Cited by 1,281Adipose Tissue and MetabolismMitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

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Scarpulla, Richard C.·2011·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Abstract

The PGC-1 family of regulated coactivators, consisting of PGC-1α, PGC-1β and PRC, plays a central role in a regulatory network governing the transcriptional control of mitochondrial biogenesis and respiratory function. These coactivators target multiple transcription factors including NRF-1, NRF-2 and the orphan nuclear hormone receptor, ERRα, among others. In addition, they themselves are the targets of coactivator and co-repressor complexes that regulate gene expression through chromatin remodeling. The expression of PGC-1 family members is modulated by extracellular signals controlling metabolism, differentiation or cell growth and in some cases their activities are known to be regulated by post-translational modification by the energy sensors, AMPK and SIRT1. Recent gene knockout and silencing studies of many members of the PGC-1 network have revealed phenotypes of wide ranging severity suggestive of complex compensatory interactions or broadly integrative functions that are not exclusive to mitochondrial biogenesis. The results point to a central role for the PGC-1 family in integrating mitochondrial biogenesis and energy production with many diverse cellular functions. This article is part of a Special Issue entitled: Mitochondria and Cardioprotection.

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Crossref · 10.1016/j.bbamcr.2010.09.019

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  • PGC-1α and NCoR1 oppositely regulate several transcription factors, including nuclear respiratory factors, estrogen-related receptors and PPARs.

    “In fact, PGC-1α and NCoR1 oppositely regulate several transcription factors, including nuclear respiratory factors, estrogen-related receptors and PPARs (Scarpulla, 2011; Andreux et al, 2013; Mottis et al, 2013).”

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  1. [10]Valcarce C Navarrete RM Encabo P Loeches E Satrustegui J Cuezva JM Postnatal development of rat liver mitochondrial functions J. Biol. Chem 1988 263 7767 7775 2897364
  2. [12]Williams RS Garcia-Moll M Mellor J Salmons S Harlan W Adaptation of Skeletal Muscle to Increased Contractile Activity J. Biol. Chem 1987 262 2764 2767 2880844
  3. [70]Lin J Puigserver P Donovan J Tarr P Spiegelman BM PGC-1β: A novel PGC-1-related transcription coactivator associated with host cell factor J. Biol. Chem 2002 277 1645 1648 11733490

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Authors
Scarpulla, R. C.
Affiliations
Northwestern University (US)
Corresponding author
Scarpulla, Richard C.
Venue
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Publisher
Elsevier BV
Published
2011-07
Volume
1813
Issue
7
Pages
1269-1278
ISSN
0167-4889 (ISSN-L)
OpenAlex
W2155446034
Cited by
1,281
References
103
Citations by year
2026: 84 · 2025: 84 · 2024: 95 · 2023: 98 · 2022: 89 · 2021: 116 · 2020: 123 · 2019: 105 · 2018: 86 · 2017: 90 · 2016: 69 · 2015: 65 · 2014: 55 · 2013: 58 · 2012: 50
FWCI
3.92
Type
journal article
Language
en
Open access
Locations
  • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of General Medical Sciences (GM 32525-27)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
PGC-1α, PGC-1β, mitochondrial biogenesis, transcriptional regulation, NRF1, Nrf2, estrogen-related receptor alpha, chromatin remodeling, AMPK, SIRT1, post-translational modification, energy metabolism, respiratory function
MeSH terms
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, ERRalpha Estrogen-Related Receptor, Animals, Gene Expression Regulation, Humans, Mitochondria, Receptors, Estrogen, Transcription Factors, Transcription, Genetic, Trans-Activators, Chromatin Assembly and Disassembly, NF-E2-Related Factor 1, NF-E2-Related Factor 2, Mice, Gene Regulatory Networks, AMP-Activated Protein Kinases, Gene Knockout Techniques

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