, J., Wu, P.-H., Tarr, P. T., Lindenberg, K. S., St-Pierre, J., Zhang, C.-Y., Mootha, V. K., Jäger, S., Vianna, C. R., Reznick, R. M., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.013 · Cited by 1,162 · see citing works
Primary response genes induced by growth factors and tumor promoters.
Herschman, H. (1991) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.60.070191.001433 · Cited by 1,077 · see citing works
Adiponectin and AdipoR1 Regulate PGC-1α and Mitochondria by Ca2+ and AMPK/SIRT1
Iwabu, M., Yamauchi, T., Okada-Iwabu, M., Sato, K., Nakagawa, T., Funata, M., Yamaguchi, M., Namiki, S., Nakayama, R., Tabata, M., et al. (2010) · Nature · doi:10.1038/nature08991 · Cited by 971 · see citing works
Leone, T. C., Lehman, J. J., Finck, B. N., Schaeffer, P. J., Wende, A. R., Boudina, S., Courtois, M., Wozniak, D. F., Sambandam, N., Bernal-Mizrachi, C., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030101 · Cited by 951 · see citing works
Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, C. V., & Semenza, G. L. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.04.001 · Cited by 885 · see citing works
The Mechanism of Action of Thyroid Hormones
Zhang, J., & Lazar, M. A. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.439 · Cited by 718 · see citing works
Gleyzer, N., Vercauteren, K., & Scarpulla, R. C. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.4.1354-1366.2005 · Cited by 711 · see citing works
Arany, Z., He, H., Lin, J., Hoyer, K., Handschin, C., Toka, O., Ahmad, F., Matsui, T., Chin, S., Wu, P.-H., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.03.002 · Cited by 694 · see citing works
Mootha, V. K., Handschin, C., Arlow, D., Xie, X., St. Pierre, J., Sihag, S., Yang, W., Altshuler, D., Puigserver, P., Patterson, N., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401401101 · Cited by 688 · see citing works
Schreiber, S., Emter, R., Hock, M. B., Knutti, D., Cardenas, J., Podvinec, M., Oakeley, E. J., & Kralli, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308686101 · Cited by 657 · see citing works
Uldry, M., Yang, W., St‐Pierre, J., Lin, J. D., Seale, P., & Spiegelman, B. M. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.002 · Cited by 644 · see citing works
Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis
Li, F., Wang, Y., Zeller, K. I., Potter, J. J., Wonsey, D. R., O’Donnell, K. A., Kim, J., Yustein, J. T., Lee, L. A., & Dang, C. V. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.14.6225-6234.2005 · Cited by 615 · see citing works
Handschin, C., Chin, S., Li, P., Liu, F., Maratos-Flier, E., LeBrasseur, N. K., Yan, Z., & Spiegelman, B. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704817200 · Cited by 611 · see citing works
Metabolic adaptations through the PGC‐1α and SIRT1 pathways
Rodgers, J. T., Lerín, C., Gerhart‐Hines, Z., & Puigserver, P. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.034 · Cited by 599 · see citing works
Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors
Giguère, V. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0017 · Cited by 584 · see citing works
Graham, B. H., Waymire, K. G., Cottrell, B. A., Trounce, I. A., MacGregor, G. R., & Wallace, D. C. (1997) · Nature Genetics · doi:10.1038/ng0797-226 · Cited by 556 · see citing works
Lin, J., Puigserver, P., Donovan, J., Tarr, P., & Spiegelman, B. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100631200 · Cited by 552 · see citing works
St‐Pierre, J., Lin, J. D., Krauss, S., Tarr, P. T., Yang, R., Newgard, C. B., & Spiegelman, B. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301850200 · Cited by 543 · see citing works
Davis, A. C., Wims, M., Spotts, G. D., Hann, S., & Bradley, A. (1993) · Genes & Development · doi:10.1101/gad.7.4.671 · Cited by 531 · see citing works
The action of thyroid hormones at the cell level
Tata, J., Ernster, L., Lindberg, O. R., Arrhenius, E., Pedersen, S., & Hedman, R. (1963) · Biochemical Journal · doi:10.1042/bj0860408 · Cited by 528 · see citing works
Nuclear control of respiratory gene expression in mammalian cells
Scarpulla, R. C. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20743 · Cited by 489 · see citing works
Self-citationNuclear Receptor Signaling and Cardiac Energetics
Huss, J. M., & Kelly, D. P. (2004) · Circulation Research · doi:10.1161/01.res.0000141774.29937.e3 · Cited by 472 · see citing works
