The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A brief overview of electroporation pulse strength–duration space: A region where additional intracellular effects are expected
Open accessAbstract
Electroporation (EP) of outer cell membranes is widely used in research, biotechnology and medicine. Now intracellular effects by organelle EP are of growing interest, mainly due to nanosecond pulsed electric fields (nsPEF). For perspective, here we provide an approximate overview of EP pulse strength-duration space. This overview locates approximately some known effects and applications in strength-duration space, and includes a region where additional intracellular EP effects are expected. A feature of intracellular EP is direct, electrical redistribution of endogenous biochemicals among cellular compartments. For example, intracellular EP may initiate a multistep process for apoptosis. In this hypothesis, initial EP pulses release calcium from the endoplasmic reticulum, followed by calcium redistribution within the cytoplasm. With further EP pulses calcium penetrates mitochondrial membranes and causes changes that trigger release of cytochrome-c and other death molecules. Apoptosis may therefore occur even in the presence of apoptotic inhibitors, using pulses that are smaller, but longer, than nsPEF.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mitochondrial membrane permeabilization in cell death
Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598
An approach to electrical modeling of single and multiple cells
Gowrishankar, T. R., & Weaver, J. C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0636434100 · Cited by 204
Second-order model of membrane electric field induced by alternating external electric fields
Kotnik, T., & Miklavcic, D. (2000) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.855935 · Cited by 150 · cited 1×
“The significant differential vulnerability arises from the disparity in cell size, due to membrane-based field amplification (voltage concentration) [32,33].”
Background
Cited by
Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts
Stewart, M. P., Langer, R., & Jensen, K. F. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00678 · Cited by 747
A Review of Basic to Clinical Studies of Irreversible Electroporation Therapy
Jiang, C., Davalos, R. V., & Bischof, J. C. (2015) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2014.2367543 · Cited by 332
Basic Features of a Cell Electroporation Model: Illustrative Behavior for Two Very Different Pulses
Son, R. S., Smith, K. C., Gowrishankar, T. R., Vernier, P. T., & Weaver, J. C. (2014) · The Journal of Membrane Biology · doi:10.1007/s00232-014-9699-z · Cited by 99
Self-citation
Metadata
- Authors
- Weaver, J. C., Smith, K. C., Esser, A. T., Son, R. S., & Gowrishankar, T. R.
- Venue
- Bioelectrochemistry
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 87
- Pages
- 236-243
- ISSN
- 1567-5394 (ISSN-L)
- OpenAlex
- W2093294263
- Cited by
- 285
- References
- 3
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A brief overview of electroporation pulse strength–duration space: A region where additional intracellular effects are expected. https://app.cochat.ai/papers/10.1016/j.bioelechem.2012.02.007
- The paper
- Weaver, J. C., Smith, K. C., Esser, A. T., Son, R. S., & Gowrishankar, T. R. (2012). A brief overview of electroporation pulse strength–duration space: A region where additional intracellular effects are expected. Bioelectrochemistry. https://doi.org/10.1016/j.bioelechem.2012.02.007
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