Regulation of oxidative phosphorylation in the mammalian cell
Balaban, R. S. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.3.c377 · Cited by 446 · see citing works
Wang, J., Wilhelmsson, H., Graff, C., Li, H., Oldfors, A., Rustin, P., Brüning, J. C., Kahn, C. R., Clayton, D. A., Barsh, G. S., et al. (1999) · Nature Genetics · doi:10.1038/5089 · Cited by 435 · see citing works
Genome-wide Orchestration of Cardiac Functions by the Orphan Nuclear Receptors ERRα and γ
Dufour, C. R., Wilson, B. J., Huss, J. M., Kelly, D. P., Alaynick, W. A., Downes, M., Evans, R. M., Blanchette, M., & Giguère, V. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.03.007 · Cited by 418 · see citing works
Direct Coupling of Transcription and mRNA Processing through the Thermogenic Coactivator PGC-1
Monsalve, M., Wu, Z., Adelmant, G., Puigserver, P., Fan, M., & Spiegelman, B. M. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00031-9 · Cited by 395 · see citing works
Scarpulla, R. C. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.006 · Cited by 389 · see citing works
Self-citationMitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance
Ricquier, D., & Bouillaud, F. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00003.x · Cited by 385 · see citing works
Targeted Disruption of Mouse Yin Yang 1 Transcription Factor Results in Peri-Implantation Lethality
Donohoe, M. E., Zhang, X., McGinnis, L. K., Biggers, J. D., Li, E., & Shi, Y. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.7237 · Cited by 375 · see citing works
Andersson, U., & Scarpulla, R. C. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.11.3738-3749.2001 · Cited by 374 · see citing works
Self-citationArany, Z., Lebrasseur, N., Morris, C., Smith, E., Yang, W., Ma, Y., Chin, S., & Spiegelman, B. M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2006.12.003 · Cited by 370 · see citing works
Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor α.
Luo, J., Sladek, R., Carrier, J., Bader, J.-A., Richard, D., & Giguère, V. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.7947-7956.2003 · Cited by 370 · see citing works
Initiation and Beyond: Multiple Functions of the Human Mitochondrial Transcription Machinery
Bonawitz, N. D., Clayton, D. A., & Shadel, G. S. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.11.024 · Cited by 337 · see citing works
Lai, L., Leone, T. C., Zechner, C., Schaeffer, P. J., Kelly, S. M., Flanagan, D. P., Medeiros, D. M., Kovacs, A., & Kelly, D. P. (2008) · Genes & Development · doi:10.1101/gad.1661708 · Cited by 326 · see citing works
Metodiev, M. D., Lesko, N., Park, C. B., Cámara, Y., Shi, Y., Wibom, R., Hultenby, K. R., Gustafsson, C. M., & Larsson, N. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.001 · Cited by 310 · see citing works
Lelliott, C. J., Medina-Gomez, G., Petrovic, N., Kis, A., Feldmann, H. M., Bjursell, M., Parker, N., Curtis, K., Campbell, M., Hu, P., et al. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040369 · Cited by 280 · see citing works
Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis
Hance, N., Ekstrand, M. I., & Trifunovic, A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi184 · Cited by 272 · see citing works
Sonoda, J., Mehl, I. R., Chong, L.-W., Nofsinger, R. R., & Evans, R. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611623104 · Cited by 266 · see citing works
MTERF3 Is a Negative Regulator of Mammalian mtDNA Transcription
Park, C. B., Asin-Cayuela, J., Cámara, Y., Shi, Y., Pellegrini, M., Gaspari, M., Wibom, R., Hultenby, K. R., Erdjument‐Bromage, H., Tempst, P., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.046 · Cited by 266 · see citing works
ERRα: a metabolic function for the oldest orphan
Villena, J. A., & Kralli, A. (2008) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2008.07.005 · Cited by 252 · see citing works
PGC-1β in the Regulation of Hepatic Glucose and Energy Metabolism
Lin, J., Tarr, P. T., Yang, R., Rhee, J., Puigserver, P., Newgard, C. B., & Spiegelman, B. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303643200 · Cited by 242 · cited 2× · see citing works
“Although initially implicated in liver gluconeogenesis [70], PGC-1β was subsequently found to be a poor inducer of gluconeogenic genes in liver and cultured hepatocytes because of its failure to interact with hepatic nuclear receptor 4α (HNF4α) and forkhead transcription factor O1 (FOXO1) [73,74].”
BackgroundHuo, L., & Scarpulla, R. C. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.2.644-654.2001 · Cited by 242 · see citing works
Self-citationThe PGC-1-related Protein PERC Is a Selective Coactivator of Estrogen Receptor α
Kressler, D., Schreiber, S., Knutti, D., & Kralli, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201134200 · Cited by 239 · see citing works
Powelka, A. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26040 · Cited by 236 · see citing works
Orphan nuclear receptor estrogen-related receptor α is essential for adaptive thermogenesis
Villena, J. A., Hock, M. B., Chang, W. Y., Barcas, J. E., Giguère, V., & Kralli, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607696104 · Cited by 215 · see citing works
Fernández-Vizarra, E., Tiranti, V., & Zeviani, M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.05.028 · Cited by 214 · see citing works
Meirhaeghe, A., Crowley, V., Lenaghan, C., Lelliott, C. J., GREEN, K., Stewart, A., Kevin, H. A. R. T., Schinner, S., Sethi, J. K., Yeo, G. S. H., et al. (2003) · Biochemical Journal · doi:10.1042/bj20030200 · Cited by 210 · see citing works
Herzig, R. P., Scacco, S., & Scarpulla, R. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.17.13134 · Cited by 197 · see citing works
Self-citationDhar, S. S., Ongwijitwat, S., & Wong-Riley, M. T. T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707587200 · Cited by 188 · see citing works
Hypomorphic mutation of PGC-1β causes mitochondrial dysfunction and liver insulin resistance.
Vianna, C. R., Huntgeburth, M., Coppari, R., Choi, C. S., Lin, J., Krauss, S., Barbatelli, G., Tzameli, I., Kim, Y.-B., Cinti, S., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.11.003 · Cited by 181 · see citing works
Williams, R. S., Garcia-Moll, M., Mellor, J., Salmons, S., & Harlan, W. R. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61572-8 · Cited by 176 · see citing works
Hallberg, M., Morganstein, D. L., Kiskinis, E., Shah, K., Kralli, A., Dilworth, S. M., White, R., Parker, M. G., & Christian, M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00504-08 · Cited by 164 · see citing works
Goto, H., Motomura, S., Wilson, A. C., et al. (1997) · Genes & Development · doi:10.1101/gad.11.6.726 · Cited by 149 · see citing works
The ETS Transcription Factor GABPα Is Essential for Early Embryogenesis
Ristevski, S., O’Leary, D. A., Thornell, A., Owen, M. J., Kola, I., & Hertzog, P. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.5844-5849.2004 · Cited by 142 · see citing works
The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry
Morrish, F. M., Neretti, N., Sedivy, J. M., & Hockenbery, D. M. (2008) · Cell Cycle · doi:10.4161/cc.7.8.5739 · Cited by 130 · see citing works
c-MYC apoptotic function is mediated by NRF-1 target genesPreprint
Morrish, F. M., Giedt, C. D., & Hockenbery, D. M. (2003) · Genes & Development · doi:10.1101/gad.1032503 · Cited by 123 · see citing works
Valcarce, C., Navarrete, R. M., Encabo, P., Loeches, E., Satrústegui, J., & Cuezva, J. M. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68565-5 · Cited by 113 · see citing works
Vercauteren, K., Pasko, R. A., Gleyzer, N., Marino, V. M., & Scarpulla, R. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00585-06 · Cited by 109 · see citing works
Self-citationXiao, P., & Capone, J. P. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.9.4974 · Cited by 108 · see citing works
Ongwijitwat, S., & Wong‐Riley, M. T. T. (2005) · Gene · doi:10.1016/j.gene.2005.06.015 · Cited by 108 · see citing works
Ramachandran, B., Yu, G.-S., & Gulick, T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707389200 · Cited by 104 · see citing works
Serum- and Polypeptide Growth Factor-Inducible Gene Expression in Mouse Fibroblasts
Winkles, J. A. (1997) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60033-1 · Cited by 101 · see citing works
Minireview: The PGC-1 Coactivator Networks: Chromatin-Remodeling and Mitochondrial Energy Metabolism
Lin, J. D. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0344 · Cited by 101 · see citing works
[39] Use of fibroblast and lymphoblast cultures for detection of respiratory chain defects
Robinson, B. H. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)64041-5 · Cited by 100 · see citing works
Gopalakrishnan, L., & Scarpulla, R. C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42320-9 · Cited by 100 · see citing works
Self-citationVogel, J. L., & Kristie, T. M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.4.683 · Cited by 93 · see citing works
Murdock, D. G., Boone, B. E., Esposito, L., & Wallace, D. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.20.14429 · Cited by 85 · see citing works
Vercauteren, K., Gleyzer, N., & Scarpulla, R. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710150200 · Cited by 83 · see citing works
Self-citationIdentification of the promoter of the human von Hippel-Lindau disease tumor suppressor gene.
Kuzmin, I., Duh, F. M., Latif, F., et al. (1995) · PubMed · Cited by 74 · see citing works
PGC-1-related coactivator and targets are upregulated in thyroid oncocytoma
Savagner, F., Mirebeau‐Prunier, D., Jacques, C., Guyétant, S., Morgan, C., Franc, B., Reynier, P., & Malthièry, Y. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.076 · Cited by 74 · see citing works
Role of RIP140 in metabolic tissues: Connections to disease
White, R., Morganstein, D. L., Christian, M., Seth, A., Herzog, B., & Parker, M. G. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.017 · Cited by 71 · see citing works
Vercauteren, K., Gleyzer, N., & Scarpulla, R. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806434200 · Cited by 70 · see citing works
Self-citationBiogenesis of mitochondrial membrane proteins
Becker, T., Gebert, M., Pfanner, N., & van der Laan, M. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.04.002 · Cited by 70 · see citing works
Mirebeau‐Prunier, D., Pennec, S. L., Jacques, C., Guéguen, N., Poirier, J., Malthièry, Y., & Savagner, F. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07516.x · Cited by 67 · see citing works
Structural Organization and Promoter Analysis of the Bovine Cytochrome c Oxidase Subunit VIIc Gene
Seelan, R. S., & Grossman, L. I. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.10175 · Cited by 62 · see citing works
RIP140 Expression Is Stimulated by Estrogen-related Receptor α during Adipogenesis
Nichol, D., Christian, M., Steel, J. H., White, R., & Parker, M. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604803200 · Cited by 61 · see citing works
Wan, B., & Moreadith, R. W. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.44.26433 · Cited by 56 · see citing works
Basu, A., Lenka, N., Mullick, J., & Avadhani, N. G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.9.5899 · Cited by 53 · see citing works
Xiao, P., & Capone, J. P. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.9.4974-4977.1990 · Cited by 53 · see citing works
Heart mitochondrial DNA and enzyme changes during early human development
Marı́n-Garcı́a, J., Ananthakrishnan, R., & Goldenthal, M. J. (2000) · Molecular and Cellular Biochemistry · doi:10.1023/a:1007031919298 · Cited by 52 · see citing works
Torraco, A., Díaz, F., Vempati, U. D., & Moraes, C. T. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.06.003 · Cited by 37 · see citing works
Effect of thyroid hormone administration on synthesis and degradation of cytochrome c in rat liver
Booth, F. W., & Holloszy, J. O. (1975) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(75)90511-1 · Cited by 32 · see citing works
Raharijaona, M., Pennec, S. L., Poirier, J., Mirebeau‐Prunier, D., Rouxel, C., Jacques, C., Fontaine, J., Malthièry, Y., Houlgatte, R., & Savagner, F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007964 · Cited by 28 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [10]Valcarce C Navarrete RM Encabo P Loeches E Satrustegui J Cuezva JM Postnatal development of rat liver mitochondrial functions J. Biol. Chem 1988 263 7767 7775 2897364
- [12]Williams RS Garcia-Moll M Mellor J Salmons S Harlan W Adaptation of Skeletal Muscle to Increased Contractile Activity J. Biol. Chem 1987 262 2764 2767 2880844
- [70]Lin J Puigserver P Donovan J Tarr P Spiegelman BM PGC-1β: A novel PGC-1-related transcription coactivator associated with host cell factor J. Biol. Chem 2002 277 1645 1648 11733490
Cited by
Sorted by citations
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Vazquez, F., Lim, J.-H., Chim, H., Bhalla, K., Girnun, G., Pierce, K., Clish, C. B., Granter, S. R., Widlund, H. R., Spiegelman, B. M., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2012.11.020 · Cited by 715 · see citing works
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Ivankovic, D., Chau, K., Schapira, A. H. V., & Gegg, M. E. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13412 · Cited by 264 · see citing works
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Jamwal, S., Blackburn, J. K., & Elsworth, J. D. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107705 · Cited by 236 · see citing works
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Wang, Y., Liu, Z., Han, Y., Xu, J., Huang, W., & Li, Z. (2018) · PLOS ONE · doi:10.1371/journal.pone.0191182 · Cited by 62 · see citing works
Zhou, J., Poudel, A., Chandramani-Shivalingappa, P., Xu, B., Welchko, R., & Li, L. (2019) · Endocrine · doi:10.1007/s12020-018-1826-7 · Cited by 59 · see citing works
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Yao, S., Yuan, Y., Zhang, H., Meng, X., Jin, L., Yang, J., Wang, W., Ning, G., Zhang, Y., & Zhang, Z. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.07.028 · Cited by 41 · see citing works
Kemper, M. F., Stirone, C., Krause, D. N., Duckles, S. P., & Procaccio, V. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.11.009 · Cited by 42 · see citing works
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Niu, W., Wang, H., Wang, B., Mao, X., & Du, M. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108804 · Cited by 39 · see citing works
Kemper, M. F., Zhao, Y., Duckles, S. P., & Krause, D. N. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.159 · Cited by 38 · see citing works
Vaughan, R. A., Mermier, C. M., Bisoffi, M., Trujillo, K. A., & Conn, C. A. (2014) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-013-0301-4 · Cited by 34 · see citing works
Li, X., Dong, L., Li, A., Yi, J., Brotto, M., & Zhou, J. (2022) · Biomolecules · doi:10.3390/biom12020333 · Cited by 33 · see citing works
Liu, Y., Guo, C., Liu, S., Zhang, S., Mao, Y., & Fang, L. (2021) · Clinical Interventions in Aging · doi:10.2147/cia.s308893 · Cited by 32 · see citing works
Effects of sulforaphane on brain mitochondria: mechanistic view and future directions
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- Authors
- Scarpulla, R. C.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Scarpulla, Richard C.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 1813
- Issue
- 7
- Pages
- 1269-1278
- ISSN
- 0167-4889 (ISSN-L)
- PMC
- PMC3035754
- OpenAlex
- W2155446034
- Cited by
- 1,281
- References
- 103
- Citations by year
- 2026: 84 · 2025: 84 · 2024: 95 · 2023: 98 · 2022: 89 · 2021: 116 · 2020: 123 · 2019: 105 · 2018: 86 · 2017: 90 · 2016: 69 · 2015: 65 · 2014: 55 · 2013: 58 · 2012: 50
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (GM 32525-27)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- PGC-1α, PGC-1β, mitochondrial biogenesis, transcriptional regulation, NRF1, Nrf2, estrogen-related receptor alpha, chromatin remodeling, AMPK, SIRT1, post-translational modification, energy metabolism, respiratory function
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, ERRalpha Estrogen-Related Receptor, Animals, Gene Expression Regulation, Humans, Mitochondria, Receptors, Estrogen, Transcription Factors, Transcription, Genetic, Trans-Activators, Chromatin Assembly and Disassembly, NF-E2-Related Factor 1, NF-E2-Related Factor 2, Mice, Gene Regulatory Networks, AMP-Activated Protein Kinases, Gene Knockout Techniques
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